Gene ROS (Human)

ROS

Species: Human
Alias: MCF3, ROS, ROS1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6q22.1,

Classification

Group: TK
Family: Sev

Sequence

Name Sequence Type Origin Length Description Download
ROS.NA RNA Sugen Kinome 7395 None Fasta, JSON
ROS.AA Protein Sugen Kinome 2356 None Fasta, JSON
ROS.kin_dom Protein Kinase Domain Sugen Kinome 271 None Fasta, JSON

Protein domain

Protein domains of ROS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FN3 ROS.AA FN3 108-186 19 2e-06 28.82 SMART 1-69 (69) Show / Hide 
Range on Protein: 108-186
Range on HMM: 1-69/69
Sequence Identity: 19% (18 aa)

ADLPTA---PFASSIGSH------NMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPF----TEYIFRVVWIFT--AQLQ
 . |.    . .....|.       .||.||         |....                  |.|. |.|     ||| |||. .    |   
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 204-281 20 9.9e-11 42.9 SMART 1-69 (69) Show / Hide 
Range on Protein: 204-281
Range on HMM: 1-69/69
Sequence Identity: 20% (19 aa)

ETAPLI---RNIESSSPD------TVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPN----TIYRFSIAAVNE--VGEG
  .|       ... ...      .|..||.||      |.||                   . .    |.    | |.|...|||.  .|||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 567-667 15 1e-05 26.33 SMART 1-69 (69) Show / Hide 
Range on Protein: 567-667
Range on HMM: 1-69/69
Sequence Identity: 15% (18 aa)

PGRPQE---LSVL-FGSH------QALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSA----M
|| |.    |.|   .|.      .. ..||||             |..                                       |. |.       
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------------IVGYR-----------------------------------YTVTGLKPGQYPWT

KYKVSVRASSP--KRPG
.|...||| .   . .|
EYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 957-1036 17 0.001609 18.94 SMART 1-69 (69) Show / Hide 
Range on Protein: 957-1036
Range on HMM: 1-69/69
Sequence Identity: 17% (16 aa)

PDSVQES-SFRIE-GNAS------SFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPY----ALFNLSVTPY--TYWGKG
|.... . ..|..  ...      |... |. ||     .| |.                   .||.||.|.       . .|. .  .  | |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK-PP-----IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 1053-1146 13 0.063296 7.69 SMART 1-69 (69) Show / Hide 
Range on Protein: 1053-1146
Range on HMM: 1-69/69
Sequence Identity: 13% (14 aa)

PENPRIFILPSGKCCNKNEV----VVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPR----CFIAFQVRAFTS--
|  |.  . .. .  ....      |. .|..|          .. |                          . ..| .|         |.|||...  
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGND

KGPG
.|.|
AGEG
FN3 ROS.AA FN3 1478-1548 11 0.034736 9.95 SMART 1-69 (69) Show / Hide 
Range on Protein: 1478-1548
Range on HMM: 1-69/69
Sequence Identity: 11% (10 aa)

PLAKTN---LTWYGITSPTP----TYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPF----STYMIQIAVKNY--YSDP
| . .|   |..  .|| .     .  .   .             |....   . ...|.|     ..| ......|   .   
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------------IVGYR---YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 1567-1651 15 0.006858 16.06 SMART 1-69 (69) Show / Hide 
Range on Protein: 1567-1651
Range on HMM: 1-69/69
Sequence Identity: 15% (16 aa)

PEAVQL---INTTVRSDT------SLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGG----NIYVLKVLAC----HS
| ...    .  |  ..|      |. .|| .          |.|.                           || |. |      |. .| |     . 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAG

EE
| 
EG
FN3 ROS.AA FN3 1668-1747 17 6.5e-07 30.22 SMART 1-69 (69) Show / Hide 
Range on Protein: 1668-1747
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

PEKPYS---LVPENT---------SLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPY----TSYNVRVVVVYK--TGEN
|  |     |. ...         |..  ||.|     ....                         . .|.|.|.    | |..||..|..   || 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 ROS.AA FN3 1762-1848 14 0.057833 8.03 SMART 1-69 (69) Show / Hide 
Range on Protein: 1762-1848
Range on HMM: 1-69/69
Sequence Identity: 14% (15 aa)

PNKPGI---PKLLEGSKN------SIQ--WEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKG------IFQFRVVAANN
|  |.    ... . ...      |..  |..       |..|.                                . ..||         .|||.| | 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-------------------------------YTVTGLKPGQYPWTEYEFRVRAVNG

--LGFG
   | |
NDAGEG
Kinase ROS.AA Sev 1954-2224 76 3.5e-251 840.74 In-house 1-277 (277) Show / Hide 
Range on Protein: 1954-2224
Range on HMM: 1-277/277
Sequence Identity: 76% (211 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMA
|.||..||||||||||||.|.||.|||..|..||.|||.||||||||.||||||||||||.||||..|.||||.|||||||.|.|||||||.|||.|||.
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

TFYGPL----LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS--PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIF
||..|.    |||.|||..|.||||||.|||.|||.|||||.|||||||||||.  .|.||||||||||||||||||||.||||||||||||||||||.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL
|||||||.||||.|||.||||||||||||..|||.||.||||..||.||||||..|.|||.|.|.|||.||..|..|
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase ROS.AA Pkinase_Tyr 1954-2224 50 3.3e-151 512.72 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1954-2224
Range on HMM: 1-270/270
Sequence Identity: 50% (141 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE--KIEFLKEAHLMSKF-NHPNILKQLGVCL-LNEP--QYIILELMEGGDLLTYL
.|.   ||.|||||||.||. .    ....|.||||.|| |.....  . .|..|| .|... .||||.. .|||.   ||   ||..|.|..||||.||
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYY-RKRGEGLLPVRWMAPESLMDGI
|| |     .. ||. ||.. |..|.||. |||....||||||||||||.     ....|||.|||||||||. ||| ||||.| ||..|||||....|.
RKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-----ENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

FTTQSDVWSFGILIWEILTLGHQP-YPAHSNLDVLNYV-QTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL
|||.|||||||.|.|||.|.| || ||  || .|..|. . |.|...|.||||.. .||.|||...|..||||  |. ||
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ROS.AA TyrKc 1954-2224 43 1.6e-147 497.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 1954-2224
Range on HMM: 1-280/280
Sequence Identity: 43% (132 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF--NHPNILKQLGVCLLN-------EPQYIILELMEGGDLL
.||   ||.|||||||.||.          |.||||.||...    . .|..|| .|.|.  .||||.. .|||.         || .|..|.|..|||.
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

TYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKN-------DYYRK----RGEGLLP
 |||| |        |.. ||.. |..|..|. ||.....||||||||||||. .      .|||.||||.||||         |||||     | ..||
DYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

VRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPA-----HSNLDVLNYVQTGGRLEPPRN--------CPDDLWNLMTQCWAQEPDQRPTFHRI
.||||||....|.|||.|||||||...|||.|.| ||||       || .|..||..|.|...| |        |||.. ..|.|||. .|..||||  |
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

QDQL
 ...
HECF
Kinase ROS.AA ALK 1954-2226 48 1.2e-127 430.38 In-house 1-273 (273) Show / Hide 
Range on Protein: 1954-2226
Range on HMM: 1-273/273
Sequence Identity: 48% (134 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMA
.||   || |||||||.|    . |  | ...||.|||.     |.   |..||  |.||||.|. . .|.|.   | .|.||.|||||.. .||  |  
ITLVRALGHGAFGEVYMGQYSHMPG-DSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPH

TF--YGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI-YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQ
       .||  ||  .| |. .|| |||  |||||| |||||| . |   . |..||.||| |||| |. ||||| |  ..|| || || .||||||. 
PESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKG--PGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSK

SDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
.||||||.| |||. ||  ||| ..| .|.  | .|||..||||||   ...|||||  .|  ||.|  |  ..| 
TDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase ROS.AA TK 1954-2224 26 5.6e-126 424.59 In-house 1-486 (486) Show / Hide 
Range on Protein: 1954-2224
Range on HMM: 1-486/486
Sequence Identity: 26% (130 aa)

LTLRLLLGSGAFG---EVYEGTAVDILGVGSGE-------------------IKVAVKTLKKG-STDQE-KIE-----------FLKEAHLMSKFN----
.||   ||.|.||   |||.|.. .. . .. .                   ..||||.||.| ...|| ...           ||.||. |....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNILKQLGVCLLN------------EPQYIILELMEGGD----LLTYLRKARMATFYGPL--------------------------------------
 ||||.. .|||. .            || .|..|.|..||    |..|||| |  ..  .                                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTLVDLVDLCVDISKGCVYLERM------HFIHRDLAARNCLVSVKDY------TSPRIVKIGDFG---
                               ||. .|.  |..|..|. ||...      .|.|||||||||||. ..        .....||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDIYKNDYYRKRG------------------------EGLLPVRWMAPESLMDGI---------FTTQSDVWSFGILIWEILTLGHQPYPA-H
     ||||||..|.|....                         | ||.||||||.|.|..         |||.|||||||.|.|||.|.| .||.  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------LDVLNYVQTGGRL--------------EPPRNCPD-------------DLWNL-MTQCWAQEPDQRPTFHRIQDQL
||          .|..|...||||              ..| .|||             ... . |.|||. .|..||||  ...||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ROS.AA InsR 1954-2226 45 7.50000000001e-118 397.45 In-house 1-278 (278) Show / Hide 
Range on Protein: 1954-2226
Range on HMM: 1-278/278
Sequence Identity: 45% (128 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEI--KVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKAR
..|   .| |.|| ||||.| .|.  . ...  ..|.||.. . .. |.||||.||  | .||. .. . ||||   .| |.. |.|. ||| .|||  |
IVLIRECGQGSFGMVYEGIAKGIV-PDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

MATF--YGPLL------TLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLM
       ...       .| ...    .|  |  ||.   |.|||||.|||.|. .|.|    |||||||..||||  ||||| | |.||||||||||| 
PEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVN-HDFT----VKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLK

DGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYV-QTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
||.|||.|||||||...||. ||| |||   ||  ||.|.   |. |.|| |||. .  || .||.  |  ||||  | . |. 
DGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase ROS.AA UTK 1954-2224 38 5e-113 381.81 In-house 1-296 (296) Show / Hide 
Range on Protein: 1954-2224
Range on HMM: 1-296/296
Sequence Identity: 38% (114 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIE----FLKEAH---LMSKFN-HPNILKQLGVCLLNEPQYIILELMEGGDLLT
. |. .||.||||||........ . . .| .||||........| . |    |..||    .|..|. |||.|. .|||.  || .|..|.||.|||..
VQLGRQLGQGAFGEVHKARFTQCSEHM-YEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

YLRKARMATF-YGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVK--DYTSPRIVKIGDFG---LARDIY---------KNDYYRKRGEG
|||..| ...  . .||| .... ..||. |  ||....|.|||||||||||     . .  ...||.|||   ..|...           .||.... .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

LLPVRWMAPESLMDG-IFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGG--RLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL
 .|.||||||.| ..  |||.|||||||.. |||.| | .||| .|| .|.  |  ||  |...|. ||.....||..||...|. ||.|... .|.
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ROS.AA TK-Unique 1954-2224 38 5.5e-102 345.13 In-house 1-294 (294) Show / Hide 
Range on Protein: 1954-2224
Range on HMM: 1-294/294
Sequence Identity: 38% (114 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN-HPNILKQLGVCLLN-EPQYIILELMEGGDLLTYLRKAR
|..  ..|.||||.|. |... | .. .  ..||||.||...||..| .||||. .|..   ||||.. ||.|  . ||..||.| ...|.|..|||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

MATFYG----------------PL---LTLVDLVDLCVDISKGCVYLER--MHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYK-NDYYRKRGE
.|.. .                |.   ... ||.  ...| .|  ||..  ....||||.|||.|..        ..||.|||.|||.|. ..| .....
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQ

GLLPVRWMAPESLM--DGIF-TTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNC-PDDLWNLMTQCWAQEPDQRPTFHRIQDQL
| .|.||||||||   .|.. ||.|||||||.|.|||.||| .|||  .. |... .. | |.. | .| .... ||| .||  ||..||.|  | ..|
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ROS.AA Src 1954-2224 44 3.7e-97 329.08 In-house 1-255 (255) Show / Hide 
Range on Protein: 1954-2224
Range on HMM: 1-255/255
Sequence Identity: 44% (121 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMA
..|   ||.| ||||..|.         |..||||||||.|. ..|   ||.|| .| |. |..... . ||   || ||. |.|. | ||.||.|    
IKLCRKLGQGQFGEVWMGYW-------NGNTKVAVKTLKPGTMSPE--AFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

TFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYK--NDYYRKRGEGLLPVRWMAPESLMDGIFTTQS
.  |  | | .|.|.   ...|  |||.| .||||||||| ||. .      ..|..|||||| . |   | |  | .  .|..|.||| .  | ||. |
DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN-----VCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWN-LMTQCWAQEPDQRPTFHRIQDQL
||||||||..|| | |  |||  .| .||  |. | |.  |.|||| | . .|.||| ..|.||||| ..|. |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ROS.AA Fer 1954-2225 34 4.5e-95 322.15 In-house 1-283 (283) Show / Hide 
Range on Protein: 1954-2225
Range on HMM: 1-283/283
Sequence Identity: 34% (100 aa)

LTLRLLLGSGAFGEVYEG--TAVDILGVGSGE--IKVAVKTL-KKGSTDQEKIEFLKEAHLMSK-FNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYL
 ||   ||.||||||| |  |   ..|...    ..|.||..   ..|. ...||..|| .| . ..|||. |  ||| . .| .|..|.. ||.|..||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSV-KDYTSPRIVKIGDFGLARD--IYKNDYYRKRGEGLLPVRWMAPESLMD
.|         .... .... | ....|  ||. .. ||||.||||||..  |..      || |||..|.   |..||. |  .  .|.||.|||.. .
KKNKNK-----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKK---CKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQT

GIFTTQSDVWSFGILIWEILTLGHQPYPA------HSNLD---VLNYVQTGGRLEPPRNCPDDLWNLMT-QCWAQEPDQRPTFHRIQDQLQ
||... .||||||...||| | | .|||.        |..   . .... | .. .| ..|... ..|. |||...|..|||.  |. .| 
GIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase ROS.AA Met 1955-2218 36 8.7e-95 311.21 In-house 1-271 (271) Show / Hide 
Range on Protein: 1955-2218
Range on HMM: 1-271/271
Sequence Identity: 36% (105 aa)

TLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLK-KGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEP--QYIILELMEGGDLLTYLRKA
 .   .| | || || |.  |  |    |...|.|.|.    || ..|. ||.|. .|. |.|||.|. .|.||  |    ...|. |..|||.|. |  
HFDDVIGQGHFGCVYHGMYHDNDGN---EHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNP

RMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI-YKNDYYRKRGEGL---LPVRWMAPESLM---
  .      ..  ||.. | .. ||  |.   .|.|||||.|||. . .     ..||..||||.||. |   ||  . .     |||.|||||.|    
QNN------PCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEH-----FTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGV

-----DGI-FTTQSDVWSFGILIWEILTLGHQPYPAHSN-LDVLNYVQTG--GRLEPPRNCPDDLW-NLMTQCWAQEPDQRPTFH
     . . |||.|||||||...|| .| |  |||  .|  |.. . ..|   ||  |  ||| |   .| .||  .| .||.| 
CLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase ROS.AA FGFR 2058-2224 49 4.7e-72 244.86 In-house 131-293 (293) Show / Hide 
Range on Protein: 2058-2224
Range on HMM: 131-293/293
Sequence Identity: 49% (83 aa)

PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFG
| ||  ||| .   . .|  ||.    ||||||||| ||.  ||    . || |||||||| ..|||||...| ||. |||||.| | ..|.||||||.|
PNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVT-DDY----VMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYG

ILIWEILTLGHQPYPAHS-NLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL
.|.|||.|.| ||||      .   | ..| |.|.| ||. ..  .| |||  .|.|||||  . ..|
VLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase ROS.AA S_TKc 1954-2227 23 9.9e-47 162.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 1954-2227
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEG--GDLLTYLRKAR
 ..  ..|.||||.|| .. ..         .||.| .|        . ...|  ...| .|||| | ..|.   .  |...|...|  |||..|..| .
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

MATFYGPL---LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFT
       |   ..  .   ..  | ..  |. ....|||||   | |..         .||.|||||| .                 .|||| |    ..
RHG----LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYG

T-QSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQD------QLQLF
.  .|.||.|....| |. |  |.|     ..    .  |        ........ .|.  .|..|||   .        . . |
KCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ROS.AA Pkinase 1954-2226 22 1.2e-37 134.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1954-2226
Range on HMM: 1-293/293
Sequence Identity: 22% (71 aa)

LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEK-IEFLK--EAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGG----DLLTY
...   .|||.||.||... ..         .||||..|| ... .| .. ..  |...| ..|||||.. ....  .   |...|..|||    || .|
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRKARMATFYGPL-LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPV----RWMAPES
..       .|.. ..  .. . .  | .|  |. .| .|||||   |.|.. .... . .|||.|||||. ..       ... .  .    ..|||| 
IST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEV

LM-DGIFTTQSDVWSFGILIWEILTLGHQPYPAH----SNLDVLNYVQTGGRLEPPRNCP-----------------------DDLWNLMTQCWAQEPDQ
.. .   .. .|.||.|....| |. |. |.| |    . .| .  ..  .. ......|                       ...  ... |... | .
IRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RPTFHRIQDQLQL
|||.. |     .
RPTAEQILQHPWF
Kinase ROS.AA FGFR 1954-2051 38 1.8e-16 52.59 In-house 1-100 (293) Show / Hide 
Range on Protein: 1954-2051
Range on HMM: 1-100/293
Sequence Identity: 38% (39 aa)

LTLRLLLGSGAFGEVYEGTAVDILGV-GSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF--NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKA
|||   || |.||.|  ..|. |       ||.|||| ||.. ||.. .    |   | |    |.||.. ||.|  . | |.| |. . | |  .||. 
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMM-KMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRAR

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