Gene SgK071 (Human)
SgK071
Sequence
Protein domains of SgK071.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | SgK071.AA | SgK071 | 30-296 | 60 | 4.8e-205 | 687.49 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 30-296 Range on HMM: 1-283/283 Sequence Identity: 60% (171 aa) VLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFN-ELSFQEVIEDKRKAKKI .||.|||||.|||.|||.|||..|.|||||||||||.|..||||.|||.||.|.||.||...|..|..|....|||.||... ...|......|||.||| LLYMLNPGAQGVNFVVEHMETGKKFVIKQVECMDDHHANKALEEVMPLQKLQHPHICVYHDMFVHWDKEEAAMYLCIVMDYYKMGDFDRFMKEKRKKKKI IDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEE---------------DPFRKSWMAPEALNFSFSQ ...||||...||.|.|.|||||..||||.||||||.|....||||||......||||.|||.||.. |.....|||||.|.|.||| MCEEWMQRWCGQMLHAIEYLHHRNIIHRDLKPSNIYLTDQMHCKLQDFGIQTIMTDKHKWNCRARTENTALSGPSTLILSADVWSMYWMAPEVLEFPFSQ KSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSPGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITF |||||||||||||||.|||||.||.||||...||.|||||..||||||||||||.....|||.||.|.|.|||.||||.|||| KSDIWSLGCIILDMTTCSFMDDTEMMHLRMGIRQHPGSLKEILKTMEEKQIPDVDDYYQLLPFMLHINPQDRISIKDVMHITF |
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| S_TKc | SgK071.AA | S_TKc | 28-297 | 20 | 5.1e-21 | 77.07 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 28-297 Range on HMM: 1-231/231 Sequence Identity: 20% (59 aa) YQVLYQLNPGALGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNEL---SFQEVIEDKRK |..| .. || |. . . .|. . ||.. ... |. | | .| .| . . | . .|..|||. . . ..|..... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR AK--KIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTDKAKWNIRAEEDPFRKS--WMAPEALNFSFSQ-KSDIWS . . .. . . .. |...||||.| . |||| |||.|| | . | |. | . .. . | . .|||| | ... |.|.|| HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL--GYGKCKCDWWS LGCIILDMTS-CSFMDGTEAMHLRKSLRQSPGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVH-------ITFL .|||. | . . . . . . | .. . ..... .|| ||..|.|. .. . .. CGCILYEMLCGYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | SgK071.AA | Ciliate-E2-Unclassified | 28-224 | 20 | 8.5e-21 | 68.88 | In-house | 1-260 (352) | Show / Hide |
Range on Protein: 28-224
Range on HMM: 1-260/352
Sequence Identity: 20% (55 aa)
YQVLYQLNPGALGVNLVVEEMETK---------VKHVIKQVECMD-DHYASQALEELMP-----------LLK---LRHAHISVYQELFITWNGEISSLY
| ...|.. |. |. ... ..| .....|| | | .. ..|.. ... | | |. .. .... . . .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC----FQDKQN
LCLVMEF-NELSFQEVIED-------------KRKAKKIIDSEWMQ-----NVLGQVLDALEYLHHLD-IIHRNLKPSNIILISSD---HCKLQDLSS--
...|||. . .. .. |.. ..| .||.. . .. . . |.|..|||||| ||||..||.||.. .. ..|. |...
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISK
------NVLMTD---KAKWNIRAEEDPFR--KSWM----APEALNF-SFS----QKSDIWSLGCII
| |. | . ... . . | . | ||| | . |.||||||.|.
KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
|
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| Kinase | SgK071.AA | Ciliate-E2 | 103-224 | 21 | 7.6e-18 | 57.83 | In-house | 108-286 (365) | Show / Hide |
Range on Protein: 103-224
Range on HMM: 108-286/365
Sequence Identity: 21% (41 aa)
YLCLVMEF-NELSFQEVIEDKRK--------AKKIIDSEWMQNVLGQVLD---------------ALEYLHHLD-IIHRNLKPSNIILISSDHCKLQDLS
.. ||||. . . .. |....| . | .. . .... |.|. |||||| ||||..||.||.. .|. |.
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFG
S----NVLMTDKAKWNIRAEEDPFRK--------------------------SWMAPEALNFS----------FSQKSDIWSLGCII
. . .. . . .... .| | |||| || . |.||||||.|.
LSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
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| Kinase | SgK071.AA | NEK-Unclassified | 117-234 | 33 | 2e-17 | 53.94 | In-house | 82-198 (258) | Show / Hide |
Range on Protein: 117-234 Range on HMM: 82-198/258 Sequence Identity: 33% (41 aa) EVIEDKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLM---TDKAKWNIRAEEDPFRKSWMAPEALNF-SFS . | .|| .| . .| |. | | |||| |||.|| | .| . | | |||. . ||.|| . . RRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGT------MCWMSPEVCQDQPYN QKSDIWSLGCIILDMTSCS-FMD .||.|||||||. | | |.| NRSDVWSLGCIIYEMCTCEPFFD |
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| Kinase | SgK071.AA | AGC | 103-173 | 29 | 6.1e-15 | 33.59 | In-house | 107-196 (395) | Show / Hide |
Range on Protein: 103-173 Range on HMM: 107-196/395 Sequence Identity: 29% (27 aa) YLCLVMEF-----------NELSFQEVIEDKRKAKKIIDSEWMQNVLGQ-------VLDALEYLHH-LDIIHRN-LKPSNIILISSDHCKL ||..|||. . . . ..| ... | |. . . . .. |||||| ..|||| ||| || | . |.|| YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRR-KEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKL |
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| Kinase | SgK071.AA | TKL | 140-230 | 18 | 1.5e-13 | 45.2 | In-house | 140-285 (364) | Show / Hide |
Range on Protein: 140-230 Range on HMM: 140-285/364 Sequence Identity: 18% (27 aa) QVLDALEYLHHLD--------IIHRNLKPSNIILISSDH--------------CKLQDLSSNVLMT---DKAKWN----------IRAEEDPFRK---SW .. ...||| . ||||.||..|| . . . ||. |. |. .. .. ... . | DIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRW MAPEALN-----------------FSFSQKSDIWSLGCIILDMTSC ||||.|. |..|.|.|..| | .. . .. MAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR |
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| Kinase | SgK071.AA | STE | 103-173 | 28 | 4.7e-12 | 38.98 | In-house | 111-188 (359) | Show / Hide |
Range on Protein: 103-173 Range on HMM: 111-188/359 Sequence Identity: 28% (24 aa) YLCLVMEFNE-LSFQEVIEDKRKAKK----------IIDSEWMQNVLGQVLDA-LEYLHHLDIIHRNLKPSNIILISSDHCKL .|...||. . |. ..|. | . .| .. .. .. |.| . |.||| . |||| .||.|| | .|| ELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKL |
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| Kinase | SgK071.AA | CMGC | 28-165 | 17 | 5.5e-12 | 34.73 | In-house | 1-217 (513) | Show / Hide |
Range on Protein: 28-165 Range on HMM: 1-217/513 Sequence Identity: 17% (39 aa) YQVLYQLNPGALGVNLVVE----------------EMETKVKHVIKQVECM-DDHYAS----------QALEELMPLLKLR-----------------HA |... .. |. | |.. ..||. . || . ... | || |.. | .|. | YEIIKKIGEGTYG--VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN HISVYQELFITWN-GEISSL----------YLCLVMEFNELSFQEVIEDKRKA----KKIIDSEWM-------------QNVL------GQVLDALE--Y .| .. | . | . .|.||.|. . . ..|..... ... || .. . |.| .|. | NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY LHHLD--IIHRNLKPSNIIL .| . |||| |||.|| . CHSHWGNIIHRDLKPENILI |
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| Kinase | SgK071.AA | Pkinase | 52-173 | 24 | 1.2e-10 | 38.77 | Pfam | 29-153 (293) | Show / Hide |
Range on Protein: 52-173 Range on HMM: 29-153/293 Sequence Identity: 24% (32 aa) VKHVIKQVECMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIEDK----RKAKKII--DSEWMQNVLGQVLDAL || . |. | .. ... | |. ...|.| .| . . | . . ....|||. | |.. . ..... . . . .... |.| .| VKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGL EYLHHLDIIHRNLKPSNIILISSDHC----KL ||.| |||| |||.|| . . .|. |. EYCHSMGIIHRDLKPENILIDNNGHIDACVKI |
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| Kinase | SgK071.AA | ULK | 103-163 | 26 | 3.4e-08 | 24.78 | In-house | 94-161 (329) | Show / Hide |
Range on Protein: 103-163 Range on HMM: 94-161/329 Sequence Identity: 26% (18 aa) YLCLVMEFNEL-SFQEVIEDKRK------AKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNI .. ..||. . ... |. ..| ||.. . .... | | .. .|| |||| .||.|| NIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNI |
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| Kinase | SgK071.AA | Pkinase | 201-297 | 15 | 7.8e-08 | 28.79 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 201-297 Range on HMM: 177-293/293 Sequence Identity: 15% (20 aa) WMAPEALN--FSFSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLRQSP------GSLKAVLKTME---EKQIPDV---------------------E .|||| .. ..|.|.||.|||. | . .. . .. .. . ..|. . ..| | YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC------------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSE TFRNLLPLMLQIDPSDRITIKDVVHITFL ... .. .|. ||..|.|...... .. ECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | SgK071.AA | TyrKc | 28-295 | 17 | 1.3e-07 | -99.54 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 28-295
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)
YQVLYQLNPGA-----LGVNLVVEEMETKVKHVIKQVECMDDHYASQALEELMPLLKL--RHAHISVYQELFITWNGEISS--------LYLCLVMEFNE
. . .| || .|. .. .| . ..|. . || .| .| . | ... |..|||. .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNI-------VRLYGVCTQQGRNFMYIEPLMIVMEYMP
L-SFQEVIEDKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKL------QDLSSN-------VLMTD----KAK--WNIRA
. . .. . ..|. . . . . |. . ||||. .||| | |. . . ..| |. . . .| . ||
HGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR-
EEDPFRKSWMAPEALNFS-FSQKSDIWSLGCIILDMTSCSFMDGTEAMHLRKSLR-------QSPGSLKAVLKTMEEKQIPDV-------ETFRNLLPLM
|||||..|.. |. |||.|| | . | . . .. |. . . .|. . .|. . . .|
--------WMAPECINYGKFTTKSDVWSFGVCM-----------WEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM
LQI---DPSDRITIKDVVHIT
.| ||.|| | ......
KQCWHEDPEDRPTFSEIHECF
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| Kinase | SgK071.AA | ULK | 103-163 | 25 | 1.6e-07 | 22.85 | In-house | 91-157 (324) | Show / Hide |
Range on Protein: 103-163 Range on HMM: 91-157/324 Sequence Identity: 25% (17 aa) YLCLVMEFNEL-SFQEVIEDKRK-----AKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNI .....||. . ... |. ..| ||.. . .... | . .. .|| |||| .||.|| NIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNI |
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| Kinase | SgK071.AA | STE | 201-227 | 44 | 1e-05 | 16.3 | In-house | 228-261 (359) | Show / Hide |
Range on Protein: 201-227 Range on HMM: 228-261/359 Sequence Identity: 44% (15 aa) WMAPEALN---FS----FSQKSDIWSLGCIILDM ||||| .. . . |.||||||| |. | WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM |
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| Kinase | SgK071.AA | ULK | 202-224 | 44 | 1.1e-05 | 15.9 | In-house | 218-246 (329) | Show / Hide |
Range on Protein: 202-224 Range on HMM: 218-246/329 Sequence Identity: 44% (13 aa) MAPEALNFS-----FS-QKSDIWSLGCII |||. |. .. |.||||||||. MAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | SgK071.AA | ULK | 277-297 | 33 | 1.2e-05 | 15.76 | In-house | 309-329 (329) | Show / Hide |
Range on Protein: 277-297 Range on HMM: 309-329/329 Sequence Identity: 33% (7 aa) MLQIDPSDRITIKDVVHITFL |||.|..|||.. .. .. .. MLQYDEKDRISWEELFNHPWF |
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| Kinase | SgK071.AA | ULK | 202-224 | 44 | 1.3e-05 | 15.97 | In-house | 214-242 (324) | Show / Hide |
Range on Protein: 202-224 Range on HMM: 214-242/324 Sequence Identity: 44% (13 aa) MAPEALNFS-----FS-QKSDIWSLGCII |||. |. .. |.||||||||. MAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | SgK071.AA | ULK | 277-297 | 33 | 1.5e-05 | 15.78 | In-house | 304-324 (324) | Show / Hide |
Range on Protein: 277-297 Range on HMM: 304-324/324 Sequence Identity: 33% (7 aa) MLQIDPSDRITIKDVVHITFL |||.|..|||.. .. .. .. MLQYDEKDRISWEEIFNHPWF |
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| Kinase | SgK071.AA | AGC | 202-224 | 44 | 2.9e-05 | 8.01 | In-house | 274-295 (395) | Show / Hide |
Range on Protein: 202-224 Range on HMM: 274-295/395 Sequence Identity: 44% (11 aa) MAPEALNFSFSQKSDIWS--LGCII |||| | .. |.|| |||.. MAPEIL---YGKACDWWSFGLGCLM |
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| Kinase | SgK071.AA | Pkinase_Tyr | 201-221 | 59 | 0.000122 | 16.34 | Pfam | 180-201 (270) | Show / Hide |
Range on Protein: 201-221 Range on HMM: 180-201/270 Sequence Identity: 59% (13 aa) WMAPEALNFS-FSQKSDIWSLG |||||..|.. |. |||.|| | WMAPECINYGKFTTKSDVWSFG |
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| Kinase | SgK071.AA | CMGC | 268-297 | 33 | 0.001568 | 6.44 | In-house | 484-513 (513) | Show / Hide |
Range on Protein: 268-297 Range on HMM: 484-513/513 Sequence Identity: 33% (10 aa) ETFRNLLPLMLQIDPSDRITIKDVVHITFL . ...|| |||.||..|||... .. PQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | SgK071.AA | Ciliate-E2 | 272-297 | 29 | 0.003796 | 6.63 | In-house | 335-365 (365) | Show / Hide |
Range on Protein: 272-297 Range on HMM: 335-365/365 Sequence Identity: 29% (9 aa) NLLPL----MLQIDPSDRIT-IKDVVHITFL .|. ||| ||. ||| .... .. DLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | SgK071.AA | Ciliate-E2-Unclassified | 272-297 | 30 | 0.006326 | 6.01 | In-house | 327-352 (352) | Show / Hide |
Range on Protein: 272-297 Range on HMM: 327-352/352 Sequence Identity: 30% (8 aa) NLLPLMLQIDPSDRITIKDVVHITFL .|| ||. .|. |||.... .. DLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | SgK071.AA | CMGC | 208-224 | 25 | 0.006559 | 4.36 | In-house | 302-325 (513) | Show / Hide |
Range on Protein: 208-224 Range on HMM: 302-325/513 Sequence Identity: 25% (6 aa) NFS-------FSQKSDIWSLGCII . . .... |.||.|||. HYTNHNYSMHYTTPIDMWSVGCIF |
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