Gene RSK1 (Human)

RSK1

Species: Human
Alias: RSK3 (original kinome, RPS6KA2, S6K-alpha2, RSK, HU-2, S6K-alpha, Hs.RPS6KA2, MAPKAPK1C, Hs.90859, p90-RSK3, pp90RSK3, RSK1, now swapped with RSK1), RSK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6q27, Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb,

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
RSK1.NA RNA Sugen Kinome 3112 None Fasta, JSON
RSK1.AA Protein Sugen Kinome 744 None Fasta, JSON
RSK1.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON
RSK1.kin_dom2 Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of RSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK1.AA AGC 71-330 34 1.6e-188 492.84 In-house 1-395 (395) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-395/395
Sequence Identity: 34% (137 aa)

FELLKVLGQGSFGKVFLVRKVTRP---DSGHLYAMKVLKKAT---LKVR-DRVRTKME------------RDILADVN----------HPFVVK-LHYAF
||.|||.|.||||||.||||....   |.|..||||||||..   .| . .  .|. |            |.||. .|          |||.|| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLILDFLR---------GG-DLFTRLS---KEVMFTEEDVKFYLAE-------LALGLDHLHS-LGIIYRD-LKPENILLDEEGHIKLTDFG
|.. .  ||......          || .||..|    ||  |.|| ..||.||       ..|.|..||| .|||.|| ||||||||||.|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEAIDHE--------------------------------------------------KKAYSFCG--TVEYMAPEVVNRQGHSHSADWWS--YGVLMF
|.|| .. .                                                  .....|||  | ||||||..    .....||||  .|.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGSLPFQGK----------DRKETMTLIL------KAKLGMP----------QFLSTEAQSLLRALFKRNPANRLGSGPD-----GAEEIKRHVFY
|||||  ||.|.          ...|.. .|.      . |. .|          ...| ||..|.. |....|..|||.|..     ||||||.| . 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK1.AA RSK 71-330 53 1.4e-186 626.14 In-house 1-271 (271) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-271/271
Sequence Identity: 53% (146 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
.||....|||||.||....|....|....||||..||||..|.|||....||.||....|||.|||||.||.|||.|.|.||.||||||.||.|..||.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE----GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLT
..||||.||.|| ...|||.||..|||||||||.|.|    ||||..|||..|...|.......||.|..||||||..||||....||||.||||.||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GSLPFQGKDRKETMTLILKAKLGM-------PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY
| .|||.|.|...|..|...||||       ..|.| ||..|||....|.|.||||.||.|.|.||.| ..
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK1.AA RSK 74-330 55 2.5e-170 572.16 In-house 1-278 (278) Show / Hide 
Range on Protein: 74-330
Range on HMM: 1-278/278
Sequence Identity: 55% (154 aa)

LKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDR-VRTKM-ERDILADVN-HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM---
|||||||..|||||.||.|. |.|..|||||||||....|.. .|..| ||.||.... |||.|.||||||||||||||....|||.|||.|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKE-AIDHEKKAYSFCGTVEYMAPEVVN----RQGHSHSADWWSYGV
|.|....||.||..| ..|||..|||.|||||||||.|.   ||||||||||..|.  .||......||.|.||||||...    . ||....|||| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLTGSLPFQG---KDRKETMTLILKAK--LGMP--QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY
||.||||| .||||   ..|||.|. |.|.|  |.||  |.||.||..|.|....|.|..|||.||..|||||.| . 
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK1.AA Akt 71-330 48 2.2e-144 464.48 In-house 1-264 (264) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-264/264
Sequence Identity: 48% (130 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLY-AMKVLKKATLKVRDRVR-TKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|..|||||.|||||||||.|    |.. .| |||||||  .  .. |. || || ||  .||||.|.|||.|||. |||...|.  ||.||. |...  |
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALGLDHLHSLGIIYRD-LKPENILLDEEGHIKLTDFGLSKEA-IDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWS-YGVLMFEML
.|.  .|| ||. |...|||| .||||| |||||||.|..|||.||||||.||  | .  |...|||| ||.|||. | .||. ..|||.  |..|.||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGSLPFQGKDRKETMTLILKAKLGMP--QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY
.| .||  .|... . .|. ... .|   ..| |...|.. | ...| .|||.||..|.||||| ..
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK1.AA p70 71-330 47 1.9e-139 469.54 In-house 1-299 (299) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-299/299
Sequence Identity: 47% (142 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKA--TLKVRDRVRTK-------------------------MERDILADVNHPFVVKLHYAFQTE
||||||||.| .||||.|||||  |.| .||||||.||  .   .|   |.                          || ||  |.|||...|||||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK----------AYSFCG
|||||||..| || ||. | .. .. |. ..|||.|  . | |||..|||||||||||..|.. ||..||||||.|| |   ..           ..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAK--LGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY
| ||||||.. | ||.|  |||| |.||. ||||. || |  ||.|.  |||.|  | .|  |. |.  |...| ||.|. |.|.||. |..|..| |.
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK1.AA AktR 71-330 45 1e-121 410.69 In-house 1-268 (268) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-268/268
Sequence Identity: 45% (124 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK-ATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|...|.||.| ||||.||.|  | |.. .||||..||    . . . .| .||.|..  .|||| |||||.|||. ||..|... .||.||. |.|.  |
FHVYKCLGKGAFGKVYLVQKK-R-DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

TEEDVKFYLAELALGLDHLHSL-GIIYRDLKPENILLDEEGHIKLTDFGLSK-EAID-HEKKAYSFCGTVEYMAPEVVNR-QGHSHSADWWSYGVLMFEM
.||...|| |.  |.|..||.   |||||||||||||||.||.|.||||||| . ..  . ||||||||.||||||.... .||  |.|||. |.. .||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LTGSLPFQGKDRKETMTLILKAK-LGMPQF--LSTEAQSLLR-ALFKRNPANRLGSGPDGAEEIKRHVFY
.||  ||. |....   .|..   .  |.   .| ....|.   |...|| .|||..  |.||||.| . 
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK1.AA MSK 74-325 40 2.7e-108 366.08 In-house 1-277 (277) Show / Hide 
Range on Protein: 74-325
Range on HMM: 1-277/277
Sequence Identity: 40% (112 aa)

LKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK--MERDILADV-NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
|||||.|. ||.|..||... |.| |||||.|.|||.  . ..      || .| .. .||..|.||||||.. ..||......|| |||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE---GHIKLTDFGLSKEAIDH-EKKAYSFCGTVEYMAPEVVN----RQG-HSHSADWWSYGVLM
. . ....|| . .||.|..|||.|||||||||.|.|   ||.||.|||....     |....|.|.| .|||||...     .| .. . |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FEMLTGSLPFQ--GKDRK-------ETMTLILKAKLGMP----QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIK
..||||  |||  ..||.       | |  |.|..   |    |  |..|. |.. |  ..|. ||| .. .|.|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK1.AA S_TKc 71-330 34 2.1e-106 360.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRG--GDLFTRLSKEVM-
.|.|...|.|.||||...|..    .|...|.|..|          ... |..||   .||..|||...||. ..||...... |  ||||... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSH-SADWWSYGVLM
     |.| ...||.......|...||.|||.||||||||||||  |||..||||...        ..|||| .||||||.   |... ..|||| |...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGA--EEIKRHVFY
.|||.|  ||.      .| ...|  .      | || ...| .....|..|..     .  ..|| | . 
YEMLCGYPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK1.AA Pkinase 71-328 30 1.1e-95 329.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 71-328
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM--ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGG----DLFTRLS-
.......|.||||.|   .| .. ..|...|.|..|| . |   ...     |  |.. .|||..|.|...|......|.......||    |||...| 
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVMF--TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHI----KLTDFGLSKEA-IDHEKKAYSFCGTVEYMAPEVVN-RQGHSHSADW
 ..  |  .|...|||. ... ||...|| |||.|||||||||.|..|||    |..||||.| . . .   ...|||| .||||||.. .|......|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSYGVLMFEMLTGSLPFQGK------DRKETMTLILKAKLGMPQFLS---------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRH
||.|....|||.| .||.|.      | .. . .|....|  . . .                      |...... .....|. |..     ||.|. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

--V
  .
PWF
Kinase RSK1.AA Ciliate-E2 71-330 23 9.9e-87 294.44 In-house 1-365 (365) Show / Hide 
Range on Protein: 71-330
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)

FELLKVLGQGSFGKVFLVRKVTRP--------------------DSGHLYAMKVLKKATLKVRDRVRTKM-----------ERDILADVNHPFVVKLHYA
....|..|||.||.|.....   .                    . . .||||..||  ..   ..   |           |. ||  .|||...|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLILDFLRGGDLFTRLS------------------KEVM-FTEEDVK-------FYLAELALGLDHLHSLG-IIYRDLKPENILLDEEGHI
||  .. ..||..... ||||| ..                   ||.  .... ..       ||.|.. |.| .||| . ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLSKEAIDHEK-------------------------------KAYSFCGTVEYMAPEVVNRQG---------HSHSADWWSYGVLMFEMLTGSLP
|..||||||.. | ..                                ....||| .|||||..|...         .....|.|| ||...|||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGKDRKETMTLILKAKLGMPQF------------------LSTEAQSLLRA----LFKRNPANRLGSGPDGAEEIKRHVFY
|        .  |.. |.  |..                  .| |.. |..     .....| .|..    |.|.|. | . 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase RSK1.AA CAMK 76-330 21 9.3e-84 269.65 In-house 1-425 (425) Show / Hide 
Range on Protein: 76-330
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

VLGQGSFGKVFLVRKV-TR---------PDSGHLYAMKVLKKATLK--------------------------VRDRVRTKMERDILAD-------VNHPF
.||.||||||.|..   |           . |. .|.|...|  ||                           .|| . . | .|.         ..|| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VVKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DLFTRLSKE---------------VMFTEEDVKFYLAELALGLDHLHSL
..||. ...            |  |        .|...   ..  ||    ||| .. .                  |||.....|   .. .....||.
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIIYRDLKPENILLDEE-----------------GHIKLTDFGLSKEAIDHE-----------------------KKAYSFCGTVEYMA-PEVVNR----
.|. |||||||||||.                  . ||..|||.... .. |                       .| . |||| |||| |||.|.    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------QGHSHSADWWSYGVLMFEMLTGSLPFQGK-------------DRKETMTLILKAKLG-MPQFLST-----------------------EA
          .... ..| || ||... ||.| .||.|.             . .|..  |.|.|    | ..|.                       |.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QSLLRALFKRNPANRLGSGPDGAEEIKRHVFY
..|.| . ...| .|.      .|....| ..
KDLIRKMLQVDPEKRM-----TIEQCLNHPWM
Kinase RSK1.AA CAMK1 71-314 29 1.2e-64 186.86 In-house 1-265 (276) Show / Hide 
Range on Protein: 71-314
Range on HMM: 1-265/276
Sequence Identity: 29% (79 aa)

FELLKVLGQGSFGKVFLVRKVTR-PDSGHLYAMKVLK-KATLKVRDR---VRTKMERDILADV---NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRL
.|. |..| |.|..|.|. .       |. ||.|... |  .|  |.    . ..| .|.  |   .||...|..  .... ..||... . ||.|| | 
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

SKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL---DEEGHIK--LTDFGLSKEAIDHEK-KAYSFCGTVEYMAPEVVNR---QGHSHSAD
 .   .||.|      ...  . ..||.||  |||||||.|.   ||.  ||  . ||||||  .||.  . .  ||| .|.||||...   .... . |
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSK-IFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

WWSYGVLMFEMLTGSLPFQGKD-RKETMTLILKAKLGMPQF----LSTE-AQSLLRALFKRNPANRL
 || ||  . .|.|  ||....  .| . .|.|.....| .     | . |  ... . . .| .|.
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRY
Kinase RSK1.AA S_TK_X 331-392 39 4.2e-25 90.63 SMART 1-79 (79) Show / Hide 
Range on Protein: 331-392
Range on HMM: 1-79/79
Sequence Identity: 39% (31 aa)

STIDWNKLYR--REIKPPFKPAVA----QPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQL-----------FRGFSFVA
. |||.|||.  .||.||||| .      | || .||.|||. ||...|  ||. ....            ||||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase RSK1.AA Pkinase_Tyr 71-292 27 1.6e-21 73.49 Pfam 1-237 (270) Show / Hide 
Range on Protein: 71-292
Range on HMM: 1-237/270
Sequence Identity: 27% (67 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLY-AMKVLKKATLKVRD--RVRTKMERDILADV-NHPFVVKLHYAFQ-TEGK--LYLILDFLRGGDLFTRLS
 ...|.||.|.||.|.. .    ||....  | |.| | .   ..  |     |  |.    .|| .|.|. .    ..   .|... .  .||| . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY-SFCG----TVEYMAPEVVNRQGHSHSADW
|    .  .| .|   . .. | |...|.| ..| |||   |.|..|....| .||||..    ...  |    |     .  ||||. |    ..  | 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGVLMFEMLT-GSLP-FQGKDRKETMTLILKAKLGMPQ
||.||||.|..| |  | ..| .  | . .| .    ||.
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase RSK1.AA TyrKc 71-328 23 1.1e-17 63.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-328
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV--NHPFVVKLHYAFQTE-------GKLYLILDFLRGGDLFTR
 .|.|.|| | ||.|.. .           | |.||. .     |     |  |.  .  .|| .|.|. .  ..       . |.... .  .|||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVM-FTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH-----EKKAYSF----CGT----VEYMAPEVVNRQG
| |    .. .|   .    | | ..||| ..| |||   |.|..|....| .|||||..  |.     .|. |.     .|     .  ||||. |   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HSHSADWWSYGVLMFEMLT-GSLPFQG-----KDRKETMTLILKAKLGMPQFL---------STEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV
 ..  | ||.||.|.|..| |  |  |     .. .| . .. . .  ..            ..|  .. .   ...|..|        .||..  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEIHECF
Kinase RSK1.AA Pkinase_C 350-394 40 1.4e-13 51.07 Pfam 1-46 (46) Show / Hide 
Range on Protein: 350-394
Range on HMM: 1-46/46
Sequence Identity: 40% (19 aa)

AVAQPDDTFYFDTEFTSRTPKDSP--GIPPSAGAHQLFRGFSFVATG
 |  |.|| .||.|||. .|.|.|  .   |.|.. .||||..|.  
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase RSK1.AA RSK 427-684 56 6.6e-190 637.19 In-house 1-271 (271) Show / Hide 
Range on Protein: 427-684
Range on HMM: 1-271/271
Sequence Identity: 56% (153 aa)

YVVKETIGVGSYS---ECKRCVHKATNMEYAVKVIDKSKRDPS-----EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSE
| ..| ||.||.|    ||.|.||.||..||.|.|.|..||..     ||..|.||||.||.|..|..|..|...||.....||||.|.|..|.||.|||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

REASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLA
||..|....| ...|||||||.|||||||.||||.||||||....|||||||||||.|||.|||.|||||..|||||||||.|. ||.||.|.|.|.||.
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTA-----KQVLQHPWV
|.|||.|.| |||..|. ||..|.|....|||...|..||||...|||.|||.||.|     .|..||||.
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK1.AA RSK 429-684 43 9.20000000001e-158 530.41 In-house 1-278 (278) Show / Hide 
Range on Protein: 429-684
Range on HMM: 1-278/278
Sequence Identity: 43% (123 aa)

VKET--IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS--------EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKF---
.|.   .|.|... |..|.|..|...||.||..|.|....        .|..||.|..|||.|.||..........||..|..|||||.......|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQGYDEGCDIWSLG
|||.||.|.. .| ..||.||.||..||||||.|||| ||| |.. ....||||.||.|.. |...||.|||....|||.||    . |.|. ||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

ILLYTMLAGYTPFANGPSD-TPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLT-----AKQVLQHPWV
.|.|.||.|..||.. | | ...||..||..|||.|...||...|..||||..||||.|||.||.     |....|||| 
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK1.AA CAMK1 427-684 38 1.4e-117 343.39 In-house 1-276 (276) Show / Hide 
Range on Protein: 427-684
Range on HMM: 1-276/276
Sequence Identity: 38% (107 aa)

YVVKETIGVGSYSECKRCVHKAT---NMEYAVKVIDKSKRDPSE-----------EIEILLRYG--QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKI
|.....|| |. || ..|.|| |   . .||.|.||| |.  ..           ||||. . .  .||||| ....|.. .|.|||.||. ||||.|.|
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK-KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

LRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLR-ICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR---QGYDEGCDI
.  ....|..|. . . | . |||.||.|.||||||| |.||.|.. . .  | |.||| .|..  ...|. |.| |  .||||||..   ..||  ||.
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSLGILLYTMLAGYTPFANGPSDT-PEEILTRIGSGKFTLSGGNWNTVSET-AKDLVSKMLHVDPHQRLTAKQVLQHPWV
|| |. .|..| || ||    ...  .|..  | .....     |. .|.  |||....|| ||| .|.|..|.|.|||.
WSIGVITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase RSK1.AA Pkinase 427-684 35 9.40000000001e-114 389.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 427-684
Range on HMM: 1-293/293
Sequence Identity: 35% (104 aa)

YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGG----ELLDKIL--R
|.....|| ||......|.|| |. ..|||.|.|.......        ||.|..|  .||||..|.|.. |..|.|.|.|...||    .| | |   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QKFF--SEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL-RAENGLLMTPCYTANFVAPEVLK-RQGYDEGCDIWS
.. |  ||.|. |..  | . .||.||.|..||||||.|||....  ...|..|||||.|||.    |. ..|.| | ...||||.. .|.|.  .|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILLYTMLAGYTPFANG----PSDTPEEILTRIGSGKFTLSGGNWNTVS-----------------ETAKDLVSKMLHVDPHQRLTAKQVLQHPWV
.|..|| || |..|| .     . ... ... ||.....  .  .|...|                 |..||.....|..||..|.||.|.|||||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RSK1.AA AGC 427-684 23 1.1e-108 281.62 In-house 1-395 (395) Show / Hide 
Range on Protein: 427-684
Range on HMM: 1-395/395
Sequence Identity: 23% (94 aa)

YVVKETIGVGSYSECKRCVHK------ATNMEYAVKVIDKSK---------RDPS-------------EEIEILLRYGQ---------HPNIIT-LKDVY
. .. .|| ||....  . .|      .|.  ||.||..|..          .               || .|| .. .         ||.|.  |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDGKH--VYLVTELMR---------GG-ELLDKIL---RQKFFSEREASFVLH---TIGKT-----VEYLHS-QGVVHRD-LKPSNILYVDESGNPECLR
 | .|  .|.| |.|          || ||.  .    ... |.| .| | .     |        .||||| .|..||| ||| |||  ..      ..
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKI-CGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIK

ICDFGFAKQLRAE-----------------------------------------------------NGLLMTPCYTANFVAPEVLKRQGYDEGCDIWS--
..|||..|... .                                                     .  .  || |....|||.|    |.  ||.||  
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFG

LGILLYTMLAGYTPFANGPSD-------TPEEILTRIGSGKFTLSGGNWNT------------VSETAKDLVSKMLHVDPHQRLT----------AKQVL
||.|.| ||.||.|| . . .       .|.|.  .| .|..... .                .|. ||||..|.|..|| .||.          |... 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

QHPWV
.||| 
NHPWF
Kinase RSK1.AA S_TKc 427-684 36 2.6e-106 360.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 427-684
Range on HMM: 1-231/231
Sequence Identity: 36% (100 aa)

YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRG--GELLDKILRQKF------FSE
| . ..|| |.......|.|| |. ..|.|.|.   ..   ||.|| .  .||||..|.||..| .|.|.|.|.. |  |.|.| | ...       |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

REASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDE-GCDIWSLGILLYTML
 .| |... | . .||.||.|..||||||.|||  .      .. |||||.|.||       .| | | ...|||||   ||.   ||.||.|..|| ||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

AGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQ-------HPWV
.||.||      ...... .||              |. |||...|.|..|| .|.|| ..||       |||.
CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK1.AA CAMK 432-684 25 1.8e-105 340.88 In-house 1-425 (425) Show / Hide 
Range on Protein: 432-684
Range on HMM: 1-425/425
Sequence Identity: 25% (108 aa)

TIGVGSYSECKRCVHKATN------------MEYAVKVIDKS--------------------------------KRDPSEEIEILLRYG------QHPNI
|.| ||... |.|.|| |.             ..|.|.|||.                                ..    ||||. .        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLKDVYDDGKH-------------------VYLVT---ELMRGGEL----LDKILRQKF---------------FSEREASFVLHTIGKTVEYLHSQGV
| | .||.|...                   .|.|.   |.. ||||    .|.| ...                |.||||... . |   |.|.||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYVDESGNPE-------------CLRICDFGFAKQLRA-----------------------ENGLLMTPCYTANFVA-PEVLKR------
||||||| |||..| ... .              . |.|||||....                        |. .. |.| |  ..| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDEGCDIWSLGILLYTMLAGYTPFANGPSD----------TPEEILTRIGSGKFTLSGGN------------WNTVSET--------AKD
        ..|.. ||.||.|..||.|| || ||     .          ...|.. .| .||..                 |. .|.         .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVSKMLHVDPHQRLTAKQVLQHPWV
|..||| ||| .|.|..|.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase RSK1.AA MSK 429-684 36 6.6e-90 304.11 In-house 3-277 (277) Show / Hide 
Range on Protein: 429-684
Range on HMM: 3-277/277
Sequence Identity: 36% (100 aa)

VKETIGVGSYSECKRCVHKATNMEYAVKVID-----KSKRDPSE---EIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSERE
|. |.| |... |..|||. |. .||.|..       ... ...   |. .|..  ||||| .|.... |  | ||| |. .||||. .| . . |.| |
VLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESE

ASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQG-YDEGCDIWSLGILLY
.....  .   |...|. |..|||||| |||. ||. | . ... |||||. . .. .  . .||.|  . |||.|.     .| ||| ||.||||..||
CRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGH-VKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILY

TMLAGYTPFA-NGPSDT-----PEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWV
||| |  ||. |...         ||  ||  |.| . |  |...|. ||||....| .||  ||..   ..| | 
TMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK1.AA Ciliate-E2 427-684 23 6.5e-80 271.79 In-house 1-365 (365) Show / Hide 
Range on Protein: 427-684
Range on HMM: 1-365/365
Sequence Identity: 23% (92 aa)

YVVKETIGVGSYS-----ECKRCVH------------------KATNMEYAVKVIDKS--KRDPSEEIEI--------------LLRYGQHPNIITLKDV
| . . || |...     . ..  .                  |.....||.|.. |.  .   .|. ..              .|.  .||||| ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YD--DGKHVYLVTELMRGGELLD--KILRQKF---------FSEREASFVLHTIGK---------------TVEYLHSQG-VVHRDLKPSNILYVDESGN
.   | ...|||.|.  ||.|.|  |. ..|.         |.|.|....   | .                .|||||.. ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PECLRICDFGFAKQLRAENG-------------------------------LLMTPCYTANFVAPEVLKRQG---------YDEGCDIWSLGILLYTMLA
   . |.|||..|..  .|                                .  | |.|....|||.|....         ||. |||||||..|| || 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GYTPFANGPSDTPEEILTRIGSGKFTLSGG--------------NWNTVSETAKDLVSK----MLHVDPHQRLT-AKQVLQHPWV
|..||           .  |  .|. ..                .|. .|. .||| .|    || .|| .|.| ..|.|.||| 
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase RSK1.AA p70 477-684 29 4.3e-34 119.6 In-house 86-299 (299) Show / Hide 
Range on Protein: 477-684
Range on HMM: 86-299/299
Sequence Identity: 29% (67 aa)

QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE
.||.|. |   . ..   ||. | . ||||     |.  . |  |.| |  |    |.||..|.. ||||| |..  .. |    .   |||  |.   .
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCM-LNQQG---HVVLTDFGLCKESIHD

NGL----------LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGK--FTLSGGNWNTVSETAKDLVSKM
             . | | |  . |||.| | |..  .| ||||.|.| || |  ||     ... ..   |  ||   .|        .. ..||. |.
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFT---GENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKL

LHVDPHQRLT-----AKQVLQHPWV
|  .| ||..     |... .||. 
LKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK1.AA Akt 495-623 36 4.4e-28 86.79 In-house 76-203 (264) Show / Hide 
Range on Protein: 495-623
Range on HMM: 76-203/264
Sequence Identity: 36% (48 aa)

YLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRD-LKPSNILYVDESGNPECLRICDFGFAKQL-RAENGLLMTPCYTANFVAP
|.|.. . ||||   . |...||| .| |    |    |.|||.... || ||| ||| .|. |.   ....||| .|.    ..   .| | |.   ||
YFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENIL-MDKDGH---ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAP

EVLKRQGYDEGCDIWS-LGILLYTMLAGYTPF
|.|. .|..  .|.|. ||...| |. |  ||
EILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase RSK1.AA AktR 477-623 33 2.2e-25 90.67 In-house 59-205 (268) Show / Hide 
Range on Protein: 477-623
Range on HMM: 59-205/268
Sequence Identity: 33% (51 aa)

QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAK--QL
.|| |. |..   . .. ... | ..||||.. . ..|.||| .| |    |   .||||..  .. ||||| |||  || |.   ..| ||| .|    
NHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENIL-LDEDGH---VKITDFGLSKLQFM

RAENGLLMTPCYTANFVAPEVLKR-QGYDEGCDIWSLGILLYTMLAGYTPF
.... .  . | |   .|||.... .|..  .|.|..||..| |..|..||
MHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPF
Kinase RSK1.AA TyrKc 427-682 19 2.6e-15 24.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 427-682
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE---EIEILLRYG-QHPNIITLKDVYDDG-------KHVYLVTELMRGGELLDKILRQK-
 . ....| | . |  ... |   .. |||.. ...    .   |..|. ..| .||||. |  |  ..       . ...|.|.| .| |.| . . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAE-----NGLLMTPCY--TANFV------APEVLKRQGYD
 .. ..     . | .  |||||....||||   |.|. ..     . .|.||| .. .  .     ..   ..     ....      |||...   . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EGCDIWSLGILLYTMLA-GYTPFAN---GPSDTPEEILTRIGSGKFTLSGGN------WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHP
.  |.|| |.... ..  | .|  .       ...|.. .. .|.      |          .|  . . ..  | ||..| | ... .  
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase RSK1.AA Pkinase_Tyr 427-508 27 5.5e-09 31.05 Pfam 1-96 (270) Show / Hide 
Range on Protein: 427-508
Range on HMM: 1-96/270
Sequence Identity: 27% (27 aa)

YVVKETIGVGSYSECKRCVHK----ATNMEYAVKVIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYD-DGKH--VYLVTELMRGGELLD
 .  ...| |.. | .... |     |... |||.. | . ....        |..|.  .|.||||. |  |   .|..  .|.|.|.| .| |||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase RSK1.AA Akt 651-684 35 1.2e-08 23.66 In-house 226-264 (264) Show / Hide 
Range on Protein: 651-684
Range on HMM: 226-264/264
Sequence Identity: 35% (14 aa)

NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWV
...|  .|||.|..|. ||..||     .|... .||| 
DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK1.AA Pkinase_Tyr 533-614 29 3.6e-08 28.29 Pfam 125-205 (270) Show / Hide 
Range on Protein: 533-614
Range on HMM: 125-205/270
Sequence Identity: 29% (26 aa)

EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL-------RAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLY
|||.|.. .||||   |.|  .    . . .||||| |. .       |.  |  .    .    |||...   . .  |.|| |.|..
EYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTKSDVWSFGVLMW
Kinase RSK1.AA AktR 653-684 31 6.1e-07 23.19 In-house 231-268 (268) Show / Hide 
Range on Protein: 653-684
Range on HMM: 231-268/268
Sequence Identity: 31% (12 aa)

VSETAKDLVS-KMLHVDPHQRLT-----AKQVLQHPWV
.|...|||.  | |  .| .||.     ....  ||| 
FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK1.AA AktR 427-462 27 0.015551 6.1 In-house 1-37 (268) Show / Hide 
Range on Protein: 427-462
Range on HMM: 1-37/268
Sequence Identity: 27% (10 aa)

YVVKETIGVGSYSECKRCVHK-ATNMEYAVKVIDKSK
..| . .| | ...   . .|  ..  || |.|.|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKK