Gene PAK4 (Human)

PAK4

Species: Human
Alias: PAK4
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19q13.1,

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
PAK4.NA RNA Sugen Kinome 3064 None Fasta, JSON
PAK4.AA Protein Sugen Kinome 591 None Fasta, JSON
PAK4.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of PAK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK4.AA PBD 10-67 31 3.1e-19 69.72 Pfam 1-60 (60) Show / Hide 
Range on Protein: 10-67
Range on HMM: 1-60/60
Sequence Identity: 31% (19 aa)

EISAP-SNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES-ARRPKPLVDPACITSIQPGAP
.||.| .||.|..| |.|. ...|||.|..||.|   |  ..|.. ..|........  .
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK4.AA PBD 11-46 50 1.7e-16 62.06 SMART 1-38 (38) Show / Hide 
Range on Protein: 11-46
Range on HMM: 1-38/38
Sequence Identity: 50% (19 aa)

ISAPS-NFEHRVHTG-FDQHEQKFTGLPRQWQSLIEES
||.|. ||.|.|| | .|.....||||| |||.|.  .
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK4.AA PAKB 321-572 86 7.6e-228 763.21 In-house 1-252 (252) Show / Hide 
Range on Protein: 321-572
Range on HMM: 1-252/252
Sequence Identity: 86% (219 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
|||..|||||||||||||| ...|..|||||||||||||||||||||||||||||.|.||||.||||||||||||||.||||||||||||||||||||.|
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP
|..|||||..||||||||||||||||||||||||||||||||||||||||.||||||||||||||.|||||||.||||||||||||||||||||||||||
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
|.|||.|||..||||||.|||||.|..||||.|||||.||.||.|||.||||
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK4.AA STE20 321-572 46 1.5e-151 509.75 In-house 1-288 (288) Show / Hide 
Range on Protein: 321-572
Range on HMM: 1-288/288
Sequence Identity: 46% (135 aa)

LDNFIKIGEGSTGIVCIATVRSSGKL----VAVKKMDLRKQ----QRRELLFNEVVIMRDYQHENVVEMYNSYLVG----DELWVVMEFLEGGALTDIVT
 ... |||.||.| |. |. ...|..    ||.|||.|.|.    ...|....|..||....|.|.|..|.|||..    ||||.|||...|| ||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

HT----------RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK-----EVPRRKSLVGTPYWMAPELISR----
|.          .|||||||..|  |||.|. ||....||||||.| ||||.||.|||.|||.|||..|     . ..|...||||||||||.|..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIR--DNLPPRLKN--LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
  .|.  .|||||||. |||..||||||...|..|| ||   .| ||.||.   || ||... |.|. |..||..|.|| .||||||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK4.AA PAKA 322-572 51 8.70000000001e-135 454.08 In-house 2-260 (260) Show / Hide 
Range on Protein: 322-572
Range on HMM: 2-260/260
Sequence Identity: 51% (133 aa)

DNFIKIGEGSTGIVCIATVRSSGKL--VAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR------MN
... |||.|..| | .|| .. ..   ||.|.|.. .| . ||. ||  .|....|.|.|  . |||| ||||||||..||| |||..|...      |.
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEP
|.|||.||  .||.|. .|....|||||||| |||  ||.||. ||||||| ..|  .|.. ||||||||||.|.|  |.. |||||||||.|||..|||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
|| |||||.||  |  |  | .|. .|.|.... |||. |  |. .||.| |||.||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK4.AA STE 321-572 30 4e-118 398.72 In-house 1-359 (359) Show / Hide 
Range on Protein: 321-572
Range on HMM: 1-359/359
Sequence Identity: 30% (110 aa)

LDNFIKIGEGSTGIVCIATVR------SSGKL---------VAVKKMDLRKQ-----------------QRRELLFNEVVIMRDYQ--HENVVEMYNSYL
...  |||.|..| |. |  .      ..|..         .|.|.|.|...                 . .. . .|. ||....  |.|.|. | .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------DELWVVMEFLEGGALTDIVTH---------------TRMNEEQIAAVCLAVLQA-LSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA
..       ||||..||...|| |.||. |               .|..|.|||..| ..|.. |. || ...||||||.. |||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QVSKEVP----------------RRKSLVGTPYWMAPELISR------LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDN-----------
|......                .|...|||| ||||| |..       .|.  .||||||...|||..|.||.....|..|| || .|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----LPPRLKN-----------------LHKVSPSLKGFLDRLLVRDPAQRATAAELLK--HPFL
     ||.|..                  ||.||..| |... |..|| .|.|| .|||  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK4.AA S_TKc 321-572 28 2.4e-92 314.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 321-572
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG--GALTDIVTHTR-------
 .   |||.|. | |. .. ...|..||.|...       | . .|. |..  .|.|.| .| ..   |.|..|||...|  | | |.  . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP-EVDIWSLGIMVIEMVD
..| ... ..  ...||  .| .|.||||.| . |||..  ..|..|||...|.       ....|||..||||..   .||. ..|.||.|....||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK-------HPFL
|.||.    . . .|.|.             ||..| |....|..||..| || |.|.       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK4.AA Pkinase 321-572 29 8e-86 296.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 321-572
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL--LFN--EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGG----ALTDIVT---H
.    |||.|| | |.... ...||.||||....|..   ..  ...  |. ||.  .|.|.|..| ..  .|....|||..|||     | |...   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRM--NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV----KLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSL
...   |...  ... .|..|  .|..|.||||.|.. ||. ..| .    |..|||...|.     .  ....|||..||||.|  . .|||.||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMVIEMVDGEPPYFNE----PPLKAMKMIRDNLPPRLKNLHKVS---------------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL
|....||. |.||. ..    . .  |.||. ...|.|.     .                     ...| |....| .||..| ||...|.||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK4.AA MST 322-572 40 9.2e-78 246.73 In-house 2-254 (254) Show / Hide 
Range on Protein: 322-572
Range on HMM: 2-254/254
Sequence Identity: 40% (102 aa)

DNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL--VGDELWVVMEFLEGGALTDIVTHTR--MNEEQI
|   |.|.|| | |  |. ...||.||.|..        . . .|  || . . ...|  | ||.     ..| |||. ..| . ||.  |.   ||.||
DIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQI

AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN
|...  .|| |  ||    ||||||.  ||| |.|  ||.|||  .| .     | ...||||||||| |  . |   .|||||||  |||  |.|||..
ACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSD

EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
  |  ||.||  . || .|. .. |. .  |. . |...| ||.|| .||.||| 
IHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK4.AA YSK 326-572 37 7.5e-76 227.78 In-house 6-257 (257) Show / Hide 
Range on Protein: 326-572
Range on HMM: 6-257/257
Sequence Identity: 37% (96 aa)

KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTH---TRMNEEQIAAVC
.|| || | |  .  .  .. ||.|  || .     |..  |. .  .    ..   | ||| .  ||..||.. || . |         . |..|| . 
CIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIIL

LAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR--LPYGPEVDIWSLGIMVIEMVDGEPPYFNEP
  .|..|. || . .||||||.  .||. .| ||| |||  .|.   . .|   ||||||||||.|      |   .|||||||  .||  |||||    
REILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPYCDYH

PLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
|...|  |  | ||.|.  .. | ..| | .  |. ||.|| .| ||||| | 
PMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK4.AA KHS 322-572 40 9.2e-72 240.63 In-house 2-258 (258) Show / Hide 
Range on Protein: 322-572
Range on HMM: 2-258/258
Sequence Identity: 40% (105 aa)

DNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAV
.   ..| |  | |  |    |..|.||| . .  ..  ...  |...|.| .| |.|  . |||  | ||..||.  ||.| ||   |  ..| ||| |
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLPYGPEVDIWSLGIMVIEMVDGEPPYFN
|  .||.|  ||..| .|||||   ||||..| ||| |||  ||..  . .||| .|||||||||  .   .  |.   |||..||  ||. .  || |.
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

EPPLKA-MKMIRDNL-PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
  |..| . | . |  ||.||. || |..   |.   |...| .| ||  ||.|||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK4.AA SLK 323-572 36 4.3e-68 228.77 In-house 2-259 (259) Show / Hide 
Range on Protein: 323-572
Range on HMM: 2-259/259
Sequence Identity: 36% (93 aa)

NFI-KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAA
. |  .|.|  | |  |  .  ... | | ......   |  . |. |. . .| |.|..|..| . ..||...|| .|||.  |.   .  . |.||. 
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

VCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-----SRLPYGPEVDIWSLGIMVIEMVDGEPP
||  ...||  || . |||||.|   ||.| || |.| |||  |.  ... .| . .|||||||||..        ||   .||||||| .||| ..|||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

YFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
. .  |.. .  |.   ||.|..  . | . | || . ||.|| .| |.|.|..|...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase PAK4.AA CAMK 326-572 17 5.3e-68 217.95 In-house 1-425 (425) Show / Hide 
Range on Protein: 326-572
Range on HMM: 1-425/425
Sequence Identity: 17% (76 aa)

KIGEGSTGIVCIATVRSSG------------KLVAVKKMDLRKQQR----------------------------RELLFNEVVIMRD-------YQHENV
..|.|| |.|  .. ....            . ||.| .| .| .                             |. ...|. ||.         .|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEMYNSYL------------VGDE--------LWVVM---EFLEGG----A-LTDIVTH---------------TRMNEEQIAAVCLAVLQALSVLHAQG
. .|  |               .         .. ||   |. .||      .  || |                |..|.. . .   ...|.  .| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDIKSDSILLTHD-----------------GRVKLSDFGFCAQVSK-----------------------EVPRRKSLVGTPYWMA-PELISR-----
..|||.| . |||...                 . .|..|||| ... .                       | .  |  .|||. || ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMK-------------MIR----DNLPPRLKN---------LHKVSPS--------LK
          .|||..|.||.|..   |. |.||.  .     ..             .|.    |  || ...          ...| .         |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

GFLDRLLVRDPAQRATAAELLKHPFL
 .. ..|..|| .|.|... |.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PAK4.AA MSN 321-572 37 1.8e-67 221.76 In-house 1-265 (265) Show / Hide 
Range on Protein: 321-572
Range on HMM: 1-265/265
Sequence Identity: 37% (99 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDY-QHENVVEMYNSYL------VGDELWVVMEFLEGGALTDIVTHTR--
 .    .| |  | |        |.|.|.| ||.|.    |.   |. ... |  | |..  |  ..        . ||.||||   |..||.| .|.  
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQ-EINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

-MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS-----RLPYGPEVDIWSLGIMV
 . |. || .|  .|. |. ||.. |||||||   .||||.  ||| |||  ||... | || . .||||||||| |      .  |    |.||.||  
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
||| .|.||  .  |..|. .|  | ||.||  .| |   . |... |...  || .....|||||.
IEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase PAK4.AA Pkinase_Tyr 321-530 25 9.1e-21 70.96 Pfam 1-232 (270) Show / Hide 
Range on Protein: 321-530
Range on HMM: 1-232/270
Sequence Identity: 25% (59 aa)

LDNFIKIGEGSTGIVCIATVR----SSGKLVAVKKM--DLRKQQ--RRELLFNEVVIMRDY-QHENVVEMYNSYL-VGDE--LWVVMEFLEGGALTDIVT
.    |.|||. | |. .| .    . .  ||||..  .  ..|  |....  |. ||. . .|.|.| .|   .  |.   ...|||. ..| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HT-----RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVP-RRKSLVGTPY-WMAPELISRLPYGPEVDIWS
       . . ...   |. . .... |.... ||||.    .|.|... || .||| .  . ...   | ..    |  ||||| |.   .  . |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGIMVIEMVD-GEPP-YFNEPPLKAMKMI-RDN
 |.   |..  || | | . ..   ...| .|.
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
Kinase PAK4.AA TyrKc 321-572 22 2.6e-17 57.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 321-572
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDY--QHENVVEMYNSYLVG-------DELWVVMEFLEGGALTDIVTHTR
.    |.|||  |.|. .| .     ||||..   .   || . .|  ||. .  .|.|.| .|   . .       . |..|||. ..|.| |    .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKE--------VPRRKSLVGTP-----YWMAPELISRLPYGPEV
   . ..    |. . .  . || ...||||.    .|......|| |||| .  .  .        . | |.  |.       ||||| |    . .. 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMVIEMV-DGEPPYFN-----EPPLKAMKMIRDNLPPRLKNLHK--------VSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
|.|| |..  |.  .|..|| .      ..  ... ...    |..  .          .. .     .   .||..| | .|.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF