Gene TIE1 (Human)

TIE1

Species: Human
Alias: JTK14, TIE, TIE1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p34.1-p34.2,

Classification

Group: TK
Family: Tie

Sequence

Name Sequence Type Origin Length Description Download
TIE1.NA RNA Sugen Kinome 3960 None Fasta, JSON
TIE1.AA Protein Sugen Kinome 1138 None Fasta, JSON
TIE1.kin_dom Protein Kinase Domain Sugen Kinome 269 None Fasta, JSON

Protein domain

Protein domains of TIE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG TIE1.AA IG 131-213 19 0.000777 19.99 SMART 1-58 (58) Show / Hide 
Range on Protein: 131-213
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

KVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSS---GIYSATYLEASPLGSA--FFRLIVR
   .||. |.|..|.  |.      . |.                    |.. ||||  |   |.|  .    .  ...  ...|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
EGF TIE1.AA EGF 223-256 40 7e-06 26.84 SMART 1-32 (32) Show / Hide 
Range on Protein: 223-256
Range on HMM: 1-32/32
Sequence Identity: 40% (16 aa)

GCTKECPGCLHG-----GVCHDHDGECVCP-PGFTGTRCE
 |     .| ||     |.|.    .| || ||.|| |||
ECA----PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE
EGF_CA TIE1.AA EGF_CA 227-256 42 8.6e-05 13.34 SMART 4-34 (34) Show / Hide 
Range on Protein: 227-256
Range on HMM: 4-34/34
Sequence Identity: 42% (15 aa)

ECPGCLHGG---VCHDHDG--ECVCPPGFTGTRCE
||  | .||   .|.. .|  .| ||||.| ..||
EC-PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF TIE1.AA EGF 224-254 38 0.000373 16.95 Pfam 1-36 (36) Show / Hide 
Range on Protein: 224-254
Range on HMM: 1-36/36
Sequence Identity: 38% (14 aa)

CTKECPGCLHGGVCHDH--DGECVCPPG---FTGTR
|...  .|.|.| |.|   . .| ||||   .|| |
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_2 TIE1.AA EGF_2 224-255 35 0.004737 13.03 Pfam 1-29 (29) Show / Hide 
Range on Protein: 224-255
Range on HMM: 1-29/29
Sequence Identity: 35% (12 aa)

CTKECPGCLHGGVCHDH-DGECVCPPG-FTGTRC
|   | |  |.|.| .  .| |.|..| ..|  |
C---CNG--HHGTCNNQGCGKCQCDDGWWQGDHC
EGF TIE1.AA EGF 267-303 20 0.224245 4.71 SMART 1-32 (32) Show / Hide 
Range on Protein: 267-303
Range on HMM: 1-32/32
Sequence Identity: 20% (9 aa)

SCQEQCPGISGCRGL-----TFCLPDPYGCSCG-SGWRGSQCQ
 |.       .|          |.   | | |   |..| .|.
ECA-------PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE
EGF_2 TIE1.AA EGF_2 272-302 30 29.072198 1.18 Pfam 1-29 (29) Show / Hide 
Range on Protein: 272-302
Range on HMM: 1-29/29
Sequence Identity: 30% (11 aa)

CPGISGCRG-LTFCLPDPYG---CSCGSG-WRGSQC
|     | |   .|  .  |   |.| .| | | .|
C-----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC
EGF_2 TIE1.AA EGF_2 319-344 41 3e-09 32.4 Pfam 1-29 (29) Show / Hide 
Range on Protein: 319-344
Range on HMM: 1-29/29
Sequence Identity: 41% (13 aa)

CQCQN-GGTCDRFSG---CVCPSG-WHGVHC
| |.. .|||... |   |.|..| |.| ||
C-CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC
EGF TIE1.AA EGF 314-345 34 0.025736 14.94 SMART 1-32 (32) Show / Hide 
Range on Protein: 314-345
Range on HMM: 1-32/32
Sequence Identity: 34% (13 aa)

DCRLQCQCQNG-----GTCDRFSGCVCP-SGWHGVHCE
.|     |..|     |||     | ||  |..| .||
ECA---PCHHGGCEQHGTCI-SYTC-CPGPGYTG-RCE
EGF TIE1.AA EGF 315-343 27 1.4376 4.97 Pfam 1-36 (36) Show / Hide 
Range on Protein: 315-343
Range on HMM: 1-36/36
Sequence Identity: 27% (10 aa)

CRLQ-CQCQNGGTCDRFS---GCVCPSG---WHGVH
|  .   |...||| .      | || |   ..| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_2 TIE1.AA EGF_2 306-315 36 4.017313 3.87 Pfam 19-29 (29) Show / Hide 
Range on Protein: 306-315
Range on HMM: 19-29/29
Sequence Identity: 36% (4 aa)

CAPG-HFGADC
| .| ..|..|
CDDGWWQGDHC
IG TIE1.AA IG 357-444 9 0.051695 8.43 SMART 1-58 (58) Show / Hide 
Range on Protein: 357-444
Range on HMM: 1-58/58
Sequence Identity: 9% (9 aa)

ASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADS---GFWECRVSTSGGQDSR--RFKVNVK
 . .. ..    ...| ..        .| ..                      ... .. ..||   |   |...  .||..    ... |.
PP-VTVKEGETVTLTC-VS--------QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
FN3 TIE1.AA FN3 446-530 17 0.0007 20.14 SMART 1-69 (69) Show / Hide 
Range on Protein: 446-530
Range on HMM: 1-69/69
Sequence Identity: 17% (17 aa)

PPVPLAA--PRLLTKQSR------QLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPK----TGYSVRVQLSRPGEGGEG
|. |     .|.    |.      ....|              ...||                  .|. .|.|     | |..||.    ...|||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 TIE1.AA FN3 543-631 18 0.014617 13.21 SMART 1-69 (69) Show / Hide 
Range on Protein: 543-631
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

PEPLLQP-WLEGWHVEGT-----DRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPG----THYQLDVQLYHCTLLGPA
| |   | .|.  .|  |     . ...||. |            .. .                   . .|||.||    | |.  |. .  .  |. 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 TIE1.AA FN3 644-726 19 2.4e-11 44.94 SMART 1-69 (69) Show / Hide 
Range on Protein: 644-726
Range on HMM: 1-69/69
Sequence Identity: 19% (19 aa)

PPAPRH---LHAQALSDS------EIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNAS----TRYLFRMRASI---QGLG
|..|..   |.. . ...       ..|.||.|      |  |.                         ...|| .     |.| || ||     .| |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase TIE1.AA Tie 847-1107 85 8.10000000001e-229 704.62 In-house 1-267 (267) Show / Hide 
Range on Protein: 847-1107
Range on HMM: 1-267/267
Sequence Identity: 85% (229 aa)

EGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHG
|||||||..||||||||||..||||.||||||.|||||.|||||.||.|||||||||.|||..|||||.|||||||||||||||||||.||||||||||.
EGNFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREHT

T------ASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFG
|      ||||||.|.|.||.|.|.||||||.||.|||||||||.||.||...||||||||||.||||||||||||||||||||||||||||||||||.|
TRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYG

VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
|||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||.||
VLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
TyrKc TIE1.AA TyrKc 839-1107 41 5.5e-136 458.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-280/280
Sequence Identity: 41% (127 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLG-HHPNIINLLGACKNR-------GYLYIAIEYAPYGNLLDFLR
||... .|||.||.| ... |     .. |.|||||.|    ..||  |....|||| |||||..|.|.|          . |.|  ||.|.|.|.|.||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVY--------VKKT----MGR--LP
|.|                 |. ..|| |. ..|.||.||..|..|||||||||.|||||.  ||.||||||  . .        ....     |.  ||
KHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCG-----MTCAELYEKLPQGYRMEQPRN--------CDDEVYELMRQCWRDRPYERPPFAQI
.||||.|..||...|||||||||||..||| ..|..|| |     |. .|..|.. |||||.|| |        | ||.|..|.|||.  | .|| |..|
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

ALQL
  ..
HECF
Pkinase_Tyr TIE1.AA Pkinase_Tyr 839-1107 46 8.3e-135 457.19 Pfam 1-270 (270) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-270/270
Sequence Identity: 46% (130 aa)

ITFEDLIGEGNFGQVIRAMIK--KDGLKMNAAIKMLKEYASEND--HRDFAGELEVLCKLGHHPNIINLLGACK-NRGY--LYIAIEYAPYGNLLDFLRK
|||   .|||.||.| ..  |  .|. |.  |.|||||.|.. .  ..||  |......|||||||..|.|.|   ..   .||  ||.|.|.|||.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

SRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVY-VKKTMGRLPVRWMAIESLNY
 |                 |.  .|| .. . |.||.||..|..|||||||||.||.||.  ||.||||.|     . | .|.. |.||..||| |..||
HR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY

SVYTTKSDVWSFGVLLWEIVSLGGTP-YCGMTCAELYEKL-PQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
...||||||||||||.|||...|..| | ||. .|.||..  .||||..|.|| ||.|.||.|||.  | .|| |..|  ||
GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TIE1.AA TK 839-1107 26 1.2e-116 392.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-486/486
Sequence Identity: 26% (130 aa)

ITFEDLIGEGNFG---QVIRAMIK-----------------------KDGLKMNAAIKMLKEY--ASENDHRD--------------FAGELEVLCK-LG
||... .|||.||   .| ... .                       |.| |.  |.|||||   .|.....|              .| |....|  ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNIINLLGACKNR------------GYLYIAIEYAPYGN----LLDFLRKSRVLETDPAFAREH----------------------------------
|||||..|.|.|               . ..|  ||.|.|.    |.|.|||.|  .....   ..                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------GTASTLSSRQLLR-------------------FASDAANGMQYLSEK------QFIHRDLAARNVLVGENLA-----------SKIADFGLSR-
         ..|. ..||.                   .. ..|.||.||..|      .|.||||||||.|||||.             ||||||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----------GEEVYVKKT------------------------MGRLPVRWMAIESLN---------YSVYTTKSDVWSFGVLLWEIVSLG-GTPYCGMT
           .. |..|.                         |.||.|||| |.||         | ..||||||||||||.|||...| ...| ||.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

---------CAELYEKLPQG--------------YRMEQPRNCD--------------DEVYELMRQCWRDRPYERPPFAQIALQL
         ..|..|.| .|              .||.|| .|               .|.|.||.|||.  | .|| |.|.  ||
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TIE1.AA TK-Unique 839-1107 41 2.8e-115 389.27 In-house 1-294 (294) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-294/294
Sequence Identity: 41% (123 aa)

ITFEDLIGEGNFGQVIRAMIKK----DGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRG-YLYIAIEYAPYGNLLDFLRKSR
....|.||||.||||.|.....    .. . ..|.||||..|.. |..||  |.... .|| ||||...||.|   .   .|..||.|.|||...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-V---------LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSE--KQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKK-TMGRLPV
 .         |  |.. ...    ...|...|..|| . |.||.||..  |...||||.|||||..|..  ||.|||..|    ..||... . ||.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAIESLN--YSVY-TTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNC-DDEVYELMRQCWRDRPYERPPFAQIALQL
|||| |||   . .| ||||||||||||.|||..||..|| ||  ... |....||||.|| .|  .|.|.||..||.. | ||| |.||. .|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TIE1.AA FGFR 839-1107 42 3.9e-111 375.52 In-house 1-293 (293) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-293/293
Sequence Identity: 42% (125 aa)

ITFEDLIGEGNFGQVIRAMIK---KD--GLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSR
 |    .||| ||||..|  |   .|    ..  |.||||. ... |  |   |.|..   | |.|||||||.|   | ||. .||.. ||| ||||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

VLETDPAFARE-------HGTAST--------LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRL
  . |  .  .       . .. .        |....| ..|   | ||.||  .  ||||||||||||...   ||.||||.|.    . | |.| |||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMT-CAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
|. ||| |.|   |||..|||||.|||||||  .||.|| .     |||. |  |.||| | ||  |.| .|.|||.  | .||.|.|.  .|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TIE1.AA UTK 839-1107 33 8.8e-92 311.22 In-house 1-296 (296) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-296/296
Sequence Identity: 33% (102 aa)

ITFEDLIGEGNFGQVIRAMIKKDG---LKMNAAIKMLK-EYASENDHR---DFAGELE---VLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDF
. . ...|.|.||.| .|. ...    ..|  |.| .. . ... ...   ||  |     .. .. .|||...|.| | . . ..|..||.. |.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRKSRV-LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGEN-------LASKIADFG---LSRGEE------------
||..|  ..         .    |...|.| .|.| |.|||||....|.||||||||.||...       .  ||||||   .||.              
LRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESY

VYVKKTMGRLPVRWMAIESLNYS-VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQG--YRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQ
 | .   .|.|.|||| |.|..   .|||||||||||..|||.. | .|| ||. ... . .  |  |||..|. | ..||.||..||.  | ||| | .
YYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

IALQL
.  |.
LVQQM
Kinase TIE1.AA Src 839-1107 39 8.6e-91 307.93 In-house 1-255 (255) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-255/255
Sequence Identity: 39% (107 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETD
|.... .|.|.|| |  .. ..   ... |.| ||.     .  .|  | ... ||  |.....|.  |      ||  ||   |.|||.|.|       
IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-------

PAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE----VYVKKTMGRLPVRWMAIESLNYSVYTTKS
       |. ..|. .||. .|   |.||.||.....|||||||||||||||.. |.||||| |  .    .|. ..  ..|..|.| | .|| ..|.||
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYE-LMRQCWRDRPYERPPFAQIALQL
||||||.||.|||. | .|| ||| .|  ... .|||| .|.|| ||.|| .|.|||. .| .|| |. .   |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TIE1.AA RTKB 839-1107 36 2.2e-84 284.38 In-house 1-264 (264) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-264/264
Sequence Identity: 36% (101 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLE
.      |.| ||.| .| ..  .       | | ||  ||. .. ||  |. |.  || |||.| ..| |     . . .|.. .||| |.||..|  .
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

TDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR-GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKS-
 .|          .|...||. |. . |.|| .|. .. |||||.||||||. .|. ||.|||..|  ..  ...|  |||..|||.||. .. ||||| 
HNPQ---------SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSG

DVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
|||||||  ||| |||||||     ... . |  |.|...||    .....|..||   . .|| |. ..  .
DVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase TIE1.AA Ret 966-1109 55 4e-72 245.65 In-house 147-293 (293) Show / Hide 
Range on Protein: 966-1109
Range on HMM: 147-293/293
Sequence Identity: 55% (81 aa)

GMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
||.||||   .||||||||||| | .  || ||||.|    .  |||.  .|.|| |||||||   ||||||||||||||.|||| .|. || | .   |
GMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERL

YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGR
.. |  ||||. | ||  |.| .|||||.. |  || |. |.  . .
WQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase TIE1.AA VEGFR 964-1107 50 1.1e-67 231.16 In-house 183-332 (332) Show / Hide 
Range on Protein: 964-1107
Range on HMM: 183-332/332
Sequence Identity: 50% (76 aa)

ANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG----EEVYVKKTM-GRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMT
|.|| .|...  |||||||||.|. ||   || ||||.|        ||.|.  |||| .|||.||.   ||||.|||||.||.|||| |||| || |  
ARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQ

-CAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
   |.. .|  ||||. |  |  |.|. | .||.  | ||| |.  .  |
IDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase TIE1.AA PDGFR 956-1107 50 5.1e-64 204.3 In-house 203-358 (358) Show / Hide 
Range on Protein: 956-1107
Range on HMM: 203-358/358
Sequence Identity: 50% (79 aa)

LLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGT
|| |..  |.|| .|  |  .||||||||||. .    || |||| |       || |   |||| ||| ||.  .||||.|||||.|.||||| ||||.
LLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLGGN

PYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
|| ||   .. | .  .||||.||    .|.|| |..||   |  ||.| |. . |
PYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase TIE1.AA Pkinase 839-1107 20 4.9e-38 135.57 Pfam 1-293 (293) Show / Hide 
Range on Protein: 839-1107
Range on HMM: 1-293/293
Sequence Identity: 20% (65 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAG-----ELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYG----NLLDFL
....  ||.|.||.| ... |..|     |.| .|    ....          |.... .| .||||. |.... .....|.  ||.. |     | |..
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLAS----KIADFGLSRG--EEVYVKKTMGRLPVRWMAIE
.            ..||. . .| ... ...   . |..|. .. .|||||   |.|. .|       ||.||||..   .  ..  |      ..|| |
ST-----------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE

SLN-YSVYTTKSDVWSFGVLLWEIVSLGGTPYCGM----TCAELYEKLPQGYRMEQPRNCD-----------------------DEVYELMRQCWRDRPY
 .. .. |..|.|.||.|..|.| .. | .|..|     . .. .... .  . . .....                       .|  .... |..  |.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

ERPPFAQIALQ--L
.|| ..||     .
KRPTAEQILQHPWF
Kinase TIE1.AA S_TKc 839-1110 23 6.1e-38 133.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 839-1110
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPY--GNLLDFLRKSRVLE
 .. ..||.| ||.| ..  ||   .   |||..|        ...  |...| |  |||||..|.... . ..||.  ||..   |.|.|...| .   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTT-KSD
..          . ..  .  ...   .....|. ....|||||   |.|. |    ||.||||.|        |       .|| | |    |.. |.|
LR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCD

VWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL------QLGRM
.||.|..|.| .. | .|..  . .....|.            ..|. ...|.|..  | .||   ..        .   .
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TIE1.AA PDGFR 839-933 39 4.3e-22 67.4 In-house 1-98 (358) Show / Hide 
Range on Protein: 839-933
Range on HMM: 1-98/358
Sequence Identity: 39% (39 aa)

ITFEDLIGEGNFGQVIRAM---IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSR
  |    | | ||.|. |    . | .  |  |.||||. |          || ..  ||.| ||.||||||   |  ||  ||  || ||..|.. |
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR
Kinase TIE1.AA Ret 839-933 34 7.2e-21 67.97 In-house 1-100 (293) Show / Hide 
Range on Protein: 839-933
Range on HMM: 1-100/293
Sequence Identity: 34% (36 aa)

ITFEDLIGEGNFGQVIRAMIKKDGLKMNA-----AIKMLKEY-ASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRG--YLYIAIEYAPYGNLLDFLR
  ..|  ||| ||||..|   .  ..  .     |.||||.  |.    .|   |...| |.  ||..| |.|||   .   . . .||. || |  |||
LQLDDTLGEGHFGQVVKAQAFH--IRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLL-KQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

KSR
 ||
LSR
Kinase TIE1.AA VEGFR 845-933 40 3e-18 65.57 In-house 7-101 (332) Show / Hide 
Range on Protein: 845-933
Range on HMM: 7-101/332
Sequence Identity: 40% (39 aa)

IGEGNFGQVIRAM---IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGAC-K---NRGYLYIAIEYAPYGNLLDFLRKSR
.|.| ||||. |    |.|       | ||||| |    ||    ||..|  .||| |  |.||.| |   .. .. | .|| ..|||...||  |
LGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVI-VEYCCFGNLSNYLRTKR