Gene MLK4 (Human)

MLK4

Species: Human
Alias: KIAA1804, dJ862P8.3, RP5-862P8.2, MLK4
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q42.2,

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
MLK4.NA RNA Sugen Kinome 5809 None Fasta, JSON
MLK4.AA Protein Sugen Kinome 1036 None Fasta, JSON
MLK4.kin_dom Protein Kinase Domain Sugen Kinome 275 None Fasta, JSON

Protein domain

Protein domains of MLK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MLK4.AA SH3 41-101 39 1.7e-21 78.65 SMART 1-58 (58) Show / Hide 
Range on Protein: 41-101
Range on HMM: 1-58/58
Sequence Identity: 39% (25 aa)

GLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQ--RRLGIFPANYVAPCR
.   |||||.|...||||...|. ..||..|     |.||| |...   . |.||.|||....
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 MLK4.AA SH3_1 44-94 33 1e-12 45.96 Pfam 1-49 (49) Show / Hide 
Range on Protein: 44-94
Range on HMM: 1-49/49
Sequence Identity: 33% (18 aa)

AALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQ--RRLGIFPA
 |||||.|...||||...|  ..|.... .     .|| |...  .. |.||.
VALYDYQAQQPDELSFKKGDIIHVIEKSDD----WDWWKGRCNNTGQEGWFPS
SH3_2 MLK4.AA SH3_2 48-100 22 2.7e-11 42.45 Pfam 7-68 (68) Show / Hide 
Range on Protein: 48-100
Range on HMM: 7-68/68
Sequence Identity: 22% (15 aa)

DYEA-RGEDE-----LSLRRGQLVEVL---SQDAAVSGDEGWWAG-QV--QRRL--GIFPANYVAPC
||.. ....|     |....|....|.   ..|.      .|| .  .  ..|   | || ..|..|
DYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-----NWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase MLK4.AA MLK 124-398 69 5e-200 667.13 In-house 1-280 (280) Show / Hide 
Range on Protein: 124-398
Range on HMM: 1-280/280
Sequence Identity: 69% (205 aa)

LELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAA---AESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPD
|..||.||.||||.||||.|.|.||||||.|||||||....   ||.||.|||||.||.|||||.||||||..||||||.|..|||.|||..|..     
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK-----

PRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIE-----------------HDDICNKTLKITDFGLAREWHRTTKMS
          |||||||||||||||||| |||.||.|||.||||||||||.||||.                 |.|.|||.|||||||||||||.||.||
----------RIPPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMS

TAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL
.|||||||||||||.|..|||||.|||||||||||||||||||||.||||||||.||||||||||||||.||||..||.||||.||.|. ||.||
AAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase MLK4.AA MLK 124-398 45 1.4e-160 539.77 In-house 1-291 (291) Show / Hide 
Range on Protein: 124-398
Range on HMM: 1-291/291
Sequence Identity: 45% (135 aa)

LELKELIGAGGFGQVYRATWQGQE-----VAVKAARQDPEQDAAAA---AESVRREARLFAMLRHPN----IIELRGVCLQQPH-LCLVLEFARGGALNR
....| ||.|.||.|....|....     ||||..|.... |.. .   .. ...|.|....|.|||    ||...|||||.|. .|.|.|...|| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALAAANAAPDPRA-PGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT-T-KMSTAGT
 |..|.  ..... ... ..|........|||.|.|||| |||..| .|| ||||||.|||..| |.| |....||||.|||..|.||.. | .||.|||
VLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGT

YAWMAPEVI---KSSLFSKGSDIWSYGVLLWELLTGEVPYR-GIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL
|||||||||   ... .|. .|.||.||.|||.||.||||. ..|..|.|..||.|.|..||||||||...||||.||.|||| ||||. |...|
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK4.AA TKL 130-398 27 4.8e-103 348.64 In-house 1-364 (364) Show / Hide 
Range on Protein: 130-398
Range on HMM: 1-364/364
Sequence Identity: 27% (104 aa)

IGAGGFGQVYRATWQG----------QEVAVKAARQDP-----------------------EQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPH-
|| ||||.||...|.|          ..||||  ...                        ...|  . .  ..|...  .||||||. . |.|.. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVLEFARGGA-LNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAF-----VPILHRDLKSSNILLLEKIEH
            ||.| |.. ||  |.. .                     .|....|| .||||| ||| . .      ||.||||||.|||. |. ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTN

DD------ICNKTLKITDFGLAREWHRT---------------------TKMSTAGTYAWMAPEVIKSS----------------LFSKGSDIWSYGVLL
..      . . ..||.||||.|.....                     |.|.  ||..||||||.. .                 .|. .|..|.|..|
VSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL

WELLTGEVPYRGIDGLAVA---------YGVAVNKLTLPIP------------STCPEPFAKLMKECWQQDPHIRPSFALILEQL
||.||...||....   .          ..|....| .|||            ..||....|||..||..||. ||||  ||..|
WEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK4.AA TyrKc 124-398 30 1.1e-83 285.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 124-398
Range on HMM: 1-280/280
Sequence Identity: 30% (95 aa)

LELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML--RHPNIIELRGVCLQQ-------PHLCLVLEFARGGALNRALAA
..|.. .| | ||.||..||  ..||||  . |         |  .||||.  .|  .||||. | |||.||       . |..|.|.. .|.|.  | .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

ANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT--------TKM----
                 ...  |.....|||.|| |||.    .. ||||   |.|. |.         | ||.||||.|...          ...    
HRPK-------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEH

-STA--GTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGI----DGLAVAYGVAVNKLTLPIPST--------CPEPFAKLMKECWQQDPH
 ..     . |||||.|. . |.  ||.||.||..||..| |. || |.       . ..    .   .|.|          ||.   ..||.||. ||.
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE

IRPSFALILEQL
 ||.|. | |..
DRPTFSEIHECF
Kinase MLK4.AA Pkinase 124-398 25 1.2e-78 272.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 124-398
Range on HMM: 1-293/293
Sequence Identity: 25% (81 aa)

LELKELIGAGGFGQVYRATWQGQE--VAVKAARQDPEQDAAAAAESVR-REARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGG----ALNRALAAAN
..... ||.|.||.||.....| .  ||||  . . ...     . .| .|... ..|.||||..|....   .|...|.|...||     | . . .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

AAPDPRAPGPRRARRI--PPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR---EWHRTTKMSTAGTYAWM
          .| ...  ..... ... ||.||. |.|..    |.|||||..|||. .. . |.    ..||.|||||.   . . .  .. .||. .|
----------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYM

APEVIK-SSLFSKGSDIWSYGVLLWELLTGEVPYRGI------DGLAVAYGVAVNKLTLPIPSTCP-------------------EPFAKLMKECWQQDP
|||||. ..  .. .|.||.|..|.|.|.|. |..|       | ... . .   .|  ..| .|.                   |.. ...| |...||
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

HIRPSFALILEQ--L
. ||... ||.   .
KKRPTAEQILQHPWF
Kinase MLK4.AA LZK 178-398 47 1.4e-77 261.14 In-house 44-241 (241) Show / Hide 
Range on Protein: 178-398
Range on HMM: 44-241/241
Sequence Identity: 47% (107 aa)

LRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEH
|.||||||..||| | |  | ..|.   | |   |              |  | |.|. .|.|  ||| || |||      | |||||| |||    | |
LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVL--------------RERRTITPQLMVDWSKQIAQGMHYLHQHK---IIHRDLKSPNIL----ISH

DDICNKTLKITDFGLAREWHRT--TKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAK
.|.    .|| |||  ..|     |||| .|| ||||||||.    |   ||||.|| |||.||.|.||. .|  |. .||  | | ||.|||||| |  
NDV----VKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKL

LMKECWQQDPHIRPSFALILEQL
||| ||.| |  ||||  ||  .
LMKQCWSQKPRNRPSFRQILMHW
Kinase MLK4.AA Pkinase_Tyr 124-398 33 3.6e-72 245.04 Pfam 1-270 (270) Show / Hide 
Range on Protein: 124-398
Range on HMM: 1-270/270
Sequence Identity: 33% (98 aa)

LELKELIGAGGFGQVYRATWQ------GQEVAVKAARQDPEQDAAAAA---ESVRREARLFAML-RHPNIIELRGVCL-QQPH--LCLVLEFARGGALNR
... . .|.| ||.||..||       ...||||  ..    .|   .   |.  |||..   | .||||. | |||. |. .  ...|.|.. .| |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

ALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-----H-RTTKMST
 | .               ...... |.....|||.|| ||..    .. ||||   |.|. |        |.. ||.||||||         |... . 
YLRKHR----------EDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGK

AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVP-YRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL
     |||||.|. . |.  ||.||.|||.||..| || | | |..   |   .. .   .|.|  ||..  .|||.||..||  ||.|. |.|||
-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK4.AA TKL-Unique 126-398 32 2.1e-70 240.2 In-house 1-290 (290) Show / Hide 
Range on Protein: 126-398
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)

LKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR-HPNIIELRGVCL----QQPHLCLVLEFARGGALNRALAAANAAPD
  ..||.||.||||...| | .||.|      |       .  ..| ..  .|. ||||  . |.|     ..|..|.|.|.  || |.  |.  |    
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNN----

PRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTA-----------GTYA
.     ..   ... . |. | .||.|| ||| .    |.||||||||.|. ..     |     || ||||..   . .||..            |.. 
NNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSN---IAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFR

WMAPEVIKS--SLFSKGSDIWSYGVLLWELLTGEV------PYRGIDGLAVAYGVAV--NKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL
||||||...  ...|. ||..|.|. |||..|...      ||.|.|  ...  |..   .. .|||. ||. . .|...|| .|| .||||  |.. |
WMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK4.AA TK 124-398 19 2.3e-68 228.06 In-house 1-486 (486) Show / Hide 
Range on Protein: 124-398
Range on HMM: 1-486/486
Sequence Identity: 19% (94 aa)

LELKELIGAGGFG---QVYRATWQG---------------------------QEVAVKAARQDPEQDAAAAAE-------------SVRREARLFA--ML
..| . .|.| ||   .||...|.|                           ..||||  . . ......  .             .  .|. ..   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNIIELRGVCLQQ------------PHLCLVLEFARGGA----LNRALAAANAAPDPRAPGPR-----------------------------------
.||||. | |||.|.            .....|.|.. .|     |   | .      . ...|                                    
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------RARRIPPHVLVNWAVQIARGMLYLHEEAFVPI----LHRDLKSSNILLLEKIEHD---DICNKTLKITDFG--
                           . .....| |. ...|||.|| |||.  .        ||||   |.|. |.       | |  . ||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAREWHRTTKMSTAGTYA----------------------------WMAPEVIKSSL---------FSKGSDIWSYGVLLWELLT-GEVPYRGI
      |||. .. .   ....|                             |||||....           |.  ||.||.|||.||..| |..|| | 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

DGL---------AVAYGVAVN--------------KLTLPIPSTCP--------------EPFAKLMKECWQQDPHIRPSFALILEQL
            .  .   ..              .. .| |  ||              | .. ||..||. ||  ||.|. ..|||
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK4.AA LRRK 124-400 27 1.6e-66 227.28 In-house 1-351 (351) Show / Hide 
Range on Protein: 124-400
Range on HMM: 1-351/351
Sequence Identity: 27% (102 aa)

LELKELIGAGGFG-QVYRATWQG----------------------------QEVAVKAARQDP------------------------------EQDAAAA
|.  |.|| ||||  ||||.|.|                            |.||.|    ||                              ..|.. |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

AESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAAN-AA----PDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV-P
  . |.|. .   |.||||. | |.|..  .||.|.|.|. |.|.. | .    .    .           .|.....   |.|||.|| |||   .  |
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMK----------AHISWMLKLKIALQIAKGMEYLHS--HNPP

ILHRDLKSSNILLLEKIEH-------DDICNKTLKITDFGLAR--EWHRTT-KMSTAGTYAWMAPEVIK---SSLFSKGSDIWSYGVLLWELLTGE-VPY
|.|||||| |||| .  ..       ...|    || |||. |     ...  .   |.  |||||...    . ..  .|. |.|..||||||..  |.
IIHRDLKSPNILLWSSPQNHSPNYPNAHVC---AKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPF

RGIDGLAVA---YGVAV---NKLTLPIPST-CPE-----PFAKLMKECWQQDPHIRPSFALILEQLTA
...|. ..    . .     ..|  .||.. ||.      . .|...|||.||  ||.|  |...|  
DEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK4.AA UTK 124-398 29 2e-63 215.86 In-house 1-296 (296) Show / Hide 
Range on Protein: 124-398
Range on HMM: 1-296/296
Sequence Identity: 29% (92 aa)

LELKELIGAGGFGQVYRATWQG-------QEVAVKAARQDPEQDAAAAAE---SVRREAR---LFAMLR-HPNIIELRGVCLQQPHLCLVLEFARGGALN
..| ...|.| ||.|..|...        . ||||...  .. ||  . |    ...|||   . .... |||.. | |||.|.  ...|.|....| | 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

RALAAANAAPDPRAPGPRRARRIPP-HVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG---LAREWHR-------
  |  .  .|.        .. .   | .. .|..||||| |||.  ||   ||||   |.|. .    .  |  . || |||   ..|. ..       
SYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFV---HRDLAARNCLVHMHRM-MWHCMMVCKIADFGRGGMSRRVNTFHFSNRY

------TTKMSTAGTYAWMAPEVIKSS-LFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNK-LTLPIPSTCPEPFAKLMKECWQQDPHIRP
      .    .. . .|||||.. .   |.  ||.||.||..||..| | .|| |.   .|.  |     . .| |  ||.|  .||..||..||  ||
WESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERP

SFALILEQL
.|  ...|.
DFEDLVQQM
Kinase MLK4.AA ZAK 236-397 43 8.6e-59 201.64 In-house 102-257 (257) Show / Hide 
Range on Protein: 236-397
Range on HMM: 102-257/257
Sequence Identity: 43% (71 aa)

VLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR-EWHRTTKMSTAGTYAWMAPEVI-KSSLFSKGSDIWSYGVL
. . || |||.|| ||| .| . | |||||| |.     |. . .|    || |||  |   | .| ||  || .|||||.|  |   .   |.||||| 
HIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVV----IDKNGVC----KICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVV

LWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQ
|||.|| ||||.. ... ..  .     .| ||. || ||..|| .||. ||  ||..  |   
LWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase MLK4.AA S_TKc 124-401 26 4.9e-57 196.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 124-401
Range on HMM: 1-231/231
Sequence Identity: 26% (76 aa)

LELKELIGAGGFGQVYRATWQG--QEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARG--GALNRALAAANAAP
 |. ..|| |.||.||.... .  ..||.|  .           |..||| ..  . .||||. | .|.    ||..|.|.. |  | | . .   .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

DPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSS
 .        ...|. .   .. ||.... |.|.     |.||||| .|||| |          ..||.||||||.      ..  ||  .|||||.   
LR--------FPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---

LFSK-GSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILE------QLTAI
 ..|  .|.|| |..|.|.|.|. |..    ... . . .           ....  ... |.| ||  ||.   .|.      .   .
GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK4.AA Dicty4 244-400 35 1.3e-47 156.93 In-house 121-277 (277) Show / Hide 
Range on Protein: 244-400
Range on HMM: 121-277/277
Sequence Identity: 35% (59 aa)

IARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR----EWHRTT-KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELL
.|||| .||.   . |.||||||.|.|  .        |.. |..||||..    .   ..  |...|| .||||||  .  .   .|  |.| .|||.|
AARGMNWLHC-CNPVIIHRDLKSHNLLVDK--------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEIL

TGEVPYR--GIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQ--LTA
|.. ||   ...   .. .|.  || .|||. || ....|...||  ||  ||||. |...  | .
TRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK4.AA Dicty4 124-205 32 3.1e-19 60.94 In-house 1-87 (277) Show / Hide 
Range on Protein: 124-205
Range on HMM: 1-87/277
Sequence Identity: 32% (28 aa)

LELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCL----QQPHLCLVLEFA-RG
.   ..|| |.||.||..|| |.||||| .  . . . ..  .. |.|. . . .|||||. . | |.    . . .| | |.  .|
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKG
Kinase MLK4.AA ZAK 124-208 30 1.4e-07 23.26 In-house 1-79 (257) Show / Hide 
Range on Protein: 124-208
Range on HMM: 1-79/257
Sequence Identity: 30% (28 aa)

LELKELIGAGGFGQVYRATWQGQE-----VAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPH-LCLVLEFARGGAL
. . . .| | || |||| |  |      .|||                . .||     .|| |||   |.|.  |     | |.|  | |
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFK------------IEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSL
Kinase MLK4.AA LZK 124-160 37 0.018678 4.0 In-house 2-37 (241) Show / Hide 
Range on Protein: 124-160
Range on HMM: 2-37/241
Sequence Identity: 37% (14 aa)

LELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQD
 || . .| |  | |.|  .....||||  |.  | |
SEL-QWLGSGAQGAVFRGWFRNETVAVKKVRDLKETD