Gene PAK5 (Human)

PAK5

Species: Human
Alias: MGC26232, PAK5, PAK7, KIAA1264
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 20p12.3,

Classification

Group: STE
Family: STE20
Subfamily: PAKB

Sequence

Name Sequence Type Origin Length Description Download
PAK5.NA RNA Sugen Kinome 4778 None Fasta, JSON
PAK5.AA Protein Sugen Kinome 719 None Fasta, JSON
PAK5.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of PAK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK5.AA PBD 10-67 31 2.3e-21 77.07 Pfam 1-60 (60) Show / Hide 
Range on Protein: 10-67
Range on HMM: 1-60/60
Sequence Identity: 31% (19 aa)

EISGP-SNFEHRVHTGFDPQEQKFTGLPQQWHSLLADT-ANRPKPMVDPSCITPIQLAPM
.||.| .||.|..| |.|.|...|||.|..| .|| ..   .|.....|.......  ..
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK5.AA PBD 11-46 52 2.2e-15 58.36 SMART 1-38 (38) Show / Hide 
Range on Protein: 11-46
Range on HMM: 1-38/38
Sequence Identity: 52% (20 aa)

ISGPS-NFEHRVHTG-FDPQEQKFTGLPQQWHSLLADT
|| |. ||.|.|| | .|.|...||||| || .||  .
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK5.AA PAKB 449-700 87 1.1e-227 762.66 In-house 1-252 (252) Show / Hide 
Range on Protein: 449-700
Range on HMM: 1-252/252
Sequence Identity: 87% (221 aa)

LANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATV
| |..|||||||||||||||||||.||||||||||||||||||||||||||||.|.|.|.|||||||||||||||||.||||||||||||||||||||||
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

CLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPP
|..||.||.|||.||||||||||||||||.|||.||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

LQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
||||.||||..|||.|..||||..||.||| ||||.|.||.|||||| ||||
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK5.AA STE20 449-700 46 6.5e-149 501.02 In-house 1-288 (288) Show / Hide 
Range on Protein: 449-700
Range on HMM: 1-288/288
Sequence Identity: 46% (133 aa)

LANFIKIGEGSTGIVCIATEKHTGKQ----VAVKKMDLRKQ----QRRELLFNEVVIMRDYHHDNVVDMYSSYLVG----DELWVVMEFLEGGALTDIVT
  .. |||.||.| |. |..|.||..    ||.|||.|.|.    ...|....|..||....| |.| .| |||..    ||||.|||...|| ||||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

HT----------RMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSK-----EVPKRKSLVGTPYWMAPEVISR----
|.          .|||||||..|  ||..|.|||....||||||.| ||||.||..||.|||.|||..|     . .||...||||||||||||..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-LPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIR--DSLPPRVKD--LHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
  .|.. .|||||||. |||..||||||...|..|| .|   .  ||. ||   || |. .. |.|..|...|..|.||..|| |||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK5.AA PAKA 450-700 52 3.1e-134 452.26 In-house 2-260 (260) Show / Hide 
Range on Protein: 450-700
Range on HMM: 2-260/260
Sequence Identity: 52% (135 aa)

ANFIKIGEGSTGIVCIATEKHTGKQ--VAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTR------MN
... |||.|..| | .||...|...  ||.|.|.. .| . ||. ||  .|....|.|.|. ..|||| ||||||||..||| |||..|...      |.
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEP
|.||| ||  .|..|...|....|||||||| ||| .||..|. ||||||| ..|  ||.. ||||||||||||.|  |.  |||||||||.||||.|||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
|| ||||| ||  |     |  || .|.|. .. |||. |  .. .||.||||| ||||
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK5.AA STE 449-700 29 1.3e-116 393.71 In-house 1-359 (359) Show / Hide 
Range on Protein: 449-700
Range on HMM: 1-359/359
Sequence Identity: 29% (108 aa)

LANFIKIGEGSTGIVCIATEKH---------------TGKQVAVKKMDLRKQ-----------------QRRELLFNEVVIMRDYH--HDNVVDMYSSYL
. .  |||.|..| |. |  ..               ||. .|.|.|.|...                 . .. . .|. ||....  |.|.|  | .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------DELWVVMEFLEGGALTDIVTH---------------TRMNEEQIATVCLSVLRA-LSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCA
..       ||||..||...|| |.||. |               .|..|.|||..| ..|.. |.|||....||||||.. |||     .||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QVSKEVP----------------KRKSLVGTPYWMAPEVISR------LPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDS-----------
|......                ||...|||| |||||||..       .|.| .||||||...|||..|.||.....|..|| .| ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----LPPRVKD-----------------LHKVSSVLRGFLDLMLVREPSQRATAQELLG--HPFL
     ||. .|                  ||.|. .. |... |...|..|.||..||   |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK5.AA S_TKc 449-700 29 1.1e-92 315.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 449-700
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

LANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEG--GALTDIVTHTR-------
     |||.|. | |. ...|.||..||.|...       | . .|. |..  ||.|.| .| ..   |.|..|||...|  | | |.  . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT-EVDIWSLGIMVIEMID
..| ... ..  ...|| |.|..|.||||.| . |||..  .||..|||...|.       ....|||..|||||.   .||. ..|.||.|....||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLG-------HPFL
|.||.    . . ...|.             |. .. |.. .|...|..| || |.|        ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK5.AA Pkinase 449-700 29 4.4e-85 293.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 449-700
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

LANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRREL--LFN--EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGG----ALTDIVT---H
.    |||.|| | |.....| |||.||||....|..   ..  ...  |. ||.  .|.|.| .| ..  .|....|||..|||     | |...   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRM--NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRI----KLSDFGFCAQV-SKEVPKRKSLVGTPYWMAPEVIS-RLPYGTEVDIWSL
...   |...  ... .||.| |.|..|.||||.|.. ||. ..| |    |..|||...|.     .  ....|||..||||||  . .||..||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMVIEMIDGEPPYFNE------PPLQAMRRIRDSLPPRVKDLH------------------KVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
|....||. |.||. ..       ..| ..||..  ...  .                    ..|. .. |.. .| . |..| ||...| ||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK5.AA YSK 454-700 37 7.7e-78 233.87 In-house 6-257 (257) Show / Hide 
Range on Protein: 454-700
Range on HMM: 6-257/257
Sequence Identity: 37% (94 aa)

KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-ELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTH---TRMNEEQIATVC
.|| || | |  . ...|.. ||.|  || .     |..  |. .  .    ..   | ||| .  ||..||.. || . |         . |..||.. 
CIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIIL

LSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISR--LPYGTEVDIWSLGIMVIEMIDGEPPYFNEP
  .| .|.||| . .||||||.  .||. .| .|| |||  .|.   . ||   ||||||||||||      | . .|||||||  .||  |||||    
REILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPYCDYH

PLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
|. .| .|  . ||. .. .. |  .  | .. |. .|.|| .|.||| | | 
PMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK5.AA MST 454-700 41 1.6e-76 242.73 In-house 6-254 (254) Show / Hide 
Range on Protein: 454-700
Range on HMM: 6-254/254
Sequence Identity: 41% (104 aa)

KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL--VGDELWVVMEFLEGGALTDIVTHTR--MNEEQIATVC
|.|.|| | |  |. | ||| ||.|..        . . .|  || .   ...|  | ||.     ..| |||. ..| . ||.  |.   ||.|||...
KLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACIL

LSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPL
 ..|. | |||.   ||||||.  |||  .|  ||.|||  .| .    || ...|||||||||||  . | . .|||||||  |||  |.|||..  | 
YDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPM

QAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
 ||  |  . ||  || .. |. .  |.   |...|.||.|| .|| ||| 
RAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK5.AA KHS 452-700 40 5.4e-73 244.83 In-house 4-258 (258) Show / Hide 
Range on Protein: 452-700
Range on HMM: 4-258/258
Sequence Identity: 40% (103 aa)

FIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCL
  ..| |  | |  | ...... .||| . .  ..  ...  |...|.| .| |.|  . |||  | ||..||.  ||.| ||   |  ..| ||| || 
LQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCR

SVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEP
 .|..| |||..| .|||||   ||||..| .|| |||  ||..  . |||| .|||||||||| .   .  |.   |||..||  ||. .  || |.  
ETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFDLH

PLQAMRRIRDS--LPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
|..|.  .  |   ||..|| || |.    |. . |...| .| ||. || |||.
PMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK5.AA CAMK 454-700 18 5.5e-69 221.2 In-house 1-425 (425) Show / Hide 
Range on Protein: 454-700
Range on HMM: 1-425/425
Sequence Identity: 18% (78 aa)

KIGEGSTGIVCIATEKHTG------------KQVAVKKMDLRKQQR----------------------------RELLFNEVVIMRD-------YHHDNV
..|.|| |.|  ...|.|.            ..||.| .| .| .                             |. ...|. ||.         .| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VDMYSSYL------------VGDE--------LWVVM---EFLEGG----A-LTDIVTH---------------TRMNEEQIATVCLSVLRALSYLHNQG
. .|  |               .         .. ||   |. .||      .  || |                |..|.. ...   .. |. |.|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDIKSDSILLTSD-----------------GRIKLSDFGFCAQVSK-----------------------EVPKRKSLVGTPYWMA-PEVISR-----
..|||.| . |||...                 . ||..|||| ... .                       | .| |  .|||. || |||...     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------LPYGTEVDIWSLGIMVIEMIDGEPPYFNEP----------------PLQAMRRIRDS-LPPRVKD---------LHKVSSV--------LR
          .|| ..|.||.|..   |  |.||.  .                  ..  .. . .  || ...          ...|           .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

GFLDLMLVREPSQRATAQELLGHPFL
 ..  ||...|..|.|... | ||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PAK5.AA SLK 451-700 35 5.5e-68 228.42 In-house 2-259 (259) Show / Hide 
Range on Protein: 451-700
Range on HMM: 2-259/259
Sequence Identity: 35% (92 aa)

NFI-KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIAT
. |  .|.|  | |  | .| ...  | | ......   |  . |. |. . .| |.|..|..| . ..||...|| .|||.  |.   .  . |.||. 
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

VCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-----SRLPYGTEVDIWSLGIMVIEMIDGEPP
||  .. || .||.. |||||.|   ||.| || ..| |||  |.  ... || . .||||||||||.        ||   .||||||| .||| ..|||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

YFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
. .  |.  . .|. | ||...   . |.  . ||   ||..| .| |...|. |...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase PAK5.AA STE11 454-700 31 2e-62 213.71 In-house 6-303 (303) Show / Hide 
Range on Protein: 454-700
Range on HMM: 6-303/303
Sequence Identity: 31% (93 aa)

KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR---------RE-----LLFNEVVIMRDYHHDNVVDMYSSYLV---GDELWVVMEFLEGGALTDIVT
.||.|. | |  .  ..||. .|||.. ....           ..     ..  |. .|.  .| | | .| . |     |.. . ||. .|| | ..  
IIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLR

HTR----MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGR-IKLSDFGFCAQVSKEVPKRKS----------LVGTPY--------WMAPE
| .    ..|  |      .|..|.||| .|.|||||| . ||| |||  .||.||| . ..... .. ..          . ||||        |||||
HKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPE

VISRLP---YGTEVDIWSLGIMVIEMIDGEPPYFNEP--PLQAMRRIRDSLPPRVKDLHKVS------SVLRGFLDLMLVREPSQRATAQELLGHPFL
||.. .   ||. .||||||  ||||. | ||. |    . .|| .|  .  |      ..|        .| ||.. ....|. |.||..|| |||.
VIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase PAK5.AA Pkinase_Tyr 449-657 27 3.6e-25 85.85 Pfam 1-231 (270) Show / Hide 
Range on Protein: 449-657
Range on HMM: 1-231/270
Sequence Identity: 27% (63 aa)

LANFIKIGEGSTGIVCIATEK----HTGKQVAVKKM--DLRKQQ--RRELLFNEVVIMRDY-HHDNVVDMYSSYL-VGDE--LWVVMEFLEGGALTDIVT
.    |.|||. | |. .| |     |. .||||..  .  ..|  |....  |. ||. . ||.|.| .|   .  |.   ...|||. ..| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HT-----RMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQV-SKEVP--KRKSLVGTPYWMAPEVISRLPYGTEVDIWS
       . . ...   |. . ....||.... ||||.    .|.|... .| .||| .  . ...    ||..      |||||.|.   . |. |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGIMVIEMID-GEPP-YFNEPPLQAMRRI-RD
 |.   |..  || | | . .. . ...| .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase PAK5.AA TyrKc 449-700 23 7.4e-20 73.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 449-700
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

LANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDY--HHDNVVDMYSSYLVG-------DELWVVMEFLEGGALTDIVTHTR
.    |.|||  |.|. .| |    |||||..   .   || . .|  ||. .  ||.|.| .|   . .       . |..|||. ..|.| |    .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKE-------VPKRKSL-VGTP-----YWMAPEVISRLPYGTEV
   . ..    |. . .  .||| ...||||.    .|.......| |||| .  .  .         .||.   |.       |||||.|    . |. 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMVIEMI-DGEPPYFN-----EPPLQAMRRIRDS-LPPRVKD------LHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
|.|| |..  |.  .|..|| .      .. ........   .|. ..       .  . . .        ..|..| | .|.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF