Gene skMLCK (Human)

skMLCK

Species: Human
Alias: MLCK, skMLCK, MYLK2, KMLC
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 20q11.1,

Classification

Group: CAMK
Family: MLCK

Sequence

Name Sequence Type Origin Length Description Download
skMLCK.NA RNA Sugen Kinome 2793 None Fasta, JSON
skMLCK.AA Protein Sugen Kinome 596 None Fasta, JSON
skMLCK.kin_dom Protein Kinase Domain Sugen Kinome 256 None Fasta, JSON

Protein domain

Protein domains of skMLCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase skMLCK.AA MLCK 285-540 62 9.69999999999e-236 629.15 In-house 1-257 (257) Show / Hide 
Range on Protein: 285-540
Range on HMM: 1-257/257
Sequence Identity: 62% (161 aa)

MNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTM
.. .| ||.|||| |. |.||.||...|||.|| ..|||||.|. |||.||||.|.||||...| ||..|.|..||||.||||||||||||.|||| ...
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

VFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEK-LKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFL
...||||.|. .||.....|||||||||.|.. |.| .|||||||||.|.|.|| .||.||||||..|||||||... .|||||.|||.||||||||||.
HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM

GDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
||.| ||.|||.|..|.||.|.|...|||||||.|.| |||.. || |..||.||||
GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase skMLCK.AA DAPK 287-540 42 1.1e-118 328.54 In-house 1-264 (264) Show / Hide 
Range on Protein: 287-540
Range on HMM: 1-264/264
Sequence Identity: 42% (113 aa)

SKEALGGGKFGAVCTCMEKATGLKLAAKVIKK-QTPKD-----KEMVLLEIEVMNQLN-HRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVD--EDYH
  | || |.| .|  | .| ||.. ||| ||| .. ..      |  . || .  ..  | |.| | .. ||  ...|  ||  |||||  ..   |. .
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREE-C

LTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHL--VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYML
|.|.|   |..|| .|. ..|  .. ||||||.||.  .    .  .|||||||.|. .. | ..  .||||.. ||.|||. .|  ||||| |||||..
LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM

LSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
||| ||||||.  ||. |.   |  |.||.|. .| .||||   | ||| . ||.|..|| |||.
LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase skMLCK.AA CAMK 290-540 25 1.1e-115 374.42 In-house 1-425 (425) Show / Hide 
Range on Protein: 290-540
Range on HMM: 1-425/425
Sequence Identity: 25% (109 aa)

ALGGGKFGAVCTCMEKATG------------LKLAAKVIKKQ----------------------------TPKDKEMVLLEIEVMNQ-------LNHRNL
 || | || |  |..| |.             | |.|.|.|.                            .|||...|. |||.|..       |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLYAAIETPH-------------------EIVLFM---EYIEGGEL----FERIVDE--------------DYHLTEVDTMVFVRQICDGILFMHKMRV
|.|| ..|.||                   .....|   ||..||||    |..||.               . ..|| ..  ..||||... ..|.. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHLDLKPENILCVNTTG---------------HLVKIIDFGLARRYNP------------------------NEKLKVNFGTPEFLS-PEVVNY------
 |.||||||||...  .               . .||||||.|....|                        ..|.|  .||||. . |||.|.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------DQISDKTDMWSMGVITYMLLSGLSPFLGD-------------DDTETLNNVLSGNWYFDEETFEA------------VSDE--------AKD
        . .. |.||||.|||.|..|.| .|| ||             .| |.. ....|...|... |              .|||        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FVSNLIVKDQRARMNAAQCLAHPWL
..... ..|   ||...|||.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase skMLCK.AA Trio 286-540 35 9.90000000001e-107 274.57 In-house 2-258 (258) Show / Hide 
Range on Protein: 286-540
Range on HMM: 2-258/258
Sequence Identity: 35% (92 aa)

NSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMV
. .| .| | |. |  | .||||. .||| | .. ..||| |. | |..  | |  ...| .. |||   .|  | . .||| ..... .  ..| .. .
TFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYR-MMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWG-SYCESEVKT

FVRQICDGILFMHKMRVLHLDLKPENILCVNTTG--HLVKIIDFGLARRYNPN--EKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSP
...|.  ..   |  ..||||.||||.. .   .    .||.||| |  ..|   | .    |.||| .||... . .|  || ||.||.|| .||| ||
YMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISP

FLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
|....| ||. |.. |.  | |..|  || .||.|.  . . | ..|  |..||.|||.
FYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
Kinase skMLCK.AA DAPK 285-540 43 4.3e-99 286.45 In-house 1-264 (264) Show / Hide 
Range on Protein: 285-540
Range on HMM: 1-264/264
Sequence Identity: 43% (116 aa)

MNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPK------DKEMVLLEIEVMNQLN-HRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYH
    | .| | |  |  | || ||.. ||| |||   .        | .  |. .  ..  | | | | .. |.  ..||  | . |||||  . ... .
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKE-C

LTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHL--VKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYML
|.|.    |. || ||. .||  .. |.|||||||   .       .||||||||.|  | .  |  ||||||  ||.|||   .  ||||| ||||| |
LNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYIL

LSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
||| ||||||   ||| |.   |  |||| |   |  ||||.  |.||| . ||  ..|| ||| 
LSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase skMLCK.AA CAMK1 288-540 34 1.8e-91 266.16 In-house 4-276 (276) Show / Hide 
Range on Protein: 288-540
Range on HMM: 4-276/276
Sequence Identity: 34% (94 aa)

KEALGGGKFGAVCTCMEKAT---GLKLAAKVIK-KQ-TPKDK----EMVLLEIEVMN---QLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDED
.. .| | |. |  | .| |   | . | |.|. |. . |..    |... |||.|    ...| | |..|   |.. .. | ||.. |||||.|||. .
GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKG

YHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNT-TGHLVK--IIDFGLARRYNPNE-KLKVNFGTPEFLSPEVVNY---DQISDKTDMWSM
 . || |    ..||.. . .||.. . | ||||||.|...   .. .|  |.||||.......| ..|  .|||..  |||...   .  . . |||| 
-NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSI

GVITYMLLSGLSPFLGDD-DTETLNNVLSGNWYFDEETFEAVSDE-AKDFVSNLIVKDQRARMNAAQCLAHPWL
||||| || | .|| ... | | .  .... . |..  .  .||. ||||.......|   | ...|||.|||.
GVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase skMLCK.AA S_TKc 285-540 30 5.5e-87 296.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 285-540
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

MNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEG--GELFERIVDEDYH-----
    . .| | || |. | .| || . | |.||       |... ||... . .| |...|| .... ... ..|||..|  |.||..|..  .|     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISD-KTDMWSMGVITYMLL
..| ..  ...|||... ..|.....| ||||||||. .     .||.||||||..      .   |||....|||.   . .  | |.|| |.| | .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLA-------HPWL
.|  ||   .. .......              |.|||||.... .|| . |. | ..|.       |||.
CGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase skMLCK.AA DRAK 287-540 40 2.5e-85 265.04 In-house 1-259 (259) Show / Hide 
Range on Protein: 287-540
Range on HMM: 1-259/259
Sequence Identity: 40% (104 aa)

SKEALGGGKFGAVCTCMEKATGLKLAAKVIKK-QTPKDKEM-VLLEIEV-MNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFE-RIVDEDYHLTEVD
    .| ||| .|  | .| ||   ||| .|| .  .| .| .| || | |.     ..| | .  ||  |..| .||  |||.|.  . |..  ..| |
TAKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKD

TMVFVRQICDGILFMHKMRVLHLDLKPENI-LCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSP
 .  .||| .|. ..|.  . |||||| || |   .    .||.|||..|  .  | .    |||... ||. ||| |.  ||||| ||.||..|...||
VQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP

FLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
|.|||  ||  |.   |  . ||.|. .|..| ||.  |.|..   ||.| .|| ||||
FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase skMLCK.AA Pkinase 285-540 33 9.8e-82 282.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 285-540
Range on HMM: 1-293/293
Sequence Identity: 33% (98 aa)

MNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKE--MVLL--EIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGG----ELFERIV-DED
   .. .| | || |. |..| || . | |.|||.. |...    ..  ||..|. ||| | ..|| . |.. .| . ||| |||    .||..|  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

YHL--TEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHL---VKIIDFGLARR--YNPNEKLKVNFGTPEFLSPEVVN-YDQISDKTDMWS
  .  .| .   ...||. |. ..|.|...| ||||||||..  .||.   |||.|||||.   | .|. ...  |||....|||.. .  .. | ||||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

MGVITYMLLSGLSPFLGD------DDTETLNNVLSGNWYFDEETFEAVS-----------------DEAKDFVSNLIVKDQRARMNAAQCLAHPWL
.|.| | .|.|  || |.      |. . ....... . ||...   .|                 .|.|||..... ||   | .|.|.| |||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase skMLCK.AA CDPK 285-540 35 2.6e-75 230.5 In-house 1-271 (271) Show / Hide 
Range on Protein: 285-540
Range on HMM: 1-271/271
Sequence Identity: 35% (96 aa)

MNSKEALGGGKFGAVCTCMEK-ATGLKL-AAKVIKKQTPKDKE---MVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFME--YIEGGELFERIVDEDYH
.  |. || | || |. . .| .|. .  | |.|.|   ||||   ... |||.. || | | |..|   .    . . ||  | .|||||..|... . 
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH-

LTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENIL-CVNTTGH----LVKIIDFGLARRYNPN-----EKLKVNFGTPEFLSPEVVNYDQISDKTDMWS
.|| ..   .|||   .  .|.  . | |||||||| . . ..      .|.||.|.......|     .|..  .|||  ..||| .      | | ||
FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWS

MGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
 ||| | ||.|  || |. | |....|  |.  |. . .. .|||||| .......|.  || |.|.|.||| 
CGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase skMLCK.AA CAMK-Unique 285-540 23 9.5e-72 236.08 In-house 1-363 (363) Show / Hide 
Range on Protein: 285-540
Range on HMM: 1-363/363
Sequence Identity: 23% (87 aa)

MNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVL--------------------LEIEVMNQLNHRNLIQLYAA----IETPH-------
    . .| | || |  || ..|| | | |..||||.. | ...                     |....  ..| |.|.||       ...        
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------EIVLFMEYIEGGELFERIVDE-------------------DYHLTE--VDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNT-------
        .....|||..||.||. |..                      |..|   ||   ....   . .||.  . | |||.|||.  .        
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

-------TGHLVKIIDFGLARRYNPNEKLK---VNFGTPEFLSP--------------EVVNYDQISDKT----DMWSMGVITYMLLSGLSPFLGDDDT-
         . .|..||||.. || |..     .  |||....|              ||.| . .. .     | ||.|||.|..|.| .|| ....  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ETLNNVLSGNW-YFDEETFEA---VSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
       |.. . ..|.  .||.. ..    .|.|||||| .. . |.  | .|.. | |.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase skMLCK.AA Ciliate-E2 285-540 21 1.8e-66 227.11 In-house 1-365 (365) Show / Hide 
Range on Protein: 285-540
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

MNSKEALGGGKFGAVCTCMEKATGLKLAAKV--------------------IKKQTPKDKEMVLLEIEVMN----------------QLNHRNLIQLYAA
 .  . .| | || |. |  . .. . | |.                    .| . ....|... || .|.                |||| |.|..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--TPHEIVLFMEYIEGGELFERIVDED----------YHLTEVDTMVFVRQICD---------------GILFMHKMR-VLHLDLKPENILCVNTTGH
 .  . . | | |||..||.||..| . .            .||     . .||..               .. ..|.   ..| |.||||||       
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

LVKIIDFGLARRYNPN----------EKLKVNF-----------------------GTPEFLSPEVVNYDQ---------ISDKTDMWSMGVITYMLLSG
 .|||||||...|...          ....  .                       |||....||..|. .          . | |.||.||| |..|.|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

LSPFLGDDDTETLNNVLSGNWYFDEE--------------TFEAVSDEAKDFVSN----LIVKDQRARMN-AAQCLAHPWL
  ||        ... . ... |...               .. .|.|.||. ..    ...||.  |.. . |.| |||.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase skMLCK.AA Pkinase_Tyr 285-470 27 1.2e-16 57.03 Pfam 1-202 (270) Show / Hide 
Range on Protein: 285-470
Range on HMM: 1-202/270
Sequence Identity: 27% (57 aa)

MNSKEALGGGKFGAVCTCMEK----ATGLKLAAKVIKKQTPKD---KEMVLLEIEVMNQL-NHRNLIQLYAAIE--TPH-EIVLFMEYIEGGELFERIVD
    . || | || |. .  |     |... | |..| .. ..   .|. . |...| || .| |...||...     . .| . ||| ..| | .   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---DYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKL-KVNFGTPEF----LSPEVVNYDQISDKTDM
    . .||  |   . .||..|  . . ..  | ||   |.|  .  .. ||| ||||||   . .   ..  |.. .    ..||. ||   . |.| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDV

WSMGV
|| ||
WSFGV
Kinase skMLCK.AA TyrKc 285-536 22 1.5e-15 28.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 285-536
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

MNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQL--NHRNLIQLYAAIETP-------HEIVLFMEYIEGGELFERIVDED
   .. || | || |. .. |   .. | |..|. .   .|. . |...| .|  .| |...||... ..       . . . ||| ..| | ... .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

YHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPN-------EKLKVNF--GTPE-----FLSPEVVNYDQISD
 .|.  |   |  ||..|  . |.... | ||   |.|  .     ||| ||||.|            .  ..    |.        ..||. ||   . 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KTDMWSMGVITY-MLLSGLSPFLG-----DDDTETLNNVLSGNWYFDEET-----FEAVSDEAKDFVSNLIVK--DQRARMNAAQCLA
|.| || ||  . ..  | .|  |      ...| ...| .|.     .      |   .||  .  .       ..| ....   . 
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF