Gene PLK1 (Human)

PLK1

Species: Human
Alias: PLK1, STPK13, PLK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 16p12-p13,

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
PLK1.NA RNA Sugen Kinome 2214 None Fasta, JSON
PLK1.AA Protein Sugen Kinome 603 None Fasta, JSON
PLK1.kin_dom Protein Kinase Domain Sugen Kinome 248 None Fasta, JSON

Protein domain

Protein domains of PLK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PLK1.AA PLK 53-305 66 5.69999999999e-201 660.03 In-house 1-258 (258) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-258/258
Sequence Identity: 66% (172 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRR-KALTEP
| ||.||||||||||.|. | .||.|.|.|.|||||. |||||||| .|| |||.| |...|.|| ||||...|..|||.|..|||...|||| |.||||
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL--SKKGHSFEVDVWSIGCIMYTLLVGKP
|.|||..||| |..|||..|.|||||||||||||....||||||||||..|||||||||.||||||||||||  .|.|||.|||.||.||||||||.|||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFETSCLKETYLRIKKNEYSIPKH--INPVAASLIQKMLQTDPTARPTINELLNDEFF
||||...|||| |||.|.||.|.|  |...|..||||||...|. ||||...|...||
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase PLK1.AA PLK1 53-305 77 7.29999999999e-181 599.54 In-house 1-253 (253) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-253/253
Sequence Identity: 77% (196 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPE
|..||||||||||.|.||.|.|||||||||.||||||.|.|||.||..||.|||.|.|.|.|.|| ||||...|..||||||||||.||||||||.||||
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

ARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFE
.|||..|||.||||||.|..|||||||||||||..|.|||||||||||.||||||||||||||||||||||.|||||||||.||||||||.||.|.||||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

TSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF
|.||||||.|||||||.||.||...||.||.|||..|||.||||...||||||
TKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase PLK1.AA PLK2 53-305 55 6.1e-163 528.78 In-house 1-257 (257) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-257/257
Sequence Identity: 55% (143 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRR----RSLLELHKRRKAL
| ||. |||||||.|.|. | ||  |.|.||||.|   ||||||||  || .|| | | |.|.|| .||| | ....||.|.|    .|..   | |. |
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGK
|||| |||.|||| |  |||  ..|||||||||.|.|.  |||||||||| ..|  .....|.||||||||||||...|||.| |.|. ||||||.|.| 
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCGR

PPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF
|||||. ||||| .|. | | .| |  |.| .|| .||  ||  || . ... ..||
PPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase PLK1.AA PLK-Unclassified 53-305 55 1.2e-147 496.86 In-house 1-264 (264) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-264/264
Sequence Identity: 55% (146 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRR-------
| ||.||||||||||... . .||...| ||.||| | |  .|.|   || || || |...| |  .|||.. |  .||.|   .| |..|||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKK-GHSFEVDVWSIGCIMYT
| |||.|...|. ||| . .||| ||.|||||||||.|||.. ||||.|||||||.|.|||.||| ||||||||||.|  |. |||.|||.||.||| ||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLVGKPPFETSCLKETYLRIKKNEYSIP--KHINPVAASLIQKMLQTDPTARPTINELLNDEFF
||.|||||||.  | || .|| |.|| |  .||   | .|||. |...|  ||||...... |.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase PLK1.AA AGC 53-305 22 4.7e-98 253.48 In-house 1-395 (395) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-395/395
Sequence Identity: 22% (88 aa)

YVRGRFLGKGGFAKCFEISDA------DTKEVFAGKIVPKSL--------LLKPHQRE------------KMSMEISIHRSLA------HQHVVG-FHGF
.   . .|||.| |..   .       ||....| |.. |.          ..  ..|            .  .|   |.  .      |. .|   |  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTH-NHPIKSHHPFIVKILHYS

FEDNDF--VFVVLELCR----------R-RSLLELHK--RRKALTEPEARYYLRQ-------IVLGCQYLHR-NRVIHRD-LKLGNLFLNEDLEVKIGDF
|.|.|   .. |.|..              ..| |..  ... ..|..||.|. .       |||. .|||. . .|||| ||. |. |.||  .|. ||
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

GLATKVEYDG--------------------------------------------------ERKKTLCG--TPNYIAPEVLSKKGHSFEVDVWS--IGCIM
||....  ||                                                  .| .|.||  ||.|.|||.|    .....| ||   ||.|
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YTLLVGKPPFETS----------CLKETYLRIK------KNEYSIP----------KHINPVAASLIQKMLQTDPTARPT----------INELLNDEFF
| .|.|.|||               .|.. .|.      ...  .|          ... | | .||.|.|. ||. |..          ..|. | ..|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PLK1.AA S_TKc 53-305 33 5.7e-97 329.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRR--RSLLELHKRRKA---
|  .| .|||.|.|..   . .|....| ||..          |..  ||.|...  | ..| ....|.| |....|.|.|     .|... |.|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSF-EVDVWSIGCIMYT
   ..| .||.|..||... .|.|....||||||  |..|.|  ..||.|||||...       .|.||||.|.|||||   |... ..|.||.|||.| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLN-------DEFF
.|.|.|||.   ..... .|.           | | ..|.|.|| ||. |||. |.|.       ...|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PLK1.AA CAMK 58-305 21 8.4e-94 302.61 In-house 1-425 (425) Show / Hide 
Range on Protein: 58-305
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

FLGKGGFAKCFEISDADTK------------EVFAGKIVPKSLLLK-------------------------PHQREKMSMEISIHRSLA-------HQHV
 ||.|.|.| ..  .  |.            . .| ||..|. | .                         |. |...  ||.|...|        | ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGFHGFFED-------------------NDFVFVVL---ELCRRR----SLLELHKRR---------------KALTEPEARYYLRQIVLGCQYLHRNRV
. .. ..||                   ..... |.   |.|        |..  ...               . .|| |||.| |||. . .|.| . .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLGNLFLNED-----------------LEVKIGDFGLATKVEY-----------------------DGERKKTLCGTPNYIA-PEVLSK------
.|||||. |. |...                   .|| |||.|.|..                        .|.  || |||| |.| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGHSFEVDVWSIGCIMYTLLVGKPPFETS-------------CLKETYLRIKKNEYS-IPKHINPV-----------------------AAS
        .......|.||.|.|.|..|.|.|||. .             ...|.. .|.| .|. .|... |.                       . .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIQKMLQTDPTARPTINELLNDEFF
||.||||.||. |.|| . ||....
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PLK1.AA Pkinase 53-305 28 2e-88 304.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMS-MEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRR----SLLELHK--RR
|..|| .|.|.|.....  . .| ...| ||..|.   .  ....   .||.|...| | ..| ....|||.| . .|.|.|.      .| .. .  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KAL--TEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEV----KIGDFGLATKV-EYDGERKKTLCGTPNYIAPEVLS-KKGHSFEVDVWSI
...  .| |.. |..||. | .|.|....||||||. |...... ..    ||.||||| .. .  ..  .|.||||.|.||||.   .... .||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIMYTLLVGKPPFETS------CLKETYLRIKK--NEYSIPKHIN-------------------PVAASLIQKMLQTDPTARPTINELLNDEFF
|||.| .| |.|||  .      . .. . ||..  .....|. ..                   . . ..| ..|. ||. |||. ..|....|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PLK1.AA CAMKL 53-305 28 3.4e-84 268.55 In-house 1-297 (297) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-297/297
Sequence Identity: 28% (85 aa)

YVRGRFLGKGGFAKCFEISD-ADTKEVFAGKIVPKSLLLKPHQREKMSM------------EISIHRSLA---HQHVVGFHGFFEDNDF------VFVVL
|  |. ||||.|.|     .   |.|  | ||. |. . .  . .|.              ||.|...|    |.... ..  .|. ..      .. |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCRRRS--LLELHKRR----KALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDL--EVKIGDFGLATKVE-Y---DGERKKTLCGTPNYI
|.|   .  |..  ...    . ..|.||| | |||| . .|.|.....|||.|. |. | |.    .|| |||.... . .   .|.  || ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLSK--KGHS-FEVDVWSIGCIMYTLLVGKPPFETSCLK-------ETYLRIKKNEYSIPKHINP-VAASLIQKMLQTDPTARPTINELLNDEFF
|||....  | .  ..||.||.| |.|....|. ||.  ...       . |..|..  | .|... .  . .||.||||..|. |||| ...|....
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase PLK1.AA SAK 53-305 39 1e-78 267.73 In-house 1-254 (254) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-254/254
Sequence Identity: 39% (101 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKRRKALTEP
|  .  |||||||  .      |    | |.. | |. |    ...  |. ||  | |  ..    .|||| .|..|||.|.   ..  ...| .  || 
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

EARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPF
||| ...||| |  |||   ..|||| | |. |  |...|| ||||||...   |.  |.|||||||.||. ..  |  . ||||.||..||||.|.|||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

ETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF
.|   |.|  ..   || .| |.   |  ||.|||. .|. | |..  |   | 
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase PLK1.AA ULK 53-305 27 2.1e-74 253.52 In-house 1-329 (329) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)

YVRGRFLGKGGFAKCFEISDADTK----EVFAGKIVPKS-LLLKPHQRE------KMSMEISIHRSLA--------HQHVVGFHGFFEDNDF--VFVVLE
|.  . |||| |.| ..  . .||    |..| |...|. .  |....|          || | . |         |...| .. .||. ..  .. ..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCRRRSLLELHKRRKA----------LTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDL------------EVKIGDFGLATKVEYDG----
.|    | .. |..|           |.|.||. ...||. |...|| ...||||.|. |  ....              .||.|||.| .|..|.    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-ERKKT----LCGTPNYIAPEVLS----KKGHS-FEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIP--------------------KHIN
 .   .    ||||| | ||..|.    .| .. ...|.||.|||.| .|.|||||...   ..||.|..... .|                    ..| 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PVAASLIQKMLQTDPTARPTINELLNDEFF
|   .||..||| |.. | .. ||.| ..|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase PLK1.AA ULK 53-305 26 6.7e-74 251.82 In-house 1-324 (324) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

YVRGRFLGKGGFA-KCFEISDADT---KEVFAGKIVPKSLLLK-PHQRE------KMSMEISIHRSLA---HQH--VVGFHGFFEDNDF--VFVVLELCR
|.  . |||| |. | ..  . .|   ....| |...|. . | ....|      .   ||.| . |    |..  .| .. .||. ..  .. ..|.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

RRSLLELHKRRKA---------LTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDL------------EVKIGDFGLATKVEYDG---ERKKT
   | .. |..|          |.|.||. ...||. |...|| . .||||.|. |. ....              .||.|||.| .|....      .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LC------GTPNYIAPEVLS----KKGHS-FEVDVWSIGCIMYTLLVGKPPFETSCLKETYLR--------------IKKNEYSIPK-----HINPVAAS
..      ||| | ||..|.    .| .. ...|.||.|||.| .| ||.||...   ..||.              ||..   .||     .| |   .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIQKMLQTDPTARPTINELLNDEFF
||..||| |.. | .. |..| ..|
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase PLK1.AA Pkinase_Tyr 92-236 30 1.4e-19 66.92 Pfam 42-199 (270) Show / Hide 
Range on Protein: 92-236
Range on HMM: 42-199/270
Sequence Identity: 30% (48 aa)

PHQ--REKMSMEISIHRSL-AHQHVVGFHGFFE-DNDF--VFVVLELCRRRSLLE-LHKR---RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGN
..|  ||..  |..| ..|  |...| ..|    . .   ...|.|..   .||. |.|.   ...|| ..   . .||  |..||.... |||||   |
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARN

LFLNEDLEVKIGDFGLATKVEYDGE---RKKTLCGTP-NYIAPEVLSKKGHSFEVDVWS
  ..|.. |||.|||||  . |. .   ||.. .  |    |||... .  . . ||||
CLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS
Kinase PLK1.AA TyrKc 53-304 23 3.5e-16 39.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL--AHQHVVGFHGFFEDN-------DFVFVVLELCRRRSLLE-LH
 . |. || | | . ..   ..  .  | | . ..       || .  |..| ..|   |...| ..|   .        . ...|.|..   .|.. |.
ITLGKKLGEGAFGEVYK-GTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD---GERKKTLC-----GTP-----NYIAPEVLSKKGHS
|.|. |. ..  ..  ||  |..|||....|||||   |  ..|.. |||.||||. ... |   ||.|..       |.         |||.. ..  .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FEVDVWSIGCIMY---TLLVGKPPFET-----SCLKETYLRIKKNEY-SIPKH--------INPVAASLIQKMLQTDPTARPTINELLNDEF
.. |||| |  |.   |.  |..| .         .| . ..|. ..  .|..          .   .....  . ||  ||| .|.  ..|
TKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
POLO_box PLK1.AA POLO_box 417-480 33 1e-27 103.21 Pfam 1-74 (74) Show / Hide 
Range on Protein: 417-480
Range on HMM: 1-74/74
Sequence Identity: 33% (25 aa)

YSDKYGLGYQLCDNSVGVL-FNDSTRLILYNDGD-SLQYIE--RDGTESYLTVSS------HPNSLMKKITLLK
|..|||..|||....|.|. |||.|..||  ... ...||.  ......... |.      .| .|.||.|.||
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box PLK1.AA POLO_box 515-584 50 9.9e-32 116.54 Pfam 1-74 (74) Show / Hide 
Range on Protein: 515-584
Range on HMM: 1-74/74
Sequence Identity: 50% (37 aa)

FRTRSAIILHLSNGSVQINFFQDHTKLILCPLMA-AVTYID--EKRDFRTYRLSLLEEYGC-CKELASRLRYAR
.||...|. .||||.||.||| ||||.|||| |  ||||||  ... ..||.|| ..|.|| ...|...|.|..
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK