Gene PKG2 (Human)

PKG2

Species: Human
Alias: PRKGR2, PKG2, cGKII, PRKG2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 4q13-q21.3,

Classification

Group: AGC
Family: PKG

Sequence

Name Sequence Type Origin Length Description Download
PKG2.NA RNA Sugen Kinome 3328 None Fasta, JSON
PKG2.AA Protein Sugen Kinome 762 None Fasta, JSON
PKG2.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of PKG2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP PKG2.AA cNMP 168-284 26 2.1e-22 81.64 SMART 1-123 (123) Show / Hide 
Range on Protein: 168-284
Range on HMM: 1-123/123
Sequence Identity: 26% (33 aa)

FLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQG---------EKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALD
..|.||.|.. . ...|. | |. |.||..||.||.|.... .|...|..          |...  .     |||||.|    |.... |..... ....
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL---RRPRTAAARACCECCTIW

REVFQNIMRRTAQARDEQYRNFLRSV
|  ||..|.  .| .. .||.... .
RIDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding PKG2.AA cNMP_binding 186-271 28 1.8e-19 69.46 Pfam 1-91 (91) Show / Hide 
Range on Protein: 186-271
Range on HMM: 1-91/91
Sequence Identity: 28% (26 aa)

GRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLS-----SIPMWTTFGELAILYNC-TRTASVKAITNVKTWALDREVFQNIMRRTAQ
 |.|. |..|..||.|..|.... .|...|.. ..         .     |||.|...|. .|||.|.|.| .. |...||.|...|..  .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP PKG2.AA cNMP 286-409 26 2e-30 108.3 SMART 1-123 (123) Show / Hide 
Range on Protein: 286-409
Range on HMM: 1-123/123
Sequence Identity: 26% (34 aa)

LLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQS---TEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVI
..|||.|. |....|..|...| .|.||.|.|. |..|.|. .|.|.|..    . .... |....|..|..||| ||.    |... .| .  . |  |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL----RRPRTAAARACCECCTI

DRETFNQTVGTFEELQKYLEGYVANLN
.| .|.. ..  .. .  .    ..| 
WRIDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding PKG2.AA cNMP_binding 304-396 34 1.8e-24 86.66 Pfam 1-91 (91) Show / Hide 
Range on Protein: 304-396
Range on HMM: 1-91/91
Sequence Identity: 34% (32 aa)

VEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDD-VRSANIIAEENDVACLVIDRETFNQTVGTFEE
|..| ||..|...|.... |.|. .|||||.. .|. ..  .. .|..|..||| ||. ..  |.|...| . |. |..|.||.|.| . .. |
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQ-ILGFLGPGDFFGEMALFTNQNPRTATVVA-LTDCECWRIPREDFRQLMQQHPE
Kinase PKG2.AA PKG 453-711 72 9.5e-219 733.0 In-house 1-260 (260) Show / Hide 
Range on Protein: 453-711
Range on HMM: 1-260/260
Sequence Identity: 72% (188 aa)

LEIIATLGVGGFGRVELVKVKNE-NVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEP
|.||||||||||||||||..... ...||.||..|.|||||.||||..|||.|..|....|||.|||||.|.||||||.|||.|||||.||||||.||..
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

TSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFS
|..|..|||.|||||||| .|||||||||||.||..||.||||||||||||.|.|||||||||||||||.|||||||.|||.|.||||..||||||||||
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFS

GVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL
|.|.|.|||.|||||....|||||||.....|..|||.|||||||..||||||||||.|.
GSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PKG2.AA AGC 453-711 29 1.3e-166 434.86 In-house 1-395 (395) Show / Hide 
Range on Protein: 453-711
Range on HMM: 1-395/395
Sequence Identity: 29% (117 aa)

LEIIATLGVGGFGRVELVKVK------NENVAFAMKCIRKKH-IVDTK--QQEHVYSE------------KRILEELC----------SPFIVK-LYRTF
 |.. ..| |.||.| ||. |        .  .|||...||| ||..|  ..||...|            ..|||..           .||||| |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDNKY--VYMLLEACL---------GG-ELWSILR---DRGSFDEPTSKFCVAC-------VTEAFDYLHR-LGIIYRD-LKPENLILDAEGYLKLVDFG
.|...  .|...| .          || ||...|.   ..|.|||....|  |.       .. |..|||. .|||.|| |||||. ||..|..||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKKIGSG---------------------------------------------------QKTWTFCG--TPEYVAPEVILNKGHDFSVDFWS--LGILVY
..|.. ..                                                   ..||||||  ||||.|||..    .....| ||  ||.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLTGNPPFSGV----------DQMMTYNLILKGI----EKMDFP----------RKITRRPEDLIRRLCRQNPTERLGNLKN-----GINDIKKHRWL
|.||| |||.|           ..| ....|..|.    .|  ||          |...    |||..|.  .|..|||...|     |...||.| | 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKG2.AA PKA 453-711 50 1.2e-127 430.38 In-house 1-263 (263) Show / Hide 
Range on Protein: 453-711
Range on HMM: 1-263/263
Sequence Identity: 50% (134 aa)

LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIV-KLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEP
 |||.||| | ||||.|.. |.    .|||...|  ||..||.||| .||.|| .. .|||| |.| ||.|..| ||..| . |||. | || .|.|..|
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TSKFCVA-CVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNK-GHDFSVDFWSLGILVYELLTGNPP
..|| .|  .. |..||| . ||||||||||. .| .|..|. |||||||. .   ||| |||||| |||.|..| ||  ||| |.||||.||.|.| ||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FSGV--DQMMTYNLILKGIEKMDFPRKITRRP---EDLIRRLCRQNPTERLGNLKNGINDIKKHRWL
|.    |.| .|. |..|  | .||| .. .     |||..|   ..|.|.||.|||.||||.|.| 
FYDHNRDPMQIYEKICNG--KIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PKG2.AA AktR 454-711 41 2.5e-99 336.27 In-house 2-268 (268) Show / Hide 
Range on Protein: 454-711
Range on HMM: 2-268/268
Sequence Identity: 41% (110 aa)

EIIATLGVGGFGRVELVKVK-NENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELC-SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEP
.... || |.||.| ||. | ...  .||| |.||.|.. .|..|.. |. |.|..|  ||||||. .|..... . ..| | |||| ..|. .. |.| 
HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE

TSKFCVACVTEAFDYLHRL-GIIYRDLKPENLILDAEGYLKLVDFGFAK--KIGSG-QKTWTFCGTPEYVAPEVILN-KGHDFSVDFWSLGILVYELLTG
...|  | .  |..|||    ||||||||||. || .|..|..||| .|  .. .  .|. .|||||||.|||.|.. |||..|||.|..||..||..||
QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTG

NPPFSG--VDQMMTYNLILKGIEKMDFPRKITRRPEDLIR-RLCRQNPTERLGNLKNGINDIKKHRWL
.|||      ||  . .|   . | ..| ...    |||  .|  .||..|||  .||. .||.| | 
CPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKG2.AA Akt 454-711 38 2.6e-97 311.64 In-house 2-264 (264) Show / Hide 
Range on Protein: 454-711
Range on HMM: 2-264/264
Sequence Identity: 38% (102 aa)

EIIATLGVGGFGRVELVKVKNENVAF-AMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPT
...  || | ||.| ||| |. .  . ||| ..|..|.. .| ||.  |..||.   .||||.|.  | .... |. .. | |||| . |. .. |.|..
DFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDR

SKFCVACVTEAFDYLHRLGIIYRD-LKPENLILDAEGYLKLVDFGFAKKI-GSG-QKTWTFCGTPEYVAPEVILNKGHDFSVDFWS-LGILVYELLTGNP
 .| .| .  | ..||  .||||| |||||. .|..|...| ||| .|..  .  .|| |||||||| |||.....||. .||.|. ||.. ||...|.|
ARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRP

PFSGVDQMMTYNLILKGIEKMDFP--RKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL
||   |.   . .|.   ..  ||  ..|     |||..|.  .|..|||. .|....|| | |.
PFYNQDHHQMFKKIKN--QPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKG2.AA SGK 454-711 34 7e-93 287.14 In-house 2-283 (283) Show / Hide 
Range on Protein: 454-711
Range on HMM: 2-283/283
Sequence Identity: 34% (99 aa)

EIIATLGVGGFGRVELVKVKNE------------------NVAFAMKCIRKKHIV-------DTKQQEHVYSEK-RILEELCSPFIVKLYRTFKDNKYVY
... ..| |.||.| .|| | .                     .||| ..|.||.         |.| |. .|.  ||  . .||||.|   |   .. |
DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY

MLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK-KIGSGQKTWTFCGTPEYVAPEVILNKG
. ..   |||. . |. ...| |. ..| .| .  | .||| . ||||||||||. ||..|...| ||| .| .|   ..| |||||||| ||||.. ..
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQP

HDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL
|| .|| |.||.. ||...| |||   .    |  |..  ... .|. ..    |||  |   .|..|||  |..  .||.| . 
HDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIIN--QPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase PKG2.AA S_TKc 453-711 33 6.6e-92 312.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 453-711
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLG--GELWSILRDRGS---
 ||. ..| |.||.| ... |. .  .|.|.|.          ||...| .||..   |.||||| .| | ...|| .| | |  |.| .....||.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDF-SVDFWSLGILVYEL
   |.| . .| .. . .| .|.|..|||.|||||||. ||    .|. |||.|...       ||||||.|.||||.   |... ..| ||.|...||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGI--NDIKKHRWL
|.| |||.  ...|....|.            ..   |.||.... .|..|..  .      |||.| |.
LCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKG2.AA RSK 456-711 37 7.3e-92 311.5 In-house 1-278 (278) Show / Hide 
Range on Protein: 456-711
Range on HMM: 1-278/278
Sequence Identity: 37% (104 aa)

IATLGVGGFGRVELVKVK---NENVAFAMKCIRKKHIVDTKQ-QEHVYSEKRILEELC-SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGS---
.  || ||.| | |.. .   . .  .||| ..|. || ..  ..|.  | .|||.   .||||.|. .|......|. .| | ||||   |. ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDA---EGYLKLVDFGFAKK-IGS-GQKTWTFCGTPEYVAPEVIL----NKGHDFSVDFWSLGI
|.| . .|  | .. | ..|| .|||.||||||| ..|    || .||.||||.|.   . .|.| |||.| ||.|||..     ..||| ..| ||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LVYELLTGNPPFSG---VDQMMTYNLILKGIEKMDFP--RKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL
| ||.|||.||| |    ..  . . |.||   ...|   ....   ||||..   .|  |||  ......||.| |.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKG2.AA Ciliate-E2b 453-711 36 6.7e-91 276.42 In-house 1-272 (272) Show / Hide 
Range on Protein: 453-711
Range on HMM: 1-272/272
Sequence Identity: 36% (99 aa)

LEIIATLGVGGFGRVELVKV-KNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRG--SFD
...|  || | || | ||.  ||..  .||||| |  |. .    |  .|| .|| .  |||.|..|.|||....|...| | |.|| ...|. |   . 
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

EPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQK----TWTFCGTPEYVAPEVIL-----NKGHDFSVDFWSLGILV
.  |.| .| .  .. ||| ..|||||.|||| ..| .||.||.|.| || . . .     | | .|||.| |||.|      .||  ..|| ||.||  
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

YELLTGNPPFS--GVDQMMTYNLILKGIEKMDFPRKITRRPE--DLIRRLCRQNPTERLGNLKNGINDIKKHRWL
||.. | .|.     |.   |  |.|. .. .||  .. .    .|. ..   .|  |||     ..  | | | 
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG---GSYSWLKSHPWF
Kinase PKG2.AA Pkinase 453-711 32 5.2e-90 310.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 453-711
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVY-SEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGG----ELWSILR--DR
..|. ..| |.||.| . . |...  .|.|.|.|.|. . |.|.|.  || .|. .|..|.||.||..| |....|| .| | ||    .|.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSF--DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYL----KLVDFGFAKK--IGSGQKTWTFCGTPEYVAPEVIL-NKGHDFSVDFWSL
|.|  .| . ||..  . .. .|.|. |||.|||||||. .| .|..    |. |||.||.  . ... ..||||||.|.|||||. ..... .|| ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILVYELLTGNPPFSGV------DQMMTYNLILKGIEKMDFPRKIT-------------------RRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL
|...||.|.|.|||.|       |||  ...|.... . |.| ...                   .   |.|.......|..|..     . .|..| |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase PKG2.AA RSK 454-711 36 4.4e-82 279.0 In-house 2-271 (271) Show / Hide 
Range on Protein: 454-711
Range on HMM: 2-271/271
Sequence Identity: 36% (99 aa)

EIIATLGVGGFGRVELVKVK---NENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDE
|..  .|.| |. | ..| .     |  .||| |.|. .. . .      |  ||..  .||||||.  | | ..||| .. . ||.|   |   ..| |
ELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

PTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAE----GYLKLVDFGFAKKIGSGQK-TWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLT
   ||  | .. | .||| .||..||||||| ..|.|    | .|..||||||.  .  . . |||.| .|.||||.  .||| ..|.||.|.| || ||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GNPPFSGVDQMMTYNLILKGIEKM-----DFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL
|..|| . .   . |.|..  . |       . .|...  ||.|..   .|. |||.  ||...||.| |.
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase PKG2.AA Ciliate-E2 453-711 24 9.3e-80 271.28 In-house 1-365 (365) Show / Hide 
Range on Protein: 453-711
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

LEIIATLGVGGFGRVELVKVKNENVAFA-----------------------MKCIRKKHIVDTKQQEHVY----------SEKRILEELCSPFIVKLYRT
 ..|  .| |.|| | ..||....  ||                       ||...|. |  .|| .|..           ||.|||.| .|.|.|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DNKYVYMLLEACLGGELWSILRDR-----------GSFDEPTSK---------------FCVACVTEAFDYLHRLG-IIYRDLKPENLILDAEGYL
|.  |....|. .| | ||.|.......           ..|.|   |               | .||. .|. |||  . ||.||.||||...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLVDFGFAKKIGSG--------------------------------QKTWTFCGTPEYVAPEVILNKG---------HDFSVDFWSLGILVYELLTGNPP
|..|||..||.                                   . ..|.||||.|.|||.. .|.         .|...|.||||.. ||.|.|.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FSGVDQMMTYNLILKGIEKMDFPR--------------KITRRPE--DLIRR----LCRQNPTERLGNLKNGINDIKKHRWL
|        .. |...  . ..|               .    .|  |||..    .   .| .|..    |...|..| |.
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PKG2.AA TyrKc 453-702 19 1e-11 -33.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 453-702
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEEL--CSPFIVKLYRTFKDN-------KYVYMLLEACLGGELWSILR
.. . .|| | ||.| . . |   .  | |.... .      .|  ..| ||. .|    | ||.||    .        . .....| . .| | . ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DRGSFDEPTSKFCVAC--VTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSG------QKTWTF----CGTP----EYVAPEVILNKGH
...    ......  |  . .  .|||. ..| |||   |  .....  |  ||| ...|...      ... .     .|         |||.|  .  
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DFSVDFWSLGILVYELLT-GNPPFSG-----VDQMMTYNLILKGIEKMDFPRK--------ITRRPEDLIRRLCRQNPTERL--GNLKNGI
 .  | || |.. .|..| | .| .|     ..    .... .| . |. |           .    ..... .. .| .|    ...  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKG2.AA S_TK_X 712-762 17 2.9e-07 31.38 SMART 1-79 (79) Show / Hide 
Range on Protein: 712-762
Range on HMM: 1-79/79
Sequence Identity: 17% (14 aa)

NGFNWEGLKA--RSLPSPLQRELK----GPIDHSYFD-KYPP--EKGMPPDE-------------------LSGWDKDF
 |..|..| .  . .. | . ..|    .|.| |.|| ...    . .|.|.                     |....|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF