Gene PKD2 (Human)
PKD2
Sequence
Protein domains of PKD2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PKD_Nterm_DUF | PKD2.AA | PKD_Nterm_DUF | 45-129 | 45 | 7.8e-44 | 143.98 | In-house | 1-87 (87) | Show / Hide |
Range on Protein: 45-129 Range on HMM: 1-87/87 Sequence Identity: 45% (40 aa) VSFHIQIGLTREFVLLPAA-SELAHVKQLACSIVDQKFPECGFYG-LYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASA ..|| |.|..|| | .... |. .| |||....||.|.||... |||||.||.||..|.|.||.. |. |. ||.|.|.||||.. CHFHFQCGFHREMVCVEGHELTLTALKELACQFIEQKYPDCGCCNRLYDKIYLFRHDYNSPNILQMITSASDVTEGCLIEIVLSACP |
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| C1_1 | PKD2.AA | C1_1 | 139-191 | 40 | 1.4e-16 | 64.49 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 139-191 Range on HMM: 1-55/55 Sequence Identity: 40% (22 aa) HALTVH-SYRAPAFCDHCGEMLFG-LVRQGLKCDGCGLNYHKRCAFSIPNNCSGA | .| ... |.||.||||...| | .||.||. |..|.|.||. |..| . HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
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| C1 | PKD2.AA | C1 | 139-188 | 25 | 1.6e-13 | 52.21 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 139-188 Range on HMM: 1-61/61 Sequence Identity: 25% (16 aa) HALTVHSYRAPAFCDHCGEMLFGLVRQ-----GLKCDGCGLNYHKRCAFSIPN-------NC | ... |..|.||..|..|. .| |..| |....||.|. .|. .| HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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| C1_3 | PKD2.AA | C1_3 | 150-181 | 25 | 5e-05 | 14.28 | Pfam | 1-30 (30) | Show / Hide |
Range on Protein: 150-181 Range on HMM: 1-30/30 Sequence Identity: 25% (8 aa) AFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCA .|. ||. . . . . .| | . |..|| FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA |
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| C1 | PKD2.AA | C1 | 265-314 | 32 | 6.7e-20 | 73.36 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 265-314 Range on HMM: 1-61/61 Sequence Identity: 32% (20 aa) HTFLIHSYTRPTVCQACKKLLKGLFRQ-----GLQCKDCKFNCHKRCATRVPN-------DC |.. .... .|| |. |.|...|.|.| |..| .||..|||.|...||. .| HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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| C1_1 | PKD2.AA | C1_1 | 265-317 | 36 | 9e-18 | 68.89 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 265-317 Range on HMM: 1-55/55 Sequence Identity: 36% (20 aa) HTFLIH-SYTRPTVCQACKKLLKG-LFRQGLQCKDCKFNCHKRCATRVPNDCLGE | . | .. .|| | |.... | |..||..| .|..|||.||...||. | . HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN |
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| C1_3 | PKD2.AA | C1_3 | 276-307 | 25 | 1e-06 | 18.22 | Pfam | 1-30 (30) | Show / Hide |
Range on Protein: 276-307 Range on HMM: 1-30/30 Sequence Identity: 25% (8 aa) TVCQACKKLLKGLFRQGLQCKDCKFNCHKRCA |..|.. ... . . | | |. |..|| FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA |
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| PH | PKD2.AA | PH | 398-511 | 21 | 1.2e-09 | 39.26 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 398-511 Range on HMM: 1-82/82 Sequence Identity: 21% (25 aa) TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTAN-ATYFVGEMPGGTPGGPSGQGAEA ...|||. ..| .|... .|. .|...... .. ..||||.. ||. ||||.. . || | .| VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P------------CFEIHH-DRTYYFQCE------------SEEE ARGWETAIRQALMPV .. | .||..|. . MQEWMQAIQKAIHNN |
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| PH | PKD2.AA | PH | 398-478 | 25 | 7.2e-09 | 34.62 | Pfam | 1-72 (92) | Show / Hide |
Range on Protein: 398-478 Range on HMM: 1-72/92 Sequence Identity: 25% (21 aa) TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANA-TYFV .|||. .. | .|... | .|. .... . |. . ||||.. .|. . . .||||.|.| . ||.. VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN------KRPHCFQIRT-DRRTYYF |
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| Kinase | PKD2.AA | PKD | 551-807 | 84 | 3.8e-230 | 770.88 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 551-807 Range on HMM: 1-260/260 Sequence Identity: 84% (219 aa) IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQ--ESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPE |||||||||||||.||||.||.|||.||||||||||||||| |.|.||||||||...|||.|.||||.|||...||||||.||||||||||||||||.| IFPDEVLGSGQFGIVYGGIHRHTGRHVAVKVIDKLRFPTKQSGEEQMRNEVAILQQVCHPGVVCLECMCETPDRIFVVMEKMHGDMLEMILSSEKGRLNE RLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASA-DPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSG |.|||||||||.||..||..||||||||||||||.|. ..|||||||||||||||||||||||||||||||||||| |.||||||||||||||.|||||| RVTKFLITQILCALKYLHHQNIVHCDLKPENVLLSSMGSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG TFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL ||||||||||||||||||||||..||..|| .|||||||||||||||||.|||.|||||| TFPFNEDEDINDQIQNAAFMYPPNPWKEISENAIDLINNLLQVKMRKRYTVDKCLSHPWL |
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| Kinase | PKD2.AA | CAMK | 556-807 | 23 | 5.70000000001e-108 | 349.1 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 556-807
Range on HMM: 1-425/425
Sequence Identity: 23% (98 aa)
VLGSGQFGVVYGGKHRKTG------------RDVAVKVIDK----------------LRFP----------TKQESQLRNEVAILQS-------LRHPGI
.||.|.||.|. ..|..|. . ||.|.||| ... | . ..|.|..|... |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VNLECMFE------------TPEK--------VFVVM---EKLHG-----DMLEMILSSEK-------------GRLPERLTKFLITQILVALRHLHFKN
..| ..| | .| .. || | | |....| . .. ||..|| ..... ||. |....| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IVHCDLKPENVLLASADPFP--------------QVKLCDFGFARIIGE------------------------KSFRRSVVGTPAYLA-PEVLLN-----
|||.||||||.|| . .. ..|..|||||... . . ..|||.| | ||||.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
---------QGYNRSLDMWSVGVIMYVSLSGTFPFNED---------------EDINDQIQNAAFMYPASP------------WSHISAG--------AI
..|... ||||.|||.|. |.|..||..| ... .|... . .| .. |..|| ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DLINNLLQVKMRKRYSVDKSLSHPWL
|||...||| ||.... |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | PKD2.AA | RAD53 | 554-807 | 33 | 8.6e-95 | 282.76 | In-house | 4-305 (305) | Show / Hide |
Range on Protein: 554-807
Range on HMM: 4-305/305
Sequence Identity: 33% (102 aa)
DEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFP------TKQESQLRNEVAILQSLRHPGIVNLECMFETP-EKVFVVMEKLHG-DMLEMILSSEKGR
...|||| ||.|. .. .||.. ||.| ||| .| .| ..|..||| ||. | || |.... |.|| . .. |.|. | . .. | |. |..
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSN-KRC
---LPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP---------------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQ-
. | |.. |.. |.. || ..|.| ||||||.|... | ..|. ||| ....||.|| . |||.|.||||....
QMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKG
--------------GYNRSLDMWSVGVIMYVSLSGTFPFNED-------EDINDQIQN-AAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSH
||... |.|| |.| |..|.|. || .| ....|| | . . .| |. || | |||...|.| |||..|. |.|
HNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNH
PWL
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PWM
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| Kinase | PKD2.AA | S_TKc | 551-807 | 32 | 7.8e-94 | 318.96 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 551-807
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)
IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG---DMLEMILSSEKGR--
...|.| ||.|| ..|.|||| ||.|.|. ..|.|..||.. .|| ||.| .|.. .....||| . | |....| . ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
--LPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNR-SLDMWSVGVIMY
.|| ..|.. ||. || ..| ..|.|.||||||.|| . ..|.||||.||.. ....||| |.||||| ||.. . |.||.|.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY
VSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLS-------HPWL
|.| || ... ... | |.|.|...||. .||... . | |||.
EMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | PKD2.AA | AGC | 551-807 | 21 | 8e-85 | 218.47 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 551-807
Range on HMM: 1-395/395
Sequence Identity: 21% (88 aa)
IFPDEVLGSGQFGVVYGGKHR------KTGRDVAVKVIDKLR--FPTK--QESQLRNE------------VAILQSLR----------HPGIVN-LECMF
|.| | || || ... ||. |.||..| . .| .. . .| ||. .. || ||. | . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF
ETPEK--VFVVME----KLH-----GD-MLEMILSS--EKGRLPERLTKFLITQ-------ILVALRHLHF-KNIVHCD-LKPENVLLASADPFPQVKLC
..... .. ||| . |. .| ..| .||..| ..| . . |. || .|| ..|.| | |||||.|| . .||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT
DFGFARIIG---------------------------------------------------EKSFRRSVVG--TPAYLAPEVLLNQGYNRSLDMWS--VGV
|||.. .. .. . .| || |.|||.| |... | || .|.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC
IMYVSLSGTFPFNEDE------------DINDQIQ------NAAFMYPAS------PWSHISAGAIDLINNLLQVKMRKRYS----------VDKSLSHP
.|| |.| ||. |. .. ..|. | .| .....| | |||. ||.. .|| .. .||
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP
WL
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WF
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| Kinase | PKD2.AA | CAMKL | 549-807 | 30 | 5e-79 | 251.81 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 549-807 Range on HMM: 1-297/297 Sequence Identity: 30% (92 aa) YQIFPDEVLGSGQFGVVYGGKH-RKTGRDVAVKVID--KLRFPTKQESQ-----------LRNEVAILQSLR---HPGIVNLECMFETPEK------VFV |.| ..|| | ||.| ..| | ||. ||.|.|| |.. .. .. .| |..|...|. || |. | ..||||. .. YRI--GKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL VMEKLHGD---MLEMILSSEK--GRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD-PFPQVKLCDFGFARIIGE-----KSFRRSVVGT ||| | ....| . .. ||.||. .... .||. |. ..| ..||| |.||||.|| . . ..|..||||. .. . . . |. VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGS PAYLAPEVLLN--QGYN-RSLDMWSVGVIMYVSLSGTFPFNEDEDI---------NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSL |.| |||... . |. . |.|| |||.|. . |..||..| . .| ...| .|.|.| ..||| .|||. ||.... . PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM SHPWL .|||. NHPWM |
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| Kinase | PKD2.AA | Pkinase | 551-807 | 31 | 1.3e-78 | 272.23 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 551-807 Range on HMM: 1-293/293 Sequence Identity: 31% (93 aa) IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRN--EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGD----MLEMILS-SEK . ...||| ||.|| ..|..||. ||||.|.| . ... ..|. |..|...|.|| || | ..||.. .. .||| . |. | ..| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GRL--PERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP--QVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWS |.. .|. || ..||| .| ..| ..|.|.||||||.|. .. . ||.||||.|. . .| ...||| |.||||.. .|.| .. |||| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS VGVIMYVSLSGTFPFNED--------EDINDQIQNAAFMYPASPWSHIS-----------------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL .|.|.| |.| .|| .. . ..| . .... . |. || ..|.|...|.... ||.. . | |||. CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | PKD2.AA | DCAMKL | 549-807 | 36 | 1.7e-69 | 215.23 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 549-807 Range on HMM: 1-279/279 Sequence Identity: 36% (104 aa) YQIFPDEVLGSGQFGVVYGGKHRKTG-RDVAVKV-----------------IDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKL ||| . | | | ||. .||.|| . | |. ||| . | | |||.|.|...|| |. | ..|... . ||| YQIG--RIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGK-EHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYV H-GDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGE---KSFRRSVVGTPAYLAPEVLLN || . | .. .. .|| ..|.. ||..|| .|||| |.|||| |. | .|||||| | .. . .. | ||| | |||.| QGGDLFDAITEN--TKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYT--VCGTPTYVAPEILME QGYNRSLDMWSVGVIMYVSLSGTFPF----NEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL || |.|..||| |. | | || |. |. |||. ..| .|. |. ||..| |||...||| |||. ..||| TGYGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV |
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| Kinase | PKD2.AA | CAMK-Unique | 555-807 | 24 | 4.4e-67 | 220.44 | In-house | 5-363 (363) | Show / Hide |
Range on Protein: 555-807
Range on HMM: 5-363/363
Sequence Identity: 24% (87 aa)
EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQ------------------LRNEVAILQSLRHPGIVNLECM----FETPE-----------
...|.| ||.|| .. |.|| |.|.. | . | | |..|..|.... || |. |. |....
RIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTP
----KVFVVMEKLHGD-MLEMILS-SE-----------------KGRLPE--RLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP---------
. . ||| . | ... |.. .| .|.. | ..| |.....| |. ..| ..||| |||.||... . .
RALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFP
----FPQVKLCDFGFARIIGEKSFRR---SVVGTPAYLAP--------------EVLLNQGYNRSL----DMWSVGVIMYVSLSGTFPFN-EDED-----
. .|||||| .. . .. . ...||| |.|| ||. .|.| . . | || ||||| |.| ||. |.||
YDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYEN
----INDQIQNAAF-MYPASPWSH---ISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL
| . | . . .. . |. || .|.|.. ....|. .| | |.|.|.
HDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
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| Kinase | PKD2.AA | MARK | 549-807 | 30 | 6.4e-66 | 214.51 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 549-807 Range on HMM: 1-262/262 Sequence Identity: 30% (82 aa) YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPT-KQESQLRNEVAILQSLRHPGIVNLECMFE--TPEK-VFVVMEKLHG-DMLEMILSSEK | . ..| | ...|. . |..||| ||.|...| . .. . .. |..|...| || |. | ..| |... ....|| | .... | . .. YKML--KTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPN GRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD-PFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYN-RSLDMWSVGVIM |||.|.... . .||. |. .| |||||.|.||||.|. . ..|..||||...| . . . |||.| |||..| . |. . |.|| ||.. GRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNH--NIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVL YVSLSGTFPFN--E--DEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL |. ..|.||| ..... .|.. . .| .|.|... .||. ||.| .| ... ..|||. YFMVCGYFPFDGDTQDYKELYKKILRGKYDIP----CHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | PKD2.AA | Ciliate-E2 | 555-807 | 22 | 7.5e-66 | 225.03 | In-house | 5-365 (365) | Show / Hide |
Range on Protein: 555-807 Range on HMM: 5-365/365 Sequence Identity: 22% (85 aa) EVLGSGQFGVVYGGKHRKTGR------------------DVAVKVIDKLRFPTKQESQLRNEVAILQ----------------SLRHPGIVNLECMFE-- ...|.|.||.|| .|..|... |..| . . .. .| |. .| |.. .| || |... |. KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK TPEKVFVVMEKLHG-DMLEMILSS----------EKGRLPERLTKFLITQILV---------------ALRHLHFKN-IVHCDLKPENVLLASADPFPQV . .... ||| . | |... | .. . ... |. |....||| ||..|| || |.| |.||||.|. . DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------I KLCDFGFARIIGEKSFRRS--------------------------------VVGTPAYLAPEVLLNQG---------YNRSLDMWSVGVIMYVSLSGTFP |..|||..... ... .|. ..||| |.|||.| ... |. . |.||.|||.| |.| .| KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FNEDEDINDQIQNAAFMYPAS--------------PWSHISAGAIDLINN----LLQVKMRKRYS-VDKSLSHPWL | .||.. . .| | ..| ..|||.. .||.. ||.. .. | |||. F------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | PKD2.AA | CAMK1 | 654-807 | 37 | 1.2e-63 | 183.85 | In-house | 113-276 (276) | Show / Hide |
Range on Protein: 654-807 Range on HMM: 113-276/276 Sequence Identity: 37% (62 aa) LITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVK--LCDFGFARIIGEKS-FRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVSLSG .. ||| |. ..| |.|||.|||||| |... |. ..| ..||| ..|..... . ..||| | ||||| . ..| . ||||.||| |. | | IMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCG TFPFNEDE-D--INDQIQNAAFMYPASPWSHISAG-AIDLINNLLQVKMRKRYSVDKSLSHPWL ||... | . ..| .. . .| | .|| . | |.|...| | |||.....| |||. YPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | PKD2.AA | CAMK1 | 549-628 | 28 | 3.8e-27 | 75.92 | In-house | 1-88 (276) | Show / Hide |
Range on Protein: 549-628 Range on HMM: 1-88/276 Sequence Identity: 28% (26 aa) YQIFPDEVLGSGQFGVVYGGKHRKT---GRDVAVKVID-KLRFPTKQE---SQLRNEVAILQS---LRHPGIVNLECMFETPEKVFVVME |... ...|.| |..|| ..|..| |...|.|.|| | .| . .|.||..|... . || |..... .|..... ||| YEFG--KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVME |
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| Kinase | PKD2.AA | TyrKc | 551-807 | 20 | 4.8e-14 | 4.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 551-807 Range on HMM: 1-280/280 Sequence Identity: 20% (61 aa) IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSL--RHPGIVNLECMFETP-------EKVFVVMEKL-HGDMLEMILS | ...||.|.||.|| |. . ..||||.. . . ...| |. .| .|| ||.| .. | ...||| ||| .. . . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK--------SFRRSV-VGTP-----AYLAPEVLLNQ ... |. . .|| ..|| ||..| || |.|... .|| .||| .| |... | . |. .|||.. HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG GYNRSLDMWSVGVIMY--VSLSGTFPFN------EDEDINDQIQNAAFMYPASP-----WSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL .. | || || |. .. .. . . ..... .... | . . .. ... . . .| . | . KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | PKD2.AA | Pkinase_Tyr | 554-613 | 34 | 2.5e-10 | 35.6 | Pfam | 4-69 (270) | Show / Hide |
Range on Protein: 554-613 Range on HMM: 4-69/270 Sequence Identity: 34% (23 aa) DEVLGSGQFGVVYGGKHR----KTGRDVAVKVIDKLRFPTKQ--ESQLRNEVAILQSL-RHPGIVNL ...||.|.||.|| |. . .|. .||||.. | .| . .|..|. .| .|| ||.| GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL |
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| Kinase | PKD2.AA | Pkinase_Tyr | 661-742 | 29 | 0.011358 | 9.67 | Pfam | 123-205 (270) | Show / Hide |
Range on Protein: 661-742 Range on HMM: 123-205/270 Sequence Identity: 29% (26 aa) ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGT-----PAYLAPEVLLNQGYNRSLDMWSVGVIMY .. .|. ||..| || |.|... .|| |||| || | ... ..... .|||.. . .. | || || |. GMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMW |
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