Gene p38d (Human)

p38d

Species: Human
Alias: PRKM13, p38d, P38DELTA, MGC99536, MAPK13, SAPK4, p38delta
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6p21.1-p21.3,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38d.NA RNA Sugen Kinome 1888 None Fasta, JSON
p38d.AA Protein Sugen Kinome 365 None Fasta, JSON
p38d.kin_dom Protein Kinase Domain Sugen Kinome 284 None Fasta, JSON

Protein domain

Protein domains of p38d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38d.AA p38 25-308 66 1.5e-220 739.0 In-house 1-289 (289) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-289/289
Sequence Identity: 66% (193 aa)

YVSPTHVGSGAYGSVCSAIDKRSGEK---VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTP-ASSLRNFYDFYLVMPFMQTDLQKIMGM
|.....|||||||.||.|.|.|.|.|   ||||||.|||||||.|||.|||| |||||.|||||.||||||| |.|...| |.|.|..||..||..|| .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

E-FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG
. .|...||.||||.|.|||||||||..||||||.|.||||||||.|||||||||.|.||||||.||||||||..|.||||.||||||||||||||..||
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

KTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF
.|||.|.|..|||..|.||.|.| .||.||.....|..||||.||.||.||...|..|.|||.||||||||||.|||.||..|..||.|
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38d.AA MAPK 25-308 52 1.3e-193 649.55 In-house 1-328 (328) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-328/328
Sequence Identity: 52% (172 aa)

YVSPTHVGSGAYGSVCSAIDKR------SGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QHENVIGLLDVFTP-----ASSLRNFYDFYLVMPFMQT
|.    .|.|||| ||||||||      .|.||||||.|||||.....||.|||. ||.|. .|||.|.|||.|||     ..|| .| |.|.||..|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLQKIMG-ME-FSEEKIQYLVYQMLKG--LKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE-----------------MTGYVVTRWYRAP
||..|.  .   |.. |||..||.|.|  |||||||.|.||||||.|..|||.|.|||.||||||..| |                 ||.||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILS--WMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN-DKAAKSYIQSL---PQTPRKDFTQLFPR----ASPQ
|..|.  ||||...||.||||||.||||| .|.||.||||.||...|..|.| |  ||.|..  ...|..|||||   |..|.|.....||     |.||
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AADLLEKMLELDVDKRLTAAQALTHPFF
| |||||||..| |||.|...|| ||.|
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38d.AA ERK 25-308 48 1.5e-146 493.12 In-house 1-307 (307) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-307/307
Sequence Identity: 48% (150 aa)

YVSPTHVGSGAYGSVCSAIDKR-----SGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM
|     .| |||| |||||||      .|.|||||| ...|  .|..||..||. ||.|   |||.|.|.|.. | |.  .. | |.| ..|.|||..| 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

GME--FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA-----------EMTGYVVTRWYRAPEVILSWMHYNQTVD
  .   |.. .||..||.| ||||||||.|.||||||.|. ||..| ||| ||||||  ||            ||.||.||||||||..|||  |.. .|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP-GTEFVQKLNDKAAKSYIQSLPQ--TPRKDFTQLFPRAS--PQAADLLEKMLELDVDKRLTAA
|||.|||.|||| .|.||.||||..|...|....| | . | .|.  .. |. || .||    | |..  .||.|.  ||| |||||||. | |||.|..
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

QALTHPFF
..| ||.|
ECLEHPYF
Kinase p38d.AA CMGC 25-308 28 5.5e-142 469.88 In-house 1-513 (513) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-513/513
Sequence Identity: 28% (148 aa)

YVSPTHVGSGAYGSVCSAIDKRSG--------------EKVAIKKLSRPFQSEIFAK----------RAYRELLLLKHMQ-----------------HEN
|     .|.|.|| |....|||..              |.|||||...||  |. ||          ||.||. .|||..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFTPASSLRN-----------FYDFYLVMPFMQTDLQKIMGM-----------EFSEEK------------IQYLV------YQMLKGLK--YI
...|.|.|..  | .|           |...|||. .|..|| ... .           ..|| .            |.|..      ||.|.|||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--VVHRDLKPGNLAVNEDCEL--------------------KILDFGLARHADAE------------------------MTGYVVTRWYRAPEVIL
||..  ..|||||| |. .|..|||                    || ||||||. . .                        .| |||||||||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SW---------MHYNQTVDIWSVGCIMAEMLTG--------KTLFK-----------GKDYLDQLTQILKVTGVP----------------GTEFVQKLN
.|         |||....|.||||||.|||.||        |.||.           ||...||| .| || | |                  |. ....
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------DKAAKSYIQS---LPQTPRKDFTQLFPR-----------------------------------ASPQAADLLEKMLELDV
                    .. |. ||||   .|. |.|....|||.                                   ..||| |||.|||..| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRLTAAQALTHPFF
|||.||.||| ||.|
DKRITAEQALQHPYF
Kinase p38d.AA JNK 25-275 44 3.4e-116 392.33 In-house 1-261 (309) Show / Hide 
Range on Protein: 25-275
Range on HMM: 1-261/309
Sequence Identity: 44% (117 aa)

YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP--FQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG---
|.    .|.|| | ||.| |  ....|||||..||  ||    .||||||. ..|. .|.|.|... .|||. .|  | |.|.|| .|   |  .     
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

MEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTRWYRAPEVILSWM-HYNQTVDIWSVGCIMAEM
||   | . ||.|||. | |. ||.|. |||||| |  ||.|| |||.|||.|| .|    || |||||.|||||||.  |  |   |||||||||||||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

LTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL---PQTPRKDFTQLFP
.... ||.|||. || ..| .. | |. .| ..... ..  |. ..   |. .   | ..||
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPHVRN-YVENRNMDPYYQPYNFHEHFP
Kinase p38d.AA ERK5 25-308 43 6.4e-109 368.16 In-house 1-295 (295) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-295/295
Sequence Identity: 43% (129 aa)

YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME--F
|    ..| |||| ||||. .. |..|||||.   |     ||| .||| .|.| .|.|.| . |.  |   .  . | | |.  |  || .|.  .  |
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA--------EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMA
. | | | .||.|.||||.||| |.|||||| || ||| ||||| |||.||             || || ||||||||...|   | | .|.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS-LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF
||.. . .| || |..||  |..| |.| .  .|       . |.|. .|.   ||. ...|.| .|| ||| .||  .  .|.|...|| ||| 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38d.AA ERK1 25-308 47 1.4e-104 353.79 In-house 1-289 (289) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-289/289
Sequence Identity: 47% (137 aa)

YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFS
|.    .| |||| ||||.|.. ...|||||.| ||    . .|  ||. .|.  .|||.|.. |.   |... .. | |.|   | ||| |..   . |
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML
 . | | .||.|.|||||||| |.|||||| || .|  |.||| |||||| || |      .| || ||||||||..|    | . .||||||||.||||
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

TGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF
  . .| || |||||  || | | |  . .. .  . |..|.||||  |.  . .|||.| ..| |||.|||    .||.|  .|| ||. 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38d.AA ERK7 25-308 39 8.1e-98 331.27 In-house 1-292 (292) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-292/292
Sequence Identity: 39% (116 aa)

YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMG-MEF
|     .| |||| |  |.|||... ||.||    |. .. | | .|| ..|. .. |.|.| |..|.       |  |.|||  || |||  .    . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR----ADNDRDIYLVFEFMETDLHAVIRKGNI

SEE-KIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAE--------MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCI
 ..   || .||.|. .||.||. |.|||||| |. .. .| .|. ||||||  |. |        .| || ||||||||. |.  .| . || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF
..|||.|| .| |   ..|. .||.... |  | .. .. . | . .....|..|| . |..| ....| ||| ..| .  .||||| ||| ||. 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase p38d.AA S_TKc 25-308 30 1.3e-97 331.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-231/231
Sequence Identity: 30% (91 aa)

YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT---DLQKIMGME
|    ..|.||.|.|. ...|..|..||||...         ....||. .||. .|.|.. |.|||          ..|.|| .. .   || ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

--------FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQ-TVDIWSVGCI
        |.|  .....||....|.|.|| |..|||||| |. ..|  ..|| ||||||.     | ...|.||.||||.    .|.   .|.||.|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT-------H
..|||.|...|       |. ...|. |                                     ||.| |...|.|. | .||.|| .||.       |
LYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PFF
|.|
PWF
Kinase p38d.AA CDK 25-308 36 4e-91 291.79 In-house 1-284 (284) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-284/284
Sequence Identity: 36% (116 aa)

YVSPTHVGSGAYGSVCSAIDKRSG-----EKVAIKKLSRPFQ-----SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNF-----YDFYLVMPF
|     .| |.|| |  |.||..|     . ||.||.    .      | |   | ||  |||.. |.|.. |.||..  .. ||.       .|.|...
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE-----LKILDFGLARHA---------DAEMTGYVVTRWYRAPEVIL
| .|| |.|        |. . .|.|.|| |.|| ...|||||| |. .|.. |     ||| ||||||             ..|  |||.||||||. |
MDHDLKKYMD-------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLL

SWMHYN--QTVDIWSVGCIMAEMLT---GKTLFKGKDYLDQLTQILKVTGVPGTEF---VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEK
   ||.   ..|.||||||.|||.|   .| || |.  .|||  | .. | |  .    | || |                              |||.|
GSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------------DLLNK

MLELDVDKRLTAAQALTHPFF
|| .| .||..| ||| ||.|
MLCYDPKKRISAEQALQHPYF
Kinase p38d.AA Pkinase 25-308 30 7.1e-90 309.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR--ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-----DLQ-K
|.    .|||..|.|. ...| .|..||.|..... ... . ... |  |. ..|...|.|.. |.|.|.         . |.||....      ||   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IM---GMEF--SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCEL----KILDFGLAR---HADAEMTGYVVTRWYRAPEVILSWMHYNQTV
|.   .  |  ||. ..  .||.|.||.|.|| |..|||||| |. .......    || |||||.   .   .||....|.||.|||||..  .| . |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVGCIMAEMLTGKTLFKGK----DYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAA
|.||.|||..|||.|...|.|.    . .||.  | .. | |  .  ......   . ..  . .  . .. . ...|. . |.....|..|  ||.||.
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

QALTHPFF
|.| ||.|
QILQHPWF
Kinase p38d.AA MAPK-Unclassified 25-173 44 6.4e-65 221.99 In-house 1-157 (575) Show / Hide 
Range on Protein: 25-173
Range on HMM: 1-157/575
Sequence Identity: 44% (70 aa)

YVSPTHVGSGAYGSVCSAIDKRS-GEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRN--FYDFYLVMPFMQT---DLQKIM
|     .||||||.|| |.||.. . .|||||. . |. .. .||. ||. .| .. |.|.| . |.|..  .| |  | | |.|| .|||   || .| 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNK-ELHNQEFDDIYIVMDYMQTSLFDLHQII

GMEF---SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR
       ... |||. || |.||||.|||...|||||| || .|.|| ..| |||..|
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38d.AA MAPK-Unclassified 178-308 34 2.4e-44 153.65 In-house 404-575 (575) Show / Hide 
Range on Protein: 178-308
Range on HMM: 404-575/575
Sequence Identity: 34% (60 aa)

EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG-----------KTLFKGKD--------------------YLDQLTQILKVTGVPGTEF
.||.||||||||||| .||   |   |||||.||| |||.             . ||.|.|                    . ||.  |. . | |  | 
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP----------QAADLLEKMLELDVDKRLTAAQALTHPFF
 .   .  |. ||||. . .. .||.|.. . |          .. |.. |||  .  || || ||| ||.|
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38d.AA TyrKc 25-308 20 1.8e-13 -5.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM--QHENVIGLLDVFTPASSLRNF---YDFYLVMPFMQT-DLQKIM
 .     |.||.| |. .. |   ..||.|.|          .  .||. ....   .|.|.. |. | |  .  |||      ..|| .|   ||..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQG--RNFMYIEPLMIVMEYMPHGDLKDYL

-GME--FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE-----MTGYVV------TR------WYRAPEVILSWM
   .  .. ..  .  .|  .|  |.|| ...||||   |  |.|.   || ||||.|  . .      . | .      ..      |. |||.|    
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

HYNQTVDIWSVGCIMAEMLT-GKTLFKG----KDYLDQLTQILKVTGVPGTEFV----QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKML
 ..   |.|| |  | |..| |..   |    .   ... . .|  . .                                   |.....   .. ..  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCW

ELDVDKRLTAAQALTHPFF
. | ..| | ..   | .|
HEDPEDRPTFSEI--HECF
Kinase p38d.AA JNK 280-308 41 0.000105 13.54 In-house 281-309 (309) Show / Hide 
Range on Protein: 280-308
Range on HMM: 281-309/309
Sequence Identity: 41% (12 aa)

QAADLLEKMLELDVDKRLTAAQALTHPFF
.| ||| .||  . |.|.   .|| ||  
MARDLLFRMLVINPDDRISVDDALQHPYI
Kinase p38d.AA Pkinase_Tyr 32-111 26 0.000667 13.84 Pfam 8-90 (270) Show / Hide 
Range on Protein: 32-111
Range on HMM: 8-90/270
Sequence Identity: 26% (23 aa)

GSGAYGSVCSAIDK----RSGEKVAIKKLSRPFQSEI-FAKRAYRELLLLKHM-QHENVIGLLDVFT-PAS-SLRNFYDFYLVMPFMQ
|.||.|.|. .. |      . .||.|.|     .|  . .   ||. ..|.. .|.|.. |. | |     .       |.||..|.
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMP
Kinase p38d.AA Pkinase_Tyr 136-221 34 0.015742 9.19 Pfam 122-213 (270) Show / Hide 
Range on Protein: 136-221
Range on HMM: 122-213/270
Sequence Identity: 34% (33 aa)

KGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA-DAEMTGYVVT-------RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKT
||. | .| . .||||   |  |.|.   || ||||||   . .   |...       .|. |||.|     ..   |.|| |  | |..| |..
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQