Dusty

Species: Human
Alias: Dusty, DustyPK, RIPK5, RIP5, SgK496, KIAA0472, HDCMD38P
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q31-32.1,

Classification

Group: Other
Family: Dusty

Sequence

Name Sequence Type Origin Length Description Download
Dusty.NA RNA Sugen Kinome 8040 None Fasta, JSON
Dusty.AA Protein Sugen Kinome 929 None Fasta, JSON
Dusty.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of Dusty.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Dusty.AA SgK496 652-915 89 1e-227 762.82 In-house 1-265 (265) Show / Hide
Range on Protein: 652-915
Range on HMM: 1-265/265
Sequence Identity: 89% (236 aa)

PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGG-GSSIAVLLIMERLHRDLYTGLKAGLT
|||.||.|||||||||.||||||||.||.|||||||.|||||||.|||||||.|||.|.||.||||||||||| |.||||||||||.||||||..||...
PKLEQEIGRGQYGVVYSCDNWGGHFHCAVKSVVPPDDKHWNDLAMEFHYMRSIPKHDRIVDVHGSVIDYNYGGMGCSIAVLLIMERMHRDLYTAIKANME

LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPE
||.||.||||||||||.||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||..||||
LEERLHIALDVVEGIRYLHSQGLVHRDIKLKNVLLDKHNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGHIKLPE

AFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCK
||||||||||||||||||.|||||||||||||||||||||||||||||||||||||..||.||||
AFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLRSIMDRLCK

Kinase Dusty.AA TKL 658-897 20 2.6e-39 136.91 In-house 1-355 (364) Show / Hide
Range on Protein: 658-897
Range on HMM: 1-355/364
Sequence Identity: 20% (74 aa)

LGRGQYGVVYLC--DNWGGHF------PCALKSVVPPD-------------------------EKHWNDLALEFHYMRSL-PKHERLVDLHGSVIDYNYG
.|.| .|.||     .||| .      . | |     .                         | .|.   .|.  |  .  .|. .| . |.... ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

G------GSSIAVLLIMERL-HRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQG--------LVHRDIKLKNVLLDKQNR--------------AKIT
.      |..    ..||   . .|.  |     .. |...|||.  |. .|||..        ..|||.| ||.|.|. ..              .||.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC

DLGFCK-------PEAMM---------------SGSIVGTPIHMAPELFT-----------------GKYDNSVDVYAFGILFWYICSGSVKLPEAFERC
|.|...        ...|               .....||| .||||..                  ..|. ..|||.|||..| |... .     ..  
DFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----PYYDY

ASKDHL---------WNNVRRGARPERL------------PVFDEECWQLMEACWDGDPLKRP
 . ...         . .. .| ||..             | ....  .||. ||| || |||
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP

Kinase Dusty.AA S_TKc 652-906 19 4.6e-39 137.0 SMART 1-231 (231) Show / Hide
Range on Protein: 652-906
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHR---DLYTGLKAG
 ......|.| .|.||.| . . .  .|.| .        ...  |   ...  .|. .| |...  |          . ..|| .     ||.. .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKR

--------LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDN-SVDVYAFGILFW
        ..  .   ..  ..... ..||.| .|||.|  |.|||.  . ||.| |...       ...|||  ||||..  .|.  ..|....|....
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILY

YICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQ--------PML
  ..|    |         . ......           ..|...... |.. || |||   . |        | .
EMLCGYPPFP-------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF

Kinase Dusty.AA Pkinase 652-897 21 1.2e-38 137.72 Pfam 1-282 (293) Show / Hide
Range on Protein: 652-897
Range on HMM: 1-282/293
Sequence Identity: 21% (64 aa)

PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWND--LAL--EFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERL-HR----DLY
 ..|. .|.| .|.||.| . |     |.| .  ..||.| |  ...  | ..|..| .|.  | |.... |       .  . ..|| . .     ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYVMDLF

----TGLKAGL--TLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRA----KITDLGFC----KPEAMMSGSIVGTPIHMAPEL--FTGKYD
    |  . ..  . ..   ... ...|. ..||.| .|||.|. |.|.|...      ||.| |..            ...|||  ||||.  .  .|.
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

NSVDVYAFGILFWYICSGSVKLPEA--FERCASKDHLWNNVRRGARPERLPVFD--------------------EECWQLMEACWDGDPLKRP
 .||....|..... ..|    |..   .. ...... ......  ..  |  .                    ||| .... |.. || |||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

Kinase Dusty.AA TK 652-906 15 7.2e-31 100.11 In-house 1-486 (486) Show / Hide
Range on Protein: 652-906
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

PKLGQELGRGQYG---VVYLC-------------------------DNWGGHFPCALKSVV---PPDEKHWND--------------LALEFHYMRS-LP
 .||..||.||.|   .||..                         .  ||. |.| | .    . ...   |              .|.|   |.. | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHERLVDLHG--------------------SVIDYNYGGGS---SIAVLLIMERLHRDLYTGLKAG----------------------------------
.|. .| |.|                     .. .   .|.   |    |   | ..  .   ...                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTLETRLQIALDVVEGIRFLHSQ------GLVHRDIKLKNVLLDKQNR-----------AKITDLGFCK
                               ||....| ..... .| ..|||.      ..||||.   |.|....|.           .||.| | ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------PEAMMSGSIVGTPIH------------------------------MAPELFT----------GKYDNSVDVYAFGILFWYICS-GSVKLP--E
        .   ..  . .  .                              |||| ..          ||.    ||..||.| | |.. | .  .   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

AFERCASK---DHLWNNVRRG--------------ARPERLPVFD--------------EECWQLMEACWDGDPLKRPLLGIVQPML
  .....    . . ...|||               |... |                 ||  .||  ||. || .||    .. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase Dusty.AA Dicty5 753-839 37 6.8e-27 89.59 In-house 105-194 (260) Show / Hide
Range on Protein: 753-839
Range on HMM: 105-194/260
Sequence Identity: 37% (34 aa)

TRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-PEAMMSGSI-VGTPIHMAPELFTGK-YDNSVDVYAFGILFW
..| .|.|.  ..|.||| . .|||.|  |.|. .   .|| | |     ..     . |||.  ||.|||.|. |.. .|||.|||  |
QQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLW

Kinase Dusty.AA Ciliate-E2-Unclassified 749-844 24 4.1e-26 87.57 In-house 135-266 (352) Show / Hide
Range on Protein: 749-844
Range on HMM: 135-266/352
Sequence Identity: 24% (33 aa)

LTLETRL-----QIALDVVEGIRFLHSQG-LVHRDIKLKNVLLDKQN---RAKITDLGFCK-------------------PEAMMSGSIVGTPIHM----
.| .  .     ...  ...|. .||...  .|||||. |.|.|...   . ||.|.|..|                   .. ||. ...|||. |    
FTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMW-TFCGTPNYMPQYT

APELFTG-KYDNS----VDVYAFGILFWYICSG
|||.. | .||.|    .|....|... ... |
APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG

Kinase Dusty.AA ULK 755-838 27 1.1e-24 83.11 In-house 133-246 (329) Show / Hide
Range on Protein: 755-838
Range on HMM: 133-246/329
Sequence Identity: 27% (31 aa)

LQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDK------------QNRAKITDLGFCKP------EAMMSGSIV------GTPIHMAPELFTGK-----Y
.|.  . ..| ..||... .|||||. |.|...            ....||.| ||.|       |. |  . |      |||. |||... |.     |
IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPY

DNS-VDVYAFGILF
... .|.. .|..|
YDYKCDIWSLGCIF

Kinase Dusty.AA ULK 755-838 27 1.4e-24 84.14 In-house 129-242 (324) Show / Hide
Range on Protein: 755-838
Range on HMM: 129-242/324
Sequence Identity: 27% (31 aa)

LQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDK------------QNRAKITDLGFCKP------EAMMSGSIV------GTPIHMAPELFTGK-----Y
.|.  . ..| ..||... .|||||. | |. .            ....||.| ||.|       |..|  ..|      |||. |||... |.     |
IQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPY

DNS-VDVYAFGILF
... .|.. .|..|
YDYKCDIWSLGCIF

Kinase Dusty.AA Ciliate-E2 761-844 23 2.5e-24 80.38 In-house 169-292 (365) Show / Hide
Range on Protein: 761-844
Range on HMM: 169-292/365
Sequence Identity: 23% (31 aa)

VVEGIRFLHSQG-LVHRDIKLKNVLLDKQNRAKITDLGFCK--------------PEAMMSGS---------------------IVGTPIHMAPELFTGK
.......|||..  .|||||. |.|.      ||.|.|..|               . .|  .                     |.|||  |||| . ||
IILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGK

----------YDNSVDVYAFGILFWYICSG
          || ..|....|... . ..|
KYDNQQKQKGYDYKCDIWSLGVILYEMLFG

Kinase Dusty.AA CAMK 761-837 21 2.5e-23 71.39 In-house 188-323 (425) Show / Hide
Range on Protein: 761-837
Range on HMM: 188-323/425
Sequence Identity: 21% (29 aa)

VVEGIRFLHSQGLVHRDIKLKNVLLDKQ-----------------NRAKITDLGFC--KPE------------------------AMMSGSIVGTPIHMA
........||.. ||||.|. |.|||.                  |  ||.| ||   ...                          .    .|||  ||
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PELFTGK---------------YDNSVDVYAFGIL
 ||.. ||               |. ..|. . |..
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI

Kinase Dusty.AA LISK-DD1 749-837 35 3.5e-23 80.81 In-house 120-220 (290) Show / Hide
Range on Protein: 749-837
Range on HMM: 120-220/290
Sequence Identity: 35% (37 aa)

LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQ----NRAKITDLGFCKPEAMMSGS----------IVGTPIHMAPELFTG-KYDNSVDVYA
.. . |. ||||. .. ..||| ...||| | || |.|.     .|.|. |.|| .   |....          |.||.. ||||. .| .|| |.||. 
IPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFAR---MFEQKKNQQNNRHMTICGTDNWMAPEVILGMSYDWSCDVFS

FGIL
||..
FGMV

Kinase Dusty.AA Pkinase_Tyr 653-906 25 3e-21 72.57 Pfam 2-270 (270) Show / Hide
Range on Protein: 653-906
Range on HMM: 2-270/270
Sequence Identity: 25% (70 aa)

KLGQELGRGQYGVVYLCDNW----GGHFPCALKSVVPP--DEKH--WNDLALEFHYMRSLPKHERLVDLHGSVI-DYNYGGGSSIAVLLIMERLHR-DLY
..|..||.|..|.||..       ... |.| |.. ..  ....  . |.  |   |..|..|. .| |.| .. .   .      ....||     ||.
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLL

TGLKAG------LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPE-------AMMSGSIVGTPIH-MAPE-LFTGKYDN
. |..       ||... ||..... .|  .|.|....|||.  .|.|....| .||.| | ..          . .|.    ||  |||| ...||.  
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTT

SVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNV-RRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML
  ||..||.| | |..     | ... . |   . . . ..| | .. .   .|  .||  ||. || .||    .. .|
KSDVWSFGVLMWEIFTYGE-QP-TYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase Dusty.AA TyrKc 652-906 22 4.3e-18 67.36 SMART 1-280 (280) Show / Hide
Range on Protein: 652-906
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSL-PKHERLVDLHGSVIDYNYGG-------GSSIAVLLIMERLHRDLYT
 .||..||.|..|.||..       ..| |.. .       |.  |   |..| ..|. .| |.| ...    .       .    |.  |.    . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQ----QGRNFMYIEPLMIVMEYMPHGDLKDYL

GLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMM------SGSIV------GT---PIH-MAPELF-TGKY
  . . |.... |...... .| ..|||....|||.   |.|.......||.| | ..           .  ..      |    ||  |||| . .||.
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DNSVDVYAFGILFWYICSGSVKLPEA--FERCASKDHLWNNVRRGARPERLPV--------FDEECWQLMEACWDGDPLKRPLLGIVQPML
    ||..||.. | |..   . ..   ..   | ... ..|..| |... |           .|  |.|. ||. || .||    .   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase Dusty.AA CAMK 657-669 61 4.6e-05 11.47 In-house 1-13 (425) Show / Hide
Range on Protein: 657-669
Range on HMM: 1-13/425
Sequence Identity: 61% (8 aa)

ELGRGQYGVVYLC
.||||..|.|.||
TLGRGSFGKVKLC

Kinase Dusty.AA Ciliate-E2 652-672 38 0.000625 9.36 In-house 1-21 (365) Show / Hide
Range on Protein: 652-672
Range on HMM: 1-21/365
Sequence Identity: 38% (8 aa)

PKLGQELGRGQYGVVYLCDNW
 |. . .|.|..|.||.| .|
YKFIKKIGQGNFGSVYKCKVW

Kinase Dusty.AA Ciliate-E2-Unclassified 653-669 41 0.004134 6.66 In-house 2-18 (352) Show / Hide
Range on Protein: 653-669
Range on HMM: 2-18/352
Sequence Identity: 41% (7 aa)

KLGQELGRGQYGVVYLC
|... .|.|..|.||.|
KIIKQIGQGGFGKVYKC

Kinase Dusty.AA LISK-DD1 657-668 50 0.106894 2.21 In-house 1-12 (290) Show / Hide
Range on Protein: 657-668
Range on HMM: 1-12/290
Sequence Identity: 50% (6 aa)

ELGRGQYGVVYL
| |.| .| ||.
EIGKGSFGKVYK