Gene RSK3 (Human)

RSK3

Species: Human
Alias: RPS6KA1, RSK1 (original kinome, RSK, MAPKAPK1A, HU-1, now swapped with RSK3), p90rsk, S6K-alpha 1, RSK1, RSK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p35.3-p36.1, Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb,

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
RSK3.NA RNA Sugen Kinome 2291 None Fasta, JSON
RSK3.AA Protein Sugen Kinome 758 None Fasta, JSON
RSK3.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON
RSK3.kin_dom2 Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of RSK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK3.AA AGC 84-343 34 7.50000000001e-192 501.61 In-house 1-395 (395) Show / Hide 
Range on Protein: 84-343
Range on HMM: 1-395/395
Sequence Identity: 34% (139 aa)

FELLKVLGQGSYGKVFLVRKVKGS---DAGQLYAMKVLKKAT---LKVR-DRVRSKME------------RDILAEVN----------HPFIVK-LHYAF
||.|||.|.||.|||.||||..|    | |..||||||||..   .| . .  . . |            |.||...|          |||||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLILDFLR---------GG-DLFTRLS---KEVMFTEEDVKFYLAE-------LALALDHLHS-LGIIYRD-LKPENILLDEEGHIKITDFG
|.. .  ||......          || .||..|    ||  |.|| ..||.||       ..|||..||| .|||.|| ||||||||||.||||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEAIDHD--------------------------------------------------KRAYSFCG--TIEYMAPEVVNRRGHTQSADWWS--FGVLMF
|.|| .. .                                                  .|...|||  | ||||||..    .....||||  .|.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGSLPFQGK----------DRKETMALIL------KAKLGMP----------QFLSGEAQSLLRALFKRNPCNRLGAGID-----GVEEIKRHPFF
|||||  ||.|.          ...|.. .|.      . |. .|          ...| ||..|.. |....| .|||.| .     |.||||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK3.AA RSK 84-343 56 2.8e-189 635.08 In-house 1-271 (271) Show / Hide 
Range on Protein: 84-343
Range on HMM: 1-271/271
Sequence Identity: 56% (153 aa)

FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
.||....||||..||....|....|..|.||||..||||..|.|||....||.||....|||||||||.||.|||.|.|.||.||||||.||.|..||.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEE----GHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT
..||||.||.|||...|||.||..|||||||||.|.|    |||||.|||..|...|... ...||.|..||||||..|.||.|..|||||||||.||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GSLPFQGKDRKETMALILKAKLGM-------PQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
| .|||.|.|...|..|...||||       ..|.| ||..|||....|.|.|||||| .|||.||.||.|
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK3.AA RSK 87-343 56 8.8e-174 583.63 In-house 1-278 (278) Show / Hide 
Range on Protein: 87-343
Range on HMM: 1-278/278
Sequence Identity: 56% (157 aa)

LKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDR-VRSKM-ERDILAEVN-HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM---
|||||||.||||||.||. ..|.||.|||||||||....|.. .| .| ||.||.... |||||.||||||||||||||....|||.|||.|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE---EGHIKITDFGLSKE-AIDHDKRAYSFCGTIEYMAPEVVN----RRGHTQSADWWSFGV
|.|....||.||..||..|||..|||.|||||||||.|.   |||||.||||..|.  .|| .....||.||||||||...    ..||....||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLTGSLPFQG---KDRKETMALILKAK--LGMP--QFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
||.||||| .||||   ..|||.|. |.|.|  |.||  |.|| ||..|.|....|.| .|||.| ...||||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK3.AA Akt 84-343 48 3.6e-147 473.55 In-house 1-264 (264) Show / Hide 
Range on Protein: 84-343
Range on HMM: 1-264/264
Sequence Identity: 48% (129 aa)

FELLKVLGQGSYGKVFLVRKVKGSDAGQLY-AMKVLKKATLKVRDRVRS-KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|..|||||.||.||||||.|    | ...| |||||||  .  .. |.  | || ||  .||||||.|||.|||. |||...|.  ||.||. |...  |
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALALDHLHSLGIIYRD-LKPENILLDEEGHIKITDFGLSKEA-IDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWS-FGVLMFEML
.|.  .|| ||. ||..|||| .||||| |||||||.|..|||..|||||.||  | .. ....|||| ||.|||. |  |||...|||. .|..|.||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGSLPFQGKDRKETMALILKAKLGMP--QFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
.| .||  .|... . .|. ... .|   ..| |...|.. | ...| .|||.|.....||||||.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK3.AA p70 84-343 48 4.1e-143 481.75 In-house 1-299 (299) Show / Hide 
Range on Protein: 84-343
Range on HMM: 1-299/299
Sequence Identity: 48% (145 aa)

FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKA--TLKVRDRVRSK-------------------------MERDILAEVNHPFIVKLHYAFQTE
||||||||.| |||||.||||.|.|.|..||||||.||  .   .|    .                          || || ||.||||..|||||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR----------AYSFCG
|||||||..| || ||. | .. .. |. ..|||.|  .|| |||..|||||||||||..|.. ||.. |||||.|| |  ..            ..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAK--LGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
||||||||.. | || .  |||| |.||. ||||. || |  ||.|.  |||.|  | .|  |. |.  |...| ||.|  |.||| . ...|..||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK3.AA MSK 87-338 41 3.5e-110 372.37 In-house 1-277 (277) Show / Hide 
Range on Protein: 87-338
Range on HMM: 1-277/277
Sequence Identity: 41% (114 aa)

LKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSK--MERDILAEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
|||||.|.|||.|..||. ..|.|.|||||.|.|||.  . .. .    || .|  . .||.||.||||||.. ..||......|| |||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEE---GHIKITDFGLSKEAIDH-DKRAYSFCGTIEYMAPEVVNR-----RGHTQSADWWSFGVLM
. . ....|| .|.||.|..|||.|||||||||.|.|   ||.|..|||....      .|..|.|.|..|||||...|      |. .. |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FEMLTGSLPFQ--GKDRK-------ETMALILKAKLGMP----QFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIK
..||||  |||  ..||.       | |  |.|..   |    |  | .|. |.. |  ..|  |||..  ...|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK3.AA S_TKc 84-343 36 7.29999999999e-108 365.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 84-343
Range on HMM: 1-231/231
Sequence Identity: 36% (99 aa)

FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRG--GDLFTRLSKEVM-
.|.|...|.|..|||...|..|    |...|.|..|          . . |..|| . .||.||||...||. ..||...... |  ||||... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQ-SADWWSFGVLM
     |.| ...||......||...||.|||.||||||||||||  ||||.||||...        ..|||| .||||||.   |..  ..||||.|...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGV--EEIKRHPFF
.|||.|  ||.      .|....|  .      | || ...| .....| .|..|       ..|| ||.|
YEMLCGYPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK3.AA Pkinase 84-343 29 1.1e-98 338.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 84-343
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM--ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGG----DLFTRLS-
.......|.||.|.|.. .... ..   ..|.|..|| . |   ...     |  |....|||.||.|...|......|.......||    |||...| 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVMF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI----KITDFGLSKEA-IDHDKRAYSFCGTIEYMAPEVVN-RRGHTQSADW
 ..  |  .|...|||. ... .|...|| |||.|||||||||.|..|||    ||.||||.| . . ..  ...||||..||||||.. ........|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGVLMFEMLTGSLPFQGK------DRKETMALILKAKLGMPQFLS---------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRH
||.|....|||.| .||.|.      | .. ...|....|  . . .                      |...... .....|  |..      |.|. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

PFF
|.|
PWF
Kinase RSK3.AA Ciliate-E2 84-343 25 4.3e-92 312.25 In-house 1-365 (365) Show / Hide 
Range on Protein: 84-343
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

FELLKVLGQGSYGKVFLV--RKVKG------------------SDAGQLYAMKVLKKATLKVRDRVRSKM-----------ERDILAEVNHPFIVKLHYA
....|..|||..|.|...  .||.                    .....||||..||  ..   .. . |           |. || ..|||.|.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLILDFLRGGDLFTRLS------------------KEVM-FTEEDVK-------FYLAELALALDHLHSLG-IIYRDLKPENILLDEEGHI
||  .. ..||..... ||||| ..                   ||.  .... ..       ||.|.. ||| .||| . ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KITDFGLSKEAID-------------------------------HDKRAYSFCGTIEYMAPEVVNRRG---------HTQSADWWSFGVLMFEMLTGSLP
||.||||||.. |                                .  ....||| .|||||..|. .         .. ..|.||.||...|||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGKDRKETMALILKAKLGMPQF------------------LSGEAQSLLRA----LFKRNPCNRLGAGIDGVEEIKRHPFF
|        .  |.. |.  |..                  .| |.. |..     .....| .|..    | |.|. ||.|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase RSK3.AA Ciliate-E2-Unclassified 84-343 27 2.9e-90 306.17 In-house 1-352 (352) Show / Hide 
Range on Protein: 84-343
Range on HMM: 1-352/352
Sequence Identity: 27% (98 aa)

FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSK----------MERD-------------ILAEVNHPFIVKLHYAFQTEGKLY
....|..|||..|||..... |  .  |.|||| .||.  . .  ...|          ...              ||   .||||||..|.||.. ..|
YKIIKQIGQGGFGKVYKCQHKK--QK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LILDFLRGGDLFTRLSKE-----------------VMFTEEDVK-----FYLAELALALDHLHSLG-IIYRDLKPENILLDEEG---HIKITDFGLSKEA
.......||||.  ..|                   .|||. .|     ||.|.. ..|..||. . ||.||.||||||.|..|   .|||.|||.||. 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

IDH---------------DKRAYSFCGTIEYM----APEVVNRRGHTQS----ADWWSFGVLMFEMLTGSLPFQGKDRKE---------------TMALI
..                ......||||..||    ||||  . .. .|    .|.||.||...|||.| .||.......                .  .
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

LKAK----LGMPQ-----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
 |.|      .|.      .| ||. ... |..... ....  | . |.|. ||.|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-TFEQILNHPWF
Kinase RSK3.AA CAMK 89-343 21 7.9e-87 279.72 In-house 1-425 (425) Show / Hide 
Range on Protein: 89-343
Range on HMM: 1-425/425
Sequence Identity: 21% (94 aa)

VLGQGSYGKVFLVRKVKGS----------DAGQLYAMKVLKKATLK--------------------------VRDRVRSKMERDILAE-------VNHPF
.||.||.|||.|..  .            . || .|.|...|  ||                           .|| . . | .|.         ..|| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IVKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DLFTRLSKE---------------VMFTEEDVKFYLAELALALDHLHSL
|.||. ...            |  |        .|...   ..  ||    ||| .. .                  |||.....|   .. |....||.
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIIYRDLKPENILLDEE-----------------GHIKITDFGLSKEAIDH-----------------------DKRAYSFCGTIEYMA-PEVVNR----
.|. |||||||||||.                  . |||.|||.... ..                        ..  . |||| |||| |||.|.    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RGHTQSADWWSFGVLMFEMLTGSLPFQGK-------------DRKETMALILKAKLG-MPQFLSG-----------------------EA
          .......| || ||... ||.| .||.|.             . .|..  |.|.|    | ..|.                       |.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
..|.| . ...| .|. .     |....||..
KDLIRKMLQVDPEKRMTI-----EQCLNHPWM
Kinase RSK3.AA CAMK1 84-304 32 3.2e-64 185.57 In-house 1-237 (276) Show / Hide 
Range on Protein: 84-304
Range on HMM: 1-237/276
Sequence Identity: 32% (78 aa)

FELLKVLGQGSYGKVFLVRKVKG-SDAGQLYAMKVLK-KATLKVRDR---VRSKMERDILAEV---NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRL
.|. |..| |. ..|.|. . .     |. ||.|... |  .|  |.    . ..| .|.  |   .||.|.|..  .... ..||... . ||.|| | 
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

SKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL---DEEGHIK--ITDFGLSKEAIDHDK-RAYSFCGTIEYMAPEVVNR---RGHTQSAD
 .   .||.|      ... |. ..||.||  |||||||.|.   ||.  ||  | ||||||  .|||    .  |||..|.||||...    .. .. |
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSK-IFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

WWSFGVLMFEMLTGSLPFQGKD-RKETMALILKAKLGMP
 || ||  . .|.|  ||....  .| ...|.|.....|
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFP
Kinase RSK3.AA Pkinase_Tyr 84-305 28 7.2e-24 81.47 Pfam 1-237 (270) Show / Hide 
Range on Protein: 84-305
Range on HMM: 1-237/270
Sequence Identity: 28% (69 aa)

FELLKVLGQGSYGKVFLVRKV-KGSDAGQLYAMKVLKKATLKVRD--RVRSKMERDILAEV-NHPFIVKLHYAFQ-TEGK--LYLILDFLRGGDLFTRLS
 ...|.||.|..|.|.. .   .... ..  | |.| | .   ..  |     |  |. .  .|| ||.|. .    ..   .|... .  .||| . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCG----TIEYMAPEVVNRRGHTQSADWW
|    .  .| .|   . .. | ....|.| ..| |||   |.|..|....||.||||..   . |   |   |     |  ||||. | .  |   | |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGVLMFEMLT-GSLP-FQGKDRKETMALILKAKLGMPQ
||||||.|..| |  | ..| .  | ...| .    ||.
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase RSK3.AA S_TK_X 344-405 41 4.2e-22 80.67 SMART 1-79 (79) Show / Hide 
Range on Protein: 344-405
Range on HMM: 1-79/79
Sequence Identity: 41% (33 aa)

VTIDWNTLYR--KEIKPPFKPAVG----RPEDTFHFDPEFTARTPTDSPGVPPSANAHHL-----------FRGFSFVA
  |||..||.  |||.||||| .      |.||  ||||||  ||...|  ||. |...            ||||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase RSK3.AA TyrKc 84-337 25 2.3e-18 68.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 84-337
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEV--NHPFIVKLHYAFQTE-------GKLYLILDFLRGGDLFTR
 .|.|.|| | .|.|.. .        .  | |.||. .     |     |  |. ..  .|| ||.|. .  ..       . |.... .  .|||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVM-FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHD-----KRAYSF----CGT----IEYMAPEVVNRRG
| |    .. .|   .    |   ..||| ..| |||   |.|..|....||.|||||..  |.|     |  |.     .|     |  ||||. | . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HTQSADWWSFGVLMFEMLT-GSLPFQG-----KDRKETMALILKAKLGMPQFL---------SGEAQSLLRALFKRNPCNRLGAGIDGVEEI
 |   | |||||.|.|..| |  |  |     .. .| .... . .  ..            . |  .. .   ...| .|       .|..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase RSK3.AA Pkinase_C 363-407 40 1e-13 51.49 Pfam 1-46 (46) Show / Hide 
Range on Protein: 363-407
Range on HMM: 1-46/46
Sequence Identity: 40% (19 aa)

AVGRPEDTFHFDPEFTARTPTDSP--GVPPSANAHHLFRGFSFVASS
 |  |.|| .||||||  .|.|.|  .   |......||||..|...
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase RSK3.AA RSK 440-697 56 1.1e-192 646.47 In-house 1-271 (271) Show / Hide 
Range on Protein: 440-697
Range on HMM: 1-271/271
Sequence Identity: 56% (154 aa)

YEIKEDIGVGSYS---VCKRCVHKATDTEYAVKIIDKSKRDPS-----EEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSE
||..|.||.||.|   |||.|.||.|...||.|||.|..||..     ||..|.||||.||.|..|..|..|.. ||..|..||||.|.||.|.|..|||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

REASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLA
||.......|...|.||||||.|||||||.|||| ||||.|..|..||||||||||. ||.|||.|||||..|||||||||.|.|||.||.|.|.|.||.
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTA-----MQVLKHPWV
|.|||.|.|.|||..|..||..|......||||.||| |||....|||.|||.||.|      |...|||.
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK3.AA RSK 442-697 41 2.6e-157 528.89 In-house 1-278 (278) Show / Hide 
Range on Protein: 442-697
Range on HMM: 1-278/278
Sequence Identity: 41% (117 aa)

IKED--IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPS--------EEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRY---
.|..  .|.|....|..|.|..|...||.|...|.|....        .|..||.|..|||.|.||........ .||.||..|||||.........   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG-NGLLMTPCYTANFVAPEVLK----RQGYDAACDIWSLG
|||.||.... .|......||.||..||||||.|||| ||| ....|...||||.||.|.  |...||.|||....|||.||    . |.|.|||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

ILLYTMLAGFTPFANGPDD-TPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLT-----AMQVLKHPWV
.|.|.||.|..||.. |.| ...||..||..||. |...||...|..||| ..||||.|||.||.     | ....||| 
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK3.AA CAMK1 440-697 39 4.90000000001e-119 347.68 In-house 1-276 (276) Show / Hide 
Range on Protein: 440-697
Range on HMM: 1-276/276
Sequence Identity: 39% (111 aa)

YEIKEDIGVGSYSVCKRCVHKAT---DTEYAVKIIDKSKRDPSE-----------EIEILLRYG--QHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI
||... || |. |. ..|.|| |   . .||.|.||| |.  ..           ||||. . .  .||||| ....|.. ...||||||. ||||.|||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK-KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

LRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPES-IR--VCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR---QGYDAAC
.   ...|..|...   | .   |.||.|.||||||| |.||.|.  ...| |.  ..||| .|..  ...|. |.| |  .||||||..   ..|| ||
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDK--DEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKAC

DIWSLGILLYTMLAGFTPFANGPDDT-PEEILARIGSGKYALSGGNWDSISDA-AKDVVSKMLHVDPHQRLTAMQVLKHPWV
|.|| |. .|..| |. ||    |..  .|... | ...|      ||.|||  ||| ...|| ||| .|.|. |.|.|||.
DMWSIGVITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase RSK3.AA Pkinase 440-697 34 2.6e-107 367.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 440-697
Range on HMM: 1-293/293
Sequence Identity: 34% (102 aa)

YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG----ELLDRIL--R
|.|.. || ||......|.|| |  ..|||||.|.......        ||.|..|  .||||..|.|.. |.. .|.|||...||    .| |.|   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QRYF--SEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQL-RAGNGLLMTPCYTANFVAPEVLK-RQGYDAACDIWS
.. |  ||.|. ...  | . ..|.||.|..||||||.|||. ..   ......||||.|||.    |. ..|.| | ...||||.. .|.|. ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILLYTMLAGFTPFANG----PDDTPEEILARIGSGKYALSGGNWDSIS-----------------DAAKDVVSKMLHVDPHQRLTAMQVLKHPWV
.|..|| || | .|| .     . ... ....||.....  .  .|.|||                 ...||.....|..||..|.||.|.|.|||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RSK3.AA AGC 440-697 23 9.69999999999e-107 276.45 In-house 1-395 (395) Show / Hide 
Range on Protein: 440-697
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

YEIKEDIGVGSYSVCKRCVHK------ATDTEYAVKIIDKSK---------RDPS-------------EEIEILLRYGQ---------HPNIIT-LKDVY
.|..  || ||.. .  . .|      .|.  ||.|...|..          .               || .|| .. .         ||.|.  |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDGKF--VYLVMELMR---------GG-ELLDRIL---RQRYFSEREASDVLCT-------ITKTMDYLHS-QGVVHRD-LKPSNILYRDESGSPESIRV
 | .   .|.|||.|          || ||. ..    ....|.| .|   ..        |.  ..|||| .|..||| ||| |||  ..      |. 
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKL

CDFGFAKQLRAG-----------------------------------------------------NGLLMTPCYTANFVAPEVLKRQGYDAACDIWS--L
.|||..|... .                                                     .  .  || |....|||.|    |. |||.||  |
TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGL

GILLYTMLAGFTPFANGPDD-------TPEEILARIGSGKYALSGGNW------------DSISDAAKDVVSKMLHVDPHQRLT----------AMQVLK
|.|.| ||.| .|| . ...       .|.|.  .| .|.|... .              ...|. ||| ..|.|..|| .||.          | .. .
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPWV
||| 
HPWF
Kinase RSK3.AA CAMK 445-697 26 1.2e-104 338.24 In-house 1-425 (425) Show / Hide 
Range on Protein: 445-697
Range on HMM: 1-425/425
Sequence Identity: 26% (111 aa)

DIGVGSYSVCKRCVHKATD------------TEYAVKIIDKS--------------------------------KRDPSEEIEILLRYG------QHPNI
 .| ||... |.|.|| |             ...|.|||||.                                ..    ||||. .        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLKDVYDDGKF-------------------VYLVM---ELMRGGEL----LDRILRQ---------------RYFSEREASDVLCTITKTMDYLHSQGV
| | .||.|...                   .|.||   |.. ||||    .|.| ..               ..|.||||. .   |   ..|.||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYRDESGSPE-------------SIRVCDFGFAKQLRAGNG-----------------------LLMTPCYTANFVA-PEVLKR------
||||||| |||. | ... .              | ..|||||.... |..                       .. |.| |  ..| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDAACDIWSLGILLYTMLAGFTPFANGPDD----------TPEEILARIGSGKYALSGGN------------WDSISDA--------AKD
        ..|. .||.||.|..||.|| |. ||    |.          ...|.. .| .|||                  ||.|||         .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

VVSKMLHVDPHQRLTAMQVLKHPWV
 ..||| ||| .|.|. |.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase RSK3.AA S_TKc 440-697 36 9.60000000001e-104 351.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 440-697
Range on HMM: 1-231/231
Sequence Identity: 36% (99 aa)

YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRG--GELLDRILRQRY------FSE
||| . || |.......|.|| |. ..|.|||.   ..   ||.|| .  .||||..|.||..| ...|.|||.. |  |.|.|.| ....      |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

REASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDA-ACDIWSLGILLYTML
 .|  ... | . ..|.||.|..||||||.|||  .       | .||||.|.||       .| | | ...|||||   ||.  .||.||.|..|| ||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

AGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLK-------HPWV
.| .||      ...... .||              |. ||| ..|.|..|| .|.|| ..|.       |||.
CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK3.AA MSK 442-697 35 8e-90 303.81 In-house 1-277 (277) Show / Hide 
Range on Protein: 442-697
Range on HMM: 1-277/277
Sequence Identity: 35% (98 aa)

IKED--IGVGSYSVCKRCVHKATDTEYAVKIID-----KSKRDPSE---EIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSE
.|.   .| |....|..|||. |...||.||.       ... ...   |. .|..  ||||| .|.... |    |||||. .||||. .| . ..|.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

REASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG-NGLLMTPCYTANFVAPEVLK----RQG-YDAACDIWSLGIL
 |.....  .    |..|. |..|||||| |||. ||. .   ... |||||. . .. .  . .||.|  . |||.|.     .| ||.|||.||||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDN-GHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI

LYTMLAGFTPFA-NGPDDT-----PEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV
||||| |  ||. |..|         ||  ||  |.  . |  | ..| .||| ....| .||  ||..   ..| | 
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK3.AA Ciliate-E2 440-697 23 7.1e-75 255.07 In-house 1-365 (365) Show / Hide 
Range on Protein: 440-697
Range on HMM: 1-365/365
Sequence Identity: 23% (92 aa)

YEIKEDIGVGSYSVCKRCVHKATDT-----------------------EYAVKIIDKS--KRDPSEEIEI--------------LLRYGQHPNIITLKDV
|.. . || |.... ..| .. ..                        .||.||. |.  .   .|. ..              .|.  .||||| ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YD--DGKFVYLVMELMRGGELLDRILRQR-----------YFSEREASDVLCTITK---------------TMDYLHSQG-VVHRDLKPSNILYRDESGS
.   | . .|||||.  ||.|.|.|  ..           ||.|.|....   |..                . ||||.. ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PESIRVCDFGFAKQLRAGNG-------------------------------LLMTPCYTANFVAPEVLKRQG---------YDAACDIWSLGILLYTMLA
   | ..|||..|..   |                                .  | |.|....|||.|....         || .|||||||..|| || 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GFTPFANGPDDTPEEILARIGSGKYALSGG--------------NWDSISDAAKDVVSK----MLHVDPHQRLT-AMQVLKHPWV
| .||           .  |  .|. ..                .|...|. .||  .|    || .|| .|.| . |.|.||| 
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase RSK3.AA Ciliate-E2-Unclassified 440-697 25 2.6e-62 213.33 In-house 1-352 (352) Show / Hide 
Range on Protein: 440-697
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

YEIKEDIGVGSYSVCKRCVHKATDTEY-----AVKIIDKSKRD-------PSEEIEILLRY---------------GQHPNIITLKDVYDDGKF--VYLV
|.| . || |.... ..|.|| .. .|     . ||......          |..|.  .                 .||... .|..| . .   .|.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MELMRGGELLDRI-----------------LRQRYFSEREAS-----DVLCTITKTMDYLHSQG-VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLR
||...||.|.. |                 .... |.|..|.     . .  | .  .|||... ..|||.||.|||. .. .    |...|||..|.. 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQ

AGNG---------------LLMTPCYTANFV----APEVLKRQGYD----AACDIWSLGILLYTMLAGFTPF-ANGPDD------------TPEEILARI
  |.               .. | | | |.     |||||..|.||     .|||||||..|| || |  || .|  ..            . ....  |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

GSGKYALSGGNW----DSISDAAKDVVS----KMLHVDPHQRLTAMQVLKHPWV
  ...  .  .|    . .|. ||| ..    ||| ..| .|.|. |.|.||| 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase RSK3.AA p70 490-697 28 2.3e-30 107.18 In-house 86-299 (299) Show / Hide 
Range on Protein: 490-697
Range on HMM: 86-299/299
Sequence Identity: 28% (65 aa)

QHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG
.||.|. |   . ..   ||. | . ||||     |.  . |  |.  |  |.  . .||..|.. ||||| |..  .. |    .   |||  |.   .
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCML-NQQG---HVVLTDFGLCKESIHD

NGL----------LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGK--YALSGGNWDSISDAAKDVVSKM
             . | | |  . |||.| | |.. |.| ||||.|.| || |  ||     ... ..   |  ||   .|        .  ..| . |.
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTG---ENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKL

LHVDPHQRLT-----AMQVLKHPWV
|  .| ||..     | .. .||. 
LKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK3.AA Akt 508-636 37 8.9e-28 85.8 In-house 76-203 (264) Show / Hide 
Range on Protein: 508-636
Range on HMM: 76-203/264
Sequence Identity: 37% (50 aa)

YLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRD-LKPSNILYRDESGSPESIRVCDFGFAKQL-RAGNGLLMTPCYTANFVAP
|.||. . ||||   . |.|.||| .|    . |    ..|||.... || ||| |||  |. |    |...||| .|.     .   .| | |.   ||
YFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILM-DKDG---HICLTDFGLCKENIIKDHDKTKTFCGTPEYLAP

EVLKRQGYDAACDIWS-LGILLYTMLAGFTPF
|.|. .|.. |.|.|. ||...| |. |. ||
EILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase RSK3.AA Pkinase_Tyr 440-627 25 2.2e-18 62.86 Pfam 1-205 (270) Show / Hide 
Range on Protein: 440-627
Range on HMM: 1-205/270
Sequence Identity: 25% (54 aa)

YEIKEDIGVGSYSVCKRCVHK----ATDTEYAVKIIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYD-DGKF--VYLVMELMRGGELLDRIL
 .. . .| |.. . .... |     |... |||.. | . ....        |..|.  .|.||||. |  |   .|.   .|.|||.| .| |||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

R----QRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQL-------RAGNGLLMTPCYTANFVAPEVLKRQGY
.    .. ..  .  .    | | |.||.|.. .||||   |.|  .    .  ...|||| |. .       |.. |  .    .    |||...   .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKF

DAACDIWSLGILLY
  . |.|| |.|..
TTKSDVWSFGVLMW
Kinase RSK3.AA TyrKc 440-703 19 1.3e-15 29.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 440-703
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSE---EIEILLRYG-QHPNIITLKDVYDDG-------KFVYLVMELMRGGELLDRILRQRY
 . .. .| | . .  ... |   .. ||| . ...    .   |..|. ..| .||||. |  |  ..       . ...|||.| .| |.|.. . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-FSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG-----NGLLMTPCY--TANFV------APEVLKRQGYD
 .. ..  .    | . |.||||....||||   |.|. ..      ....||| .. .  .     ..   ..     ....      |||...   . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

AACDIWSLGILLYTMLA-GFTPFAN---GPDDTPEEILARIGSGKYALSGGN-----WDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYL
 . |.|| |.... ..  | .|  .     . ...|..... .|..     |         .|.  .. ..  | ||..| |  ..        .|..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--------HECF
Kinase RSK3.AA Akt 666-697 37 2e-06 16.56 In-house 228-264 (264) Show / Hide 
Range on Protein: 666-697
Range on HMM: 228-264/264
Sequence Identity: 37% (14 aa)

ISDAAKDVVSKMLHVDPHQRL-----TAMQVLKHPWV
||...|| .|..|. ||..||     .| ..  ||| 
ISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF