Gene OSR1 (Human)

OSR1

Species: Human
Alias: OSR1, OXSR1, KIAA1101
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3p21-p22,

Classification

Group: STE
Family: STE20
Subfamily: FRAY

Sequence

Name Sequence Type Origin Length Description Download
OSR1.NA RNA Sugen Kinome 4525 None Fasta, JSON
OSR1.AA Protein Sugen Kinome 527 None Fasta, JSON
OSR1.kin_dom Protein Kinase Domain Sugen Kinome 275 None Fasta, JSON

Protein domain

Protein domains of OSR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase OSR1.AA FRAY 17-291 78 3.3e-251 789.17 In-house 1-277 (277) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-277/277
Sequence Identity: 78% (217 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQ-TSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGE-HK
||||||||.||||||..|||.|..|..||||||||||| ||||||.||||||.||||||.|.|.|||||..||||||..|..||.|||.|.....|| ||
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEPHK

SGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFG
.||.|| .|||||.|||.||.|.|||||||||.||||||.||||..|||||||||.||||||..|..||.|||||||||||||||||.||||||||||||
QGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLATGGDLSRCCVRHTFVGTPCWMAPEVMEQVHGYDFKADIWSFG

ITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
|||||||||.|||||||||||||||||||||||||...||.|.||||.||.|||. ||||||.|||||.|||.||||
ITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase OSR1.AA STE20 17-291 48 2.6e-156 525.6 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-288/288
Sequence Identity: 48% (145 aa)

YELQEVIGSGATAVVQAAYCAPKKEK----VAIKRINLEKCQ---TSMDELLKEIQAMSQCHHPNIVSYYTSFVVK----DELWLVMKLLSGGSVLDIIK
|||.|.||.|.. .|  ||. | .|.    ||||..|||||.    ......|||. |.||.|||||.||.|....    ||||.|| ...|||..||.|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

HIVAKGE-HKSG-VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLAT--GGDITRNKVRKTFVGTPCWMAPEVMEQV
| . .|  || | ...|. ||.|.||||.||.|||.|..||||.||.||||.|||.|..|||||.| | .  . | |... |.||||||.||||||....
HCMKCGKNHK-GHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPEVIQCM

----RGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL--QNDPPSLE-TGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
     |||.|.||||.||||||.|.|  ||....||.......  ||.|| |. .        .|. ..|. ....|||||||||||| .||.|.|.
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDD-K-----PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase OSR1.AA STE 17-291 35 2e-128 432.95 In-house 1-359 (359) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-359/359
Sequence Identity: 35% (130 aa)

YELQEVIGSGATAVVQAAYCA------PKKEK---------VAIKRINLEKCQ----------------TSMDELLKEIQAMSQCH--HPNIVSYYTSFV
.|..|.||.||. .|  |..       ...|.         .|||..|||.|.                . |...||||. |..|.  ||||| || ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VK-------DELWLVMKLLSGGSVLDIIKHIVAKGE-------HKSGVLDESTIATILREVLEG-LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVS
..       ||||..| ...|||. |||||   .|.       | .....|| ||.|.|..|.| |.|||... ||||.|..||||     | ..||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

AFLATGGDI-----------TRNKVRKTFVGTPCWMAPEVMEQ-----VRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN----------
. |.  ..            |. . |.|||||| ||||||..|     . |||.|.||||.|.|.||.|||  |.|...||........|          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-----DPPSLETGVQDKEM----------LKKYGKSFRKMISLCLQKDPEKRPTAAELLR--HKFF
     .||.|.. ....||           .|. ..|.  |..||||||.||||| .||.  |.|.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase OSR1.AA YSK 17-291 46 6e-111 335.36 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-257/257
Sequence Identity: 46% (129 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKH-IVAKGEHKS
.  ||.|| |   .|  ..    .. |||| |.||.     . . .|||  |||  |.|  || |.     || .|  . |||.|| .|   |       
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYV-------

GVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDIT-RNKVRKTFVGTPCWMAPEVMEQ-VRGYDFKADIWSF
| .||. ||.||||.| ||.|||..  ||||.|| |.|| |.| | ..||||.      | ||   . | |||||| ||||||  | | .||||||||| 
GQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVA------GQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSL

GITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
||||.|.|.|  || .| ||.|. |   | ||.||         ..| |.|   . .|| ||||.||.| ||| ||| 
GITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEG--------RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase OSR1.AA PAKA 17-291 39 1.1e-88 300.93 In-house 1-260 (260) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-260/260
Sequence Identity: 39% (110 aa)

YELQEVIGSGATAVVQAAYCAPKKEK--VAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIV-AKGEH
|.  | || ||.  |  |. .  ...  ||||..|... | ... .. ||  | .|.|.||| |. |..|.||||.||  ..||.  |.|..    .   
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKN-QPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCN-

KSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITR-NKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWS
   ..||. || ..||.| |||..|....||||.|  ||||| |||| |.|||  |       .|. .  |.| |||| ||||||  . . || | ||||
---YMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCA------QLTQEQQKRNTMVGTPYWMAPEVIRR-KQYDEKVDIWS

FGITAIELATGAAPYHKYPPMKVLMLTLQN-DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
 || |||.. |  || ..|| . . |  .|  |. ...         |  ..|..  ..||..|...|..| |||.| |.
LGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDP--------DKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase OSR1.AA S_TKc 17-291 31 5.8e-87 296.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-231/231
Sequence Identity: 31% (91 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSG--GSVLDIIKHIVAKGEHK
||. ..||.|| ..|  ..    ...||||.|.        . ...||| ... |||||| .| .|.  |.|..|| ...|  |...|.||.   .| ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

SGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDF-KADIWSF
  ...| ... ........|||.|..| ||||.|  |||| |   . |.|||....|            .||.||| .|||||.    ||.. |.|.||.
--PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLR-------HKFF
|.. .|...|  |..   ..... . .                     .... .|. |||||||||||| |.|.       | .|
GCILYEMLCGYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase OSR1.AA MST 17-247 41 2.6e-72 229.11 In-house 1-217 (254) Show / Hide 
Range on Protein: 17-247
Range on HMM: 1-217/254
Sequence Identity: 41% (97 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFV--VKDELWLVMKLLSGGSVLDIIKHIVAKGEHK
... | .| |.  .|  | .   .. |||| .. .   . ..|..|||  |.||  ..|| || |.      ..|.||    .|||.||.| |  .    
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN---EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMK-ITQR----

SGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFG
  .| |  ||.||. .| ||.|||.|  |||| ||||||| ..|    ||||||. |     . ..  | |..|||.|||||| ... .|| |||||| |
--TLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQL-----TDTMAKRNTVIGTPYWMAPEVIQEI-KYDCKADIWSLG

ITAIELATGAAPYHKYPPMKVLMLTLQNDPPSL
|||||.| |  ||.   || .. .  |. ||..
ITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTF
Kinase OSR1.AA KHS 17-291 41 4.7e-72 241.62 In-house 1-258 (258) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-258/258
Sequence Identity: 41% (116 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG
|||   .|||    |  |     .| .|.| | .|  .  .  . .||  | .|.|||||.|. |.. .| ||..|    |||. ||         |  |
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKME-PGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIY--------HVTG

VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEV--MEQVRGYDFKADIWSFG
 | |  || . ||.|.||.||| .|..|||.|  |||| ..| |..||||||| ..    | .   || |.||| ||||||  .|.  ||.   |||. |
PLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITAT--IAK---RKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVG

ITAIELATGAAPYHKYPPMKVLMLTLQND--PPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
|||||||    |     ||..|.|  . .  || |    .||.   |. ..| . . ..| |.| |||||  ||.|.|.
ITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL----KDKH---KWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase OSR1.AA Pkinase 17-291 28 1.9e-69 241.85 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLK---EIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGG----SVLDIIKHIVA
|.. ..||||. ..|  ..     ..||.|.|....   ..|. .    ||| |  ..||||| .| .|  ||....|| .. ||    .  |.|.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

KGEHKSGVL--DESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSV----QIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRG
   ...|..  .| ..  .....|.||||.|..| ||||.|  |||. ..| .     |.|||.....     . .|   .||.||| .|||||    ..
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YDFKADIWSFGITAIELATGAAPYHKY------PPMKVLMLTLQNDPPSLETGVQD------------KEMLKKYGKSFRKMISLCLQKDPEKRPTAAEL
|. |.|.||.|.. .|...|  |.          .|... .... .... .    .            ..  ..  ..... |. ||.|||.|||||...
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LRHKFF
| |..|
LQHPWF
Kinase OSR1.AA SLK 17-291 37 7.8e-68 227.9 In-house 1-259 (259) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-259/259
Sequence Identity: 37% (105 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG
.|.   .| ||   |. |    .|   | | |.... .  ... . ||. .|.|.|||||  | .. . ..||...    || |  |.  .         
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKD-EEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEH-------

VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVM--EQVRG--YDFKADIWS
.| |. |. . ....|.|..||.|  ||||.||||||.  || |..||||||| .      |..| | ||.||| ||||||.  | ..   ||.||||||
PLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKH----TMQK-RDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWS

FGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
.||| ||.| .  |.|   ||.||.   . .|| ||.         .. |.|. ..  ||.|||..|.|.|.|..|...
LGITLIEMAQMEPPHHEMNPMRVLLKIQKSEPPTLEQPS-------HWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase OSR1.AA TAO 17-291 36 6.8e-64 207.5 In-house 1-254 (254) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-254/254
Sequence Identity: 36% (102 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHK
..  . || |.   |  |...  .| ||||...    |.    ....||.. . | .|||.. |   ..     ||||     ||  ||.  .  |.   
FQDLREIGHGSFGAVYFARDKHTEEVVAIKKMSYSGKQSHEKWQDIIKEVRFLQQVKHPNCIEYKGCYLREHTCWLVMEYCL-GSASDIL-DVHKKP---

SGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEV---MEQVRGYDFKADIW
   . |  || | ...|.||.|||.  .||||.||||||| |.| |..||||  .. .           ..||||| ||||||   |.  . || |.|.|
---MQEVEIAAICHGALQGLRYLHSHKMIHRDIKAGNILLTEHGQVKLADFGSASMVCPA---------NSFVGTPYWMAPEVILAMDEGQ-YDGKVDVW

SFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
| ||| ||||    |.     |  |    |||.|.|.         ... ..|.. .  |||| |..||.|.|.|||.| 
SLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQ--------QNEWSDCFHQFVDKCLQKMPQERPSAEECLRHEFV
Kinase OSR1.AA PAKB 15-291 38 1.7e-62 213.93 In-house 2-252 (252) Show / Hide 
Range on Protein: 15-291
Range on HMM: 2-252/252
Sequence Identity: 38% (108 aa)

DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELL-KEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEH
|.|     || | | .| .|. .  .  ||.|. .| | |    |||  |.  | . .|||||  | |. | |||| ||  . ||.  ||. |       
DNY---VKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQ--RRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTR-----

KSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSF
    ..|  |||. | ||. |.|||  | ||||.|   ||| .|| |   |||  | .    .. .   ||  |||| ||||||      |. ..||||.
----MNEEQIATVCRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK--EVPK---RKSLVGTPYWMAPEVISRLP-YGTEVDIWSL

GITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
||  ||.  |  ||   ||.. .     . || |         . |   . | ... .| .||..| ||.||||| |.
GIMVIEMVDGEPPYFNEPPLQAMKRIRDMHPPRL-------KNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase OSR1.AA Pkinase_Tyr 17-236 26 8.2e-31 104.98 Pfam 1-225 (270) Show / Hide 
Range on Protein: 17-236
Range on HMM: 1-225/270
Sequence Identity: 26% (61 aa)

YELQEVIGSGATAVVQAAYCA----PKKEKVAIKRINLEKCQTS---MDELLKEIQAMSQC-HHPNIVSYYTSFV-VKDE--LWLVMKLLSGGSVLDIIK
 .. ...|.||  .|  ...      .| .||.| .  |..  .   ......|.. |.|  ||||||..|   .  ..   ...|| .  .|. ||  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYD
       .  . |. ...  . ... .|.|||. .. ||||. | |.|..|.. | |.||| .  . .  |    ..|.       |||||..   . . 
KHR----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGK-FT

FKADIWSFGITAIELAT-GAAP-YHKYPPMKVL
 | |.||||..  |. | |. | |   ..  |.
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVY
Kinase OSR1.AA TyrKc 17-291 24 1.8e-28 101.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-291
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQC--HHPNIVSYYTSFVVK-------DELWLVMKLLSGGSVLDII-KH
 .| ...|.||  .|  .      ..||.| .. ..    . ....|.. |..   ||||||  |   . .       . |..|| . ..|. .| . ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

IVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATG------GDITRNKV--RKTFVGTPCWMAPEVM
           |  ..   .   . .| ||||... ||||  | |.|.||.. | |.||| | ..  .      .|  | |    . ..    |||||..
RPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EQVRG-YDFKADIWSFGITAIELATGAAPYHKY-----PPMKVLMLTLQND--PPSLETGVQDKEML---KKYGKSFRKMISLCLQKDPEKRPTAAELLR
    | . .| |.||||..  |. |  .. .        . . ..  ...   .|  . .    . .       . .. ... | . |||.||| .|.  
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--

HKFF
|..|
HECF
Kinase OSR1.AA MST 268-291 54 1.2e-12 36.4 In-house 231-254 (254) Show / Hide 
Range on Protein: 268-291
Range on HMM: 231-254/254
Sequence Identity: 54% (13 aa)

ISLCLQKDPEKRPTAAELLRHKFF
.. ||||.||.|.|| .|| | |.
VCKCLQKNPEQRWTAEQLLQHPFI
Kinase OSR1.AA Pkinase_Tyr 266-291 34 0.052441 7.42 Pfam 247-270 (270) Show / Hide 
Range on Protein: 266-291
Range on HMM: 247-270/270
Sequence Identity: 34% (9 aa)

KMISLCLQKDPEKRPTAAELLRHKFF
... .| ..|||.||| .|.  | ..
DLMKQCWHYDPEDRPTFSEI--HEQL
FRWNK_Fray OSR1.AA FRWNK_Fray 431-527 70 1.8e-68 233.76 In-house 1-97 (97) Show / Hide 
Range on Protein: 431-527
Range on HMM: 1-97/97
Sequence Identity: 70% (68 aa)

KIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
. ||.||||.||.||||||||||||||.|||||..|||.|||||||||||||||||||....||...||||.|.||......||...||||||.||.
QPPINLVLRMRNQKKELNDIRFEFTPGKDTAEGIAQELVSAGLVDGRDLVIVAANLQKLIDNPQTMKSVTFQLNSGCQPNEVPDEKALIGFAQISIH
OSR1_C OSR1.AA OSR1_C 434-465 42 4.8e-13 51.04 Pfam 1-38 (38) Show / Hide 
Range on Protein: 434-465
Range on HMM: 1-38/38
Sequence Identity: 42% (16 aa)

ISLVLRLRNSKK------ELNDIRFEFTPGRDTAEGVS
|.|.||.|..||      |...|.|||....||.|.|.
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
FRWNK_Wnk1 OSR1.AA FRWNK_Wnk1 439-499 27 0.000323 12.57 In-house 32-92 (92) Show / Hide 
Range on Protein: 439-499
Range on HMM: 32-92/92
Sequence Identity: 27% (17 aa)

RLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSV
.|.   |. . | | |   .|..| | || .  |..   |  |||   .. |   . .|  
KLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER