Gene SgK307 (Human)
SgK307
Sequence
Protein domains of SgK307.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Ank | SgK307.AA | Ank | 55-87 | 30 | 0.000229 | 20.01 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 55-87 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) LGQTALFVAALLGLRKFVDVLVDYGSDPNHRCF |.|.| .|.. | . | |...| |.|.. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | SgK307.AA | Ank | 88-120 | 36 | 0.000473 | 18.87 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 88-120 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) DGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE || || | |...|. ... ||..| |. ..| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | SgK307.AA | Ank | 27-54 | 32 | 4.200147 | 4.63 | Pfam | 6-33 (33) | Show / Hide |
Range on Protein: 27-54 Range on HMM: 6-33/33 Sequence Identity: 32% (9 aa) LHEYVKQGNYVKVKKILKKGIYVDAVNS || ... |.. || |..| |.|.. LHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Kinase | SgK307.AA | NKF5 | 340-515 | 83 | 1.4e-163 | 498.45 | In-house | 1-176 (176) | Show / Hide |
Range on Protein: 340-515 Range on HMM: 1-176/176 Sequence Identity: 83% (147 aa) ERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDI |||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||.||.||||.||.||.|||||||||||||||.|...|||||| ERRSQFPVLHMEVIVHLLLQIADALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMTESQDRGVHRDVTRMPLPTQLYNWAAPEVICQDMPTVKSDI YSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIVKSGIHVKQKDRTMNLQDIRYILKNDLK |||..|||||.||.|||.|.||..||.....|||.|||.|||.|||||||.|||.|||||.||||||||||||||| YSFCIIMQEIFTDEIPWAGRDGPEVKAKIEAGNYPEADPRLPAPYYDIVKAGIHLKQKDRWMNLQDIRYILKNDLK |
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| Kinase | SgK307.AA | Frk | 292-499 | 25 | 1.1e-14 | 47.05 | In-house | 41-246 (260) | Show / Hide |
Range on Protein: 292-499
Range on HMM: 41-246/260
Sequence Identity: 25% (54 aa)
LIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEAR
...| ||||| |.|| ||| . | .. | . |.| | . ..|. .| . |. . || | .||| | | . .
FLREAQIMKKLRHPKLIQLYAVCTVE--EPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICK
LTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIV
. | .| .. . . . .| . | ||| . . |.|||..|| ... ||.| .|. |. . | . | | . |. .|.|.
IADFGLARVLMKDNEDIYESRHGARFPIK---WTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIM
KSGIHVKQKDR
|.. . |
LECWHSDPMKR
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| Kinase | SgK307.AA | Src-Echino1 | 292-471 | 24 | 6.3e-13 | 40.7 | In-house | 41-213 (252) | Show / Hide |
Range on Protein: 292-471 Range on HMM: 41-213/252 Sequence Identity: 24% (45 aa) LIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEAR ..|| . |.|| ..|. ||| | | .| | . | | . | . ... . | .. . .| . || . ..|| |. | . . FLAEANVMKKCRHEGIVQIYAVC--SDKEPIYIVTELMSNGNLQDYLKRGKCKH--VKMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCK LTNLEY-MLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKAVVSG . .. . .| . . ..|. | ||| .| |.|||..|| ..| |..| .|..|. | . | | IADFGLARMMQKDVYCGKQGAKLPI-----KWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGMMNREVLDQVDRG |
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| Kinase | SgK307.AA | TK-Unique | 289-451 | 20 | 3.5e-12 | 38.44 | In-house | 48-234 (294) | Show / Hide |
Range on Protein: 289-451 Range on HMM: 48-234/294 Sequence Identity: 20% (40 aa) ADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRS-QFPV---------------------LHMEVIVHLLLQISDALRY .|.| | .... .||...|.. .| . | | . ...| . |.| . |...| .... . .. .| . || .. | QDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEY LHF--QGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDL-TRVPLPTQLYNWAAPEVIL--QKAA-TVKSDIYSFSMIMQEILT |. ....|| |.. | . . ... .... . ...||. .. ..| | |||... .. . | |||..|| .| ||.| LASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR---WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT |
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| Kinase | SgK307.AA | TK | 265-375 | 13 | 3.1e-11 | 33.15 | In-house | 29-264 (486) | Show / Hide |
Range on Protein: 265-375 Range on HMM: 29-264/486 Sequence Identity: 13% (31 aa) WNGS---------------------RVTVKELNLPTHPHCSRLRLAD-------------LLIAEQEHSSKLRHPYLLQLMAVCLSQDL----------E |||. .| || | . .. . . .... ...... ..|...|| ...| .||. .. | WNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQE KTRLVYERITIGT----LFSVLHERRSQFPV--------------------------------------------------------------------- .| | | | . |...| | PWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTC ---LHMEVIVHLLLQISDALRYLHFQ------GFIHR |.|. . .||.....||| . .|.|| KHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHR |
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| Kinase | SgK307.AA | TKL | 264-379 | 18 | 5.5e-11 | 35.81 | In-house | 13-168 (364) | Show / Hide |
Range on Protein: 264-379 Range on HMM: 13-168/364 Sequence Identity: 18% (30 aa) VWNG----------SRVTVKELNLPT-HPHCSRLR--------------------LADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLE-----------K .|.| | || .. . . .. . . .. | . |.|||| ..|.|..|.. . . KWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQ TRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQG--------FIHRSLSS .|.| . |.|...|| ....... |.|. .. ||| .. ||| | | LCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKS |
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| Kinase | SgK307.AA | TKL-Unique | 420-468 | 33 | 2.3e-10 | 32.96 | In-house | 190-246 (290) | Show / Hide |
Range on Protein: 420-468 Range on HMM: 190-246/290 Sequence Identity: 33% (19 aa) YNWAAPEVILQ--KAATVKSDIYSFSMIMQEILTDDI------PWKGLDGSVVKKAV ..|.||||. . . . |||.|||.... ||.| .| | .|.| ....| FRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMV |
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| TyrKc | SgK307.AA | TyrKc | 258-509 | 22 | 2.5e-10 | -55.81 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 258-509 Range on HMM: 1-280/280 Sequence Identity: 22% (68 aa) MVMTNL------------VWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKL--RHPYLLQLMAVCLSQ-----DLEKTRLVYERITIGTLFSVL .. .|. | || |. . .. | . .|| .|| ...| .||..| | .| | | | . | ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL HERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSL--------SSYAVHIISPGEARLTNLE-YMLESEDRGVQRD--LTRVPLPTQLYNWAAPEV ...| . | |. .. .||.. .||| ...||| | . . | | | .| . . ||.| ... .. .|| . | |||. RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP---IRWMAPEC ILQKAATVKSDIYSFSMIMQEILTD-DIPWKG-----LDGSVVKKAVVSGNYLEADVR--------LPKPYYDIVKSGIHVKQKDRTMNLQDIRYI | . | |||..|| | ||.|. . |. | .. . | . | .|.... |. |.| |. | . .|| . .... INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| S_TKc | SgK307.AA | S_TKc | 257-518 | 13 | 1.9e-09 | -38.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 257-518 Range on HMM: 1-231/231 Sequence Identity: 13% (42 aa) YMVMTNL-------------VWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITI--GTLFSVLHER | .. . . | .| .|... . .. | . .| .||.. .| |. . .. .| | . |.||.....| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR RSQFP--VLHMEVIVHLLLQISDALRYLHFQGFIHR------------------SLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL-- ... . ... .. ... || .|| |.| .|.||| |. | . GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----------------------------------TTFCG -YNWAAPEVILQKAATV-KSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIVKSGIHVKQKDRTMNLQDIRYILKNDLKDF .. ||||. . |.|..|. |. | |. |. . .. | .. ... |... .. ..| . .. .. . . TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW T F |
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| Kinase | SgK307.AA | LRRK | 422-471 | 29 | 8.8e-09 | 27.19 | In-house | 245-305 (351) | Show / Hide |
Range on Protein: 422-471 Range on HMM: 245-305/351 Sequence Identity: 29% (18 aa) WAAPEVIL---QKAATVKSDIYSFSMIMQEILTDD-IPWKGLD-------GSVVKKAVVSG | |||.. . | |.|.||| ||. |.|| . .| ..| . ..... .| WMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEG |
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| Kinase | SgK307.AA | UTK | 300-375 | 28 | 1.4e-08 | 25.47 | In-house | 64-142 (296) | Show / Hide |
Range on Protein: 300-375 Range on HMM: 64-142/296 Sequence Identity: 28% (23 aa) SKLR-HPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFP----VLHMEVIVHLLLQISDALRYLHFQGFIHR .... ||..|.| .||... . .|.| | | |.| | ..| | .. .. ..|.... ||| .||.|| KQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHR |
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| Kinase | SgK307.AA | TKL-Unique | 299-379 | 25 | 2.2e-08 | 25.83 | In-house | 49-140 (290) | Show / Hide |
Range on Protein: 299-379 Range on HMM: 49-140/290 Sequence Identity: 25% (24 aa) SSKLR-HPYLLQLMAVCLSQDLEKT--RLVYERITIGTLFSVLH---------ERRSQFPVLHMEVIVHLLLQISDALRYLHFQG--FIHRSLSS ..||. || ....|..| . .| | . |.| .||| .. . .. |...|.. ..|.... |||. . ||| | | MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLN---MQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKS |
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| Kinase | SgK307.AA | TKL | 420-473 | 20 | 7.7e-08 | 24.32 | In-house | 237-315 (364) | Show / Hide |
Range on Protein: 420-473 Range on HMM: 237-315/364 Sequence Identity: 20% (16 aa) YNWAAPEVILQK----------------AATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVK---------KAVVSGNY ..| ||||. .. .. |.|.||| ... |||| .|..... . .. . |.. .. PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGL |
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| Kinase | SgK307.AA | MLK | 300-379 | 27 | 8.7e-07 | 19.72 | In-house | 60-155 (291) | Show / Hide |
Range on Protein: 300-379 Range on HMM: 60-155/291 Sequence Identity: 27% (27 aa) SKLRHPY----LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFP----------VLHMEVIVHLLLQISDALRYLHFQGF---IHRSLSS ..|.|| |...|||.. . .| | . | |..|||..||. | ..... ||.. .. ||| . ||| | | RILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKS |
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| Kinase | SgK307.AA | Pkinase_Tyr | 300-375 | 28 | 1e-06 | 23.38 | Pfam | 58-135 (270) | Show / Hide |
Range on Protein: 300-375 Range on HMM: 58-135/270 Sequence Identity: 28% (22 aa) SKL-RHPYLLQLMAVCLSQDLE-KTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHR ..| .|| ...|..||..|. . .| | | | . |...|.. . | |. ... .||.... ||. ...||| KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHR |
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| Kinase | SgK307.AA | LRRK | 300-375 | 26 | 3e-06 | 18.3 | In-house | 112-190 (351) | Show / Hide |
Range on Protein: 300-375 Range on HMM: 112-190/351 Sequence Identity: 26% (22 aa) SKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERR-SQF----PVLHMEVIVHLLLQISDALRYLHFQG--FIHR |.|.||....|. .| .. ..| | ...|.| ..||... ..| ... .. . |||.....||| . .||| SHLNHPNIVSLKGFC----IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHR |
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| Kinase | SgK307.AA | MLK | 422-462 | 35 | 2e-05 | 14.96 | In-house | 199-243 (291) | Show / Hide |
Range on Protein: 422-462 Range on HMM: 199-243/291 Sequence Identity: 35% (16 aa) WAAPEVILQ-KAATV--KSDIYSFSMIMQEILTDDIPWK-GLDGS | ||||| | .. .. |.|..|. ... |.|| .| | ..|.. WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPM |
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| Kinase | SgK307.AA | TK | 422-483 | 24 | 4.2e-05 | 12.22 | In-house | 351-440 (486) | Show / Hide |
Range on Protein: 422-483 Range on HMM: 351-440/486 Sequence Identity: 24% (22 aa) WAAPEVILQKA---------ATVKSDIYSFSMIMQEILTDD-IPWKG-LDG---------SVVKKAVVSGNYL--------EADVRLPKP | |||... . | |||..|| | ||.| |. | .. | . ...| | . |.|.| WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQP |
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| Kinase | SgK307.AA | Pkinase | 420-464 | 26 | 6.4e-05 | 18.49 | Pfam | 175-226 (293) | Show / Hide |
Range on Protein: 420-464 Range on HMM: 175-226/293 Sequence Identity: 26% (14 aa) YNWAAPEVIL-QKAATVKSDIYSFSMIMQEILTDDIPWKGL------DGSVV ....|||||. .. . |.|..|. |. | |. |..| | .. PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQM |
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| Kinase | SgK307.AA | Pkinase | 301-375 | 24 | 0.000209 | 16.66 | Pfam | 56-132 (293) | Show / Hide |
Range on Protein: 301-375 Range on HMM: 56-132/293 Sequence Identity: 24% (20 aa) KLRHPYLLQLMAVCLSQDLEKTRLV--YERITIG----TLFSVLH-ERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHR .|.||. ..| .. . |... | | ||.... .|. | . .... . ..|| .| |.| .|.||| RLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHR |
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| Kinase | SgK307.AA | Pkinase_Tyr | 422-476 | 32 | 0.000287 | 15.08 | Pfam | 180-237 (270) | Show / Hide |
Range on Protein: 422-476 Range on HMM: 180-237/270 Sequence Identity: 32% (19 aa) WAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIP-WKGLDGSVVKKAV-VSGNYLEA | |||.| . |.|||..|| | ||.| ..| ..|.. . |.... .|. ... WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC |
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| Kinase | SgK307.AA | UTK | 422-483 | 32 | 0.005994 | 5.93 | In-house | 205-264 (296) | Show / Hide |
Range on Protein: 422-483 Range on HMM: 205-264/296 Sequence Identity: 32% (21 aa) WAAPEVILQK-AATVKSDIYSFSMIMQEILTD-DIPWKGLDGSVVKKAVVSGNYLEADVRLPKP | |||.. . | |||..|| . ||.| |..|. | ..|. |.. |.|.| WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGR----YRMPCP |
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