Gene PEK (Human)

PEK

Species: Human
Alias: PERK, EIF2AK3, DKFZp781H1925, WRS, PEK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2p11.1,

Classification

Group: Other
Family: PEK
Subfamily: PEK

Sequence

Name Sequence Type Origin Length Description Download
PEK.NA RNA Sugen Kinome 4564 None Fasta, JSON
PEK.AA Protein Sugen Kinome 1116 None Fasta, JSON
PEK.kin_dom Protein Kinase Domain Sugen Kinome 485 None Fasta, JSON

Protein domain

Protein domains of PEK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ PEK.AA PQQ 104-142 30 0.00257 14.25 Pfam 1-37 (37) Show / Hide 
Range on Protein: 104-142
Range on HMM: 1-37/37
Sequence Identity: 30% (12 aa)

SLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSL
  |.. | ||.| ||| .. ||. |  ..|..    .  
GDVYVHTWDGYIYALDADT-GKVKWKFKTGPPDWW-PMT
PQQ PEK.AA PQQ 234-263 20 4.641175 3.39 Pfam 1-30 (37) Show / Hide 
Range on Protein: 234-263
Range on HMM: 1-30/37
Sequence Identity: 20% (6 aa)

DILLLQRTQKTVRAVGPRSGNEKWNFSVGH
... .     ...|.  ..|..|| | .|.
GDVYVHTWDGYIYALDADTGKVKWKFKTGP
PQQ PEK.AA PQQ 384-396 30 31.611338 0.61 Pfam 1-13 (37) Show / Hide 
Range on Protein: 384-396
Range on HMM: 1-13/37
Sequence Identity: 30% (4 aa)

NSVYLGMYRGQLY
. ||.. ..|..|
GDVYVHTWDGYIY
Kinase PEK.AA PEK 593-1077 34 8.20000000001e-300 1002.28 In-house 1-758 (758) Show / Hide 
Range on Protein: 593-1077
Range on HMM: 1-758/758
Sequence Identity: 34% (265 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN--------RELAREKVMREVKALAKLEHPGIVRYFNAWLEAP----------------------
||.|||||.|||||||.||||||..|||||||..||        ||.|||||||||..||.|.|..||||||||||.|                      
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

-------------------------------------------PEKWQEKMDEIWLKDESTDWP-----LSSPSPMDAPSVKIRRMD-------------
                                           |.|||||||..|....|..|.     |..|..||.....||.||             
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENEDDNPCNRFVNKIPKKWQEKMDKCWNNNISNNWKKKLHQLKYPFKMDDDISFIRNMDQTMQNDQSRYKMQ

----PFATKEHIEIIAPSPQRSRSFSVGISCDQTSSS-------------------ESQFSPLEFSGMDHED---ISESVDAAYNLQDSCLTDCD-VEDG
    ||..|....||...|.|..|||....|||..|.                   ||||.|.||||.|.|.   .....|..||.|..|.|.|. ....
YSHDPFFKKFNKQIIIREPMRNSSFSKESYCDQDDSNDIYSNEVDFFFTPKKCYFSESQFMPSEFSGTDDEEQSWMDSNNDTMYNAQQKCMTKCFGHHKH

TMD---GNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEAT-LSISPPRPTTLSLDLTKN
.||   .|.|.|.|..||||||.|........|||.||||.|.....||.......|....|.|..|..|..||||..|.. |..|.......... ..|
MMDFSKDNKEEHTFFDCPSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNN

TTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--------------------
...|..|.....|.||||||||||.|||||..|||.|.|.....||.|.||.|.|...||||..|||||||||||.||..                    
KNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDG

----VKVGDFGLVT--------------------------------------------------------------------------------------
    .|.|||||||                                                                                      
GHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTITTISVSPSKPSSIS

------------------------AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGN----------------SYSHKVDIFSLGLILFELLYP
                        |.||..|..|....||...|||.||||.|||||||.|..                .|.|||||.|||||.|||..|
TPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHP

-FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF
 |||||||.||..|.||...|..||||||.|| ..|.|.|..|.|||.|..|.....|
GFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF
Kinase PEK.AA PEK 593-1077 31 5.8e-218 730.4 In-house 1-655 (655) Show / Hide 
Range on Protein: 593-1077
Range on HMM: 1-655/655
Sequence Identity: 31% (206 aa)

FEPIQCLGRGGF-GVVFEAKNKVDDCNYAIKRIRLPNRE----------------LAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWL
|| |||||.||| |.|....||.|.|.||||||.|....                ...|||.||||.||.|.||.||||.|||.| |.||||...||.|.
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

KDESTDWP----LSSPSPMDAPSVKIRRMD-----------------PFATKEHIEIIAPSPQRSRSFSVGISCDQTSSS------ESQFSPLEFSGMDH
.|.|||||    .|...... |..|.. .|                 ....|...|....|.......|.. ||...|.|      |.||| ..| |...
LDSSTDWPNGKHKSKDYNFH-PFEKEW-DDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFS-INF-GTEN

ED------ISESVDAAYNLQDSCLTDCD-VEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFK
|.      .|.||..... .... .... ..|.|....||.|||. |.|..|.. .... ..||....|.||||....|..  ...| .|.| .|... |
ENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSK

PTSSKSSSEATL-----------------SISPPRPTTLSLDLTKNTTEKLQPS--SPKVYLYIQMQLCRKENLKDWMNGRC------------------
. |.|...|.|                  | .. . .. . . .||.  . ...  ... ||||||..|.|..|.||.. ..                  
NQSHKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYN

-----------------------TIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV-----VKVGDFGLVT----------------
                       . ..... .|..|| ||.|.....||.|..||||||||||...|.      ||.|||||.|                
NYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQD

-------AMDQDEEEQTVLTPMPAYAR----------------------HTGQVGTKLYMSPEQIHGN-----SYSHKVDIFSLGLILFELLYPFSTQM-
       |.|.  . .|  ...|....                      |||.||| |||||||..|.      | ||||..|||.|.||..|||.|.| 
QSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMM

ERVRTLTDVRN------LKFP-PLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF
|||.||||.|.       .|| ..|..|||... ..|.|||..| .||.|  | ..  |
ERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase PEK.AA GCN2 873-1068 32 2.5e-51 176.83 In-house 271-502 (511) Show / Hide 
Range on Protein: 873-1068
Range on HMM: 271-502/511
Sequence Identity: 32% (77 aa)

EKLQPSSPKVYLYIQMQLCRKENLKD-WMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT-----------
..  ....  ||||||  | . .|..   |. ......       .| || |.. ..||.|  ||||||||||.. .. ||.|||||.|           
MNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRK

------------------AMDQDEEEQTVLTPMPA----YARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSL-GLILFELLYP-FSTQMERVRTLTDVRN
                  . |. ...|.. ...         ||| ||| .||.|||    .|  |||..|| |.|.||..|| |.|||||| .|.. |.
QQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRS

LKFPPLFTQ----KYPCEYVMVQDMLSPSPMERPEA
..||. |      ... .. |.. .|.. | .|| |
CEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSA
Kinase PEK.AA PKR 884-1075 39 1.7e-42 147.51 In-house 96-272 (272) Show / Hide 
Range on Protein: 884-1075
Range on HMM: 96-272/272
Sequence Identity: 39% (76 aa)

LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTG
|.|||  | |  |  ||. |   |  .. . | .. || . |...|||.|.||||||||||   .  .|.||||||||.. |    |  .          
LFIQMEFCDKGTLEQWMRNRRQ-EKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVTALKNDGKSRTRRK----------

QVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFP-PLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENA
  ||  |||||||    |   |||. ||||| |||    |..|...  .|.|.  |   .| .|   |  ..| .||  | .||.   |.   
--GTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDNK---EKTLLQKLLSKKPKDRPNTSEILRTL
Kinase PEK.AA STE 593-1018 12 1.5e-38 133.8 In-house 1-262 (359) Show / Hide 
Range on Protein: 593-1018
Range on HMM: 1-262/359
Sequence Identity: 12% (62 aa)

FEPIQCLGRGGFGVVFEAKNKVDD---CN------------YAIKRIRLPNRE----------------LAREKVMREVKALAKLE--HPGIVRYFNAWL
.| |...|.|.||.|. |.|. ..   ..            .|||...| | .                  ......|.| . |.   || ||.|. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAY
   ..                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

NLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPR
                                                                                                    
----------------------------------------------------------------------------------------------------

PTTLSLDLTKNTTEKLQPSSPKV--YLYIQMQLCRKENLKDWMNGRCTIEERER-----------SVCLHIFLQIAEA-VEFLHSKGLMHRDLKPSNIFF
                     |   .|.| | ..    | | .. .. . ..             |.  .|  || ..  ..|||.. .|||.||.||..
--------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL

TMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA-----------RHTGQVGTKLYMSPEQIHG------NSYSHKVDIFSLGLILFELL
     ||  |||. . ....  ..   .     .           . .  |||  .|.|| | .      . |. |.|| |||. . |..
-----VKLCDFGVCGQLTDSMANI-Q-S-----NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase PEK.AA Pkinase 883-1018 31 2.5e-37 133.06 Pfam 74-206 (293) Show / Hide 
Range on Protein: 883-1018
Range on HMM: 74-206/293
Sequence Identity: 31% (47 aa)

YLYIQMQLCRKE----NLKDWMN--GRCTI--EERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVV----KVGDFGLVTAMDQDEEEQT
..|. | .|..      |.|..    ....  .|.|   | ....||....|..||.| .||||||.||..  ....    |..||||   .|       
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWE---CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------

VLTPMPAYARHTGQVGTKLYMSPEQIH-GNSYSHKVDIFSLGLILFELL
       .   |. .||  ||.|| |  |. |..|||..|.|.||.|.|
----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML
Kinase PEK.AA Ciliate-E2 883-1019 25 1.6e-36 122.87 In-house 108-291 (365) Show / Hide 
Range on Protein: 883-1019
Range on HMM: 108-291/365
Sequence Identity: 25% (49 aa)

YLYIQMQLCRKENLKDWMNGRCTIEERERS--------VCLHIFLQIAE---------------AVEFLHSKG-LMHRDLKPSNIFFTMDDVVKVGDFGL
..|. | .|   .|.|... ... .  |..         ...|. ||..               |.|.||||.  .|||.||.||.|     .|. ||||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGL

VTAMDQDEEEQTVLTPMPAYARHTG---------------------QVGTKLYMSPEQIHGNS---------YSHKVDIFSLGLILFELLY
 .  |.|....|   ..       .                     ..||  ||.|| . | .         |..|.||.||| ||.|.|.
SKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
Kinase PEK.AA HRI 883-1077 35 2e-36 125.83 In-house 393-613 (613) Show / Hide 
Range on Protein: 883-1077
Range on HMM: 393-613/613
Sequence Identity: 35% (79 aa)

YLYIQMQLCRKENLKDWMN-----GRCTIEERER-----S--VCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV----VKVGDFGL-----VTA
.|.||||||    |.||.      .|  ..| |      .  |   || || | . . | .. .|||.|| |||    |     ||.|||||     .. 
MLHIQMQLC-ELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACEDILQE

M--------DQDEEEQTVLTPMPAYAR-HTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYV
         |||  .  .    |   . ||  ||| .| ||||  |  |  | | .|.|.|||||  || | |||   || ||  . |     . |    
PKTPMRFRRDQDFDWTNR---NPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAK

MVQDMLSPSPMERPEAINIIENAVF
 .| .       || || ..   .|
YIQHLTRRNASQRPSAIQLLQSELF
Kinase PEK.AA S_TKc 593-1077 13 5.9e-35 123.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 593-1077
Range on HMM: 1-231/231
Sequence Identity: 13% (68 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDA
.| .. .|.|.||.|. ...| ..  .|||.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

PSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEA
                                                                                                    
----------------------------------------------------------------------------------------------------

SPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCR
                                                     .  .|  .  .   |    |  .  .           .||. | .| 
----------------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCD

K--ENLKDWMNGRCTIEE---RERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGT
    .|.| .  | .          .. ... ||..|.|..||.| .||||||.||...   ..|..|||| . .                   | ..||
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGT

KLYMSPEQIHGNSYSH-KVDIFSLGLILFELLY---PFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIE-------NAV
  ||.|| .   .|.. |.|. |.| ||.|.|.   ||. ||...  .                |    ... .|   | .|| |  . .          
PWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase PEK.AA STE-Unique 884-1051 24 6.7e-29 99.46 In-house 369-585 (616) Show / Hide 
Range on Protein: 884-1051
Range on HMM: 369-585/616
Sequence Identity: 24% (53 aa)

LYIQMQLCRKENLKDWMNGRCT---------IEERERSVCLHIFLQIAEAVEFLHSKG--LMHRDLKPSNIFFTMDD-----VVKVGDFGLVTAMDQDEE
..|.| .| .  |..  .  ..         ..| |    . . .||.|. |.|||..    ||||||.|||.. |.      ||..|||. | .  |. 
VWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETE---VIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHF

EQ----------------------TVLTPMPAY----ARHTGQVGTKLYMSPEQIHGN-----SYSHKVDIFSLGLILFELLYPFSTQMERVRT--LTDV
|                          |||          .. .||  ||.|| | ..     .|..||||.||| ..|...  . ....| .   . . 
EKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEM

R-NLKFPPL--FTQKYPCEY
. .....|.  ...  |  .
CIHIHCQPPQCPIENIPPKC
Kinase PEK.AA GCN2 593-672 41 3.7e-27 91.87 In-house 1-84 (511) Show / Hide 
Range on Protein: 593-672
Range on HMM: 1-84/511
Sequence Identity: 41% (35 aa)

FEPIQCLGRGGFGVVFE-AKNKVDDCNYAIKRIRLP--NRELARE-KVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDE
|| |.|||.|||| |   ..|..| ..||||.....  .|.| .. | ||||| |..| |...|||..||.| . |.  .  ..
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNN
Kinase PEK.AA WEE 884-1017 26 1.8e-25 82.44 In-house 80-229 (297) Show / Hide 
Range on Protein: 884-1017
Range on HMM: 80-229/297
Sequence Identity: 26% (44 aa)

LYIQMQLCRKEN--LKDWM----NGRCTIEERERSVCLHIFLQIAEAVEFLHSK-GLMHRDLKPSNIFFTMDD--------------------VVKVGDF
.|||| .|.. .  | .|     |.   ..| .     .|...|.... ..||. |..| |.||.|||.....                    . | |||
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWM---IWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDF

GLVTAMDQDEEEQTVLTPMPAYARHTGQV---GTKLYMSPEQIHG---NSYSHKVDIFSLGLILFEL
|.|| |.                ..  ..   |   ||.|| ..|   .... | ||||||. ..||
GHVTDMNS--------------NNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYEL
Kinase PEK.AA WEE 593-661 38 9.4e-23 73.21 In-house 1-77 (297) Show / Hide 
Range on Protein: 593-661
Range on HMM: 1-77/297
Sequence Identity: 38% (30 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLE-------HPGIVRYFNAWLEA
|. .| .|.| || |. .....| | ||||... | |..  |.   |||.|...|        || ||||..|| |.
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEED
Kinase PEK.AA PEK-Unclassified 593-660 33 1.7e-22 74.92 In-house 1-74 (835) Show / Hide 
Range on Protein: 593-660
Range on HMM: 1-74/835
Sequence Identity: 33% (25 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLP------NRELAREKVMREVKALAKLEHPGIVRYFNAWLE
|  .| .|.|||..|.   .|.|.  ||.|.|..             || ..|| ..|.. || |.||.  | |
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIE
Kinase PEK.AA HRI 593-660 44 3.7e-20 67.23 In-house 1-69 (613) Show / Hide 
Range on Protein: 593-660
Range on HMM: 1-69/613
Sequence Identity: 44% (31 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAR-EKVMREVKALAKLEHPGIVRYFNAWLE
||    .|.||.| |.  ..| |   ||||.|.   |      |..|||| || |.|. ||||  ||.|
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase PEK.AA PEK-Unclassified 982-1076 31 1e-19 64.98 In-house 731-835 (835) Show / Hide 
Range on Protein: 982-1076
Range on HMM: 731-835/835
Sequence Identity: 31% (33 aa)

TGQVGTKLYMSPEQI-----------HGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAIN
|  .|| .| |.||             .. | |. ||.|.| |.|... .. | ||||.|.  ..    |  |  |.|    ...| ||  |  ||  . 
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRP-LLS

IIENAV
 ||  .
KIEQTL
Kinase PEK.AA PKR 593-658 46 1e-17 59.87 In-house 1-61 (272) Show / Hide 
Range on Protein: 593-658
Range on HMM: 1-61/272
Sequence Identity: 46% (31 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAW
|. |  .| |||| || || ..|   |.|||..  |     ||  .||.|||||.|  ||.|   |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNN-----EKAEHEVQALAKLDHVNIVHYHSCW
Kinase PEK.AA STE-Unique 594-660 31 4.1e-16 53.23 In-house 1-72 (616) Show / Hide 
Range on Protein: 594-660
Range on HMM: 1-72/616
Sequence Identity: 31% (23 aa)

EPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAR-----EKVMREVKALAKLEHPGIVRYFNAWLE
. .| .|||.||.|. ..||.|  ..||| |.| ..   .     ..  .|. ....| |..||.|  .||.
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase PEK.AA Pkinase 593-660 23 1.1e-13 49.46 Pfam 1-71 (293) Show / Hide 
Range on Protein: 593-660
Range on HMM: 1-71/293
Sequence Identity: 23% (17 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNREL-AREKVMR--EVKALAKLEHPGIVRYFNAWLE
.. ....|.|.||.|.....| . . .|.|.|......   ..   |  |.. ...| || |||.. .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED
Kinase PEK.AA PEK-Unclassified 914-964 39 2.1e-12 38.68 In-house 615-667 (835) Show / Hide 
Range on Protein: 914-964
Range on HMM: 615-667/835
Sequence Identity: 39% (21 aa)

CLHIFLQIAEAVEFLHSKG-LMHRDLKPSNIFFTMD-DVVKVGDFGLVTAMDQ
|  |  ||  |  . |. . . |||.|| ||| .     .|.||||||. ...
CREITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKKIEK
Kinase PEK.AA TyrKc 593-1075 13 2.9e-12 -24.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 593-1075
Range on HMM: 1-280/280
Sequence Identity: 13% (73 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL--EHPGIVRYFNAWLE--------APPEKWQEKMDEIWLKD-----
 . .. ||.| ||.|.... |    . |.| ..       ||  ||| . . ||  .|| ||| . . ..         |.    | |.   |||     
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMD
. .                                                                                                 
RPK-------------------------------------------------------------------------------------------------

GNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQP
                                                                                                    
----------------------------------------------------------------------------------------------------

SSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQD------EEEQTV
                                  .  |.. .|||.  |.||||.. ||||   |.  . . .||..||||  . . |      ..  ..
-------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

----LTP--MPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL----YPFSTQ----MERVRTLTDVRNLKFPPLFTQKYP-----CEYV
     .   .|              |.|| |  . ...| |..| |  ..|..     | . .    |.  . . .|.. . .|     ||     |   
KEHKGGKTMLPIR-----------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDE

MVQDMLS---PSPMERPEAINIIENA
| | |..     | .||   .|.|  
MYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PEK.AA Ciliate-E2 593-658 17 7e-10 30.08 In-house 1-101 (365) Show / Hide 
Range on Protein: 593-658
Range on HMM: 1-101/365
Sequence Identity: 17% (18 aa)

FEPIQCLGRGGFGVVFEAKNKVDDCN-----------------------YAIKRI--RLPNRELAREKVMREVK----------ALAKLEHPGIVRYFNA
.. |...|.|.||.|...|.. ....                       ||.|..  .  .  .  ...|||..           | .| || |.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

W
.
F
Kinase PEK.AA Pkinase_Tyr 915-976 35 8.9e-05 16.8 Pfam 114-177 (270) Show / Hide 
Range on Protein: 915-976
Range on HMM: 114-177/270
Sequence Identity: 35% (23 aa)

LHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAM-DQDEE-EQTVLTPMP
|.. .|||.. |.|.||.. ||||   |.  | . |||..||||  .. . |.   ..  ...|
LQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLP
Kinase PEK.AA Pkinase_Tyr 593-654 30 0.000242 15.33 Pfam 1-69 (270) Show / Hide 
Range on Protein: 593-654
Range on HMM: 1-69/270
Sequence Identity: 30% (21 aa)

FEPIQCLGRGGFGVVFEAKNK----VDDCNYAIKRIRLPNRELA--REKVMREVKALAKL-EHPGIVRY
 . .. ||.| ||.|.... |     ...  |.| ..    . .  ||. |||.| . .|  || |||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase PEK.AA Pkinase_Tyr 991-1018 32 1.333888 2.66 Pfam 181-208 (270) Show / Hide 
Range on Protein: 991-1018
Range on HMM: 181-208/270
Sequence Identity: 32% (9 aa)

MSPEQIHGNSYSHKVDIFSLGLILFELL
|.|| |. . ...| |. | |  ..|..
MAPECINYGKFTTKSDVWSFGVLMWEIF