Gene SYK (Human)

SYK

Species: Human
Alias: SYK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9q22,

Classification

Group: TK
Family: Syk

Sequence

Name Sequence Type Origin Length Description Download
SYK.NA RNA Sugen Kinome 5081 None Fasta, JSON
SYK.AA Protein Sugen Kinome 635 None Fasta, JSON
SYK.kin_dom Protein Kinase Domain Sugen Kinome 249 None Fasta, JSON

Protein domain

Protein domains of SYK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 SYK.AA SH2 15-92 34 2.1e-36 108.71 Pfam 1-81 (81) Show / Hide 
Range on Protein: 15-92
Range on HMM: 1-81/81
Sequence Identity: 34% (28 aa)

FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR---KAHHYTIERELNGTYAIAGGRTHASPADLCHYH
...|.|.|.|||..| ..|. || .|.|.|... |...||| ..    . .|| | |. ||.| |.|.....| ..|....
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 SYK.AA SH2 13-98 37 4.7e-30 107.08 SMART 1-87 (87) Show / Hide 
Range on Protein: 13-98
Range on HMM: 1-87/87
Sequence Identity: 37% (33 aa)

LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAG--GRTHASPADLCHYHSQESDG
 |...|||.|||||. | ..|| || .|.|.|..  |...||| ...| .|| |.|. .| | |..  .|.. |  .| ..... ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 SYK.AA SH2 168-244 39 1.4e-38 115.06 Pfam 1-81 (81) Show / Hide 
Range on Protein: 168-244
Range on HMM: 1-81/81
Sequence Identity: 39% (32 aa)

WFHGKISREESEQIVLIGSKTNGKFLIRARD-NNGSYALCLLHEG---KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHY
|.||||||.| |.. . . ...| ||.| .. . |.|.|.....|   .| |||| ....|.. | ...||..|..|||||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 SYK.AA SH2 166-250 42 5.4e-32 113.52 SMART 1-87 (87) Show / Hide 
Range on Protein: 166-250
Range on HMM: 1-87/87
Sequence Identity: 42% (37 aa)

MPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTGKLSIPE--GKKFDTLWQLVEHYSYKADG
.||.||.||||| ||. . ... .| ||.| ... .|.|.|.. ..||| |||| ....|| .| |  ..||..| .||.||.  ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase SYK.AA Syk 371-620 65 1e-206 693.04 In-house 1-257 (257) Show / Hide 
Range on Protein: 371-620
Range on HMM: 1-257/257
Sequence Identity: 65% (169 aa)

TLEDKELGSGNFGTVKKGYYQMK-----KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-
...|.|.|.||||.|.||.|.||     |....||.|.||...|.||.|.|...||.||.|||.|.||||||||.||..|.|||||||||..|||||.| 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

HVKDKNIIELVH-QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW
.....|..||.| ||.|||.||||..||||||||||||||..|||||||||.||||.||..||.|.|||||||||||||||.|||||.|||||||||.||
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFA
|.||||||||..|||.||....|.|.||.||.|||.|||.|||.||.|....||.| 
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Pkinase_Tyr SYK.AA Pkinase_Tyr 370-626 43 1.8e-127 432.31 Pfam 1-270 (270) Show / Hide 
Range on Protein: 370-626
Range on HMM: 1-270/270
Sequence Identity: 43% (119 aa)

LTLEDKELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPA-LKDELLAEANVMQQL-DNPYIVRMIGICE--AES--WMLVMEMAELGPLNKYLQ
.|.  |.||.|.||.|.||..   ...   .||||.||. | ... .......||..| || ..| |||..|.|    |.  ...||| ...| | .||.
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

Q----NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY-KAQTHGKWPVKWYAPECINYYKFSSKSDVW
.    ..... | ...  .|...|| |||. |..||||||||.|.  .. .||.||||....  .. || .....||.|.||.|||||||.||..|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGVLMWEAFSYGQKP-YRGMKGSEVTAML-EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL
|||||||| |.||..| | ||. .|| ... |.|.|| || .|| |.|||| .|| || |.|| |...  .|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase SYK.AA TyrKc 371-626 40 1.2e-122 414.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 371-626
Range on HMM: 1-280/280
Sequence Identity: 40% (116 aa)

TLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL--DNPYIVRMIGICEA--------ESWMLVMEMAELGPLNKYL
   .|.||.|.||.| || .       .|||| ||..|     . ... ||..| .|  ..| |||..|.|          |  |.||| ...| |..||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD------ENYYKAQT--HGK--WPVKWYAPECINYYKF
. .|. .. |  ..  .|.. || ||.. |..||||||||.|.  .| .||||||||...  |      . ||....  .||  .|..|.|||||||.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SSKSDVWSFGVLMWEAFSYGQKPYRG-----MKGSEVTAMLEKGERMGCPAG--------CPREMYDLMNLCWTYDVENRPGFAAVELRL
..|||||||||.||| |.|||.|| |     |. .|| . ...|.|| .|.         || |||..|  || .| |.|| |...  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SYK.AA TK 371-626 24 3.1e-105 353.83 In-house 1-486 (486) Show / Hide 
Range on Protein: 371-626
Range on HMM: 1-486/486
Sequence Identity: 24% (117 aa)

TLEDKELGSGNFG---TVKKGYYQMK-----------------------KVVKTVAVKILK--NEANDPALKD----------ELLAEANVMQQLD----
    |.||.|.||   .| || ....                       ... .||||.||  ..... . .|          . |.||..|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NPYIVRMIGICEAES-------------WMLVMEMAELGP----LNKYLQQNRH---------------------------------------------
  | |||..|.|  .              ||.|||....|     | .||...|.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VKDKNIIELVHQVSMGMKYLEES------NFVHRDLAARNVLLVTQHY-----------AKISDFG---
                               .  .  .   .|.. || ||..       |||||||||||.|.  ..            .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKALRADENYYKAQ-----------------------THGKWPVKWYAPECIN---------YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK
     |....  |..||...                       . ||.|..|.||||.|         | ||..||||||||||||| |.|||.|| |. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

G----------SEVTAMLEKG--------------ERMGCPAGCP--------------REMYDLMNLCWTYDVENRPGFAAVELRL
            ||  .|..|               || .|..||               |.||||  || || | || |...  .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase SYK.AA UTK 375-626 33 7e-96 324.84 In-house 5-296 (296) Show / Hide 
Range on Protein: 375-626
Range on HMM: 5-296/296
Sequence Identity: 33% (97 aa)

KELGSGNFGTVKKGYYQMKK---VVKTVAVKILKNEANDPALKD---ELLAEAN---VMQQLD-NPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQN
..||.|.||.| |. ..  .    .  |||| ....|...  ..   ... ||.   .|.|..  |...|..|.|   | ||.|.|..| | | .||. .
RQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRH

RH--------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH-------YAKISDFG---LSKALRA--------DENYYKAQTHGKWPVK
|.        ...   .. . ... || ||.. .||||||||||.|.  ..        .||.|||   .|... .        . .||.||  ..||..
RPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIR

WYAPECINYY-KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG--ERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL
|.|||....  .|..|||||||||..|| ...|..|| ||   .|.. ...|   || ||..||...|.||. ||.||...|| |  .. ..
WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase SYK.AA Ack 370-626 38 1.1e-86 292.49 In-house 1-266 (266) Show / Hide 
Range on Protein: 370-626
Range on HMM: 1-266/266
Sequence Identity: 38% (104 aa)

LTLEDKELGSGNFGTVKKGYYQM--KKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRH
.||  ..||.| || |..|       |..  ||||.|. .  . |   |..| |...| .|| | .||  |.  .    |.|.|.|..| |   | .  |
ITLC-EKLGDGCFGVVWRGEWTNPGGKHIQ-VAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK--H

VKDKNI-IELVH----QVSMGMKYLEESNFVHRDLAARNVLLVTQ-HYAKISDFGLSKALRADENYYKAQTHG--KWPVKWYAPECINYYKFSSKSDVWS
 ..    | . .    |. ||| ||| ....||||||||.|| ..   .||.||||. ||   |.||. . |   | |  | ||||... .||..||||.
CRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWM

FGVLMWEAFSYGQKPYRGMKGSEVTAMLE-KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL
||| .|| ||||..|. |. |...   .. .|||   |  ||.. |..|  ||. ... || |.|..  |
FGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase SYK.AA Fer 370-627 35 3.3e-86 292.7 In-house 1-283 (283) Show / Hide 
Range on Protein: 370-627
Range on HMM: 1-283/283
Sequence Identity: 35% (102 aa)

LTLEDKELGSGNFGTVKKG------YYQMKKVVKTVAVKILKN--EANDPALKDELLAEANVMQQ-LDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKY
 ||..| ||.|.||.|.||      . ... ||  ||||  |.  |. . . . |...||..|.. .| |..|. .|.|   .  |.|||..  | | .|
VTLGKK-LGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LQQNRH--VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT-QHYAK--ISDFGLSKALRADENYYKAQ-THGKWPVKWYAPECINYYKFSSKS
|. | .  |.|. .|. ..|.. ||.||.. | .|||.||||.|.   ... |  |||||.|.... ... ||   .. | |..| |||....  .|.|.
LKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKT

DVWSFGVLMWEAFSYGQKPYRG----MKGSEV-----TAMLEKGERMGCPAGCPREMYDLMN-LCWTYDVENRPGFAAVELRLR
|||||||..|| |. |..|| |    ||  .|      .  .|| .| .| ..| |.. .|   ||..| |.|| .. .  .|.
DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase SYK.AA Src 370-626 41 3.8e-85 289.2 In-house 1-255 (255) Show / Hide 
Range on Protein: 370-626
Range on HMM: 1-255/255
Sequence Identity: 41% (108 aa)

LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQ---QNRH
..|..| ||.|.|| | .||.  .. .| |||| ||         . .|.||..| .|. . .|..  .|  |     | |  . | | .||.   . ||
IKLCRK-LGQGQFGEVWMGYW--NGNTK-VAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEA
.. .. |..  ||. ||.|||. |..||||||||||  ..  .|. |||| . .  |.. | |..  | |.|| |||.||| .|. ||||||||.|..| 
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

FSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD-LMNLCWTYDVENRPGFAAVELRL
..||. ||.||.  ||  ..|.| || ||..|| |.|. .|  ||  | | || |.     |
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase SYK.AA FAK 372-631 38 2.2e-84 282.68 In-house 2-285 (285) Show / Hide 
Range on Protein: 372-631
Range on HMM: 2-285/285
Sequence Identity: 38% (110 aa)

LEDKELGSGNFGTVKKGYYQMKKV-------------------------VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWML
   . .| | || | .| |   |                          .  ||.|  |..  |.  |.. ..|| .|.|.| | ||..||||| .   .
TLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCC-DDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

VMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN
.||....| | .||| |.   |    |    |..| | |||  .||||| |||||| . .   |  |||||  .  |. ||||   || |.|| .|| ||
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMH-DHSYYKASPKGKLPIKWMSPESIN

YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYY
.  | . |||| ||| |||  .|| ||. ..| ..|   .|.|||.  |. ||  .| || .|| ||   || |  .  .|.. | 
FRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase SYK.AA EGFR 371-627 41 3.6e-82 272.62 In-house 1-258 (258) Show / Hide 
Range on Protein: 371-627
Range on HMM: 1-258/258
Sequence Identity: 41% (108 aa)

TLEDKELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVK
.  .| |||| |||| || .  . ..|   ||.|.| .|. .|  ..|.| || ||  .|.|..||..|.| ... .||  .  .| |  |..|.. .. 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVL-REQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIG

DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS
 .. .    |.  ||.||||   |||||||||||. .    || ||||.| | .||. |.||  || |.|| | ||| . .. ..|||||.|| .||   
SQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQ-GGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMT

YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR
.||||| |.. .|.  .||||||.  |  |   .| .|  ||  | . ||.|     ...
FGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase SYK.AA Frk 375-630 39 7.8e-79 268.22 In-house 5-260 (260) Show / Hide 
Range on Protein: 375-630
Range on HMM: 5-260/260
Sequence Identity: 39% (103 aa)

KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVM-EMAELGPLNKYLQ----QNRHVKDK
..|||| || |  | .    .   |||| ||  . ||    ..|.|| .|..|  | ....  .|  |  .... |. . | | .|||    . |... .
RRLGSGQFGEVWEGLWN---NTTPVAVKTLKPGTMDPN---DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQ

NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN-YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY
 ....  ||  || |||. |..||||||||||.  .   || |||| . |  |.   | ...  . |.|| ||| .|| ||. ||||||||.|. |   |
QLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITY

GQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY
|. || || . ||  |...| || .|..|| ..|..|  ||  | ..|| |  .. .| .|.
GRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase SYK.AA Csk 370-626 41 4.2e-77 262.46 In-house 1-251 (251) Show / Hide 
Range on Protein: 370-626
Range on HMM: 1-251/251
Sequence Identity: 41% (109 aa)

LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES--WMLVMEMAELGPLNKYL--QQNRH
|.| . . | |.|| |. | || .|    |||| .|...|  |  . .|||| || ||  |  |..||.   .     .|||    | |  ||      .
LHLGE-CIGHGEFGDVMQGEYQNRK----VAVKCIKCDGNGMA--QAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHV

VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA-QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWE
.. .  .     |  || |||. .||||||||||.|.  .  ||.|||||.|    .|..     | || |.|| |||     |||.||||||||.|.||
ITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK----EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWE

AFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL
 .|.|  ||  .  ..| .  ||| ||  | ||| . | .|. ||  .  .|| |. |  .|
IYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase SYK.AA S_TKc 371-630 21 2.4e-46 161.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 371-630
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

TLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAEL--GPLNKYLQQNRH---
    ...|.| ||.|.|..       . ||.||.|         . .. | ..... . |.||....... ..  .|||...   | | .|......   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KSDVWSFGVL
        .  ...|.  ...|. . ...||||   |.|| .    ||.||||.. |          |.      . ||| .   ...  |.|.||.|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

MWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL-----RLRNYY
..| .. |. |..     .. .|..|          ..|. |... |...| |.||.   .       ..  . 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SYK.AA Pkinase 371-622 22 1.2e-36 130.6 Pfam 1-287 (293) Show / Hide 
Range on Protein: 371-622
Range on HMM: 1-287/293
Sequence Identity: 22% (68 aa)

TLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA--EANVMQQLDNPYIVRMIGICEAESWML-VMEMAELG----PLNKYLQ--
    . .|||.||.|.|..   |.  |.|||||.| . ...  . ...   |. .|. |. |.|||.....| ....  ||| .| |     |  |..  
YHIGRKIGSGSFGCVYKCHH--KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

QNRHV--KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA----KISDFGLSKALRADENYYKAQTHGKWPV---KWYAPECIN-YYKFSS
... .   .. ..  . |.  |..|. . ...||||   |.|.. . .     ||.||||.| ..     |  ..  ....    . ||| |. . . ..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVWSFGVLMWEAFSYGQKPYRGM----KGSEVTAMLEKGERMGCPAGCP-----------------------REMYDLMNLCWTYDVENRPGFAAV
|.|.||.|....| .. |. |..|     .  .  .|...  .   .  .|                       .|. |... |...| . ||... .
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI