Gene PCTAIRE1 (Human)

PCTAIRE1

Species: Human
Alias: PCTK1, PCTGAIRE, FLJ16665, PCTAIRE, PCTAIRE1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Xp11.23,

Classification

Group: CMGC
Family: CDK
Subfamily: PCTAIRE

Sequence

Name Sequence Type Origin Length Description Download
PCTAIRE1.NA RNA Sugen Kinome 3034 None Fasta, JSON
PCTAIRE1.AA Protein Sugen Kinome 570 None Fasta, JSON
PCTAIRE1.kin_dom Protein Kinase Domain Sugen Kinome 282 None Fasta, JSON

Protein domain

Protein domains of PCTAIRE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PCTAIRE1.AA PCTAIRE 239-520 82 2e-247 828.29 In-house 1-291 (291) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-291/291
Sequence Identity: 82% (240 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVK
|||||||||||||||||..|||||||||||||||||||||||||||||||||||||||||||||||||...|||||||.|.|||||.||||||.||||||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG
|||||||||||||||.|.||||||||||||||||||||||||||||||.||||||.|||||||||||.|.|||||||||||||||||||||.||||||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

ST------VEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLD---SDGADLLTKLLQFEGRNRISAEDAMKHPFF
||      |..|||.||||||||.|.||||. |||||.|||.|.||...|..||||||   ....||||.|||.|..||.|||.|||||.|
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase PCTAIRE1.AA PFTAIRE 239-520 62 4.5e-197 661.01 In-house 1-287 (287) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-287/287
Sequence Identity: 62% (178 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVK
| ||.|||||.|||||||.|...  .||||||||. |||.|.|||||.||||.|||||||.|||||||.. ||.||||...||.||.| . . ....||.
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG
||||||||||.|||...||||||||||||| . |||||||||||||||.|..|||.|||||||||||.|||||.|||..||||||||| || .|.|.|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

S-TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYP--KYRAEALLSHAPRLD--SDGADLLTKLLQFEGRNRISAEDAMKHPFF
  .. .||  ||..||||||.||||. .  ..| .  .   |. . |    ||..   .. ||..|.|| |.|.|.||..||.||.|
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase PCTAIRE1.AA CDK5 239-520 60 2.6e-182 581.38 In-house 1-287 (287) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-287/287
Sequence Identity: 60% (173 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNV
| |..|.|||||.||||.. | |  .||||..||. | || |.|||||..||| ||| ||| |||.||.|| ||||||..|.||| |.|.|.  ..|| .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMA-TGRPLF
| |..|||.|||.|| ..|||||||||||||| .|||||||||||||  || ..|| |||||||||||.|.||  ||| |||| .|||| ||| .|||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK--TYNYPKYRAEA-LLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF
||. ||.||  ||.|.|||.|..||.|    ..|    .||.| |.  . .. |.||. | ||| |.||..   ||||..|..||.|
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PCTAIRE1.AA CDK 239-520 47 4.7e-180 580.94 In-house 1-284 (284) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-284/284
Sequence Identity: 47% (153 aa)

YIKLDKLGEGTYATVYKGKSKLTD-----NLVALKEIRLEH-----E-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTE-----------KSLTLVFEY
| ||.|.|||||..|||...|.|.     ..||||.||.|.     | || |.|||||.||||.| |.|||.|||..||.           ..|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGE-----LKLADFGLARAKSI------PTKTYSNEVVTLWYRPPD
.| |||.|.|          .| ...||||||.|||.....||||||||.|||..||     ||.||||||||..|      |..||..||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

ILLGSTDYS--TQIDMWGVGCIFYEMAT---GRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKL
.||||..||  |.||||.|||||.||.|   ..|||||..  .||. ||||.|||||..|||. .  ..                         ||| |.
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LQFEGRNRISAEDAMKHPFF
|...  .|||||.|..||.|
LCYDPKKRISAEQALQHPYF
Kinase PCTAIRE1.AA CDC2 239-520 49 1.5e-158 491.25 In-house 1-301 (301) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-301/301
Sequence Identity: 49% (150 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGA---PCTAIREVSLLKDLK-HANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLD-DCG--NI
| |. |.|||||  |||.| . |. .|||| ||||.|.     | ||||| |.||.|| | |||.|||.||  ..| .|||||| |||.|.|   .    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

INMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYS--NEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEM
.  ..|| ...|.|.|...||.....||||||||.||.. |..|.|||||||| .|| .||    ||||||||.| ||||. .||| .||| .||||.||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPR---------LDSDGADLLTKLLQFEGRNRISAEDAMKH
   .| .|||.|    .||  ||||||||.|.||||. .. ..|.  .|....  | .. |.         || .| ||| ..|| .  .||||..|..|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PFF
|.|
PYF
Kinase PCTAIRE1.AA CMGC 239-520 26 3.9e-142 470.35 In-house 1-513 (513) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-513/513
Sequence Identity: 26% (135 aa)

YIKLDKLGEGTYATVYKGKSKLTD--------------NLVALKEIRLE----------HEEGAPCTAIREVSLLKDLK-----------------HANI
| ...|.|||||..|||.. |.|.              ..||.| |...          ...| |..|.||...|| |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTLHDIIHTEK-----------------SLTLVFEYLDKDLKQYLDDCG------NIINM-------------HNVKLFL------FQLLRGLA--YCHR
|.|.||.....                 .| |||||.|.||.||....       . ...             ||.| |.      .|.||||.  |||.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

QK--VLHRDLKPQNLLINERGEL--------------------KLADFGLARAKSIP---------------------TKTYSNEVVTLWYRPPDILLGS
..  ..||||||.|.|||...||                    |..||||||. ...                     ...|...|||.|||.| ||||.
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

TDYS---------TQIDMWGVGCIFYEMATG--------RPLFPGSTV-----------EEQLHFIFRILGTPT---------------EETWPGILSNE
..|.         |.||||.|||||.|| ||        .|||||..             .||. ||..|||||               ||.||..... 
KHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLP

EFKT-------------YN------------YPKYRAEALLSHAPR-----------------------------------LDSDGADLLTKLLQFEGRN
....             ..            .|...   . .  |.                                   .|... ||| |.||..  .
WYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RISAEDAMKHPFF
||.||.|..||.|
RITAEQALQHPYF
Kinase PCTAIRE1.AA CDK7 239-520 39 1.3e-116 312.15 In-house 1-288 (288) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-288/288
Sequence Identity: 39% (116 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIR-----LEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIIN
| |....|||..|||||.  . |.  || |.|.      | . |   |||||. .|. ..| |.. | ||.    .. |||...| ||     |   |  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

MHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGR
  ..| .  ..|.|| ||||  .||||||| |||.|| |.||.|||||||.   | . |.  ||| ||| |  | |   | | .||| ||||| |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAE---ALLSHAPRLDSDGA-DLLTKLLQFEGRNRISAEDAMKHPFF
| .||     ||  ||..|||||||.||..    ....|.  |   .     | |     || . ||. ... ..  .|... .. |.|.|
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMC---CMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PCTAIRE1.AA PITSLRE 239-520 41 1.1e-101 344.16 In-house 1-295 (295) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-295/295
Sequence Identity: 41% (122 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE---HEEGAPCTAIREVS-LLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCG---
. .|.. .||||  ||..| |.||  |||| . .|     || | |..||.. .|. |.| |||..  |.   .  .  .|.||.. |||  ..      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

NIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEM
       .| .. ||||| .. |  ...|||||  |||..  | ||..||||||    | | |.  ||||||| | .|||.  ||| .||| ||||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN-YPKYRAEALLSHAP---RLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF
 |..|||.|.   .|.. ||  .|||||  |||. .   .|  |  |.|    | .. |   ..   | ||| ..| .   |||.|.||.|||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase PCTAIRE1.AA S_TKc 239-520 28 8e-101 342.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDK---DLKQYLDDCGNI----
| .|.|.|.|....|||.. | |. .||.|.|.        ....||...||  .| |||.|.|.... ..| .|.||.|    ||..|....|      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-INMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYST-QIDMWGVGCIFYEM
 ..   .. .. |....|.|||.....||||||.|.|..|  ..|..||||||         .  ..|.||..| .|     |..  .|.| .|||.|||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMK-------HPFF
..|.|.||      |.. .|...|                                    .... |.. |.||.. ..|..| .|..       ||.|
LCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PCTAIRE1.AA Pkinase 239-520 31 1.6e-96 331.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEG-APCTAIR--EVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC-------
| .. |.|.|....|||.. | |  .||.|.|...||.   . |..|  |....| |.| |||.|.|. ...... .|.||....|.  .| .       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

