Gene TAK1 (Human)

TAK1

Species: Human
Alias: TGF1a, TAK1, MAP3K7
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6q15-q16,

Classification

Group: TKL
Family: MLK
Subfamily: TAK1

Sequence

Name Sequence Type Origin Length Description Download
TAK1.NA RNA Sugen Kinome 2850 None Fasta, JSON
TAK1.AA Protein Sugen Kinome 606 None Fasta, JSON
TAK1.kin_dom Protein Kinase Domain Sugen Kinome 248 None Fasta, JSON

Protein domain

Protein domains of TAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TAK1.AA TAK1 36-283 52 5e-187 627.62 In-house 1-284 (284) Show / Hide 
Range on Protein: 36-283
Range on HMM: 1-284/284
Sequence Identity: 52% (149 aa)

IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE------SESERKAFIVELRQLSRVNHPNIVKLYG--ACLN-PVCLVMEYAEGGSLYNVLHGAEPLPYYT
|..|..||.|..|||||||||.|..|.|..|      .|.|.|....|..|.|||.||||.||||  || . ..||||||...|||.|.||||.| ..||
IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFLHGAKPKWEYT

AAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEV----------------------FEGS
.||||||..||.||||||||||||..||||.||.|.||......||||||||.||....||.|.|...||||||                      |...
HAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTFCDMHQMMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCE

NYSEKCDVFSWGIILWEVITRRKPFDEIGGP--AFRIMWAVHNGTRPPLIKN---LPKPIESLMTRCWSKDPSQRPSMEEIVKI
.|..|||..|||||.||||.|..|.|.|..|  |.|||||.|||.|||...|   .||.||..|..||...|..||||.|.||.
KYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase TAK1.AA MLK 36-284 42 3.7e-145 488.52 In-house 1-291 (291) Show / Hide 
Range on Protein: 36-284
Range on HMM: 1-291/291
Sequence Identity: 42% (124 aa)

IEVEEVVGRGAFGVVCKAKWRAKD-----VAIKQIE--------SESERKAFIVELRQLSRVNHPN----IVKLYGACLNP---VCLVMEYAEGGSLYNV
|...|..| |.||.|.|..||.||     ||.|...        ...|...|  | |.|....|||    |...||.||.|   .|.||||.||||||||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGAEPLPY-----------YTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA-----GGTVLKICDFGTACDIQTH---MTNNKGSAAWM
||||.. ..           |. .|||.|.|||..|..|||||.||..||||||..|.|. .     ....||||||||..|....   |..|.|..|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEVF---EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM
||||.   ... |||||||.|||..|||..||. |....  |.....|...||.|||.... |.....||..||. ||..|||. .||.. 
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase TAK1.AA TKL 42-284 27 1.7e-107 363.39 In-house 1-364 (364) Show / Hide 
Range on Protein: 42-284
Range on HMM: 1-364/364
Sequence Identity: 27% (104 aa)

VGRGAFGVVCKAKWRA----------KDVAIKQIESES-----------------------------ERKAFIVELRQLSRVNHPNIVKLYG--------
.|.|.||.|.|.|||           ||||.|.. |..                             .|. ...|....|| .|||||...|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-ACLNP------VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP-----KALIHRDLKPPNLLLVAGGTV------------
 .|..|       |.||||..||||...||           . ..|.|....|..|||||.|     ...||||||..|.|.   .|.            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-LKICDFGTACDIQTH---------------------MTNNKG-SAAWMAPEVFEGS----------------NYSEKCDVFSWGIILWEVITRRKPFDE
 .||||||.. .....                     .|.... . .||||||..|.                 |||||||.|.||.|||..||..|...
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

IGGP--------AFRIMWAVHNGTRPPLI------------KNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM
.. .           .|.....| |||.             .. |... .||..||. ||..|||..||.|..
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TAK1.AA TKL-Unique 38-284 35 8.7e-77 261.41 In-house 1-290 (290) Show / Hide 
Range on Protein: 38-284
Range on HMM: 1-290/290
Sequence Identity: 35% (102 aa)

VEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN-HPNIVKLYGACL----NPV--CLVMEYAEGGSLYNVLH-------G
. ...|.|..|.|.|.||| ..|||||..     | .... |. |.. ... . |||||...|.|      |   |.|||| .|||||.|||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

AEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGG----TVLKICDFGTACDIQ--THMTNN----------KGSAAWMAPEVFE
 ..    . .  ..  ....||  |||. .|.  ||||||..|.|.. .        ||||||..      . ||||          .||. ||||||..
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

G--SNYSEKCDVFSWGIILWEVITRRK------PFDEIGGPAFRIMWAVH-NGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM
.  . ||||.||.| ||.||| .||        |....   . . | ..   . |||.  ..|| .  |...||  ||||||| .||..  
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase TAK1.AA Dicty4 36-286 34 2.8e-75 250.53 In-house 1-277 (277) Show / Hide 
Range on Protein: 36-286
Range on HMM: 1-277/277
Sequence Identity: 34% (96 aa)

IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER--KAFIVELRQ----LSRVNHPNIVKLYGACL----NP--VCLVMEYAEGGSLYNVLHG-----
| .|.  |.|.|| | |..|| |.||.|   .  .    ... |.|.    ..   ||||....|||.    .|  .| |.||   |.||..||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--AEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DI-QTH-MTNNKGSAAWMAPEVFEGSNYSEKC
    .|.. .   ||  .. . .|...||.  |   ||||||. |||  .  .| |.|||| .     .. ..  ..  .|...||||||  .  | || 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP-VIIHRDLKSHNLLVDKNWRV-KVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHN-GTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKI--MTH
||.| ||.|||  ||  |.   . | . .  || | . |||. .. |... .|...||..||..|||.|||...  . |
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase TAK1.AA Pkinase 36-284 28 9.2e-65 226.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 36-284
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

IEVEEVVGRGAFGVVCKAKWRAKD--VAIKQIESESERKAFIV------ELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGG----SLYNVLHGAEP
.......|.|.||.|.|....     ||.|.|. ..|.. . .      |.. . |.||||||.||...   . ...||||.|||    .|. .... . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

LPYY--TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTV---LKICDFGTACDI---QTHMTNNKGSAAWMAPEVFE-GSNYSEKCDV
   .  .  .. ....|  .|..|.|||     ||||||| |.|..  |..   .|||||| |. .   .. ||   |.  .|||||   |. |. |.|.
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FSWGIILWEVITRRKPFDEIGG----PAFRIMWAVHNGTRPPLIKNLP-----------------------KPIESLMTRCWSKDPSQRPSMEEIVKI--
.| |.||.|....| ||.  |     .  . |. . .  .|||  . |                       ..  .....|. |||..||. |.|..   
WSCGCILYEMLCGRPPFP--GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

M
.
F
Kinase TAK1.AA S_TKc 36-289 29 3.4e-64 220.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-289
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

IEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACL-NPVCLVMEYAEG--GSLYNVLHGAEPLPY---YTA
 |. ...|.||||.|.|....   . ||||.|      . .. |.. |.. .||||||||...  . ...||||..|  |.|. ...   . ..   .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

AHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSE-KCDVFSWGIILWEVITRR
 || ... |  ....|.||..    ||||||| |.||     ..|||||| |. .    |   |.  .|||||.    |.  |||. | |.||.| ....
-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

KPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK----IMTHLMR
 ||.      ....  .            ...  ... .|. |||..||.  |. .    |. |   
PPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TAK1.AA TyrKc 36-284 30 1e-63 218.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-284
Range on HMM: 1-280/280
Sequence Identity: 30% (87 aa)

IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRV--NHPNIVKLYGACL---------NPVCLVMEYAEGGSLYNVLHGAEPLPY
|. ... |.||||.|.|..|.  .||.| . ... |..|. |.| ....  .|||||.|||.|.          |...||||...|.| . |.  .|   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

YTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI----------QTHMT----NNK--GSAAWMAPEVFEGSNYSE
 . ..  |.|.| ..| .||||.    .|||||   | |. ... . ||.||| . ||          .. ..    . |      |||||..  . ...
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KCDVFSWGIILWEVITR-RKPFDE-IG--GPAFRIMWAVHNGTRPPLIKN--------LPKPIESLMTRCWSKDPSQRPSMEEIVKIM
| ||.|.|. .||. |.  .|  . |    ......  | .| |.|  .|         |. . ..|..||  ||..||...||....
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TAK1.AA Pkinase_Tyr 36-284 32 2.8e-62 211.56 Pfam 1-270 (270) Show / Hide 
Range on Protein: 36-284
Range on HMM: 1-270/270
Sequence Identity: 32% (89 aa)

IEVEEVVGRGAFGVVCKAKWR------AKDVAIKQI--ESESE---RKAFIVELRQLSRV-NHPNIVKLYGACL---NP--VCLVMEYAEGGSLYNVLHG
|.  .. |.||||.|.|..|.        .||.| .   . .|   |..|. |.. ..   .|||||.|||.|.    |  ...||||...|.|.. |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

A-EPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-----Q-THMTNNKGSAAWMAPEVFEGSNYSEKCD
  |. .  |  .  ..|.| ..| .||.|..   .|||||   | |.  .. | |||||| | ||       .  .. |    |||||..  . ...| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VFSWGIILWEVIT-RRKP-FDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM
| | |. .||..|  ..| . ..  . .... ..  .| | |  .| |..| .||..|| .||..||...||. ..
VWSFGVLMWEIFTYGEQPTYPGM--SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TAK1.AA DRK 36-286 35 2.6e-59 199.52 In-house 1-258 (258) Show / Hide 
Range on Protein: 36-286
Range on HMM: 1-258/258
Sequence Identity: 35% (93 aa)

IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER-KAFIVELRQ----LSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAA
| .   .||| .| |    ||   ||.|      .    |. |...    ...  ||||.   |.|.||  .| .|||   |||||.||  ..       
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH--DESIEMDWP

HAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC------DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEV
  ..  . |  |. |||.  |   ||||||  | |||      |. ||| .       .  . ||   |   | ||||     | || ||.|..|.|||.
LMKQMMFDCAKGMIYLHCCNP-IIIHRDLKSHN-LLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWEC

ITRRKPFDEIGGPAFRIMWAVHN-GTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTH
.||  |.   | | | .  .|   | |||  .. | .   ||..||. ||..||||.|.....  
VTRQDPY--FGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase TAK1.AA TK 36-284 16 2.5e-58 193.82 In-house 1-486 (486) Show / Hide 
Range on Protein: 36-284
Range on HMM: 1-486/486
Sequence Identity: 16% (81 aa)

IEVEEVVGRGAFG---VVCKAKWRAK---------------------------DVAIKQI-----ESESERKA--------------FIVELRQLS--RV
|..... |.|.||   .|.|..|| .                           .||.|..     .|. |...              .  |. ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPNIVKLYGACLNP--------------VCLVMEYAEGGS----LYNVLHGAEP---------------------------------------------
.|||||.|||.|. .              ...||||...|.    | . |.   |                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LPYYTAAHAMS----------------WCLQCSQGVAYLHSMQPKAL----IHRDLKPPNLLLVAGGT----------VLKICDFGTAC
           |.     ..                  .|.| ..| .||||.. . .    .||||   | |.  ...          | ||.||| . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------------DIQTHMT------------------------NNKGSAAWMAPEVFEGS---------NYSEKCDVFSWGIILWEVITRR-KPFDEIG
             |  . ..                        . |    |||||....           ...| ||.|.|. .||. |.  .|. .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

GP--------AFRIMWAVHNG--------------TRPPLIKNLP--------------KPIESLMTRCWSKDPSQRPSMEEIVKIM
             .|  . .|               |.|  .. |              . .. ||..||..||..||....... .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TAK1.AA ZAK 36-283 36 2.5e-50 173.5 In-house 1-257 (257) Show / Hide 
Range on Protein: 36-283
Range on HMM: 1-257/257
Sequence Identity: 36% (97 aa)

IEVEEVVGRGAFGVVCKAKWRAKD-----VAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVC---LVMEYAEGGSLYNVLHGAEPLPYY--
| . . .| | || | .|.|   |     .|.| .    |. | |     || . | ||.  || |. |      | |||| ||||   |  .   .   
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKV-FKIEKEAEI-----LSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSS

----TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN--KGSAAWMAPEVF-EGSNYSEKCDVFSWGII
       | | |  |  .|. |||   |   ||||||  |  . . | |.|||||||  |.  | |     | ..|||||.       .| |||.|.|..
SGGNSMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNG-VCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVV

LWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKI
|||. ||  |. .  .  |.| |  |  . |       |.|.  ||  ||  || .||.|  |. |
LWEMLTREVPYKDYEE--FQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase TAK1.AA LRRK 135-286 32 9.5e-41 141.69 In-house 171-351 (351) Show / Hide 
Range on Protein: 135-286
Range on HMM: 171-351/351
Sequence Identity: 32% (59 aa)

LQCSQGVAYLHSMQPKALIHRDLKPPNLLL-----------VAGGTVLKICDFGTAC--DIQTHM-TNNKGS-AAWMAPEVFEG---SNYSEKCDVFSWG
|| . |..||||  |. .||||||.|| ||           ..  .. ||.|||.     . ..  .. ..    |||||.  .   ..|.|| |..| |
LQIAKGMEYLHSHNPP-IIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFG

IILWEVITRR-KPFDEIGGP-----AFRIMWAVHNGTRPPLIKN-LPK-----PIESLMTRCWSKDPSQRPSMEEIVKIMTH
.|||| .||.  ||||. ..       .|  .. .| ||..  .  |        ..|.. ||. || .||....|||..  
MILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase TAK1.AA MLK 36-164 35 1.8e-30 97.76 In-house 1-136 (280) Show / Hide 
Range on Protein: 36-164
Range on HMM: 1-136/280
Sequence Identity: 35% (49 aa)

IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV---------ELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPY
....|..| | || | .| |... ||.|   .. |. .            | | .   .||||..| |.||.    ||||||..|||| .|. |.     
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK----R

YTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL
        |  |  .|  |||   | ..||||||  | |.
IPPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI
Kinase TAK1.AA MLK 169-284 37 6.5e-26 82.45 In-house 165-280 (280) Show / Hide 
Range on Protein: 169-284
Range on HMM: 165-280/280
Sequence Identity: 37% (44 aa)

TVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCW
..||| ||| | .  .|      |  |||||||.  | .|.  || |.|..||| .|.  |. .| . |     |. |.   |  .  | |   ||  ||
KQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAM-NKLTLPIPSTCPEPWAKLMQDCW

SKDPSQRPSMEEIVKIM
 .|| .||. .||.. .
NQDPHKRPKFSEILQQL
Kinase TAK1.AA LRRK 36-117 27 4.1e-25 85.77 In-house 1-147 (351) Show / Hide 
Range on Protein: 36-117
Range on HMM: 1-147/351
Sequence Identity: 27% (40 aa)

IEVEEVVGRGAFG-VVCKAKWRA----------------------------KDVAIKQIES--------------------------------ESERKAF
.. || .|||.|| .| .||||                             ..||||...                                 ....   
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IVELRQ----LSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLH
  |.|.    .|. ||||||.|.| |..| |.|||||  |.|| .||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLH