Gene PKN2 (Human)

PKN2

Species: Human
Alias: PRO2042, PKN2, MGC71074, PRK2, PRKCL2, Pak-2, MGC150606, PAK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p22.2,

Classification

Group: AGC
Family: PKN

Sequence

Name Sequence Type Origin Length Description Download
PKN2.NA RNA Sugen Kinome 6104 None Fasta, JSON
PKN2.AA Protein Sugen Kinome 984 None Fasta, JSON
PKN2.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of PKN2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HR1 PKN2.AA HR1 47-114 32 2.1e-21 79.87 Pfam 1-74 (74) Show / Hide 
Range on Protein: 47-114
Range on HMM: 1-74/74
Sequence Identity: 32% (24 aa)

DIKDRIKREIRKELKIKEGAENLRKV---TTDKKS----LAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPED
. .......|..|.||||||||.|..   |||.|.    .. ... |. ||.|.|.|...|..|... .. .|..
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN2.AA HR1 136-208 36 1.2e-19 73.54 Pfam 1-74 (74) Show / Hide 
Range on Protein: 136-208
Range on HMM: 1-74/74
Sequence Identity: 36% (27 aa)

NRLKALQKQLDIELKVKQGAENMIQMY--SNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNA
.||..|.|....|.|.|.|||||...|  ... .|.||..  .|| |..|..||| .|||. .  | ..   . .
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
HR1 PKN2.AA HR1 217-289 26 2.7e-20 75.91 Pfam 1-74 (74) Show / Hide 
Range on Protein: 217-289
Range on HMM: 1-74/74
Sequence Identity: 26% (20 aa)

LRMEELRHHFRIEFAVAEGAKNVMKLL--GSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKS
.|...||.....| .. |||.|.....   ...  .||.....|.. .||.||...|. .||..  ...  || .
QRLQQLRKKIEREMKIKEGAENMRRAYQMTTDNKKHRKVRQQCQQMLRESNQKIEYLRMQLEKLQQRHQD-HPPN
C2 PKN2.AA C2 330-463 9 1.7e-10 42.11 SMART 1-92 (92) Show / Hide 
Range on Protein: 330-463
Range on HMM: 1-92/92
Sequence Identity: 9% (15 aa)

TLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPIS----NQSWDQ---KFT
||.|... ....                                                  |  ....       .|.... .    |  |..   .|.
TLTVHIIEARNLP-------------------------------------------------DPYVKVY-------KTKVVKNTLSGFNPVWNEWMETFY

LELDRSRELEISVYWRDWRSLCAVKFLR-------------LEDFLDNQRHGMC
..... . |...|. .  . .  . . .             |.| | ..|| ..
FDVHP-Q-LRFEVWDH--DFIGHCCIPPNNPHWHQWDGCIHLSDIL-GYRH-WW
C2_PKD PKN2.AA C2_PKD 387-489 19 6.7e-10 31.41 In-house 32-147 (183) Show / Hide 
Range on Protein: 387-489
Range on HMM: 32-147/183
Sequence Identity: 19% (23 aa)

DDLSNDVCAVLKLDNTV----VGQTSW-KPISNQSWDQKFTLELDRSRELEISVYWRDW---RSLCAVKFLRLEDFLD-----NQRHGMCLYLEPQGTLF
|. ..|.  |...|...    .|||   |..    |...|  .....|...| .. ..    .. .|    .|||        .   .. . ||||| ..
DCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAECTMKLEDCIEMCKTNSGITHIWINLEPQGKVH

AEVTFFNPVIERRPKL
. .  ||.. ......
VQIKWFNEDTDHKHHC
Kinase PKN2.AA PKN 657-916 88 6.1e-209 700.41 In-house 1-260 (260) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-260/260
Sequence Identity: 88% (230 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSE
|||.|||||||||||||..||.|.|..|||||||.||||||||.||||||||||.||..||||||||||||||.||||||||||.|||||||||.|||||
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHEDVFSE

PRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESP
|||.||||||||||||||||||.|||||||||||||||.|||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||.|
PRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGECP

FPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF
|||||||||||.||||.||||||||.|||.|||||||.||||||||.|.||||.|..|||
FPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase PKN2.AA AGC 657-916 33 8.70000000001e-185 482.93 In-house 1-395 (395) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-395/395
Sequence Identity: 33% (132 aa)

FRCCAVLGRGHFGKVLLAEYK------NTNEMFAIKALKKGD-IVARD--EVDSLMCE------------KRIFETVNSVR-------HPFLVN-LFACF
|.   |.|.|.|||| |.. |       |....|.| ||| . || ..  .|.  | |            ..|.|..|. .       |||.|. |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKEH--VCFVMEYAA---------GG-DLMMHIHTD----VFSEPRAVFYAAC-------VVLGLQYLHE-HKIVYRD-LKLDNLLLDTEGFVKIADFG
|.|.|  ..|||||.          || .|..|.. .    .|.|.|| ||||.       .||.|.|||. ..|..|| ||..|.||| .| .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGMGYG--------------------------------------------------DRTSTFCG--TPEFLAPEVLTETSYTRAVDWWG--LGVLIY
||||||..|                                                  |||.||||  |||..|||.|    |..|.|||.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGESPFPGD----------DEEEVFDSIV------NDEVRYP----------RFLSTEAISIMRRLLRRNPERRLGASEKD-----AEDVKKHPFF
|||.| .|| ||          ...|.|..|       |..|..|          |..| || .....|| ..||.|||. ..|     ||..|.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKN2.AA PKC 657-916 53 4.5e-153 499.65 In-house 1-262 (262) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-262/262
Sequence Identity: 53% (142 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFS
|.   |||.| ||||.||| |.|.|..|||.|||  |.  | |.. |.|||.... .   ||||..|. ||||...  |||||  ||||| ||     |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWK--HPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFK

EPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES
|..|.|||| ....||.|||. |.|||||||| ||| || .||||||.|||.| .||.||||||||...|||.| .  |. .|||| .||| |||..| |
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKD---AEDVKKHPFF
|| |.||.|.|.|| .|...||| || || ||.  .. .|||.|||. ...   ..|...||||
PFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKN2.AA Akt 657-916 43 6.2e-127 407.82 In-house 1-264 (264) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-264/264
Sequence Identity: 43% (116 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMF-AIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VF
|.   |||.| ||||.|.. |.|.... |.|.|||  |.....|   . |..| ...|   |||.|||   |||... .|||.|. ||.|  |.. . .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN---HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

SEPRAVFYAACVVLGLQYLHEHKIVYRD-LKLDNLLLDTEGFVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWG-LGVLIYEML
||.|| ||.| ..|....||.. |.||| ||. |.|.| .| ....|||||||. . ..|.| ||||||| ||||.|  . .|.|||||| ||...|||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

VGESPFPGDDEEEVFDSIVNDEVRYP--RFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF
 |  ||  .| .. |. | | .|..|  ...| |. .. ..|| ..|..|||. ..||...| ||.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKN2.AA Eta 657-916 51 9.1e-121 407.51 In-house 1-261 (261) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-261/261
Sequence Identity: 51% (136 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFS
|    |||.| ||||.||| |.|.|..||| |||  |.  |.|.  |.||||    .  .|||| .|..|||||. . |||||  ||||| .| ..  | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLAR--KHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFD

EPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES
|||| |||| |.. |..||.| ..||||||||.||| ||  |.||||.||||.  |  |.||||||...|||.| |  |  .|||| .|||.|||. |..
EPRARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQP

PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASE--KDAEDVKKHPFF
||  | |...|.||..|.| || .|. ||.||..  . .||..|||. .   . .....||||
PFEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKN2.AA Delta 657-916 51 2.6e-119 402.67 In-house 1-259 (259) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-259/259
Sequence Identity: 51% (135 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFS
|   .|||.| ||||.||| |..|. .|||.|||  ..  |.|.. | |.|.     ...||||  ||  ||||||. |||||  ||||| || ..  |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLAL--AWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFD

EPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES
| || |||. ...|||.||.. |.||||||||.||| .| .||||||.||| |    ..|||||||...|||..    |...||||  |||.||||.| |
EKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQS

PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF
|| |.||.|.|.||.||.  |||... || .....|. |.||.|||  .  . |...|.||
PFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase PKN2.AA Alpha 657-916 50 3.7e-119 402.18 In-house 1-259 (259) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-259/259
Sequence Identity: 50% (132 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFS
|    |||.| ||||.||| | |.|..||| |||  |.  | |.  | |||.    .  . |||| .  ||||     |||||  ||||| ||     | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPG--KPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFK

EPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES
|| |||||| .  || .|||  |.|||||||| .|| || .||||||.|||.|  .. | ||||||...|||.     | ..||||  ||| |||..|  
EPHAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQP

PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF
|| |.||.|.| .| . .| ||. .| ||..| . .| ..| .|||.  .. .|...||||
PFDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase PKN2.AA SGK 657-916 39 2.1e-112 348.51 In-house 1-283 (283) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-283/283
Sequence Identity: 39% (113 aa)

FRCCAVLGRGHFGKVLLAEYKNT------------------NEMFAIKALKKGDIV-------ARDEVDSLMCEK-RIFETVNSVRHPFLVNLFACFQTK
|.   |.| | ||||.... | .                    ..|.| |.|  |.       .. |.   | |.  |    . ..|||.|||   ||||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVIL---KNMKHPFIVNLHYAFQTK

EHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL
.   |||.|. ||..  |.     |.|.|| |||| .|. | |||. .|.||||| .|.||| .| ... ||||||||.   | |.||||||| ||||||
WKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

TETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF
    . |.|||| || . |||..|  ||   . .. .| | | . . |.. | .| ...  || ..|. |||. . |....|.||||
RKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKR-DFMEIKNHPFF
Kinase PKN2.AA AktR 657-916 41 5.3e-103 348.49 In-house 1-268 (268) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-268/268
Sequence Identity: 41% (111 aa)

FRCCAVLGRGHFGKVLLAEYK-NTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVF
|.  ..||.| |||| |.. | ......|.| .|| .|. |   . .  |. | |  . ..|||.|.|. ||||||.  |.||| .||.|  |.     |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIME--MCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

SEPRAVFYAACVVLGLQYLHEH-KIVYRDLKLDNLLLDTEGFVKIADFGLCK-EGMG-YGDRTSTFCGTPEFLAPEVLTE-TSYTRAVDWWGLGVLIYEM
|| .| ||.| ..|.|.|||.| .|.||||| .|.||| .| |||.|||| | ..|  | ... .|||||| .|||..|.   ....|||| .|..||||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LVGESPFPGDDEEEVFDSIVNDE---VRYPRFLSTEAISIMR-RLLRRNPERRLGASEKDAEDVKKHPFF
..|  ||  .. .. |..| . .   . ||  .| .. ..   .|| .||. ||| . ...|..|.||.|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKN2.AA S_TKc 657-916 34 2.6e-102 347.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAG--GDLMMHIHTDV-
..   ..|.| |||| ..  |.|.. .||| .|          .... | .| .     .||..|.|. .||. .|...||||. |  |||. .|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTR-AVDWWGLGVL
      |.| .| ||.. ....|.|.|.|.|..|||| .|.|||.   .||.||||...        .||||||...|||||   .|.. ..||| .|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDA--EDVKKHPFF
.||||.|. |||  .....|. |.          | ||....|..|...||.|..| |  .  .|.|.||.|
LYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKN2.AA RSK 660-916 38 1.1e-95 324.13 In-house 1-278 (278) Show / Hide 
Range on Protein: 660-916
Range on HMM: 1-278/278
Sequence Identity: 38% (109 aa)

CAVLGRGHFGKVLLAEYK---NTNEMFAIKALKKGDIVARDE-VDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVF-
  |||.| .||| |   .   .|.  .| | |||  ||.|.  .   | | .| |...  .|||.|.|.  |||....  .|||  ||.| .|. . .. 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQ--QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

---SEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDT---EGFVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLT----ETSYTRAVDWWGL
   || .| ||.| .|| ...||...|..||||..| |.|    || .|. |||.||..   .. .| |||.| |..|||.|.    .  ...|.||| |
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLIYEMLVGESPFPG---DDEEEVFDSIVNDE--VRYP--RFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF
|||.||||.| .|| |   .. .|... | . .  .. |   .||.|| .. |..| |.|..|||.  .|||..|.||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKN2.AA Pkinase 657-916 29 3.8e-85 293.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 657-916
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM-CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGG----DLMMHIH-
...  ..|.| ||.| ..  |.|....|.| .|| ..    ..  .   | .|   .|   ||. | |. .|..| |...||||. ||    ||. .|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--TDVF--SEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFV----KIADFGLCKE--GMGYGDRTSTFCGTPEFLAPEVLT-ETSYTRAVD
    .|  ||  . ||.  .. ||.|.|...|..||||..|.|.| .| .    ||.||||.|      ..  ..||||||...||||.   . |...||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

WWGLGVLIYEMLVGESPFPGD------DEEEVFDSIVNDEVRYPRFLS---------------------TEAISIMRRLLRRNPERRLGASEKDAEDVKK
.|..|...|||| |. ||||.      |. .... |   ....... .                      |........|...|..|..     ||....
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQ

HPFF
||.|
HPWF
Kinase PKN2.AA Pkinase_Tyr 657-859 27 3.6e-23 79.08 Pfam 1-218 (270) Show / Hide 
Range on Protein: 657-859
Range on HMM: 1-218/270
Sequence Identity: 27% (61 aa)

FRCCAVLGRGHFGKVLLAEYK----NTNEMFAIKALKKGDIVARDE--VDSLMCEKRIFETVNSV-RHPFLVNLFACFQ-TKEH--VCFVMEYAAGGDL-
 .   .||.|.||.| ....|    ||.   |.| ||       ..   ...| | .|  .     .|| .|.| ..    .|.  .. ||||...||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQ---LGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

-MMHIH---TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMG---Y-GDRTSTFCGTPEFLAPEVLTETSYTRA
   . |    . .. .. . ... .  |..||...... |||   | |.. ...|||.||||..  .    |   |...       .|||.. .  .| .
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTK

VDWWGLGVLIYEMLV-GESP-FPG
 | |  |||..|..  ||.| .||
SDVWSFGVLMWEIFTYGEQPTYPG
Kinase PKN2.AA S_TK_X 917-981 39 7.1e-21 76.59 SMART 1-79 (79) Show / Hide 
Range on Protein: 917-981
Range on HMM: 1-79/79
Sequence Identity: 39% (31 aa)

RLIDWSALMD--KKVKPPFIPTIR----GREDVSNFDDEFTSEAPILTPPREPRILSEEEQE--------MFRDFDYIA
| ||| .|    |...|||.|.|.    . .|.||||.|||.|.| |||. .| . |  ..|        .||.|.|..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKN2.AA TyrKc 657-910 23 9.5e-19 69.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 657-910
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV--NSVRHPFLVNLFACFQTK-------EHVCFVMEYAAGGDLMM
 .   .||.|.||.| ....|   .. |.| ||..       .  .| | ||   .  .   || .|.|...  ..       | .. ||||...|||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGH---HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HIHTDV--FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGY---GDRTSTFCG----TPEF------LAPEVLTET
...     .. .  . ..  .  | .|||..... |||   | |.. .. |||.||||....  .   | ....          .      .|||.. . 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

SYTRAVDWWGLGVLIYEML-VGESPFPG-----DDEEEVFDSIVNDEVRYPRFL---------STEAISIMRRLLRRNPERRLGASEKDAEDV
 .| . | |  ||...|..  |..| ||      . .||.  . . . . .            ..|  .||..  ...|| |   ||   |. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PKN2.AA Pkinase_C 936-983 41 1.5e-16 61.45 Pfam 1-46 (46) Show / Hide 
Range on Protein: 936-983
Range on HMM: 1-46/46
Sequence Identity: 41% (20 aa)

TIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADW
......|.||||.|||.|.| .||  ..| .|...|| ||.| | ...
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD