Gene PCTAIRE3 (Human)

PCTAIRE3

Species: Human
Alias: PCTK3, PCTAIRE, PCTAIRE3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q32,

Classification

Group: CMGC
Family: CDK
Subfamily: PCTAIRE

Sequence

Name Sequence Type Origin Length Description Download
PCTAIRE3.NA RNA Sugen Kinome 3212 None Fasta, JSON
PCTAIRE3.AA Protein Sugen Kinome 504 None Fasta, JSON
PCTAIRE3.kin_dom Protein Kinase Domain Sugen Kinome 282 None Fasta, JSON

Protein domain

Protein domains of PCTAIRE3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PCTAIRE3.AA PCTAIRE 174-455 79 4.5e-243 813.81 In-house 1-291 (291) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-291/291
Sequence Identity: 79% (230 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVK
|.|||||||||||||.|.|||||.||||||||||||||||||||||||||||.|||||||||||.|||...|||||||.|.|||||.|.|||.|.|||||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

IFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG
.|.|||||||||||.||||||||||||||||||||||||||||||||||||||||.|||||||||||||.|||.|||.|||||||||.|||.||||||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

ST------VKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLD---TDGIHLLSSLLLYESKSRMSAEAALSHSYF
||      ||..||.|||.||||.|.|||||....|||||.||.|..|||||||||||   .....||..||.||||.|.|||.|..|.||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase PCTAIRE3.AA PFTAIRE 174-455 60 2.3e-191 642.06 In-house 1-287 (287) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-287/287
Sequence Identity: 60% (174 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVK
|.||.|||||.||||.||.|.... .||||||||. |||.|.|||||.||||||||||||.||| |||.. ||.||||.. ||.||.| . . | ..||.
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

IFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG
 |.|||||||.|||.|..|||||||||||| . |||||||||||||||||..|||.||||||||||||||||||||| .||||||||  || .|.|.|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

S-TVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFP--CYLPQPLINHAPRLD--TDGIHLLSSLLLYESKSRMSAEAALSHSYF
  .. . | .||..||||||.|||||. . ... . |.   | |..| .  ||..   ..  |.. .| .| . |.||..|..| ||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase PCTAIRE3.AA CDK5 174-455 56 2.3e-180 575.11 In-house 1-287 (287) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-287/287
Sequence Identity: 56% (163 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNV
| |..|.|||||.||.|.| | |. .||||..||. | || |.|||||..||| ||| ||| ||| ||... ||||||..| ||| |.| |.  |.|| .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMA-TGRPLF
| ||.|||.|||.||....||||||||||||| .|||||||||||||  .| ..|| |||||||||||||.||  |||.|||| .|||  ||| .|||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFR--TYSFPCYLPQP-LINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF
||. |...| .||...|||.|..||..|  ....     .| | ... . .. |.||  |  ||. .| .. . |.||.||| | ||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PCTAIRE3.AA CDK 174-455 48 2e-176 569.1 In-house 1-284 (284) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-284/284
Sequence Identity: 48% (154 aa)

YVKLDKLGEGTYATVFKGRSKLTE-----NLVALKEIRLEH-----E-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTD-----------RSLTLVFEY
| ||.|.|||||..|.|.|.|.|      ..||||.||.|.     | || |.|||||.||||.| |.|||.||| .||.           ..|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGE-----LKLADFGLARAKSV------PTKTYSNEVVTLWYRPPD
.| |||.|.|          .| .|.||||||.|||...|.||||||||.|||..||     ||.||||||||...      |..||..||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLGSTEYS--TPIDMWGVGCIHYEMAT---GRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSL
.||||..||  ||||||.|||| .||.|   ..|||||..  . |..|||..|||||..||||| . ..                         .||...
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LLYESKSRMSAEAALSHSYF
| |. | |.|||.||.| ||
LCYDPKKRISAEQALQHPYF
Kinase PCTAIRE3.AA CDC2 174-455 50 1.1e-153 476.01 In-house 1-301 (301) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-301/301
Sequence Identity: 50% (152 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGA---PCTAIREVSLLKNLK-HANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD-HCG--NL
| |. |.|||||  |.|.. . |  .|||| ||||.|.     | ||||| |.||.|| | |||.||| ||  ..| .|||||| |||.|.|   .    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYS--NEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEM
|. ..|| .|.|.|.|...||.|.|.||||||||.||.. |..|.|||||||| ..| .||    ||||||||.| .|||.  ||||.||| .||| .||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPR---------LDTDGIHLLSSLLLYESKSRMSAEAALSH
   .| .|||.|    ..|  ||| ||||.|.|||||| . .. . .||.. || | .. |.         || .|| ||...| |.   | ||..||.|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

SYF
 ||
PYF
Kinase PCTAIRE3.AA CMGC 174-455 27 2.7e-137 454.19 In-house 1-513 (513) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-513/513
Sequence Identity: 27% (139 aa)

YVKLDKLGEGTYATVFKGRSKLTE--------------NLVALKEIRLE----------HEEGAPCTAIREVSLLKNLK-----------------HANI
| ...|.|||||..|.|.| |.|.              ..||.| |...          ...| |..|.||...||.|.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTLHDLIHTDR-----------------SLTLVFEYLDSDLKQYLDHCG---------NLMSMH-----------NVKIFM------FQLLRGLA--YCH
|.|.| ....                  .| |||||.| ||.||....          .|   |           |.| ||      .|.||||.  |||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

HRK--ILHRDLKPQNLLINERGEL--------------------KLADFGLARAKSVP---------------------TKTYSNEVVTLWYRPPDVLLG
 ..  |.||||||.|.|||...||                    |..||||||. ...                     ...|...|||.|||.| .|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

STEYS---------TPIDMWGVGCIHYEMATG--------RPLFPGSTV-----------KEELHLIFRLLGTPT---------------EETWPGVTAF
...|.         ||||||.|||| .|| ||        .|||||..             . |..||..|||||               ||.||...  
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

SEFRT-------------YS------------FPCYLPQPLINHAPR-----------------------------------LDTDGIHLLSSLLLYESK
 .. .             .|            || . |.|. |  |.                                   .| ..|.||. .| |. .
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

SRMSAEAALSHSYF
 |..|| ||.| ||
KRITAEQALQHPYF
Kinase PCTAIRE3.AA CDK7 174-455 38 3.4e-111 297.44 In-house 1-288 (288) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-288/288
Sequence Identity: 38% (110 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIR-----LEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMS
| |....|||..|||.|.. . |.  || |.|.      | . |   |||||. .|. ..| |.. | | .    .. |||...| ||         .. 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

MHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGR
  ..| .| ..|.|| |||   |||||||| |||.|| |.||.|||||||.   | . |.  ||| ||| |  | |   | | .||| ||||  |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTY-SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF
| .||      |  ||. |||||||.||..... .. .  .|| |   || .       | ..|.. ... .   |...  .|.. ||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PCTAIRE3.AA PITSLRE 174-455 39 6.8e-98 331.52 In-house 1-295 (295) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-295/295
Sequence Identity: 39% (116 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE---HEEGAPCTAIREVS-LLKNLKHANIVTLHDLI--HTDRSLTLVFEYLDSDLKQYLDHCG---
...|.. .||||  |.... |.|.  |||| . .|     || | |..||.. .|. |.| |||..   .   .  .  .|.||.. |||  ..      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

NLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEM
   .   .| .| ||||| .. |  .|.|||||  |||..  | ||..||||||    | | |.  ||||||| | .|||. .||||.||| ||||  |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS-FPCYLPQPLINHAP---RLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF
 |..|||.|.   .... || ..|||||  |||.| .  ..    || | .  | .. |   ..   |  ||  .| |  | |..|..|| | .|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase PCTAIRE3.AA CDK4 174-455 44 1.1e-94 320.88 In-house 1-290 (290) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-290/290
Sequence Identity: 44% (131 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEE--GAPCTAIREVSLLKNLK---HANIVTLHDLIH---TDR---SLTLVFEYLDSDLKQYLD
|...  .||| | ||.. |.  | . |||| .|    ||  | |   |||.|... |.   |.||| | |  |   |||    .|.|||  | ||..|||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

HCGN-LMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI
 |    |.   .|  |.|||||. . |   | ||||||||.|..  |..|||||||||  |  ..  .  ||||||| | ||| |. | ||.||| ||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLLQSY-YNTPVDMWSVGCI

HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF
  ||   ||||.|.  |. || || . |.|.|. ||   .       .|| . |.|.    | ..  |. ||   | |. . ||||...|.|.||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP---WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase PCTAIRE3.AA S_TKc 174-455 28 5.7e-94 319.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-231/231
Sequence Identity: 28% (84 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDS---DLKQYLDHCGNL----
| .|.|.|.|....|.|.| | |  .||.|.|.        ....||...||. .| |||.|.| ...  .| .|.||.|    ||..|....|      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST-PIDMWGVGCIHYEM
 ..   .. .| |....|.||| ..|.||||||.|.|..|  ..|..||||||         .  ..|.||..| ||     |.. ..|.| .||| |||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALS-------HSYF
..|.|.||      .....|...|                                    . ....... .| .. . |..|  ||        | .|
LCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PCTAIRE3.AA Pkinase 174-455 32 2.1e-88 304.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEG-APCTAIR--EVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDS-----DLKQYLD---H
|... |.|.|....|.|.. | |. .||.|.|...||.   . |..|  |....|.|.| |||.|.|  ...... .|.||..      ||. |.    |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

CGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGEL----KLADFGLARAK-SVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGV
.. ..|.. .| .| |.||||.||| ..|.||||||.|.||...|..    |..|||||. .   .   ..  ..|.||..| |..|...|....|||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIHYEMATGRPLFPGS----TVKEELHLIFRLLGTPTEETWPGVTA---FSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAAL
||| |||..|||.|||.    .  .....|.| .|.|... ||       |. ||.   .    . .    .... .........| .  |.| .|| .|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

SHSYF
 | .|
QHPWF
Kinase PCTAIRE3.AA CRK7 174-399 36 1.9e-85 290.15 In-house 1-281 (343) Show / Hide 
Range on Protein: 174-399
Range on HMM: 1-281/343
Sequence Identity: 36% (102 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE----EGAPCTAIREVSLLKNLKHANIVTLHDLIHTD---------R-SLTLVFEYLDSDLKQY
| ...  |||||  | | . | |. .|||| .|...|    || | |||||. .|. |.|.|||.|.. .  .         . |  .|||| | ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDHC-GNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPT--KTYSNEVVTLWYRPPDVLLGSTEY--------
|.       |  ..| || ||| |..||| ...||||.|  |.|.| .||.|.|||||||        . | | |.|||||||  ||| ..|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVT
                               . ||||..|||  | .|..|.|.|.   . | .|... |.|. . || |.
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVM
Kinase PCTAIRE3.AA Pkinase_Tyr 174-319 30 1.6e-16 56.56 Pfam 1-160 (270) Show / Hide 
Range on Protein: 174-319
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

YVKLDKLGEGTYATVFKGRSK----LTENLVALKEIRLEHEEGAPCTA------IREVSLLKNL-KHANIVTLHDLIH-TDRS--LTLVFEYLDS-DLKQ
 ... ||||| . .|.||. |     |.  || | ..    |||   .      .||....|.| .| ||| |.  .   ...  . .|.||    ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YLDHC---GNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARA
||      ..  .|.    . .|  .|..| . ... ||||   | |..| .  | .||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase PCTAIRE3.AA TyrKc 174-455 21 9.8e-13 -16.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 174-455
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAI-REVSLLKNL--KHANIVTLHDLIHTD-------RSLTLVFEYLDS-DLKQYLDH
 ....||||| . .|.||. |     || | .. ..       .. || .....|  .| ||| |.  . ..         | .|.|| .  |||.||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVP------TKTYS-----NEV--VTLWYRPPDVLLGSTEYS
...  .|     |..|  .| .| |.... ||||   | |..|..  | .||||.|.          ...|.     ..   . .   .| ..    ...
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TPIDMWGVGCIHYEMAT-GRPLFPG--------STVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYES
|  | |  |   .|. | | .  ||        . | | .   .|.   |  .  | .                       ..  ..   . ..   .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS---------------------FVCCPDEMYQIMKQCWHEDP

KSRMSAEAALSHSYF
..| . ..   |..|
EDRPTFSEI--HECF
Kinase PCTAIRE3.AA CRK7 431-455 40 0.000288 10.39 In-house 319-343 (343) Show / Hide 
Range on Protein: 431-455
Range on HMM: 319-343/343
Sequence Identity: 40% (10 aa)

LLSSLLLYESKSRMSAEAALSHSYF
||  .| .  | |..|| .| | .|
LLDKMLCLDPKKRFTAEECLQHDWF