GNII--NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL----KLADFGLARAK-SIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWG
.. .   .. .| .. |.||||.|||.....||||||.|.||...|..    |..|||||. .   .   ..  ..|.||..| ...|...|.. .|||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGCIFYEMATGRPLFPGS----TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKH
.|||.|||..|||.|||.    .  .|.. |.||.|.|... ||   |.  |.  .. . . . .    ....... |.....|..    |..||....|
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFF
|.|
PWF
Kinase PCTAIRE1.AA CRK7 239-520 34 5.6e-96 325.16 In-house 1-343 (343) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-343/343
Sequence Identity: 34% (118 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE----EGAPCTAIREVSLLKDLKHANIVTLHDIIHTEK-----------SLTLVFEYLDKDLKQ
| ...  |||||  ||| | | |  .|||| .|...|    || | |||||. .|. |.|.|||.|..|. |.|           |  .|||| | ||  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIV-TDKQDASEFKKHKGSFYMVFEYMDHDLMG

YLDDC-GNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPT--KTYSNEVVTLWYRPPDILLGSTDY-------
 |.      ..  ..| |. ||| |..|||....||||.|  |.|.| .||.|.|||||||        . | | |.|||||||  ||| . |       
LLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILK

-------------------------------STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPK-YRAEA
                                ..||||..|||. | .|..|.|.|.   .||  |..| |.|. . || .     ..|    . |.   
ELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRL

LLSHAP-----RLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF
.           ....  ||| |.|      |..||..  |..|
REEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase PCTAIRE1.AA CDK4 239-520 41 3e-88 299.48 In-house 1-290 (290) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-290/290
Sequence Identity: 41% (123 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEE--GAPCTAIREVSLLKDLK---HANIVTLHDIIHT------EKSLTLVFEYLDKDLKQYLD
| ..  .||| | |||.  .  | . |||| .|    ||  | |   |||.|... |.   |.||| | |. |.      |  .|.|||  | ||..|||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

DCGN-IINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCI
 |    .    .|   .|||||. . |   . ||||||||.|..  |..|||||||||  |  ..  .  ||||||| | .|| |. | | .||| ||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLLQSY-YNTPVDMWSVGCI

FYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP--GILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF
| ||   ||||.|.   .||| || . |.|.|. ||    |  . |     | ...  ...  | ..  |.||| | | ..   |.||. . .||.|
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHF-----PQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase PCTAIRE1.AA Pkinase_Tyr 239-384 31 2.2e-19 66.27 Pfam 1-160 (270) Show / Hide 
Range on Protein: 239-384
Range on HMM: 1-160/270
Sequence Identity: 31% (51 aa)

YIKLDKLGEGTYATVYKGKSK----LTDNLVALKEIRLEHEEGAPCTA------IREVSLLKDL-KHANIVTLHDIIH-TEKS--LTLVFEYLDK-DLKQ
 ... ||||| . .||||. |     |.  || | ..    |||   .      .||....| | .| ||| |. ..   ...  . .|.||  . ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YLDDC---GNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA
|| .    .. ..|.    . .|  .|..| ....  ||||   | |..| .  | .||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase PCTAIRE1.AA TyrKc 239-520 20 2.7e-13 -7.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI-REVSLLKDL--KHANIVTLHDIIHTE-------KSLTLVFEYLDK-DLKQYLDD
  ...||||| . .||||. |     || | .. ..       .. || .... |  .| ||| |. .. ..       . | .|.|| .. |||.|| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIP------TKTYS-----NEV--VTLWYRPPDILLGSTD-Y
... ..|     | .|  .| .| |.... ||||   | |..|..  | .||||.|.          ...|.     ..   . .   .|  .   .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKF

STQIDMWGVGCIFYEMAT-GRPLFPG-----STVEEQLHFIFRILGTPTEET----WPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQF
.|. | |  |   .|. | | .  ||      . .| .... .    |  .                             .  ..  ..  .. ..  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F--VCCPDEMYQIMKQCWHE

EGRNRISAEDAMKHPFF
.  .| . ..   | .|
DPEDRPTFSEI--HECF