Gene RHOK (Human)

RHOK

Species: Human
Alias: RHOK, Hs.158325, GPRK1, GRK1, RK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 13q34,

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
RHOK.NA RNA Sugen Kinome 2102 None Fasta, JSON
RHOK.AA Protein Sugen Kinome 563 None Fasta, JSON
RHOK.kin_dom Protein Kinase Domain Sugen Kinome 266 None Fasta, JSON

Protein domain

Protein domains of RHOK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS RHOK.AA RGS 57-175 22 8.4e-27 96.28 SMART 1-121 (121) Show / Hide 
Range on Protein: 57-175
Range on HMM: 1-121/121
Sequence Identity: 22% (27 aa)

EFESVCLEQPIGKKLFQQFLQSAEKH-LPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKL-FCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATL
 |...| ..|||. .|..||..   .  . || | ..|.. .....  .|||. |  .|..|.|   .| ..|.  ... ...  ... ..|.. .... 
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMEDEERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCNPHPDCFDEAQRHVY

AHLGQAPFQEYLGSLYFLRFL
 .. . .....| | |..|.|
QLMEKDSYPRFLRSDYYKRYL
RGS RHOK.AA RGS 57-174 24 4.9e-26 87.89 Pfam 1-124 (124) Show / Hide 
Range on Protein: 57-174
Range on HMM: 1-124/124
Sequence Identity: 24% (30 aa)

EFESVCLEQPIGKKLFQQFLQS-AEKHLPALELWKDIEDYDTA---DNDLQPQK-AQTILAQYLDPQAKLFCSFLDEGIVAKFKEGPVE--IQDGLFQPL
 |...| .||||..||.|||.|    . ...| |...||....   ...  .|| |. |  .|..|... .|...|  .... ...  .      .|.. 
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

LQATLAHLGQAPFQEYLGSLYFLRF
 . .. .. . .....| | |..||
QRHIYTLMEKDSYPRFLKSDYYQRF
Kinase RHOK.AA GRK 190-455 63 1e-212 713.0 In-house 1-265 (265) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-265/265
Sequence Identity: 63% (170 aa)

FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGF
|...|||||||||||.|||..||||.||||||.|||.|||||.|.|..||.||.||||||.||||||.|||..||||||||||||...||||..| ||||
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGE-NPGF

PEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAAR
.|.||.||.|.|.|||||||..||||||.||||.|||..|..||||||||||. .|| ...|..||.|.||||....|.|.||.|...||...||||..|
DEERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQ-MIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGR

GPFRARGEKVENKELKHRIISEPVKYP-DKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLF
.|||.|.|||...|...|....|.||. .|||...||.|..||.||||.|||.|.|.||..|.||.|
SPFRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase RHOK.AA GRK 190-455 62 5.1e-212 675.04 In-house 1-272 (272) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-272/272
Sequence Identity: 62% (170 aa)

FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSR---FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEEN
|...|||||||||||.|||..||||.||||.|.|||.|||||...|..||.||.|||||   |||..|||.||| .||||||||||||..|||||... |
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGN-N

-PGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEE-YDFSVDYFALGVTLYE
 |||.|.|..||.|.|.|||||.|.||||||||||||.|||..|.|||||||||.|. .||....|..||.|.||||.||.|. ||||.|...||...||
EPGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYE

MIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETC--DKLRAHPLF
||....|||...|||...|...|....|||||||||...||.||.||.||||.|||.|..||  .....||.|
MIEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase RHOK.AA AGC 190-455 26 2.1e-145 378.74 In-house 1-395 (395) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-395/395
Sequence Identity: 26% (107 aa)

FLDFRVLGKGGFGEVSACQMK------ATGKLYACKKLNKKR---LKKRKGYQGAMVE------------KKILMKVH----------SRFIVS-LAYAF
|   .|.|||.||.|  ...|      .|||.||.|.|.||.   .||..  . .|.|            ..||.|..          . |||. | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKAD--LCLVMTIMN--------GGDIRYHIYNVNE-ENPGFPEPRALFYTAQ-------IICGLEHLHQ-RRIVYRD-LKPENVLLDNDGNVRISDLG
..|    |..||  |.        ||.  ..... .   .  |.|.|| ||.|.       |...||.||. . |..|| |||||.|||.||.....| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAVELLDGQ--------------------------------------------------SKTKGYAG--TPGFMAPELLQGEEYDFSVDYFA--LGVTLY
|. |. ...                                                   .|.   |  || .|||| |    |....|. .  ||. .|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIAARGPFRARG------------EKVENKELKHRIISEPVKYP----------DKFSQASKDFCEALLEKDPEKRLGFRDET-----CDKLRAHPLF
||.. . ||..              |. .. .  ...|...||.|          ..||.  ||... ||.|||||||| ....      . ...|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RHOK.AA S_TKc 190-455 32 2.4e-86 294.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-231/231
Sequence Identity: 32% (90 aa)

FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNG--GDIRYHIYNVNEENP
.   |..|||.||.|  |. | ||...|.|...          . .. | .||.| |  .|| | ..|..  .|..||  ..|  || . .| . . . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

G--FPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDF-SVDYFALGVTLYE
.  ||| .| ||..||.|.||..|...|..|||||||.|||.  .. |.| ||| .|       . . ||| .||||.|    |.. ..|  ..|..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETC--DKLRAHPLF
|.. . ||.      . ... ..|           |.  ||| . .|.||||||..  .      . ..|| |
MLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RHOK.AA SGK 190-455 36 2.1e-82 254.22 In-house 1-283 (283) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-283/283
Sequence Identity: 36% (106 aa)

FLDFRVLGKGGFGEVSACQMKAT------------------GKLYACKKLNKKRLK-------KRKGYQGAMVEK-KILMKVHSRFIVSLAYAFETKADL
|    |.|||.||.|   . |..                  .|.|| | |.|.          |.|     | |. .|| .. . |||.| ||| ||  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPEL
 .||  .|||.  ||.   .     |||.|| ||.|.|.| ||.||   |.||||||||.||| .|.... | ||. |    . .|.  .|||  .||| 
YFVMDYVNGGEMFYHLQREKH----FPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEV

LQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLF
|.....| .|| . ||  ||||.    ||    .    ...   ||..| . |  .| . .|  . ||.|||.|||| ..   .  . || |
LRKQPHDRTVDWWCLGCVLYEMMYGLPPF----YSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFME-IKNHPFF
Kinase RHOK.AA Akt 190-455 39 4.5e-82 262.15 In-house 1-264 (264) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-264/264
Sequence Identity: 39% (107 aa)

FLDFRVLGKGGFGEVSACQMKATGKLY-ACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPG
|   .||||| || |  .. |.|.|.| | | | |... ...  . .. |..|| .. . |||.| |.| |.  |..||  .|||.. ||..      . 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQ----RKRR

FPEPRALFYTAQIICGLEHLHQRRIVYRD-LKPENVLLDNDGNVRISDLGLAVEL-LDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFA-LGVTLYEM
|.|.|| || |.||...||||.. |.||| |||||.|.|.||.... | ||. |  .  . |||   |||  .||| |.|  .. .||  . ||. .|||
FSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEM

IAARGPFRARGEKVENKELKHRIISEPVKYP--DKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLF
.  | || ..     .... . | ..|||.|  |..|.. ||. . ||.|||.||||   .. . ...|| |
MCGRPPFYNQ----DHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RHOK.AA RSK 193-455 35 5.7e-76 258.71 In-house 1-278 (278) Show / Hide 
Range on Protein: 193-455
Range on HMM: 1-278/278
Sequence Identity: 35% (99 aa)

FRVLGKGGFGEVSACQMK---ATGKLYACKKLNKKRLKKR-KGYQGAMVEKKILMKVH-SRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENP
 .|||.||.|.|. |. .   .||..|| | |.|. ...| |    .| | .||. .  . |||.| |||.|.  | |.|  ..||.  .|..  .|.  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQ--KEKHF

G-FPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDN---DGNVRISDLGLAVE-LLDGQSKTKGYAGTPGFMAPELLQ----GEEYDFSVDYFAL
| | | .| || |.|.. .|||||. |..|||||||.|.|.   .| ....| |.. .  .|  ..|. . .|  .||||.|     .. .| ..|.. |
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVTLYEMIAARGPFRARGEKVENKELKHRIISEP--VKYP--DKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLF
|| .||| . . ||.. ...   ||.  || .    .. |  .. ||. ||.  ..|..||.||||   .  . ...|| |
GVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RHOK.AA Pkinase 190-455 29 1.3e-75 262.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAM-VEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGG----DIRYHIYNVNE
.   |..|.|.||.|  |. | |||..|.|...|.. |. | .. .   | .|. .... .|| | ..||.| ....||  ..||    |   .|    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

ENPGF--PEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNV----RISDLGLAVEL-LDGQSKTKGYAGTPGFMAPELLQ-GEEYDFSVDYF
.. .|  .|  . ||  ||..|||..|...|..|||||||.|.||.|..    .|.| |||  . .  .| .....|||..||||... |..|. .|| .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGVTLYEMIAARGPFRAR------GEKVENKELKHRIISEPVKYPDKFS-----------------QASKDFCEALLEKDPEKRLGFRDETCDKLRAHP
..|..||||.  | ||. .       ...  .. ........  ...  |                 .. |||.. .|.|||.||..     .. .  ||
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHP

LF
 |
WF
Kinase RHOK.AA BARK 190-455 44 2.3e-74 253.35 In-house 1-264 (264) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-264/264
Sequence Identity: 44% (121 aa)

FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSR----FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEE
|   |..|.||||||  |    |||.|| | | |||.| ..|   |. |. .|  |       ||| ..|||.|   || .. .|||||. ||.      
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV-

NPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYA--GTPGFMAPELLQ-GEEYDFSVDYFALGVTL
   | |    || | || ||||.|.| .||||||| |.|||  | ||||||||| .     || |  |  || |.|||| || |  || | |.|.||  |
---FSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDF----SKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCML

YEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLF
| ..    |||    | . .|. .  .   |. ||.||.  .|  | ||..| .|||| . .  . .. || |
YKLLRGHSPFRQHKTK-DKHEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase RHOK.AA PKC 190-455 38 3.5e-74 239.81 In-house 1-262 (262) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-262/262
Sequence Identity: 38% (103 aa)

FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSR-FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPG
|   .||||| || |     | | ..|| | | |    .      .|.||..|       | ..|   | |.  |  ||   ||||  .|| ..      
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRR----

FPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAA
|.|..| || | |||.|  ||.. |.||||| .||||| .| ..| | |.. | . . ..|.   ||| ..||| ||..|| .|||. |.|| .||| | 
FKEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAG

RGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDET---CDKLRAHPLF
. || .  |     || . |  . . ||  .|. ... |.....|.|||||| . ..    .  |.||.|
QSPFHGEDE----DELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase RHOK.AA Delta 190-455 39 3.3e-72 246.22 In-house 1-259 (259) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-259/259
Sequence Identity: 39% (105 aa)

FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKIL-MKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPG
|   .||||| || |    .| . | || | | |  . .    .  |||...| . ... |.  |  .| ||  |  ||  .||||. ||| ...     
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHR----

FPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAA
| | || ||.. |||||. ||.. |.||||| .||||| || ..| | |.. | . |..|.. . ||| ..|||...|. | .|||... || .|||.  
FDEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIG

RGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLF
  ||  ..|     || . |. .   ||   .. .||  ..|.|.||||||| ..    ..|.|..|
QSPFHGEDE----DELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase RHOK.AA AktR 190-455 36 4.2e-72 245.85 In-house 1-268 (268) Show / Hide 
Range on Protein: 190-455
Range on HMM: 1-268/268
Sequence Identity: 36% (100 aa)

FLDFRVLGKGGFGEVSACQMK-ATGKLYACKKLNKKRLKKRKGYQGAMVEKKILM-KVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENP
|   ..||||.||.|  .| |  ..|.|| | . || ...|. .. .  |..|.  ..   ||| | |.|.||  | ..| .. ||.. .|. . .    
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK---

GFPEPRALFYTAQIICGLEHLHQR-RIVYRDLKPENVLLDNDGNVRISDLGLAV-ELLD-GQSKTKGYAGTPGFMAPELLQG-EEYDFSVDYFALGVTLY
 | | .|.|| |||. .||.|||.  |.|||||||| ||| ||.|.|.| ||.  .  .    |..   |||  |||| ..  . ...|||. |.|. .|
-FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIY

EMIAARGPFRARGEKVENKELKHRIISEP---VKYPDKFSQASKDFCE-ALLEKDPEKRLGFRDETCDKLRAHPLF
||..   || .      .... ..|....   ..|| .||.. ||...  || |.|.||||  ... . .. || |
EMVTGCPPFYHK----NQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RHOK.AA TyrKc 190-449 20 1.6e-14 11.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 190-449
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

FLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKV--HSRFIVSLAYAFETK-------ADLCLVMTIMNGGDIRYHIY
    ..|| | ||||  ...|      | |.|..         .  | | .|..|.  |   || |  .  ..         |..||  | .|| . .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDG-------QSKTKGY-AGTPG-----FMAPELLQGE
.  ..   .. .  | .  || || |.||..... |||   |.|..... |.||| ||. .. |.       . ..|    |. .      |||| ..  
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

EYDFSVDYFALGVTLYEMIAARGPFRARGEK--VENKELKHRIISEPVKYPDKFSQ--------ASKDFCEALLEK----DPEKRLGFRDETCDKL
.. .  | .. ||...|.    ..     ..  ..|.|. ... .   .....           ....  . . ..    |||.|  |..  ....
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG--YRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-HECF
Kinase RHOK.AA S_TK_X 456-535 20 8.6e-12 46.42 SMART 1-79 (79) Show / Hide 
Range on Protein: 456-535
Range on HMM: 1-79/79
Sequence Identity: 20% (18 aa)

KDLNWRQLEA--GMLMPPFIPDSKTVYAKDIQDVGAFS--TVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETG----IFGELNVWR
....|..|..  ... |||.|. |.||| . .|.. |     ....         . . .. ... ||.| .||.     |.... ..
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase RHOK.AA Pkinase_Tyr 297-386 29 4.9e-05 17.67 Pfam 116-208 (270) Show / Hide 
Range on Protein: 297-386
Range on HMM: 116-208/270
Sequence Identity: 29% (27 aa)

YTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVEL-LDGQS-KTKGYAGTPGF-MAPELLQGEEYDFSVDYFALGVTLYEMI
. .|| .|.|.|...... |||   |.|..... |.|.| |||  .  |..  ...| .  | . |||| ..  ..    |  . ||...|..
MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF