Gene PFTAIRE2 (Human)

PFTAIRE2

Species: Human
Alias: ALS2CR7, PFTAIRE2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2q33.2-q34,

Classification

Group: CMGC
Family: CDK
Subfamily: PFTAIRE

Sequence

Name Sequence Type Origin Length Description Download
PFTAIRE2.NA RNA Sugen Kinome 2159 None Fasta, JSON
PFTAIRE2.AA Protein Sugen Kinome 435 None Fasta, JSON
PFTAIRE2.kin_dom Protein Kinase Domain Sugen Kinome 285 None Fasta, JSON

Protein domain

Protein domains of PFTAIRE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PFTAIRE2.AA PFTAIRE 103-387 73 2.3e-233 781.56 In-house 1-287 (287) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-287/287
Sequence Identity: 73% (210 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVR
|..|||||||||||||||||.||.|.||||.|....|||.||||||||||||.|||||||.|||||||||||||||||.||||.|||..||||.||.|||
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPG
||.|||||||.|.|...|||||||||||||||.|||||||||||||||.||.|||.|||||||||||.|||.||||..||.||.||||.||..|||.|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

VSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFP--LPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
...|..|||||..|||.|||||||||..||||.|.||.  ...|..|. .|.|....|.||||...||...||||||||||..|.||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase PFTAIRE2.AA CDK 103-387 45 1.9e-162 523.69 In-house 1-284 (284) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-284/284
Sequence Identity: 45% (147 aa)

YLNLEKLGEGSYATVYKGISRING-----QLVALKVISMNA-----E-EGVPFTAIREASLLKGLKHANIVLLHDIIHTK-----------ETLTFVFEY
|  |||.|||.|..|||......|     |.|||| | |       | ||.|.||||| |||| | |.||| |||..|||            .|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGE-----LKLADFGLARAKSI------PSQTYSSEVVTLWYRPPD
|..||..||.          .. .|.||||||.|.|.....||||||||.||.. ||     ||.||||||||..|      |..||..||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

ALLGATEYS--SELDIWGAGCIFIEMFQ---GQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLA
 |||...||   . |.|..||||.|||.   ..||||| |  ..||.|| ...| ||||.||||.|||.|                           || 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE-IDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLL

SQMLKGFPRDRVSAQEALVHDYF
..||   |  |.||..|| |.||
NKMLCYDPKKRISAEQALQHPYF
Kinase PFTAIRE2.AA PCTAIRE 103-387 56 3e-157 528.68 In-house 1-291 (291) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-291/291
Sequence Identity: 56% (164 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVR
|  |.|||||.||||||. |.  . ||||| | .  ||| |.|||||.||||.||||||| |||||||   ||.|||||  || ||| .   ..  |||.
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPG
||.||||||||| |.. .||||||||||||   |||||||||||||||.|..||| |||||||||||.|.| |.|| ..|.|| |||| ||  |.|||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

VS-----NILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLG-RVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
        . .||. |  .|| |.| |||||. .... .. ||   . .|  .  ||   . .  || ...|.  .. |||| .|. | ||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase PFTAIRE2.AA CDK5 103-387 51 3.7e-145 461.89 In-house 1-287 (287) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-287/287
Sequence Identity: 51% (149 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNV
|  .||.||| |.||||.  .  . .|||| . .. | |||| ||||| .||| ||| ||| |||.||.   || |||..  ||  || .  |.. .| .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMF-QGQPLF
. ||.|||.|||. |..||||||||||||||.  |||||||||||||  || ..||.||||||||||| |.|.  ||   |.| .|||| ||   |.|||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAE--DLASQMLKGFPRDRVSAQEALVHDYF
|| ..  .|| .| ...| |.||.||...|||.|.|.  ..| .. .| .|  . .  ...  || ..||.  |  |.||..|| | ||
PG-NDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYP-MYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase PFTAIRE2.AA CMGC 103-387 25 7.2e-128 422.62 In-house 1-513 (513) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-513/513
Sequence Identity: 25% (131 aa)

YLNLEKLGEGSYATVYKGISRING--------------QLVALKVIS---MN-------AEEGVPFTAIREASLLKGLK-----------------HANI
| ...|.|||.|..|||.. . ..              ..||.| |.   .        ...|.|..|.|| ..|| |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VLLHDIIHTKE-----------------TLTFVFEYMHTDLAQYMSQHP------GGLHP-------------HNVRLFM------FQLLRGLA--YIHH
| |.||...|.                  | .||||| .||.||. ...      ....              ||.. ||      .|.||||.  |.| 
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

QH--VLHRDLKPQNLLISHLGEL--------------------KLADFGLARAKSIP---------------------SQTYSSEVVTLWYRPPDALLGA
.   ..||||||.|.||.| .||                    |..||||||. ...                     ...|...|||.|||.|  |||.
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

TEYS---------SELDIWGAGCIFIEMFQG--------QPLFPGVSNI----------LEQLEKIWEVLGVPT---------------EDTWPGVSKLP
..|.         .. |.|..|||| ||..|        .||||| |.           ..||.|| .||| ||               |..||...|||
KHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLP

NYNP----------------------------EWFPLPTPRSLHVVWN------------------------------RLGRVPEAEDLASQMLKGFPRD
.||.                             |.| .. ..|.   .                              |.   |.| || ..||.  | .
WYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDK

RVSAQEALVHDYF
| .|..|| |.||
RITAEQALQHPYF
Kinase PFTAIRE2.AA CDC2 103-387 47 3.5e-127 393.11 In-house 1-301 (301) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-301/301
Sequence Identity: 47% (145 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISMN-AEEG--VPFTAIREASLLKGLK-HANIVLLHDIIHTKETLTFVFEYMHTDLAQYMS-QHPG--G
|  .||.|||.|  |||.. .  .|.|||| |     .||  || ||||| |.|| || | ||| |||.||    |  ||||.. || .||  . |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYS--SEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEM
. |..|. .|.|.|.|... |.. ..||||||||.||.  |..|.|||||||| .||. ||    ||||||||.|  |||.  || . |.|  ||||.||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---FQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNR-------LGRVPEAEDLASQMLKGFPRDRVSAQEALV
    .  |||.| | | .|| || ..|| |.|.|||||..|| |..  ||  .|  |  .  .       .   ||. || .|||   | .|.||.||| 
FMDVTKKPLFHGDSEI-DQLFKIFRILGTPNEQTWPGVTQLPDYKNT-FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HDYF
| ||
HPYF
Kinase PFTAIRE2.AA CDK7 103-387 37 1.7e-108 290.07 In-house 1-288 (288) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-288/288
Sequence Identity: 37% (109 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVIS-----MNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLH
|  ....||| .|||||.     || || | |        |. |. .|||||  .|. ..| |.. | ||.  |  .  ||..| .||          | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQ
| ..  .| ..|.|| | |   .||||||| |||..  |.||.|||||||.   | . |.. ||| ||| |  | ||  | .  |.|  |||| |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP-EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
| .|| | |  ||..| . || ||| .||.......|.    || ..   |. .    .   .. || . |.   |  |... ..| ..||
PYLPGDSDI-DQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASD--DLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase PFTAIRE2.AA S_TKc 103-387 27 1.7e-87 297.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHT---DLAQYMSQHPGG----
|  |.|.|.|....|||.. .  |..||.|.|.         ...|| ..||  .| ||| |.|.... . | .|.||. .   || .|. .....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS-ELDIWGAGCIFIEM
 ...  .| .| |....|.|.| ....||||||.|.|...  ..|..||||||         .. ..|.||..|  |     |.  . |.|  |||..||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

FQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALV-------HDY
. |.|.||       |........|                                       ||| |. ...|.  |..| .| |||        | .
LCGYPPFP-------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase PFTAIRE2.AA CDK4 103-387 39 4.4e-81 275.69 In-house 1-290 (290) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-290/290
Sequence Identity: 39% (119 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISM-NAEE--GVPFTAIREASLLKGLK---HANIVLLHDIIHTKET------LTFVFEYMHTDLAQYMS
|  .  .||| | |||.  . ..|. |||| .   . ||  |.|   ||| |... |.   |.||| | |. |. .|      .| |||    ||..|. 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

QHPG-GLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCI
. |  |. |  ..  |.|||||. . |   . ||||||||.|..  |..|||||||||  |       . ||||||| |  || .  | .  |.| .|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSF-QMALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

FIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF
| ||.  .|||.| |   .||.|| .| | |.|| ||  . ||    . ||   ||..  .   .     . ||  .||   .  |.|| ..| |.||
FAEMYCRRPLFCGQSEK-DQLHKIFDVMGLPPEDDWPRDVSLPW---DHFPQRHPRPFKDFCPHMCKQ--GDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase PFTAIRE2.AA Pkinase 103-387 29 3.5e-76 264.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISM-NAEEGVPFTAIR--EASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHT-----DLAQYMS-QHP
|  ..|.|.||...|||.. . .|..||.|.|.  ....... |..|  |....| |.| ||| |.|. ..|  . .|.||.       ||. |.| .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGL--HPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGEL----KLADFGLARAK-SIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGA
|..   .. .. .| |.||||.|.| . ..||||||.|.||.. |..    |..|||||. .   ... ... ..|.||..|  ..|...|... |.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFIEMFQGQPLFPGV---SNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALV
|||..||. |.|.|||     | ..|...| ...| |..  ||  .  ....   .   . . . ..  ..   .|. |. . .|.  | .| .|...| 
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNW--SEECKDFIKWCLCKDPKKRPTAEQILQ

HDYF
|..|
HPWF
Kinase PFTAIRE2.AA CRK7 103-335 35 6.9e-73 248.46 In-house 1-287 (343) Show / Hide 
Range on Protein: 103-335
Range on HMM: 1-287/343
Sequence Identity: 35% (103 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE----EGVPFTAIREASLLKGLKHANIVLLHDIIHTK----------ETLTFVFEYMHTDLAQY
|. ..  ||| |  |||     .|..|||| . |  |    || | |||||  .|. |.|.||| |..|.  |           .   |||||  ||.  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MSQH-PGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPS--QTYSSEVVTLWYRPPDALLGATEY--------
.         . ... || ||| |..|.| . .||||.|  |.|.   ||.|.|||||||     .  . |   |.|||||||  |||...|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------SSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYN
                                | |.|. |||..| | ..|.|.| .| ..||||| .. | |. . || | ||| .|
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQG-NNEMAQLEKIYKICGSPNPNNWPEVMKLPWWN
Kinase PFTAIRE2.AA PITSLRE 103-335 39 3.2e-71 242.91 In-house 1-241 (295) Show / Hide 
Range on Protein: 103-335
Range on HMM: 1-241/295
Sequence Identity: 39% (96 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISMN---AEEGVPFTAIREAS-LLKGLKHANIVLLHDII--HTKETLTFVFEYMHTDLAQYMSQHP---
.  | . .|| |  ||..  .  .  |||| . |      || | |..|| . .|..|.| ||| .  |.   ..     |.||.  ||.  |  .    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEM
    |  .  .| ||||| .. |   ..|||||  |||.|| | ||..||||||    |   |.. ||||||| |  |||. .||  .|.|  |||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

FQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYN
 ...|||.| | | .|...|   .| |||  |||...||. .
ITMKPLFQGKSEI-DQINCIFKEMGTPTEKIWPGWTELPHWK
Kinase PFTAIRE2.AA Pkinase_Tyr 103-248 30 1.1e-16 57.15 Pfam 1-160 (270) Show / Hide 
Range on Protein: 103-248
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

YLNLEKLGEGSYATVYKGISR----INGQLVALKVISMNAEEG----VPFTAIREASLLKGL-KHANIVLLHDIIH-TKET--LTFVFEYMHT-DLAQYM
   ..|||||.. .||||. .     ... || |..  .| .       |  .|||...| | .| ||| |. ..   .|   .  |.|||   ||  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF--MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

SQH---PGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARA
 .|   .. | ..    . .|  .|..| . ..  ||||   | |... .  | .||||||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase PFTAIRE2.AA TyrKc 103-387 23 1.6e-13 -4.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 103-387
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL--KHANIVLLHDIIHTK-------ETLTFVFEYM-HTDLAQYMSQH
   ..||||| . .||||. .   . || |..  .|        .|||.... |  .| ||| |. .. ..       | |  |.||| | || .|   |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

PGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIP------SQTYS-----SEV--VTLWYRPPDALLGATEYSS
 . | .     |..|  .| .|.|.... ||||   | |... .  | .||||.|.          ...|.     ..   . .   .| ..    ....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTT

ELDIWGAGCIFIEMF-QGQPLFPG-------VSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGF
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KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDY-P-MS---------------------F--VCCPDEMYQIMKQCWHED

PRDRVSAQEALVHDYF
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PEDRPTFSEI--HECF
Kinase PFTAIRE2.AA PITSLRE 362-387 46 4e-06 18.42 In-house 270-295 (295) Show / Hide 
Range on Protein: 362-387
Range on HMM: 270-295/295
Sequence Identity: 46% (12 aa)

DLASQMLKGFPRDRVSAQEALVHDYF
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DLLNQMLTYNPKNRITASDALKHPWF
Kinase PFTAIRE2.AA CRK7 358-387 43 2e-05 14.47 In-house 314-343 (343) Show / Hide 
Range on Protein: 358-387
Range on HMM: 314-343/343
Sequence Identity: 43% (13 aa)

PEAEDLASQMLKGFPRDRVSAQEALVHDYF
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KECLDLLDKMLCLDPKKRFTAEECLQHDWF