Gene RET (Human)

RET

Species: Human
Alias: RET51, CDHF12, HSCR1, PTC, Hs.168114, RET, RET-ELE1, MEN2B, Hs.RET, MTC1, MEN2A
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 10q11.1-q11.21,

Classification

Group: TK
Family: Ret

Sequence

Name Sequence Type Origin Length Description Download
RET.NA RNA Sugen Kinome 5634 None Fasta, JSON
RET.AA Protein Sugen Kinome 1114 None Fasta, JSON
RET.kin_dom Protein Kinase Domain Sugen Kinome 284 None Fasta, JSON

Protein domain

Protein domains of RET.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Cadherin RET.AA Cadherin 172-261 27 2e-18 66.9 Pfam 1-102 (102) Show / Hide 
Range on Protein: 172-261
Range on HMM: 1-102/102
Sequence Identity: 27% (28 aa)

PSFRIRENRP-PGTFHQFRLLPVQ-FLCPNISVAYRLLEGE---GLPFRCAPDSLE---VSTRWALDREQR-EKYELVAVCTVHAG---AREEVVMVPFP
..|...|| | . . ....    . .|.|| .. |..|.|.   |  ||. ||. .   ..|.. |||||. ..|.|. ..| |..   .|. ...|   
YHFSVCENAPVGTFVMTVTATDPDDPLGPNWRIFYSILGGNPDPGHWFRIDPDTGDNGIITTTKPLDREQQNGQYHLTVMATDHDDGGPPRSSTTTVTIT

VT
|.
VC
Cadherin RET.AA Cadherin 485-505 29 1.122162 5.05 Pfam 79-102 (102) Show / Hide 
Range on Protein: 485-505
Range on HMM: 79-102/102
Sequence Identity: 29% (7 aa)

VVATDQ-Q--TSRQAQAQLLVTVE
|.|||. .  ..| . ... .||.
VMATDHDDGGPPRSSTTTVTITVC
Kinase RET.AA Ret 724-1007 73 2e-255 854.85 In-house 1-293 (293) Show / Hide 
Range on Protein: 724-1007
Range on HMM: 1-293/293
Sequence Identity: 73% (215 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN-ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDG--PLLLIVEYAKYGSLRGFLRESR
|.|..|||||.||.||||.|||..|..|||||||||||.| |..||..||||||..||||||||||||||||.||.  |..|||||.|||.||.|||.||
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLSR

KVGPGYLGSGGSRNSSSLDHPD-ERALT-----MGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIP
|.||.|..|.|.||.|..|||| .....     |...|||||||..||.||.|||||||||||||.||||||..|||||||.|||||.|||||||..|||
KIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIP

VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK
|||||||||.||.|||.|||||||||.|||||.|.|||||||||||..|||||.||.||.||||||||.|.|||||||||||||..||||.||
VKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase RET.AA Pkinase_Tyr 724-1005 42 7.4e-154 521.7 Pfam 1-270 (270) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-270/270
Sequence Identity: 42% (123 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE--LRDLLSEFNVLKQV-NHPHVIKLYGACS-QDGP--LLLIVEYAKYGSLRGFLR
...||.||||.||.|.|.|..  ..  . ..||||||||.|....  ..|...| ...||  .||....|||.|. |..|  .....||...|.|. .||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKRSQGRIPVK
. |                    .|...||| ||....|||..||.||......||||||||.||.|....||.||||.||.|..| | .||. |..|.|
KHR--------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK

WMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP-YPGIPPERLFNLL-KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
||| |.... ..||.|||||||||.|||.|.|. | |||...|...... . |.||..|.||..|.|.||.|||...|..|| |..|  .|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RET.AA TyrKc 724-1005 38 3.1e-151 509.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-280/280
Sequence Identity: 38% (121 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV--NHPHVIKLYGACSQD-------GPLLLIVEYAKYGSLRG
..|||.||||.||.|.|.|.         ..||||||||.|    ..|...| ......  .||....|||.|.|.       .||....||...|.|. 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE-------DSYVK
.||..|.                        |.| ||.||.|||..||.||......||||||||.||.|.. .||||||||||.|..       | |.|
YLRKHRPK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

RS--QGR--IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG-----IPPERLFNLLKTGHRMERPDN--------CSEEMYRLMLQCWKQ
..  .|.  .|..|||.|.......||.||||||||..||| |.|. ||||     ..........|.|.||..|.|        |..|||..|.|||. 
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

EPDKRPVFADISKDL
.|..|| |..| ...
DPEDRPTFSEIHECF
Kinase RET.AA FGFR 724-1005 49 1.9e-143 482.85 In-house 1-293 (293) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-293/293
Sequence Identity: 49% (145 aa)

LVLGKTLGEGEFGKVVKATAFHLKGR--AGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR
|.|||.|||| ||.|..|.|. ..    .  .||||||||.|..  .| || ||  ..| .  |. .|.| |.|.|.|||  ||||.. | || |||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

KVGPGYLGSGG------SRNSSSL-DHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRI
  |. |  ..        |...   |      ||  ||.|.|.|. .||.|||  | .||||||||.|| ..  |||.||||.||. . | | |.. || 
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP-PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
|.|||| |.||| .||.||||||.||||||| |.|| |||.||  | |. .||.|||||.| |||.|.| .| |||. .|. || |. .  .|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RET.AA TK 724-1005 25 4e-129 435.28 In-house 1-486 (486) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-486/486
Sequence Identity: 25% (125 aa)

LVLGKTLGEGEFG---KVVKATAFHLK--------------------GRAGYTTVAVKMLKENASPSELRDLL-------------SEFNVLKQVN----
..|||.||||.||   .| |.... ..                    .. | |.|||||||| .. |. . ..             .| ...|. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHVIKLYGACSQD------------GPLLLIVEYAKYGS----LRGFLRESRKVGPGYLGSGG---------------------SRNSSSLDHPDER-
 ||....|||.|.|.            .|.....||...|.    || .||..|. .  .. ...                     |..|.| . |.|. 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

-----------ALTMGDLIS-------------------FAWQISQGMQYLAEM------KLVHRDLAARNILVAEGRK-----------MKISDFG---
           .||. ||..                   ..|||..||.||...      ..|||||||||.||.|. .            ||.|||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRDVYEEDSYVKRS------------------------QGRIPVKWMAIESLFDHI---------YTTQSDVWSFGVLLWEIVTLG-GNPYPGI
     |.||.|..| |...|                        .|..|..||| |.|.|..         .||.|||||||||.|||.|.| . .|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PP---------ERLFNLLKTG--------------HRMERPDNCS--------------EEMYRLMLQCWKQEPDKRPVFADISKDL
.          . ....|..|              .||..|..|.              ||.|.||.|||. .|..|| |... . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RET.AA VEGFR 724-1005 42 5.5e-127 428.17 In-house 1-332 (332) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-332/332
Sequence Identity: 42% (142 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACS---QDGPLLLIVEYAKYGSLRGFLRES
| ||| ||.| ||.|..|.|| ... .. ||||||||||.|  || | |.||  .|. . .|  |  . |.|    | |||. |||| ..| |  .||  
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RKV-------------GPGYLG---------------------SGGSRNSSSLD--HPDERA-------LTMGDLISFAWQISQGMQYLAEMKLVHRDLA
|.              .  ..|                     ....|   |.|   ||| .       ||| |||... |.  || .||. | .|||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNILVAEGRKMKISDFGLSRD-VYEEDSYVKRSQ-GRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP-PERLFNLLKTGHRMERP
|||||..|    ||.||||.|.  |  . ||.. . || | ||||.||.||..|||.|||||.||.|||| .||| ||||.   | ..| || | ||..|
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

DNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
| |  |.|. ||.|| .||  || |..  . |
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase RET.AA TK-Unique 724-1005 41 1.5e-121 410.09 In-house 1-294 (294) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-294/294
Sequence Identity: 41% (125 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYT-TVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDG-PLLLIVEYAKYGSLRGFLRESR
|..|...|||.|| | ..... ...  . .  |||||||.||.. . .|.|.|....|..  ||......|.|  .. | ..| ||. .|.|...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

KV--GP---GYLGSGGSRNSSSLDHPDERA----LTMGDLISFAWQISQGMQYLAE--MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR-
..  ..   | |         ...|. ..     ....||..||||| .||.|||.  .| |||||.|||.|..|. . ||.|||..|||| .  |..  
PAMRQHQTYGNLK-------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMC

SQGRIPVKWMAIESLF--DHIY-TTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC-SEEMYRLMLQCWKQEPDKRPVFADISKD
||||||..||| |||   ...| ||.|||||||||.|||.|||. ||||.|.... .... |.||..|..| |.||| || .||. ||..|| |..| . 
SQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHR

L
|
L
Kinase RET.AA UTK 724-1005 35 5.8e-109 368.3 In-house 1-296 (296) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-296/296
Sequence Identity: 35% (111 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELR---DLLSEFN---VLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF
. ||..||.|.|| | ||.. . .....   |||| .. . ... | .   |.. | .   ..||.. ||.|..|.| |.|..|.....||.. |.|| .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRESRK-VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR-------KMKISDFG---LSRDVY----
|| .|. ..                 ... .||. .....||.|. |||||.....|||||||||.||.. |       . ||.|||   .||.|.    
LRRHRPTPP-----------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHF

-----EEDSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTG--HRMERPDNCSEEMYRLMLQCWKQEP
     | . | ...|.|.|..||| |.| .|  .||.||||||||..|||.| |  ||||.  ....  .  |  .||..|. |....||||..||...|
SNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDP

DKRPVFADISKDL
..|| | |. . .
QERPDFEDLVQQM
Kinase RET.AA Tie 732-1005 46 1.8e-103 315.88 In-house 1-267 (267) Show / Hide 
Range on Protein: 732-1005
Range on HMM: 1-267/267
Sequence Identity: 46% (128 aa)

EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG
|| ||.|.||.   .|   .   ||.||.|| ||  . ||   |  |. .|  || .| | ||| . | | . .|||.|| |  |||.|| .      . 
EGNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETD--PAF

GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTT
 . ... .      .|.   .. ||  . .|||||.. ...|||||||||||.|    ||.||||||    .. |||.  ||.||.|||||||   .|||
AREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTT

QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
.|||||.||||||||.||| || |.    |.. |  |.|||.| || .|.| || |||.. | .|| || |  .|
KSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase RET.AA Src 724-1005 36 2.3e-97 329.77 In-house 1-255 (255) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-255/255
Sequence Identity: 36% (104 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVG
. | . ||.| || | ...        | | |||| ||.     .  ..| | ...|.. |.....||  |||. | . . || . |||  .|..     
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

PGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE--EDSYVKRSQGRIPVKWMAIE
                 ...|.| . .||..|.|...||.|| .|...||||||||.|| |.   |. |||| | . .  .| |. |.  ..|.||.| |
----------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPE

SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR-LMLQCWKQEPDKRPVFADISKDL
 .  . .|. |||||||.||.|||| |  ||||   .  .  .. | || .|.|| .|.|  .|||||...|..|| |. . . |
AINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RET.AA Fer 724-1006 30 1.6e-86 293.74 In-house 1-283 (283) Show / Hide 
Range on Protein: 724-1006
Range on HMM: 1-283/283
Sequence Identity: 30% (93 aa)

LVLGKTLGEGEFGKVVKAT-AFHLKGRAGYT----TVAVKMLKENASPSE-LRDLLSEFNVLKQ-VNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFL
 .||| |||| ||.| |.. ....|   . .     |.||..|....  | ..... | .....  .||.|.|.|| |... |.... |... |||. .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE-GRKMK--ISDFGLSRD--VYEEDSYVKRSQG
... .                       .... ..| .. |...||.|| ... .|||.||||.|. . . | |  |||||.||.  .|..|.. |  . 
KKNKNK----------------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKAC

RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG----IPPERL-----FNLLKTGHRMERPDNCSEEMYRLML-QCWKQEPDKRPVFADI
..|..|.| |.. . ||.. .|||||||..||| | |  ||||    . .  .      .  | |..|  |... .|....|. |||...|..|| ...|
KVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEI

SKDLE
 . |.
CQKLK
Kinase RET.AA PDGFR 842-1005 51 2.4e-83 267.37 In-house 194-358 (358) Show / Hide 
Range on Protein: 842-1005
Range on HMM: 194-358/358
Sequence Identity: 51% (85 aa)

DERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL
|...||  ||..|. |. .|| .||    |||||||||.|...|.  || |||| ||. .  .|| .   | |||||| ||.|| .|||||||||.|.||
DSNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILL

WEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
||| .||||||||.| .  | .. | | ||..|.  .||.|  | .||  .| ||| |  ... |
WEIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase RET.AA S_TKc 724-1009 22 2.4e-47 164.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 724-1009
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKY--GSLRGFLRESRK
  .....|.| |||| |..  .         ||.|..|        .....| ..||. .||...|||...   . | .. ||.    |.|. .... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE
 |..                  . ..  .  ....|| ....|. ... .||||   |||. |    ||.||||.| .         .       .|| |
HGLR------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPE

SLFDHIYTT-QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK-----DLEKMM
 |    |..  .|.||.|..|.| .. |  |.|   ....|....           |.|.  .. .|.. .|.|||   .. .      .   .
VL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RET.AA Pkinase 724-1005 20 1.3e-42 151.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 724-1005
Range on HMM: 1-293/293
Sequence Identity: 20% (66 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELRDLLS--EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYG----SLRGFL
...|...|.| ||.|     .. . .    .|||| . |......... ..   |  ..| .|||....||...  .. . .. ||.  |    .|  ..
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RESRKVGPGYLGSGGSRNSSSLDHPDERAL--TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRK---MKISDFGLSRDVYEEDSYVKRSQ
.                        .....  .. .......|| .|..|. .|. .||||   |||.  .|      ||.||||.. .. . ...  . 
ST----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTT

GRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-------PPERLFNLLKTGHRMERPDNCS-------------------EEMYRL
      .|| | .  .  |.. .|.||.|..|.| .. |  |.||        . ..... ...  . ..|  ||                   ||.  .
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF

MLQCWKQEPDKRPVFADISKD--L
.  |... | ||| ...| ..  .
IKWCLCKDPKKRPTAEQILQHPWF
Kinase RET.AA PDGFR 724-820 44 8.3e-29 89.31 In-house 1-98 (358) Show / Hide 
Range on Protein: 724-820
Range on HMM: 1-98/358
Sequence Identity: 44% (44 aa)

LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR
|..||||| | ||||| |||. |       .|||||||. |  ||   | ||  .. .  .|  .. | |||   || ..| ||  || |  .|.  |
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR