Gene RAF1 (Human)

RAF1

Species: Human
Alias: Raf-1, c-Raf, RAF1, CRAF
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3p24-p25,

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
RAF1.NA RNA Sugen Kinome 3291 None Fasta, JSON
RAF1.AA Protein Sugen Kinome 648 None Fasta, JSON
RAF1.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of RAF1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD RAF1.AA RBD 56-131 49 7.7e-41 144.34 Pfam 1-77 (77) Show / Hide 
Range on Protein: 56-131
Range on HMM: 1-77/77
Sequence Identity: 49% (38 aa)

NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIG-EELQVDFL
....|.|||.||.||.||.||...|.|||..|..||.|.||.|.|. ..|.|.|..|||.||...| | .||.|..|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
RBD RAF1.AA RBD 56-131 52 7e-38 133.09 SMART 1-76 (76) Show / Hide 
Range on Protein: 56-131
Range on HMM: 1-76/76
Sequence Identity: 52% (40 aa)

NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFL
....|.||..|||||.||.||..||.|||..|.|||.||||.|||. |.|.|.| .|||......| |.||.|...
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
C1_1 RAF1.AA C1_1 139-187 30 7.9e-18 69.1 Pfam 1-55 (55) Show / Hide 
Range on Protein: 139-187
Range on HMM: 1-55/55
Sequence Identity: 30% (17 aa)

HNFARK-TFLKLAFCDICQKFL-----LNGFRCQTCGYKFHEHCSTKVPTMCVDW
|.. .. .| . .||. |..|.     . |..||.|.|..|..|..|||..| ..
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 RAF1.AA C1 139-184 30 6.2e-16 60.17 SMART 1-61 (61) Show / Hide 
Range on Protein: 139-184
Range on HMM: 1-61/61
Sequence Identity: 30% (19 aa)

HNFARKTFLKLAFCDICQKFLLN---------GFRCQTCGYKFHEHCSTKVPT-------MC
|.. ...| | ..|..|.|..           |.||. |.||.|..|..|||        ||
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 RAF1.AA C1_3 150-177 23 0.000492 11.76 Pfam 1-30 (30) Show / Hide 
Range on Protein: 150-177
Range on HMM: 1-30/30
Sequence Identity: 23% (7 aa)

AFCDICQKFLL--NGFRCQTCGYKFHEHCS
 .|..|.. .   ....| .| . .|| | 
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
Kinase RAF1.AA RAF 349-608 69 4.6e-203 664.69 In-house 1-282 (282) Show / Hide 
Range on Protein: 349-608
Range on HMM: 1-282/282
Sequence Identity: 69% (197 aa)

VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQA---FRNEVAVLRKTRHVNILLFMGYMTKDN---LAIVTQWCEGSSLYKHLHVQET--KF
||..||||||||||||.|.||||||||.|.|.||||||.||   |.|||||..||||.|||||||||.|..   .||||||||.||||.|.|||||  ||
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWS--GSQQVEQPTGSVLWMAPEVIR-----------MQDNNPFSF
.|..||||.||..|||||||||||||||.|||||||||..|||||||||.|||.|||  |.||.||||...|||||||||           |||.||.||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYSYGIVLYELMTGELPY-SHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIEL
||||||.|||.|||||...|| .||.||||||||.||||..|||||....|||||.||..||.|. .||||||.|||..|..
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase RAF1.AA RAF 349-606 58 4.3e-186 624.51 In-house 1-275 (275) Show / Hide 
Range on Protein: 349-606
Range on HMM: 1-275/275
Sequence Identity: 58% (162 aa)

VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP-EQFQAFRNEVAVLRKTRHVNILLFMGYMTKD---NLAIVTQWCEGSSLYKHLHVQET-KFQMF
|.. .|||.|.|||||.|.||||||||.|....||| .| |||.|||....||||.||.|||||..|.   ..|||||||.||.||.|.|||.| ||.| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

QLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK-SRWS--GSQQVEQPTGSVLWMAPEVIRMQ---------DNNPFSFQSDV
..|.||.|..|||||||||||||||.||.|||||.|..|.|.||||.||| .||.  ..||..||.|...|||||||||.         |.|||||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
|..|.|.||||.||.||.||....|||.||.|||...|.|| ...|||.||.|...|... .||||.|.||...|
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase RAF1.AA TKL 355-606 28 8.8e-98 331.15 In-house 1-364 (364) Show / Hide 
Range on Protein: 355-606
Range on HMM: 1-364/364
Sequence Identity: 28% (105 aa)

IGSGSFGTVYKGKWHG-----------DVAVKILKVV------------------------DPTPEQFQAFRNEVA-VLRKTRHVNILLFMG--------
||||.||.||||||.|           |||||..|.                         ||....|. |..|.. .....|| ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YMTKD-----NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHA--------KNIIHRDMKSNNIFLHEGLT--------------V
 .. .      .|.||...|.| ||. .||       . |....|...|.||.|||.        ..||||| ||.||...| .|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVKS------------------RWSGSQQVEQPTGSVLWMAPEVIRMQDN-------------NPFSFQSDVYSYGIVLYELMTGELPYSHI
||.||||....|                  . .....   . |.  ||||||.|.|.|              ..| ..||||.||||.|..|...||...
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

NNRDQI------IFMVGRGYAS--PDLSKLYKN---------CPKAMKRLVADCVKKVKEERPLFPQILSSI
.....|      ........ .  | .    .|         ||. ||.|  || .   |.|| | .||. .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RAF1.AA Pkinase 349-606 25 4.8e-84 290.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 349-606
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

VMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRN--EVAVLRKTRHVNILLFMGYM-TKDNLAIVTQWCEGS----SLYKHLH-VQE
  .  .|||||||.|||....|.   |||||.|...  ... |. |.  |...... .| ||. . ... .||.. .|. .|||     .|. ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKF--QMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTV----KIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDV
..|  .. .......|...|..|.|...|||||.|. ||....  ..    ||.||||| ... .  ..    ..|.  .|||||||  .... .  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YSYGIVLYELMTGELPYSHI----NNRDQIIFMVGRGYASPDLSKLYKNC------------------PKAMKRLVADCVKKVKEERPLFPQILSS--I
.|.|..|||...|..|...     | .||.  .. .... .. .  ....                  ....| .. .| .|  ..|| ..||| .  .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RAF1.AA TKL-Unique 351-606 34 2.7e-69 236.51 In-house 1-290 (290) Show / Hide 
Range on Protein: 351-606
Range on HMM: 1-290/290
Sequence Identity: 34% (101 aa)

LSTRIGSGSFGTVYKGKWHGD-VAVKILKV-VDPTPEQFQAFRNEVAVLRKTR-HVNILLFMGYMTK-----DNLAIVTQWCEGSSLYKHLH--------
 .  ||.|..|.||||||.|. ||.|....  |. .|  | |.||| .. | . | ||...||| ..      |. ||.  |.|.|||..||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VQETKFQMFQLIDIARQTAQGMDYLHAKN--IIHRDMKSNNIFLHEG-----LTVKIGDFGLATVKSRWSGSQQV-------EQPTGSVLWMAPEVIRM
  ...|. | | ...|.. ||||.||| ..  |||||.|| |. . ..     . .|| ||||....|. . .          . . || .||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QDNNPFSFQSDVYSYGIVLYELMTGEL------PYSHINNRDQIIFMVGR--GYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
   . .| .|||||.||||.|. |...      ||... ...|.. ||        | ..    .|||  . |  .| .   ..|| | .|....
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase RAF1.AA KSR 349-606 36 1.3e-67 229.59 In-house 1-272 (272) Show / Hide 
Range on Protein: 349-606
Range on HMM: 1-272/272
Sequence Identity: 36% (99 aa)

VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVV--DPTPEQFQAFRNEVAVLRKTRHVNILLFMGY-MTKDNLAIVTQWCEG-SSLYKHLHVQETKFQMFQ
. .  .|| | ||.|..| |||.||.|..     .       .|. ||. ...||| || ||||. |   .||||.  | |  .|| |.||. .|..|  
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK---SRWSGSQQVEQPTGSVLWMAPEVIR--------MQDN-NPFSFQSDVY
 ..||.| .||| ||||| ||| | || |||.     | | ||||  ..       .. .   | |    .||| ||         |.  .||| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

SYGIVLYELMTGELPYSHINNRDQIIFMVGRG-YASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
..| ..||...||.|. .     .||. ...|    ..|. .   | . || .   |    ..||| | .|.. .
AFGTIWYEMICGEWPF-KYQCAESIIWQMCQGEGMRQVLRNV--QCGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase RAF1.AA Dicty4 349-608 33 1.3e-64 214.47 In-house 1-277 (277) Show / Hide 
Range on Protein: 349-608
Range on HMM: 1-277/277
Sequence Identity: 33% (96 aa)

VMLSTRIGSGSFGTVYKGKWHG-DVAVKIL--KVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMT-----KDNLAIVTQWCEGSSLYKHLHV-----
     |||.||||.||||.| | .||||.|  . ..   .  ..||.||. . | || ||.||||. |     .  . |||  .   .||. ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QETKFQMFQLID---IARQTAQGMDYLHAKN--IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ-VEQPTGSVLWMAPEVIRMQDNNPFSFQ
 |..| .    .    .|. .|.|| .||. |  ||||| || |.   . ..||..||||.... . .  ..    . |...|||||| .   ..|.   
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMM---HQPYNEK

SDVYSYGIVLYELMTGELPYS-HINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS--IEL
.||||.||||.|. |.. ||. |. . .|... |..    | ..   ..||.  |.|...|  .  . || |..|..    | 
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIP---DWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase RAF1.AA MLK 349-606 31 3.3e-62 212.98 In-house 1-291 (291) Show / Hide 
Range on Protein: 349-606
Range on HMM: 1-291/291
Sequence Identity: 31% (94 aa)

VMLSTRIGSGSFGTVYKGKWHG-D-----VAVKILK----VVDPTPEQFQAFRNEVAVLRKTRHVN----ILLFMGYMTKD-N-LAIVTQWCEGSSLYKH
  ... ||||||| |.||.|.. |     ||||. .     .  | .. ..|. |.  ||. .| |    |  |.|  ... . ..||...|||.|||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHVQETKFQ-------------MFQLIDIARQTAQGMDYLHAKN---IIHRDMKSNNIFLHE------GLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL
|| ...|               . .....| | |.||.|||..    ||||| || || ..|      ..|.|| |||... ...   .    .. |.. 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
|||||||    ....|  .||.|.|.||.|..|.|.||. ...  .|...|.     | . .    ||. .|.|  .| .   ..|| | ||..  
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase RAF1.AA TK 349-606 17 1.8e-61 204.55 In-house 1-486 (486) Show / Hide 
Range on Protein: 349-606
Range on HMM: 1-486/486
Sequence Identity: 17% (83 aa)

VMLSTRIGSGSFG---TVYKGKWHG----------------------------DVAVKILKVV-DPTPEQFQA--------------FRNEVAVLR--KT
. |   .|.| ||   .||||.|.|                            .||||.||   . ..|.|..              . .| ....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHVNILLFMGYMTKDN-------------LAIVTQWCEGSS----LYKHLHVQETK--------------------------------------------
.| ||. . |. |..              . ||. .... .    | ..|.    |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FQMFQLIDIARQTAQGMDYLHAK------NIIHRDMKSNNIFLHEGLT-----------VKIGDFGLAT
                               . | ||. ...| |.|| |||.|      |..|||    |. ..|...           .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKS----RWSGSQQVEQPTGS----------------------------VLWMAPEVIRMQD------NNPFSFQSDVYSYGIVLYELMT-G-ELPYSHI
..|    |  .| .    ..|                            . |||||... .       .. |. .|||.|.|....|..| | | .|  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN--------RDQIIFMVGRG-----------YASPDLSKLYKNCP-------------KAMKRLVADCVKKVKEERPLFPQILSSI
.|         .... .. ||                . .    ..             ... .|  .| ..  |.|| | |... .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RAF1.AA S_TKc 349-609 24 9.7e-58 199.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 349-609
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

VMLSTRIGSGSFGTVYKGKWHG---DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEG--SSLYKHLHVQETK----
  .   ||.|.||.|||.....    ||.||.|         . .|.|...|.| .| ||  . ...  |.| .|.  |.|   .|..... . ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSF-QSDVYSYGIV
 |   .   ...|......|.| ..||||| |  ||.| |  ..||.|||||..              |.  .|||||.      ....  .|..| |..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

LYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILS------SIELL
|||...|. |..   . .... ..|               .. .| ..  | .|  |.||   ..|       . . .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RAF1.AA STE 350-597 21 1.9e-52 180.55 In-house 1-346 (359) Show / Hide 
Range on Protein: 350-597
Range on HMM: 1-346/359
Sequence Identity: 21% (74 aa)

MLS-TRIGSGSFGTVYKGKWH----GD--------------VAVKILKVVDPTP---------------EQFQAFRNEVAVLRKTR--HVNILLFMGYMT
     .||.|.||||||.. |    ..              .|.|.... . ..               |..| . .|. ...| .  | ||  . |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD--------NLAIVTQWCEGSSLYKHLH-VQETKFQM------------FQLIDIARQTAQG-MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLAT
|.        .| |.  ...| || . .. . ......             |.. |.||. .| ..||| ..||||| |. ||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

--VKSRW------------SGSQQVEQPTGSVLWMAPEVIRMQD---NNPFSFQSDVYSYGIVLYELMTGELPYSHINNRD---QIIFMVGRG-------
  ..|              ...|.    .|.  |||||||. ..   ... ....|..| |... |. ||. |..  ..     .|.|. . .       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---YASPDLSK----------------LYKNCPKAMKRLVADCVKKVKEERP
     .| |                  . ... . .|  .. | .|  ..||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase RAF1.AA Src 349-606 31 4.6e-50 168.26 In-house 1-255 (255) Show / Hide 
Range on Protein: 349-606
Range on HMM: 1-255/255
Sequence Identity: 31% (86 aa)

VMLSTRIGSGSFGTVYKGKWHG--DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLH-VQETK-FQMF
. |  ..|.| || |..|.| |  .|||| ||  .  ||.|.    |  .. | || ...      ...    |||   .  || . |.  .|..  .. 
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFL---QEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLP

QLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKS----RWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLY
||||.| | |.||.|| ..|.||||    |.   |.. .|..||||| .        . ..    |   . |.||| |. .    |.  ||| |.|| |.
QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFP---IKWTAPEAINYGR---FTIKSDVWSFGILLT

ELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKR-LVADCVKKVKEERPLFPQILSSI
|..| |  ||   .|. . . .| |||  |  ..    ||. .   .   |..|  |.|| |  . .  
EIVTYGRVPYPGMTNH-EVLQQVERGYRMPCPHN----CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RAF1.AA TyrKc 349-606 30 2.2e-49 171.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 349-606
Range on HMM: 1-280/280
Sequence Identity: 30% (89 aa)

VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT--RHVNILLFMGYMTK--------DNLAIVTQWCEGSSLYKHLHVQET
. |   .|.| ||.||||.|  .|||| ||         ..|..|  ...|   .| ||. . |. |.        . | ||.  ... .| ..|.  . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRW-----SGSQQVE----QPT--GSVLWMAPEVIRMQDNNPFSF
|..| .|.... | |.||.||| ||.||||    |. ..|..||||.||||.           |..  .     .      . |||||.|   . . |..
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYSYGIVLYELMT-GELPYSH-----INNRDQIIFMVGRGYASPDLSKLYKN-----CPKAMKRLVADCVKKVKEERPLFPQILSSI
.|||.|.|....|..| |. ||.      ..|.. .|  | .||  |     |       ||..| ..  .| .   |.|| | .| . .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RAF1.AA Pkinase_Tyr 349-490 32 2e-46 157.85 Pfam 1-158 (270) Show / Hide 
Range on Protein: 349-490
Range on HMM: 1-158/270
Sequence Identity: 32% (52 aa)

VMLSTRIGSGSFGTVYKGKWH-------GDVAVKILKVVDPTPEQ--FQAFRNEVAVLRKT-RHVNILLFMGYMT--KDN--LAIVTQWCEGSSLYKHLH
. .   .|.|.||.||||.|.        .||||.||  . ..||   ..| .|......  .| ||. ..|  |  ..   . ||.  ... .|...|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VQ---ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA
 .   . .. | .|.....| |.||.||..||.||||    |. ..|...|||.|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase RAF1.AA Pkinase_Tyr 511-606 31 2.1e-17 59.57 Pfam 180-270 (270) Show / Hide 
Range on Protein: 511-606
Range on HMM: 180-270/270
Sequence Identity: 31% (31 aa)

WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELP-YSHINNRDQIIFMV-GRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI
|||||.|.      |. .|||.|.|....|..| || | |  . | . .. ..  .||    . .  .|||. . .|  .| ..  |.|| | .|.. .
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYR---MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL