Gene Wnk4 (Human)

Wnk4

Species: Human
Alias: PRKWNK4, PHA2B, WNK4, Wnk4
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q21.2,

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
Wnk4.NA RNA Sugen Kinome 4194 None Fasta, JSON
Wnk4.AA Protein Sugen Kinome 1243 None Fasta, JSON
Wnk4.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of Wnk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Wnk4.AA WNK 174-432 80 2.9e-228 744.63 In-house 1-261 (261) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-261/261
Sequence Identity: 80% (210 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMK
.|||.|.||||||||||||||.|.|||||||||..|||..|||||.||.||||.|||||||||||.|.|||.|..||||||||||||||||||.||..||
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKKMK

PRVLQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPTGSVKIGDLGLA-TLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATS
|.||..|.||||.||||||.|.| ||.||||||||.||||.|||||||||||| |||..||||||||||||||||||||.|||.||||||||||||||||
PKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS

EYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFF
||||||||||||||||||.| |||||.|...||||||||.|||..|.||..||.||.|.||
EYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase Wnk4.AA S_TKc 174-432 24 8.5e-66 225.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTS--GTLKTYLRRFRE
 ..  .||.|.| .||.. ...|  .||  ..          ...  |...||  .|||||..||.. .      .. .|.|..    |.|..|... . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

------MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE-AVDVYAFGMC
      . . . ... .||...| ..||.   |.||||| .|....     .||.| |||..      ....|||..||||.   .|.  ..|....| .
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

MLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLA-------HAFF
. ||.. . |..   . .....|.              ||.|..|..| . | ..| |. ..|.       | .|
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Wnk4.AA Pkinase 174-432 25 3.9e-59 207.58 Pfam 1-293 (293) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSE--EVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSG----TLKTYLR
...   ||.||| .||.. . .|  .||  ..  |. .  ..|.     |....| |.||||||.||.. .  .. ..  .|.|..  |     |..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIY--MVMEYCEGGLYVMDLFDYIS

--RFREM--KPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSV----KIGDLGLAT---LKRASFAKSVIGTPEFMAPEM--YEEKYDE
  | . .   ....... .|||||| ..||.   |.||||| .|..|   .| .    ||.| |||    . . | .... |||..||||     ..|. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

AVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGRKPNSFHKVKI-------------------PEVKEIIEGCIRTDKNERFTIQDLLAHA
.||....|  . ||.. . |....      .  |..... ... . .. .                      .| |..|..|.. | ..| |....| | 
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FF
.|
WF
Kinase Wnk4.AA CAMK 179-432 17 5.5e-54 171.97 In-house 1-425 (425) Show / Hide 
Range on Protein: 179-432
Range on HMM: 1-425/425
Sequence Identity: 17% (75 aa)

EIGRGSFKTVYRGLDTDTT------------VEVAWCELQTRKLS--------------------------RAERQRFSEEVEMLKGLQ-------HPNI
..||||| .|... .. ||            ..||   . ..||.                             |...  |.|..| ||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFYDSWKS-----------VLRG-------QVCIVL-VTELMTSG----TLKTYLRRF---------------REMKPRVLQRWSRQILRGLHFLHSRV
...|. . .             .        ....|. ..|... |     |  |...                . .. |  .|. |||. ..|..||. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPILHRDLKCDNVFITGPT----------------GSVKIGDLGLATLKRAS-------------------------FAKSVIGTPEFMA-PEMYEEK--
  | |||||..|. ..                   . .|| | |.|. .. .                           | . ||||.|| ||. . |  
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------YDEAVDVYAFGMCMLEMATSEYPYSEC------------QNAAQIYRKVTSGRKPNSFHKVKI----------------------PE
             |....|. . |  .  | . ..|. .             .|  ....|...|.     .....                      .|
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

VKEIIEGCIRTDKNERFTIQDLLAHAFF
.|  | .. ..| ..|.||.. |.| ..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Wnk4.AA STE 174-432 19 1.5e-51 177.58 In-house 1-359 (359) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-359/359
Sequence Identity: 19% (73 aa)

LKFDIEIGRGSFKTVYRGLDTDTT-----------------VEVAWCELQT--------RKLSRA-------ERQRFSEEVEMLKGLQ--HPNIVRFYDS
...  .||.|.| |||.... ...                 . .   .|..         . .         |.|.. .|....| ..  |||||..|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

WKSVL--RGQ-VCIVLVTELMTSGTLKTYLR-RFREMKP-------------RVLQRWSRQILRG-LHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGD
        ..   . .. |.|  |.|   .. ..   ||              .. .  ||||.| |..|||    | |||.|..|...      ||. |
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCD

LGLATLKRAS------------------FAKSVIGTPEFMAPEMYEE-------KYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPN-
 |...    |                    ....||| .||||. .        .||. .|.. .| ...|||| ..|... ..   .... ..... . 
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

---------SFHKVKI----------------------PEVKEIIEGCIRTDKNERFTIQDLLA--HAFF
            . .                       || |. |. | . | |.| | ..||   | |.
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Wnk4.AA FRWNK_Wnk1 433-523 59 4.8e-50 172.57 In-house 1-92 (92) Show / Hide 
Range on Protein: 433-523
Range on HMM: 1-92/92
Sequence Identity: 59% (55 aa)

REERGVHVELAEEDDGEKPGLKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREK
.|..||.|||||||||||...||||.|||... .|...||.||||.|.| .|..||||||||..|..|||||. ||...|.|||.|..|||.
QEDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
Kinase Wnk4.AA STE11 180-432 25 2.3e-46 160.35 In-house 7-303 (303) Show / Hide 
Range on Protein: 180-432
Range on HMM: 7-303/303
Sequence Identity: 25% (77 aa)

IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLS------RAERQR------FSEEVEMLKGLQHPNIVRFYDSWKSV-LRGQVCIVLVTELMTSGTLKTYL
||.|.| |||.....|| ...|  . .... .      . | |       . ||....|.|.|.||||.|..  .   .. |.| .  | .  |.|.  |
IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFM--EYCPGGSLSSML

R-RFRE--MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRAS------------FAKSVIGTPE--------FM
| ..    .   | ..  .|||.||..|||    | |||.| .|...    ...|..| | |.   ..            . ||. |||         .|
RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWM

APEMYE-EK---YDEAVDVYAFGMCMLEMATSEYPYSECQN--AAQIYRKVTS-GRKPN---SFHK--VKIPEVKEIIEGCIRTDKNERFTIQDLLAHAF
|||..  |.   |. ..|. ..| ...||||   |......  .|.... ... .  |.   ..    .  .| ....  |   |...| | ..|| | |
APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPF

F
.
I
Kinase Wnk4.AA TKL 180-430 21 1.3e-45 157.89 In-house 1-364 (364) Show / Hide 
Range on Protein: 180-430
Range on HMM: 1-364/364
Sequence Identity: 21% (78 aa)

IGRGSFKTVYRGLDTDTT--------VEVAWCELQTRK-------------------------LSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRG
||.|.| .||.|    ..         .||   . ..                           .. .|... ||. |.. |.|||||.|. . ..   |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

QVCI---------VLVTELMTSGT-LKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRV------PPILHRDLKCDNVFITG-------------PTGSV
.||.          .|.|..  |. | ...       . .. ||...| ||...|||.       |||.||||| .|...                .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDLGLATLKRASF---------------------AKSVIGTPEFMAPEMYE-----------------EKYDEAVDVYAFGMCMLEMATSEYPYSECQ
||.|.||.. .  |.                       ...||| .||||. .                 ..|.|..|||.||... |..| . ||..  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NAAQI---------YRKVTSGRKPNSF-----------HKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHA
.  .|         .  .  |..|               .   |..|.... |  .| ..| . |..| . 
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Wnk4.AA Ciliate-E2 174-432 18 1.1e-44 151.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-365/365
Sequence Identity: 18% (71 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRK-------------------LSRAERQRFSEEVEMLK----------------GLQHPNIVRFYD
 ||   ||.|.| .||.. .  .  ..|    . .|                   ..  . . .. |  ...                 |.||||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

SWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKP-----------RVLQRWSRQILR---------------GLHFLHSRVPPILHRDLKCDNVFITG
....    . .| ||.|.   |.|. |.. ..  ..           .  .. ..|||.               .|..|||. . |.|||.| .|...  
CFQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF--

PTGSVKIGDLGLAT-----------------LKRAS-----------------FAKSVIGTPEFMAPEMYEEK----------YDEAVDVYAFGMCMLEM
    .|| |.||..                 ..  .                  .....|||..||||... |          ||...|....|... ||
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

ATSEYPYSECQNAAQIYRKVTSGRKPN-------------SFHKVKIPEVKEIIEG----CIRTDKNERFT-IQDLLAHAFF
 . ..|.       ||  .  . ..|.             |..|.  .|.| .|      ..  | ..|.| ....| | .|
LFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWS-QECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Wnk4.AA NRBP 179-433 31 2.5e-39 135.83 In-house 1-261 (261) Show / Hide 
Range on Protein: 179-433
Range on HMM: 1-261/261
Sequence Identity: 31% (83 aa)

EIGRGSFKTVYRGLDTDTTVEVAWCELQ--TRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFR----EM
       ...|  .||.. ||| | |.|   ||  .|.  .  .  . |  |.|.|||.|   |  . . .. .. .|| | || .| .|.. .    .|
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

KPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRA-SFAKSVIGTPEFMAPEMY---EEKYDEAVDVYAFGMCMLEM
. .  .||  |||  | .|||  |||.|  | || .||    | .|||     ....    ..       |.|||      ..   |||.|.|||| |||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQH-NGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM

ATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFR
|  |   | |||.   |  ||      . | .. |  ...|. |.. |  .| . ..|| |    
AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase Wnk4.AA Ciliate-E2-Unclassified 175-432 18 1.3e-37 128.02 In-house 2-352 (352) Show / Hide 
Range on Protein: 175-432
Range on HMM: 2-352/352
Sequence Identity: 18% (65 aa)

KFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQR-------FSEEVEMLKG---------------LQHPNIVRFYDSWKSVLRGQVCIVL
|.   ||.|.| .||.  . ..  ...  .    . ... .|        .... .. |                |.||.... .. .  . . . .| .
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFY--CFQDKQNIYI

VTELMTSGTLKTYLRRF-----------------REMKPRVLQ-----RWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTG--SVKIGDLGLAT--
|.|..  |.|. |.. .                 ..   .  .     .. .||| || .||.    |.|||.|..|....   .   .|| |.|..   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

---------------LKRASFAKSVIGTPEFM----APEMYEE-KYD----EAVDVYAFGMCMLEMATSEYPYS-EC------------------QNAAQ
                 .   .....|||..|    |||.... .||    ...|....|... || . .||.. ..                  |   .
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IYRKVTSGRKPNS--FHKVKIPEVKEIIE----GCIRTDKNERFTIQDLLAHAFF
|. | .. .| .   ..|   ||.|..|.     ..  . |.| |....| | .|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Wnk4.AA ULK 174-432 21 1.2e-35 123.98 In-house 1-324 (324) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-324/324
Sequence Identity: 21% (73 aa)

LKFDIEIGRGSFK-TVYRGLDTDTT---VEVAWCELQTRKLSRAERQ--------RFSEEVEMLKGLQ---HPN--IVRFYDSWKSVLRGQVC--IVLVT
   . ..| |||  .||.| . .|    . ||    .  |..  . .         .  |.. .| |    |||  ||..||    ... . .  | ...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYD----WFETSNHNNIYIIM

ELMTSGTLKTYLR------------RFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGS-----------VKIGDLGLATL----
|.   |.|..|.             |. |.. .      .||. |. .||..   | |||.| .|  |. ....           .||.| |.|      
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQF---FKQICNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

-KRASFAKSVI------GTPEFMAPEMYEEK-----YDEA-VDVYAFGMCMLEMATSEYPYSECQNAAQI---YRKVTSG--------RKPNSFHK----
 . .   ..        ||| .|||.  ...     |... .|.. .|. . || . .||.... .  |.   .. .  |         .|  | |    
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

VKI-PEVKEIIEGCIRTDKNERFTIQDLLAHAFF
.|| ||.|..| ...  | ..|........| .|
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase Wnk4.AA NEK 176-432 25 2.3e-35 122.17 In-house 1-286 (286) Show / Hide 
Range on Protein: 176-432
Range on HMM: 1-286/286
Sequence Identity: 25% (75 aa)

FDI--EIGRGSFKTVYRGLDTDTTVE-----VAWCELQTRKLSRAERQRFS-EEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMT-SGTLKTY-
..|  .||.||| .||.  .. .  .     ..| . .. ..|. |.|    .||  || |.|||||..|||.  . ..  |.  | |     |.|    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSF--IEEQNNCLCIVMEYCEGGGDLYQKI

--LRRFR----EMKPRVLQRWSRQILRGLHFLHSR-VP--PILHRDLKCDNVFITG-PTGS--VKIGDLGLATLKRAS--FAKS-VIGTPEFMAPEMY-E
  . . .     .  ..  .|  |.. .|...|.|  |   |||||.|. |.|.|   ...  |||||.|.. .   .  .|.. ..||| .|.||.  .
KSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQN

EKYDEAVDVYAFGMCMLEMATS--EYPYSECQ--NAAQIYRKVTSGRKPNSFHKV--KIPEVKEIIEGCIRTDKNERFTIQDLLAHAFF
..|.. .|. ..| .  ||.|   . |  | .  |  . | |.. |....  ..     .. ...|. ... |  .| .....|.. | 
KPYNNKSDIWSLGCVLYEMCTLKPKHPF-EAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Wnk4.AA TyrKc 174-432 24 1.5e-20 75.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 174-432
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGL--QHPNIVRFYDSWKSVLRGQ-------VCIVLVTELMTSGTLKT
.... ..|.| | .||.|  .   ..||   |.  .     |. | .| .... |  .||||||.|     | . |         . .|.|.|  | || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY----GVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRRFRE-MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRAS----FAKSVIGT-----PEF------MAPEMY
|||. |.  ... |  .. || .|  .|||.  .. |||| . |. .. .   |||.| ||.           .|... .       .      ||||  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EEK-YDEAVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGRKPNSFHKV-------KIPEVKEIIEGCIRTDKNERFTIQDLLAHAFF
 .. . .. ||..|| || |. |   .  .       ........| .|. .   . .         .|. .|.. | . | ..| | ...  | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Wnk4.AA OSR1_C 453-489 44 1.1e-16 64.25 Pfam 1-38 (38) Show / Hide 
Range on Protein: 453-489
Range on HMM: 1-38/38
Sequence Identity: 44% (17 aa)

LKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVA
..|||||.|...  |....|.||.| |....|..||||
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
Kinase Wnk4.AA Pkinase_Tyr 252-325 34 9.6e-10 33.62 Pfam 84-158 (270) Show / Hide 
Range on Protein: 252-325
Range on HMM: 84-158/270
Sequence Identity: 34% (27 aa)

LVTELMTSGTLKTYLRR----FREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLA
.|.|.|  | |..|||.     .  ..  |  ...|| .|. .|.|.   . |||| . |. .| .   |||.| |||
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase Wnk4.AA Pkinase_Tyr 174-237 32 1.2e-08 29.97 Pfam 1-70 (270) Show / Hide 
Range on Protein: 174-237
Range on HMM: 1-70/270
Sequence Identity: 32% (23 aa)

LKFDIEIGRGSFKTVYRGLDT----DTTVEVAWCELQTRKLSRAE--RQRFSEEVEMLKGL-QHPNIVRFY
..|. ..|.|.| .||.|  .    .|...||   |   . .  .  |. | .|....| | .||||||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase Wnk4.AA FRWNK_Fray 474-507 50 6e-06 17.83 In-house 20-53 (97) Show / Hide 
Range on Protein: 474-507
Range on HMM: 20-53/97
Sequence Identity: 50% (17 aa)

IEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVA
| | | .|.| || .||| |. ||| . |.. ||
IRFEFTPGKDTAEGIAQELVSAGLVDGRDLVIVA
Kinase Wnk4.AA Pkinase_Tyr 343-392 31 0.001592 12.56 Pfam 181-233 (270) Show / Hide 
Range on Protein: 343-392
Range on HMM: 181-233/270
Sequence Identity: 31% (17 aa)

MAPE-MYEEKYDEAVDVYAFGMCMLEMAT-SEYP-YSECQNAAQIYRKV-TSGR
|||| . . |. .. ||..|| .| |. |  | | | ..   ...|...  .|.
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGY
Kinase Wnk4.AA FRWNK_Wnk2.hmm 470-521 23 0.013124 6.24 In-house 12-63 (63) Show / Hide 
Range on Protein: 470-521
Range on HMM: 12-63/63
Sequence Identity: 23% (12 aa)

DNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKR
... . | | |  |. ||.|| ||    . |.. .   . .|. .   . . 
NHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
FRWNK_Wnk2.hmm Wnk4.AA FRWNK_Wnk2.hmm 686-748 65 9.2e-41 134.66 In-house 1-63 (63) Show / Hide 
Range on Protein: 686-748
Range on HMM: 1-63/63
Sequence Identity: 65% (41 aa)

DRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLL
||.|||||.|||.|||||.||||||.|||||..|| |.|||.|||..|....|.|||..|...
DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
FRWNK_Wnk1 Wnk4.AA FRWNK_Wnk1 703-750 31 4e-06 19.49 In-house 45-92 (92) Show / Hide 
Range on Protein: 703-750
Range on HMM: 45-92/92
Sequence Identity: 31% (15 aa)

FRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLLKR
| |||. | |||.|  || . |.. ..     . ||. .....   .|
FSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
OSR1_C Wnk4.AA OSR1_C 703-716 57 0.093056 10.14 Pfam 25-38 (38) Show / Hide 
Range on Protein: 703-716
Range on HMM: 25-38/38
Sequence Identity: 57% (8 aa)

FRFDLDGDSPEEIA
| ||.  |.|||.|
FEFDIEKDTPEEVA
Wnk.CR4 Wnk4.AA Wnk.CR4 1119-1193 55 4.3e-41 142.85 In-house 1-80 (80) Show / Hide 
Range on Protein: 1119-1193
Range on HMM: 1-80/80
Sequence Identity: 55% (44 aa)

CLSSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAML----SSRQRRLSK-GS
  .|....|..|||..|.|||.||.||..|...||. ||||||.||.|.||.||||||.|.|||    |.|.||.|| .|
SYMSSDNDSEFEDEDMWKELQRLREKHMKEIQELQAQQKKEIEELYTRMGKPPPPGIVSPHAMLTAPMSGRRRRPSKHKS