Gene PINK1 (Human)
PINK1
Sequence
Protein domains of PINK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | PINK1.AA | NKF2 | 156-507 | 58 | 1.5e-274 | 918.38 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 156-507 Range on HMM: 1-365/365 Sequence Identity: 58% (214 aa) YLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGA |..||.||.||.||||||.||..||..|..|..||....||. .......|..||.|.||||||||||......|.|.||.|.|..||..|.||.||||. YEFGQFIGQGCNAAVYEARMPNSPQHSEGNKHYGLIFNEGPN-ILAEIPPEQKPGQPKFPLAIKMMWNFEHDRDSDAHLNKMMQNEVPPYRNALKGEYGQ VTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVN-TPSPRLAAMMLLQLLEGVDHLV .|||.|...|||.||||||....|||..||..||.|..||||.|..|..|||.||..|..||||.|.|||||||... .||.....||..|.||..|||. MTYRRSRTFPKQPAPHPNIVCMFRAFCDSVRVLPDAHEDYPDMLHQRYWPEGYGHNMTMYLVMKRYRCTLRQYLWMQCHPSYWTRMMMIAQMLEACDHLH QQGIAHRDLKSDNILVELDPD--GCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVST-ARPGPRAVIDYSKADAWAVGAIAYEIFGLVN |.|.||||.||||||||.|.| .||||||||||||||....|.|||.|||.||||||.||||||..| |.||...|.||.|||.||.|||||||||..| QHGVAHRDMKSDNILVEYDFDDGACPWLVIADFGCCLACKHHGWQLPYSSWDVDRGGNACLMAPEIFTGAHPGCNHVHDYEKADTWACGAIAYEIFGQKN PFYG--------QGKAHLESRS--YQEAQLPALPESVPPDVRQLVRALLQREASKRPSARVAANVL |||. ||..||.|.. |||.|||..|.|.||..||||..||||..|||||...||||| PFYSSSGGMAREQGEMHLDSCNSDYQEDQLPQMPQSCPPVLRQLVYNLLQRDPSKRPSPQIAANVL |
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| Kinase | PINK1.AA | Pkinase | 266-512 | 20 | 2.5e-19 | 69.42 | Pfam | 55-293 (293) | Show / Hide |
Range on Protein: 266-512 Range on HMM: 55-293/293 Sequence Identity: 20% (58 aa) KQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPC-----TLR------QYLCVNTPSPRLAAMMLLQLLEGVDHLV | | ||||.| ...|.. .. . .|| .. | .. |. |.. . ....|.|.|.... KRL-NHPNIVRLYDWFED---------------------------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCH QQGIAHRDLKSDNILVELDPDGCPWLVIADFGCC-LADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPF ..|| |||||..|||. ... .. . |.|||.. ..| . .| . .. | ||||| . . .|.| |..| | || . || SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGRPPF YGQ---GKAHLESRSYQEAQLPALPESVP-----------------------PDVRQLVRALLQREASKRPSARVAANVLHLSLW .|. . | . ... | |... | .. ..... .|.. .|||. |. .|. . PGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF |
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| Kinase | PINK1.AA | S_TKc | 156-511 | 17 | 2.3e-15 | 48.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 156-511
Range on HMM: 1-231/231
Sequence Identity: 17% (64 aa)
YLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGA
| |.. |||| . || .. |||.. . |
YEILRKIGKGAFGKVYKCRHKK----------------------------------TGRIVAIKIIK------------------------EHIRREIQI
VTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPC---TLRQYLCVNTP-------SPRLAAMMLLQ
||||.. . .| . |..|| . .|..|.. . . .. |. .. |
LKK-----------HHPNIVKLYDVFQD----------------------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQ
LLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYS--KADAWAVGAIA
........ ..|| ||||| .|||. . |.||| . | ||||| |. |.| |..| |
ICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCIL
YEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARVAAN-----VLHLSL
|| . ||. . . .. .|......| .||.. .|||.| | . .| .
YEMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | PINK1.AA | Ciliate-E2 | 345-500 | 17 | 6.1e-14 | 44.22 | In-house | 168-356 (365) | Show / Hide |
Range on Protein: 345-500 Range on HMM: 168-356/365 Sequence Identity: 17% (37 aa) QLLEGVDHLVQQG-IAHRDLKSDNILVELDPDGCPWLVIADFGC---CLADESIGLQLPFSSWYVDRG-----------------------GNGCLMAPE ...... .| ... | |||.| .|||. . |.||| . |. ..... . || . . |. |||| CIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE VSTARP--GPRAVIDYS-KADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPAL---------------PESVPPDVRQLVRA----LLQREAS . . . . .|. |.| |..| | || || .. .. ..| ........ .| . .||.. . ILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPE KRPS-A ||.. . KRITGW |
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| Kinase | PINK1.AA | CAMK | 335-386 | 27 | 1e-12 | 36.56 | In-house | 177-241 (425) | Show / Hide |
Range on Protein: 335-386 Range on HMM: 177-241/425 Sequence Identity: 27% (18 aa) SPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCP------------W-LVIADFG . | |. . |....|... ...|.||||| .|||. . |. . . . |.||| TEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG |
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| Kinase | PINK1.AA | Trio | 345-386 | 38 | 8e-12 | 25.93 | In-house | 103-144 (258) | Show / Hide |
Range on Protein: 345-386 Range on HMM: 103-144/258 Sequence Identity: 38% (16 aa) QLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFG |.||.|. | ...|.| |.|..|.... . | | . |.||| QMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFG |
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| Kinase | PINK1.AA | STE | 342-388 | 33 | 1e-11 | 37.73 | In-house | 156-194 (359) | Show / Hide |
Range on Protein: 342-388 Range on HMM: 156-194/359 Sequence Identity: 33% (16 aa) MLLQLLEG-VDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCC .. |.|.| ..| ...| |||.|..|||. ..|||.| ICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVC |
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| Kinase | PINK1.AA | STE-Unique | 338-511 | 21 | 4.8e-11 | 34.9 | In-house | 404-616 (616) | Show / Hide |
Range on Protein: 338-511 Range on HMM: 404-616/616 Sequence Identity: 21% (46 aa) LAAMMLLQLLEGVDHLVQQG--IAHRDLKSDNILVELDP-DGCPWLVIADFGCCLADESIGL-------------QLPFS-------------------S ... ...|.||| ..| |. | |||||..||. | .|.||| ... . . EVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNY WYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHL--ESRSYQEAQLP-----ALPESVPPDVRQLVRALLQREAS . |. | |.||| . | . .| |.| | |.. .. . |. .. | . . |.| |.. |. .|. ...| |. . TMKYCCGTPCYMCPEVINCRNQINNPYDT-KVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPH KRPSARVAANVLHLSL .|||| . .. |. | HRPSA--HQLLHHFWL |
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| Kinase | PINK1.AA | Ciliate-E2a | 345-386 | 39 | 6.5e-11 | 28.38 | In-house | 109-154 (275) | Show / Hide |
Range on Protein: 345-386 Range on HMM: 109-154/275 Sequence Identity: 39% (18 aa) QLL-EGVDHLVQQGIAHRDLKSDNILVE-LDPDGC--PWLVIADFG ||| .|. .. |..| ||||| .||| . ..... ..|.||| QLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFG |
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| Kinase | PINK1.AA | CMGC | 271-370 | 17 | 1.5e-10 | 29.91 | In-house | 97-217 (513) | Show / Hide |
Range on Protein: 271-370
Range on HMM: 97-217/513
Sequence Identity: 17% (25 aa)
HPNIIRVLRAFTSS-------------VPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNT----------PSPRL---------
|.||.. . |... . | . |.||. ...| ||. | |.
HNNIVKLYDIFYHKNSDGNEYEDKHIIS----------------------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP
---AAMML------LQLLEGVD--HLVQQG--IAHRDLKSDNILV
.. |.|.|.. .. ... | ||||| |||.
PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILI
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| Kinase | PINK1.AA | CDC2 | 314-386 | 32 | 2.8e-10 | 27.26 | In-house | 75-148 (301) | Show / Hide |
Range on Protein: 314-386 Range on HMM: 75-148/301 Sequence Identity: 32% (25 aa) LFLVMKNYPCTLRQYLC-VNTP----SPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFG |..| . . . |..|. . . .| | . |.|.||... |..| ||||| .|||. . . . ||||| LYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN----IKIADFG |
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| Kinase | PINK1.AA | DCAMKL | 339-386 | 39 | 1.3e-08 | 22.37 | In-house | 117-164 (279) | Show / Hide |
Range on Protein: 339-386 Range on HMM: 117-164/279 Sequence Identity: 39% (19 aa) AAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFG ||.|...| . .| .| |||.| | || ..|| | .||| AAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFG |
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| Kinase | PINK1.AA | TyrKc | 156-507 | 16 | 1.7e-07 | -101.43 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 156-507
Range on HMM: 1-280/280
Sequence Identity: 16% (66 aa)
YLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGA
|. .| |. ||..|. . |.||. . . | .. |
ITLGKKLGEGAFGEVYKGTWK-------------------------------------IQVAVKMLKEDA--------------------REDFMREARI
VTYRKSKRGPKQL-APHPNIIRVLRAFTSS-------VPLL-------PGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAA
..| ||||.| . . |.. ||. |.| || | .. . ...
M---------CKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY---LRKHRPK----------------------------LCMKDLL
MMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLV-IADFGCCLADESI---GLQLPFSSWYVDR----GGNGCL----MAPEVSTARPGPRAV
. .| .| ..| .... |||| |.|| . | |.||| . . .. | |. | . ||.. | ||||. .
SFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPECI------NYG
IDYSKADAWAVGAIAYEIFGL-VNPFYG-----QGKAHLESRSYQEAQLPALPE-------SVPPDVRQLVRALLQREASKRPSARVAANVL
. .| | |. | .||| . | .| ... . | .| |. |... |. . ......||. . .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | PINK1.AA | DCAMKL | 156-174 | 47 | 0.001629 | 6.19 | In-house | 1-19 (279) | Show / Hide |
Range on Protein: 156-174 Range on HMM: 1-19/279 Sequence Identity: 47% (9 aa) YLIGQSIGKGCSAAVYEAT | || ||.| | |.|.. YQIGRIIGDGNFAVVHECR |
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| Kinase | PINK1.AA | STE | 414-500 | 19 | 0.002192 | 7.96 | In-house | 229-348 (359) | Show / Hide |
Range on Protein: 414-500 Range on HMM: 229-348/359 Sequence Identity: 19% (23 aa) MAPEVSTARPGPRAVIDYS-KADAWAVGAIAYEIFGLVNPF--YGQGKAHLESR--SYQEA----------QLPALPE-------------------SVP ||||| . . .. . .|. |.| | .| . | |. . .| .. .. .. . | ||. .. MAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS PDVRQLVRALLQREASKRPSA |. .. .. ||.. .|||.| PEFKDFINKCLQKDPNKRPTA |
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| Kinase | PINK1.AA | CAMK | 478-500 | 30 | 0.015558 | 3.18 | In-house | 394-416 (425) | Show / Hide |
Range on Protein: 478-500 Range on HMM: 394-416/425 Sequence Identity: 30% (7 aa) VPPDVRQLVRALLQREASKRPSA | .....|.| .||.. .||... VSQECKDLIRKMLQVDPEKRMTI |
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| Kinase | PINK1.AA | Ciliate-E2 | 156-173 | 33 | 0.019433 | 4.16 | In-house | 1-18 (365) | Show / Hide |
Range on Protein: 156-173 Range on HMM: 1-18/365 Sequence Identity: 33% (6 aa) YLIGQSIGKGCSAAVYEA | . . ||.|. . ||.. YKFIKKIGQGNFGSVYKC |
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| Kinase | PINK1.AA | Pkinase | 156-174 | 42 | 2.762039 | 2.09 | Pfam | 1-19 (293) | Show / Hide |
Range on Protein: 156-174 Range on HMM: 1-19/293 Sequence Identity: 42% (8 aa) YLIGQSIGKGCSAAVYEAT | ||. ||.| .. ||... YHIGRKIGSGSFGCVYKCH |
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