Gene Wnk3 (Human)

Wnk3

Species: Human
Alias: Wnk3, PRKWNK3, KIAA1566, WNK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Xp11.1-p11.22,

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
Wnk3.NA RNA Sugen Kinome 7744 None Fasta, JSON
Wnk3.AA Protein Sugen Kinome 1800 None Fasta, JSON
Wnk3.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of Wnk3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Wnk3.AA WNK 147-405 86 2.3e-233 761.34 In-house 1-261 (261) Show / Hide 
Range on Protein: 147-405
Range on HMM: 1-261/261
Sequence Identity: 86% (226 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMK
.|||.|.|||.|||||.|||||||||||||||||.||.|.|.|||||||||||.|||||||||||.|||.|.|||||||||||||||||||||||||.||
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKKMK

PKVLRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS
|||||||||||||||.|||||.| ||||||||||||||||.|||||||||||| ||...|||||||||||||||||||||||||||||||||||||||||
PKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS

EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF
||||||||||||||||||.||||.||.|...||||||||.|||.||.|| ||..||||.||
EYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase Wnk3.AA S_TKc 147-405 25 5.6e-70 239.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 147-405
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTS--GTLKTYLKRFKV
 ..  ..|.||| .|||. ...|  .||  ..          .... | ..||  .|||||..||....     ... .|.|..    |.|..|.|. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

------MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDE-SVDVYAFGMC
      . . . |....||...|...| .   ||||||| .||...     .||.| |||...     ....|||..||||.   .|.  ..|....| .
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

MLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLN-------HAFF
. ||.. . |..   . .....|.             .||.|..|..| . . ..|... ..|.       | .|
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Wnk3.AA Pkinase 147-405 25 1.4e-62 219.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 147-405
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKE--EAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSG----TLKTYLK
...   .|.|.| .|||. .  |  .||  ..  |.  . ..|.     |....| |.||||||.||..|.    |. | .|.|..  |     |..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

--RFKVM--KPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSV----KIGDLGLAT---LMRTSFAKSVIGTPEFMAPEM--YEEHYDE
  | ...   .........|||.||...| .   ||||||| .||.|   .| .    ||.| |||    . . | .... |||..||||     ..|. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGIKPASFNKVTD-------------------PEVKEIIEGCIRQNKSERLSIRDLLNHA
.||....|  . ||.. . |....      .  |..... ... . .. .  .                   .| |..|..|.... ..|......|.| 
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FF
.|
WF
Kinase Wnk3.AA STE 147-405 20 2.4e-60 206.77 In-house 1-359 (359) Show / Hide 
Range on Protein: 147-405
Range on HMM: 1-359/359
Sequence Identity: 20% (77 aa)

LKFDIELGRGAFKTVYKGLDT-----------------ETWVEVAWCELQD-------------RKLTKAEQQRFKEEAEMLKGLQ--HPNIVRFYDSWE
...  ..|.||| ||||...                   ... .   .|..             ..  . |.|....| ...| ..  |||||..|.. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SI---LKGKKCIVLVTELMTSGTLKTYLK-RFKVMKP-------------KVLRSWCRQILKG-LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLG
      | .  . .. |.|  |.|   .| .... ||             ....  ||||||| |..||     |||||.|..||..      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LATLMRTS------------------FAKSVIGTPEFMAPEMYEE-------HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG-------
... .  |                    ....||| .||||. .        .||...|.. .| ...|||| ..|... ..   .... ...       
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------IKPASFNKVTD-------------------PEVKEIIEGCIRQNKSERLSIRDLLN--HAFF
       .| ..   ..                   || |. |. | . . ..| .  .||.  | |.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Wnk3.AA FRWNK_Wnk1 406-497 72 7.3e-60 205.19 In-house 1-92 (92) Show / Hide 
Range on Protein: 406-497
Range on HMM: 1-92/92
Sequence Identity: 72% (67 aa)

AEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREK
.||||.|||||||||...|...|.||.|||||||||.||||||||||.||.|.|||||.|||.||||.|.|.|.|||||||||. ||..||.
QEDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
Kinase Wnk3.AA CAMK 152-405 16 5.6e-52 165.38 In-house 1-425 (425) Show / Hide 
Range on Protein: 152-405
Range on HMM: 1-425/425
Sequence Identity: 16% (71 aa)

ELGRGAFKTVYKGLDTETW------------VEVAWCELQDRKLT--------------------------KAEQQRFKEEAEMLKGLQ-------HPNI
.||||.| .|... ...|             ..||   .  .||.                             ..... | |..| ||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFYDSWES-----------ILKG-----KKCIVLVT---ELMTSG----TLKTYLKRF---------------KVMKPKVLRSWCRQILKGLQFLHTRT
...|. .|.             .      .|....|.   |... |     |  |...                . .. .  | . |||. .....| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHRDLKCDNIFITGPT----------------GSVKIGDLGLATLMRTS-------------------------FAKSVIGTPEFMA-PEMYE----
  |.|||||..|| ..                   . .|| | |.|. .. .                           | . ||||.|| ||. .    
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------EHYDESVDVYAFGMCMLEMATSEYPYSEC------------QNAAQIYRKVTSGIKPASFNKVTD----------------------PE
           . |....|. . |  .  | . ..|. .             .|  ....|...|       ....                      .|
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

VKEIIEGCIRQNKSERLSIRDLLNHAFF
.|  | .. . . ..|..| . ||| ..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Wnk3.AA Ciliate-E2 147-405 19 5.1e-50 169.87 In-house 1-365 (365) Show / Hide 
Range on Protein: 147-405
Range on HMM: 1-365/365
Sequence Identity: 19% (74 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE---------------------QQRFKEEAEM---------------LKGLQHPNIVRFY
 ||   .|.|.| .|||. . ..  ..|    . .|. .                       .| ..|. .|               |. |.||||...|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKP-----------KVLRSWCRQILK---------------GLQFLHTRTPPIIHRDLKCDNIFIT
.....  | ...| ||.|.   |.|. |.| .|  ..           |  .   .|||.               .|..|| . . |||||.| .||.. 
ECFQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-

GPTGSVKIGDLGLAT----------------LMRTSF------------------AKSVIGTPEFMAPEMYE----------EHYDESVDVYAFGMCMLE
     .|| |.||..                ..   .                  .....|||..||||...          ..||...|....|... |
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

MATSEYPYSECQNAAQIYRKVTSGIKPASFN-------------KVTDPEVKEIIEG----CIRQNKSERLS-IRDLLNHAFF
| . ..|.       |.  .    . .. ..             |  ..|.| .|      ..  . ..|.. . ..||| .|
MLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Wnk3.AA TKL 153-403 19 1.4e-48 167.67 In-house 1-364 (364) Show / Hide 
Range on Protein: 153-403
Range on HMM: 1-364/364
Sequence Identity: 19% (73 aa)

LGRGAFKTVYKGLDTE----------TWVEV--------AWCELQDRK---------------LTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILK-
.|.|.| .||||              ..| |          .......                .. ......||. |.. |.|||||.|. .  .. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------GKKCIVLVTELMTSGT-LKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRT------PPIIHRDLKCDNIFITG-------------PTGSV
        ... . .|.|..  |. | ...       . .. .|...| .|...||...      ||||||||| .||..                .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDLGLATLMRTSF---------------------AKSVIGTPEFMAPEMYE-----------------EHYDESVDVYAFGMCMLEMATSEYPYSECQ
||.|.||.. | .|.                       ...||| .||||. .                 . |.|..|||.||... |..| . ||..  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NAAQI---------YRKVTSGIKPASF-----------NKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHA
.  .|         .  .  | .|              .. ..|..|.... |  .. ..|.|  ..| . 
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Wnk3.AA STE11 153-405 25 1.4e-43 151.06 In-house 7-303 (303) Show / Hide 
Range on Protein: 153-405
Range on HMM: 7-303/303
Sequence Identity: 25% (77 aa)

LGRGAFKTVYKGLDTETWVEVA--WCELQDRK----LTKAEQQR------FKEEAEMLKGLQHPNIVRFYDSWESILKG-KKCIVLVTELMTSGTLKTYL
.|.||| ||||.... | ...|    |.|. .     .. | |       ..|| ...|.|.|.||||.|..  .  .. ....    | .  |.|.  |
IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLH--DNQNDHVNIFMEYCPGGSLSSML

K-RFKV--MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS------------FAKSVIGTPE--------FM
. ..    .  .| |   .|||.|||.||     |||||.| .||..    ...|..| | |. . ..            . ||. |||         .|
RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWM

APEMYE-EH---YDESVDVYAFGMCMLEMATSEYPYSECQN--AAQIYRKVTS-G--IK-PASFNK--VTDPEVKEIIEGCIRQNKSERLSIRDLLNHAF
|||..  |    |. ..|. ..| ...||||   |......  .|.... ... .  .  | ..    .  .| ....  |  .....| . ..||.| |
APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPF

F
.
I
Kinase Wnk3.AA NRBP 152-406 33 7.8e-43 148.38 In-house 1-261 (261) Show / Hide 
Range on Protein: 152-406
Range on HMM: 1-261/261
Sequence Identity: 33% (90 aa)

ELGRGAFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFK----VM
       ...|  .|||. ||| | |.|  .||  ||.  . ..  . |  |.|.|||.|   |  . . |  .. .|| | || .| .||. |     |
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

KPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-SFAKSVIGTPEFMAPEMY---EEHYDESVDVYAFGMCMLEM
. |  . || |||  | .||.  |||||  | || |||    | .|||     .. .    ..       |.|||      ..    ||.|.|||| |||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQH-NGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM

ATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFA
|  |   | |||.   |  ||  .   . . . ||  ...|. |....  .| | |.|| |    
AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase Wnk3.AA ULK 147-405 22 1.5e-42 146.33 In-house 1-329 (329) Show / Hide 
Range on Protein: 147-405
Range on HMM: 1-329/329
Sequence Identity: 22% (75 aa)

LKFDIELGRGAFKTVYKGLDTETW---VEVAWCELQDRKLTKAEQQR---------FKEEAEMLKGL--------QHPNIVRFYDSWESILKGK--KCIV
   . .|| |.| .|||| . .|    .|.  |   |..  . ...          .| | . .| |        .|||||..||    ... .  ..| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD----WFETSNHNNIY

LVTELMTSGTLKTYLK----------RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATLMRT
...|.   |.|..|.|          . |    .  .. ..||| |...|| .   |||||.| .|| |. ....           .||.| |.|  .  
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

S-----FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI----YRKVTSG--------IKPASFN---
.      ...        ||| .|||.  ...     |... .|.. .|. . || . ..|.... .  |.    .. .  .         .|  |.   
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG

--KVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF
  ..  ||.|..| ...  . ..| |. .|.|| .|
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Wnk3.AA Ciliate-E2-Unclassified 179-405 20 2.3e-42 144.74 In-house 38-352 (352) Show / Hide 
Range on Protein: 179-405
Range on HMM: 38-352/352
Sequence Identity: 20% (65 aa)

QDRKLTKAEQQRFKEEAEMLKGLQ-------------------HPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV---------------
...|. . .. ... |.. .. ..                   ||.||....    . . |..| .|.|..  |.|. |.| .|                
YKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFY----CFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQR

--MKPKVLR-----SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTG--SVKIGDLGLAT-----------------LMRTSFAKSVIGTPEFM--
     .  .      ...|||.||..||     |||||.|..||...   .   .|| |.|..                    .   .....|||..|  
KIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ

--APEMYEE-HYDES----VDVYAFGMCMLEMATSEYPYS-EC------------------QNAAQIYRKVTSGIKPAS--FNKVTDPEVKEIIE----G
  |||.... .||.|    .|....|... || . .||.. ..                  |   .|. | ..  |     . |  .||.|..|.     
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

CIRQNKSERLSIRDLLNHAFF
..  | ..|... ..||| .|
MLKKNPNKRITFEQILNHPWF
Kinase Wnk3.AA ULK 147-405 23 2.7e-41 143.49 In-house 1-324 (324) Show / Hide 
Range on Protein: 147-405
Range on HMM: 1-324/324
Sequence Identity: 23% (77 aa)

LKFDIELGRGAFK-TVYKGLDTET---WVEVAWCELQDRKLTKAEQQ--------RFKEEAEMLKGLQ---HPN--IVRFYDSWESILKGK--KCIVLVT
   . .|| |.|  .|||| . .|    . ||    .  |. | ...         .| | . .| |    |||  ||..||    ... .  . | ...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYD----WFETSNHNNIYIIM

ELMTSGTLKTYLK---------RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATL-----MR
|.   |.|..|.|         . |    .  .. ..||. |...|| .   |||||.| .|| |. ....           .||.| |.|       | 
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

TSFAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI---YRKVTSG------IKPASFNKV-------T
    ..        ||| .|||.  ...     |... .|.. .|. . || . .||.... .  |.   .. .  |      ||   ...         
QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKI

DPEVKEIIEGCIRQNKSERLSIRDLLNHAFF
 ||.|..| ...  . ..| |. ...|| .|
SPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase Wnk3.AA TyrKc 147-405 24 4.7e-26 93.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 147-405
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGL--QHPNIVRFYDSWESILKGK-------KCIVLVTELMTSGTLKT
.... .||.||| .||||  .   ..||   |.. .     .. | .||.... |  .||||||.|     .   .       . . .|.|.|  | || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY----GVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLKRFKV-MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS----FAKSVIGT-----PEF------MAPEMY
||.. .   ..| | |.| || .| ..|| .  ..||||| . |. .. .   |||.| ||.           .|... .       .      ||||  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EEH-YDESVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGIKPASFNKV-------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF
 .. . .  ||..|| || |. |   .  .       ........| .|  .     .         .|. .|.. | . . ..| . ...  | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Wnk3.AA OSR1_C 426-463 65 9.3e-21 78.98 Pfam 1-38 (38) Show / Hide 
Range on Protein: 426-463
Range on HMM: 1-38/38
Sequence Identity: 65% (25 aa)

LALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVA
..|.|...||||.|||||.||||.|.|..|.|||||||
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
Kinase Wnk3.AA Pkinase_Tyr 225-298 37 2.5e-12 42.35 Pfam 84-158 (270) Show / Hide 
Range on Protein: 225-298
Range on HMM: 84-158/270
Sequence Identity: 37% (29 aa)

LVTELMTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA
.|.|.|  | |..||..     .  ..| | ..|.|| ||...|. .   .||||| . |. .| .   |||.| |||
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase Wnk3.AA Pkinase_Tyr 147-210 36 1.3e-09 33.13 Pfam 1-70 (270) Show / Hide 
Range on Protein: 147-210
Range on HMM: 1-70/270
Sequence Identity: 36% (26 aa)

LKFDIELGRGAFKTVYKGLDT----ETWVEVAWCELQDRKLTKAE--QQRFKEEAEMLKGL-QHPNIVRFY
..|. .||.||| .||||  .    .| ..||   | . . .. .  .. | .||...| | .||||||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase Wnk3.AA FRWNK_Wnk2.hmm 450-495 32 6e-06 17.6 In-house 18-63 (63) Show / Hide 
Range on Protein: 450-495
Range on HMM: 18-63/63
Sequence Identity: 32% (15 aa)

FSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTR
| | |. |.|||.|  ||.. |  ||. ..  . .|| ..  ..  
FKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
Kinase Wnk3.AA Pkinase_Tyr 316-405 22 0.000818 13.54 Pfam 181-270 (270) Show / Hide 
Range on Protein: 316-405
Range on HMM: 181-270/270
Sequence Identity: 22% (21 aa)

MAPE--MYEEHYDESVDVYAFGMCMLEMAT-SEYP-YSECQNAAQIYRKV-TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF
||||  .| . . .  ||..|| .| |. |  | | | ..   ...|...  .|   .   . . .|. ...  | ... ..| . ...  | ..
MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
FRWNK_Wnk2.hmm Wnk3.AA FRWNK_Wnk2.hmm 756-818 68 1.2e-40 134.24 In-house 1-63 (63) Show / Hide 
Range on Protein: 756-818
Range on HMM: 1-63/63
Sequence Identity: 68% (43 aa)

DNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEIL
|.||||||||||.||||||||.|||.||.||.||||..|.||||.|||.|..|.|. .|.|..
DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
FRWNK_Wnk1 Wnk3.AA FRWNK_Wnk1 767-820 27 0.000317 12.6 In-house 39-92 (92) Show / Hide 
Range on Protein: 767-820
Range on HMM: 39-92/92
Sequence Identity: 27% (15 aa)

NNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHV
.|  . | || . |.||..|  ||| .|..|.. .      |. |   ..  . 
DNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
OSR1_C Wnk3.AA OSR1_C 773-786 50 0.393861 7.87 Pfam 25-38 (38) Show / Hide 
Range on Protein: 773-786
Range on HMM: 25-38/38
Sequence Identity: 50% (7 aa)

FKFDVDGDAPEDIA
|.||.  |.||..|
FEFDIEKDTPEEVA
Wnk.CR4 Wnk3.AA Wnk.CR4 1518-1594 46 2.5e-39 136.96 In-house 1-80 (80) Show / Hide 
Range on Protein: 1518-1594
Range on HMM: 1-80/80
Sequence Identity: 46% (37 aa)

SPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQS-TEIP--LPPASPRRPRSFKS
|.||||..||.||||...|||||||||..|...||.||.||..|||.|... .... .|  ...  ......|||...||
SYMSSDNDSEFEDEDMWKELQRLREKHMKEIQELQAQQKKEIEELYTRMGKPPPPGIVSPHAMLTAPMSGRRRRPSKHKS