Trad

Species: Human
Alias: Trad, FLJ16443, TRAD, KALRN, duo, Hs.162189, DUET, HAPIP
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3q13.3-q21,

Classification

Group: CAMK
Family: Trio

Sequence

Name Sequence Type Origin Length Description Download
Trad.NA RNA Sugen Kinome 10835 None Fasta, JSON
Trad.AA Protein Sugen Kinome 2986 None Fasta, JSON
Trad.kin_dom Protein Kinase Domain Sugen Kinome 255 None Fasta, JSON

Protein domain

Protein domains of Trad.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SEC14 Trad.AA SEC14 38-177 22 1.2e-32 115.75 SMART 1-184 (184) Show / Hide
Range on Protein: 38-177
Range on HMM: 1-184/184
Sequence Identity: 22% (42 aa)

ILKEKVAFVSGGR-------DKRGGPILTFPARS------NHDRIRQEDLRKLVTYLASVPSE--------DVCKRGFTVIIDMRGSK--------WDLI
 ...  ....|||       ||.| |.. |.|.       .|. ...| || .| .. .. ..        . .. ||..|.||.|..        |...
EHECGKHYMPGGRHGTRQGYDKDGRPVYYFRAGRHDPKGMMHSCTMHEFLRYHVYVMEKMCQHCPMCMEKMPGGQCGFHWIFDMKGWSMSHFWSPDWGWY

KPLLKTLQEAFPAEIHVALIIKPDN------FWQKQKTNFGSSKFIFETSMVS---------VEGLTKLVDPSQLTEEFDGSLD
. .....|...|. .| ..||.|        .| |.   | ..|. .   .|.         .| |.| .||..|.||. |..|
RKMWQIFQDHYPERLHKVYIINPPWWMFFFWVWWKMIKPFLDEKTREKIHFVGPNKVDDNDWKEELHKYIDPECLPEEWGGTCD

SPEC Trad.AA SPEC 191-307 18 2.2e-11 45.05 SMART 1-104 (104) Show / Hide
Range on Protein: 191-307
Range on HMM: 1-104/104
Sequence Identity: 18% (22 aa)

EEFFNSAVHLLSRLEDLQEMLARKEFP--VDVEGSRRLIDEHTQLKK--KVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLD
..|.  .  |.. ... ...|. ....   |.|. ..|...| ...|  .  .. |..|...||.|.|                        ..|   ||
QQFHRDCDELEQWMDEKEQLLSSDDYGDSKDLESVQALQKKHQAFEKEMEAHQPRVDQLNQQGQQLIQE-----------------YGHYDADEIQERLD

KLHSTRQHLHQMWHVRKLKLD
.|.. ...|...|  |. .|.
ELNQRWEELCELWEERRQRLE

Spectrin Trad.AA Spectrin 188-235 15 0.051088 10.64 Pfam 1-51 (109) Show / Hide
Range on Protein: 188-235
Range on HMM: 1-51/109
Sequence Identity: 15% (8 aa)

LSLEEFFNSAVHLLSRLEDLQEMLARKEF-PVDVEGSRRLID--EHTQLKK
. |..|.. . .|.. ...  ..|.  .. . |.|. . | .   | ....
HHLQQFQRDCDDLEQWIQEKEQWLSSEDYWGKDLEEVQALQKQWKHQAFEA

Spectrin Trad.AA Spectrin 279-308 26 0.067048 10.2 Pfam 80-109 (109) Show / Hide
Range on Protein: 279-308
Range on HMM: 80-109/109
Sequence Identity: 26% (8 aa)

PKITSLLDKLHSTRQHLHQMWHVRKLKLDQ
. |.. .. |.. ...|...|  || || .
EEIQERMEELNQRWEQLCELWEERKQKLEE

SPEC Trad.AA SPEC 313-415 19 7.5e-12 46.61 SMART 1-104 (104) Show / Hide
Range on Protein: 313-415
Range on HMM: 1-104/104
Sequence Identity: 19% (21 aa)

RLFEQDAEKMFDWISHNKELFLQSHTEIG--VSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEA-GHYASQQIKQISTQLDQEWKSFAAALDE
. | .|.. . .|..  .   | |....|   . . . .|| .|  |     .    .. .   . .| .. |||....|..  ..|.|.|..  ....|
QQFHRDCDELEQWMDEKE--QLLSSDDYGDSKDLESVQALQKKHQAFEKEMEAHQPRVDQLNQQGQQLIQEYGHYDADEIQERLDELNQRWEELCELWEE

RSTILA
|   | 
RRQRLE

Spectrin Trad.AA Spectrin 310-416 22 1e-06 27.81 Pfam 1-109 (109) Show / Hide
Range on Protein: 310-416
Range on HMM: 1-109/109
Sequence Identity: 22% (25 aa)

FQLRLFEQDAEKMFDWISHNKELFLQSHTEI-GVSYQYALDLQT--QHNHFAMNSMNAYVNINRIMSVASRL-SEAGHYASQQIKQISTQLDQEWKSFAA
 .|. | .|.. .  ||.   | .| |  .. | ... .  ||   .|  |  .  .   ... .  .| .|  ..||..|..|..   .|.| |..  .
HHLQQFQRDCDDLEQWIQEK-EQWL-SSEDYWGKDLEEVQALQKQWKHQAFEAEIAAHQDRVQQLNEQAQKLIIDEGHHDSEEIQERMEELNQRWEQLCE

ALDERSTILAM
...||   |  
LWEERKQKLEE

SPEC Trad.AA SPEC 418-533 11 0.005978 5.81 SMART 1-104 (104) Show / Hide
Range on Protein: 418-533
Range on HMM: 1-104/104
Sequence Identity: 11% (14 aa)

AVFHQKAEQFLSGVDAWCKMCSEGGLP--SEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVL
  ||........ .|   ...|   ..     ....  ...||.. . . .|. .  .. ... . | .  .. ..... .               .|. 
QQFHRDCDELEQWMDEKEQLLSSDDYGDSKDLESVQALQKKHQAFEKEM-EAHQPRVDQLNQQGQQLIQEYGHYDADEIQERL-------------DELN

HHQRRLESIWQHRKVRLH
.. ..|.  |. |. || 
QRWEELCELWEERRQRLE

SPEC Trad.AA SPEC 539-641 26 3.8e-15 57.56 SMART 1-104 (104) Show / Hide
Range on Protein: 539-641
Range on HMM: 1-104/104
Sequence Identity: 26% (28 aa)

CVFQQDVQQVLDWIENHGEAFLSKHTGVG--KSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQT-GECDPEEIYKAARHLEVRIQDFVRRVEQ
  |..|......|...     | ... .|  |.|  ..||||.|..||.  ..     |.| ....|| |  |. | .|| .  ..|. | ..  ...|.
QQFHRDCDELEQWMDEKE--QLLSSDDYGDSKDLESVQALQKKHQAFEKEMEAHQPRVDQLNQQGQQLIQEYGHYDADEIQERLDELNQRWEELCELWEE

RKLLLD
|.  |.
RRQRLE

Spectrin Trad.AA Spectrin 536-642 29 0.000107 20.63 Pfam 1-109 (109) Show / Hide
Range on Protein: 536-642
Range on HMM: 1-109/109
Sequence Identity: 29% (33 aa)

LQLCVFQQDVQQVLDWIENHGEAFLSKHTGV-GKSLHRARALQK--RHDDFEEVAQNTYTNADKLLEAAEQL-AQTGECDPEEIYKAARHLEVRIQDFVR
..|  ||.|..... ||.   |..|     . ||.|  ..||||  .|..||.  ..  .. ..| | |..| .. |  |.||| .   .|. | ..  .
HHLQQFQRDCDDLEQWIQEK-EQWL-SSEDYWGKDLEEVQALQKQWKHQAFEAEIAAHQDRVQQLNEQAQKLIIDEGHHDSEEIQERMEELNQRWEQLCE

RVEQRKLLLDM
..|.||  |  
LWEERKQKLEE

SPEC Trad.AA SPEC 644-766 19 6.1e-05 23.67 SMART 1-104 (104) Show / Hide
Range on Protein: 644-766
Range on HMM: 1-104/104
Sequence Identity: 19% (24 aa)

VSFHTHTKELWTWMEDLQKEMLEDVCA--DSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIE
  ||   .||  ||.. .. .  |  .  .....||.|.|..|. ..   .|  . ... ... ||| ..                     .     .|.
QQFHRDCDELEQWMDEKEQLLSSDDYGDSKDLESVQALQKKHQAFEKEM-EAHQPRVDQLNQQGQQLIQE--------------------YGHYDADEIQ

SVLQQLDDAQVQMEELFHERKIKLD
  |..|...  . .||  ||. .|.
ERLDELNQRWEELCELWEERRQRLE

Spectrin Trad.AA Spectrin 646-688 20 6.689526 2.75 Pfam 6-48 (109) Show / Hide
Range on Protein: 646-688
Range on HMM: 6-48/109
Sequence Identity: 20% (9 aa)

FHTHTKELWTWMEDLQKEMLEDVC-ADSVDAVQELIKQFQQQQT
|. . ..|  |...  . .  .   . ....||.| ||. ..|.
FQRDCDDLEQWIQEKEQWLSSEDYWGKDLEEVQALQKQW-KHQA

SPEC Trad.AA SPEC 893-1003 22 6.2e-11 43.58 SMART 1-104 (104) Show / Hide
Range on Protein: 893-1003
Range on HMM: 1-104/104
Sequence Identity: 22% (25 aa)

RHLQAEVKQVLGWIRNGESMLNASLVNA--SSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECAEKVALHWQQ
........... |... |  | .|   .   .|.....||..|..|.  .    |. .... .| . |  |.      .||||||.|.|  ...  .|..
QQFHRDCDELEQWMDEKE-QLLSSDDYGDSKDLESVQALQKKHQAFEKEM--EAHQPRVDQLNQQGQQLIQE------YGHYDADEIQERLDELNQRWEE

LMLKMEDRLKLVN
|  ..|.| .  .
LCELWEERRQRLE

Spectrin Trad.AA Spectrin 890-1004 24 0.000676 17.64 Pfam 1-109 (109) Show / Hide
Range on Protein: 890-1004
Range on HMM: 1-109/109
Sequence Identity: 24% (29 aa)

LQLRHLQAEVKQVLGWIRNGESMLNASLVN-ASSLSEAEQLQR--EHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVL-LQAGHYDADAIRECAEKVA
..|. .| ...... ||.  | .| .|    . .|.|...||.   |..|.  |.   | . .|.         . |. | ...||.|...|.|  | . 
HHLQQFQRDCDDLEQWIQEKEQWL-SSEDYWGKDLEEVQALQKQWKHQAFEAEIAA--HQDRVQQLN-------EQAQKLIIDEGHHDSEEIQERMEELN

LHWQQLMLKMEDRLKLVNA
 .|.||   .|.| .   .
QRWEQLCELWEERKQKLEE

SPEC Trad.AA SPEC 1133-1235 20 2e-12 48.49 SMART 1-104 (104) Show / Hide
Range on Protein: 1133-1235
Range on HMM: 1-104/104
Sequence Identity: 20% (22 aa)

VVFERSAKQALDWIQETGEFYLSTHTSTG--ETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEK-GHIHATEIRKWVTTVDKHYRDFSLRMGK
  | | ......|..|.    | ... .|   . |. |.|.|.  .|.   .. ...|. |.|... .... || .| ||..... .......   .. .
QQFHRDCDELEQWMDEKE--QLLSSDDYGDSKDLESVQALQKKHQAFEKEMEAHQPRVDQLNQQGQQLIQEYGHYDADEIQERLDELNQRWEELCELWEE

YRYSLE
 |  ||
RRQRLE

Spectrin Trad.AA Spectrin 1130-1222 23 3.6e-07 29.84 Pfam 1-95 (109) Show / Hide
Range on Protein: 1130-1222
Range on HMM: 1-95/109
Sequence Identity: 23% (23 aa)

QQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLK--EYGEFRVPAKQTKEKVKLLIQLADSF-VEKGHIHATEIRKWVTTVDKHYRD
...  | | ..... ||||. | .||.    |.. ||.|.|.|   . .|.    . ...|. | ..|. . .. ||  . ||....  ..... .
HHLQQFQRDCDDLEQWIQEK-EQWLSSEDYWGKDLEEVQALQKQWKHQAFEAEIAAHQDRVQQLNEQAQKLIIDEGHHDSEEIQERMEELNQRWEQ

RhoGEF Trad.AA RhoGEF 1285-1455 29 8.9e-59 202.5 SMART 1-211 (211) Show / Hide
Range on Protein: 1285-1455
Range on HMM: 1-211/211
Sequence Identity: 29% (63 aa)

IMAELLQTEKAYVRDLHECLETYLWEMTSGV--EEIPPGILNKEHIIFG-NIQEIYDFHNNIFLKELEKYEQL------------------PEDVGHCFV
.. ||.|||..||||||.....|. .| . .   ..|.   .. ..||| ||.|||.|| ..||.|||.. ..                  ....|.||.
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFH-RRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFM

TW---ADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQRHGLAN---------SISSYLIKPVQRITKYQLLLKELLTCCE---EGKGELKDGL
 |   .. |.|| .||.|.|.. ... .     .   |........  .|         .....||||.||||||.|||||.| ...   . . .|.. |
KWFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSNSEHRLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKAL

EVMLSVPKKAND
..| .|... |.
DCMKDVAQHCNE

RhoGEF Trad.AA RhoGEF 1285-1455 31 4.5e-48 166.87 Pfam 1-196 (196) Show / Hide
Range on Protein: 1285-1455
Range on HMM: 1-196/196
Sequence Identity: 31% (63 aa)

IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKE--HIIFGNIQEIYDFHNNIFLKELEK-----YE--QLPED--VGHCF--VT-WADKFQ
.. |..|||..|||||  ..| |. ..        |.||. .  |.||.||.|||.||.. ||..||.           ...  .|.||  .  ... |.
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA---NPPILSPDEIHTIFSNIEEIYEFHQR-FLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFK

MYVTYCKNKPDSNQLILEHAGT--FFDEIQQRHGLANS---------ISSYLIKPVQRITKYQLLLKELLTCCEE-----GKGELKDGLEVMLSVPKKAN
||..||.|.| . .|. ..  .  .|... ..  .  .         ..|.||||||||..|.||||||| ....      . .|.  ||.| .| ...|
MYSEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE-NDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHIN

D
.
E

PH Trad.AA PH 1475-1580 16 1e-11 44.86 Pfam 1-92 (92) Show / Hide
Range on Protein: 1475-1580
Range on HMM: 1-92/92
Sequence Identity: 16% (18 aa)

LILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEG-DPCKFALWSGRTPSSDNKTVLKASNIETKQEWIK
.|..  . ..     ... ..|...||.  |.. |. |       | .| ..  |.. ||..... .|. | ...       .. ...|.. | ...|..
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK-------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR----RTYYFQAESEEEMNDWMQ

NIREVIQ
 |.... 
AIQSACR

PH Trad.AA PH 1469-1582 15 1.5e-10 42.32 SMART 1-82 (82) Show / Hide
Range on Protein: 1469-1582
Range on HMM: 1-82/82
Sequence Identity: 15% (18 aa)

LDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETK
.  .| |  .             . ..|...||. .|.. |.           .| ..  |.. |.| .      | ...          ...... |..
VIKEGWLYKKS----------K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P-----CFEIHH-DR-----TYYFQCESEEEM

QEWIKNIREVIQER
|||.. |...|.. 
QEWMQAIQKAIHNN

SH3 Trad.AA SH3 1649-1710 24 1.1e-08 36.15 SMART 1-58 (58) Show / Hide
Range on Protein: 1649-1710
Range on HMM: 1-58/58
Sequence Identity: 24% (15 aa)

ELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSALCISH
.  ..| |. | .. ||... |.....||.    .||. .|        ||..||. . . .
PYVRALYDYQAQNPDELSFKKGDIITVLEKD--DDGWWKGRCNR--TGQEGWFPSNYVEEID

SH3_1 Trad.AA SH3_1 1652-1703 26 2e-08 31.54 Pfam 1-49 (49) Show / Hide
Range on Protein: 1652-1703
Range on HMM: 1-49/49
Sequence Identity: 26% (14 aa)

VVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPL-EGLVPS
|.| |. | ...||... | .....|.  . ..|. .|   .     ||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDD-WDWWKGRCNNT---GQEGWFPS

SH3_2 Trad.AA SH3_2 1650-1709 15 0.00017 18.63 Pfam 1-68 (68) Show / Hide
Range on Protein: 1650-1709
Range on HMM: 1-68/68
Sequence Identity: 15% (11 aa)

LTVVLQDFSA-GHSSE-----LTIQVGQTVELLE-RPSERPGWCLV-RT--TERSPPLEGLVPSSALCIS
. .|..|. .    .|     |....|....... .  ....|... .|  . |     |..||... . 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRR-M-RGWFPSQWVEEC

RhoGEF Trad.AA RhoGEF 1933-2103 31 6.3e-55 189.7 SMART 1-211 (211) Show / Hide
Range on Protein: 1933-2103
Range on HMM: 1-211/211
Sequence Identity: 31% (67 aa)

VLNELVQTEKDYVKDLGIVVEGFMKRIEEKG----VPEDMRGKDKIVFG-NIHQIYDWHKDFFLAELEKCIQE------------------QDRLAQLFI
|..||.|||..||.|| |.|...||.... .    .|   . . ...|| ||. ||. |..|.. |||..|.|                  .||....|.
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLD-ELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFM

KH---ERKLHIYVWYCQNKPRSEYIVAE------YDAYFEEVKQEINQ---------RLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAV
|.   |. ...|  ||.|.|... . ..       .......|.  ..         ||||.||||||.||||||.||||. |......  .  |..||.
KWFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSNSEHRLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKAL

ELMCLVPKRCND
..|. |...||.
DCMKDVAQHCNE

RhoGEF Trad.AA RhoGEF 1933-2103 28 4.5e-54 187.48 Pfam 1-196 (196) Show / Hide
Range on Protein: 1933-2103
Range on HMM: 1-196/196
Sequence Identity: 28% (56 aa)

VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMR-GKDKIVFGNIHQIYDWHKDFFLAELEK--CIQEQ-----DR--LAQLF--IK-HERKLHIYV
|..|..|||..||.|| |..|..||..... .|. .  .. ...|.||..||..|..| | .||.  .....     ..  ....|  .| ... ...|.
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCANPPILSPDEIHTIFSNIEEIYEFHQRF-LEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMYS

WYCQNKPRSEYIVAEY---DAYFEEVKQEINQ-------RLT-LSDFLIKPIQRITKYQLLLKDFLRYSEK-AGL-ECSDIEKAVELMCLVPKRCND
 ||.|.|...... ..   . .|..  .....       ||. |..|||||.|||..|.||||. |.....     . .|..||.|.|  | ...|.
EYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKENDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHINE

PH Trad.AA PH 2117-2226 17 5.2e-08 31.54 Pfam 1-92 (92) Show / Hide
Range on Protein: 2117-2226
Range on HMM: 1-92/92
Sequence Identity: 17% (19 aa)

LTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDN-DPCKFALMNRETSERVVLQAANADIQQ
.. .| |...             .. |.| ..||.. ... .          |  |.|| .. . ... .|| .|. | . . .  .....||....  .
VIKEGWLHKKG----------KRKSWKKRWFVLFNNCLYYYKDDK-------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR-RTYYFQAESEEEMN

AWVQDINQVLE
 |.|.|.... 
DWMQAIQSACR

PH Trad.AA PH 2123-2228 15 2e-06 28.95 SMART 1-82 (82) Show / Hide
Range on Protein: 2123-2228
Range on HMM: 1-82/82
Sequence Identity: 15% (16 aa)

LLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQDIN
.. . . |. .       | |.| ..||.. ... .             | || .. . ..| .      | . . .   . ..|. ... .| |.| |.
VIKEGWLYKKS-----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P-----CFEIHH-DR--TYYFQCESEEEMQEWMQAIQ

QVLETQ
.... .
KAIHNN

SH3 Trad.AA SH3 2324-2385 17 0.000266 18.27 SMART 1-58 (58) Show / Hide
Range on Protein: 2324-2385
Range on HMM: 1-58/58
Sequence Identity: 17% (11 aa)

SSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLT
  . .. || |  ..|. ...|....||  . .. . .           |||.|.. .....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNR----TGQEGWFPSNYVEEID

SH3_2 Trad.AA SH3_2 2325-2384 16 0.36192 6.98 Pfam 1-68 (68) Show / Hide
Range on Protein: 2325-2384
Range on HMM: 1-68/68
Sequence Identity: 16% (12 aa)

SMAVIKDYYA-LKENE-----ICVSQGEVVQVL---AVNQQNMCLV-YQ--PASDHSPAAE--GWVPGSILAPL
 . |..|| .  ..||     . .  |.|. |.     .. | ... .            .  ||.| ......
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG------GRRMRGWFPSQWVEEC

I-set Trad.AA I-set 2471-2565 32 7e-27 93.73 Pfam 1-92 (92) Show / Hide
Range on Protein: 2471-2565
Range on HMM: 1-92/92
Sequence Identity: 32% (31 aa)

PEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKV
|.|. .. ||..  |.|. ..|.| | |.|...|.  .| .     .|  . ..  ..|. || | |  | |.|.|||.|||  |. ...|...|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP---DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV

IG Trad.AA IG 2477-2566 27 1.8e-14 55.3 SMART 1-58 (58) Show / Hide
Range on Protein: 2477-2566
Range on HMM: 1-58/58
Sequence Identity: 27% (26 aa)

LVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDS---GIYTCIATNDHGTTST--SATVKVQ
   ||  .|.|| |.| |      .|.|.                           | | |. |.||   |.|.| ||  ||...   ..|..||
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ

IGc2 Trad.AA IGc2 2483-2555 32 2.8e-14 54.67 SMART 1-56 (56) Show / Hide
Range on Protein: 2483-2555
Range on HMM: 1-56/56
Sequence Identity: 32% (24 aa)

LLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHG
. |..|.|.|.. |.| |.|.|.      |.               .. ||.| |  | |||.|||.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP---------------WNWTLTIKNVTPEDSGYYTCYARNPWG

V-set Trad.AA V-set 2471-2565 17 7e-06 22.2 Pfam 1-128 (128) Show / Hide
Range on Protein: 2471-2565
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

PEFLVP--LV----DVTCLLGDTVILQCKVC-----------------GRP--------KPTITWKGPDQNILDTDNSSATYTVSSCDS-GEITLKICNL
.... .         ||  .|..| |.|..                  ..|        .  . .. .....  ..  . ..|.|.. | .  .|.| ||
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

MPQDSGIYTCIATN-DHGTTSTSATVKV
 | |||.|.| ..| ....  .. .. |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV

FN3 Trad.AA FN3 2569-2651 22 1.8e-13 52.03 SMART 1-69 (69) Show / Hide
Range on Protein: 2569-2651
Range on HMM: 1-69/69
Sequence Identity: 22% (22 aa)

PAAPNR---PIAQERSCT------SVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPG----CPYQFRVSASNP--WGIS
| .| .   . . . . |      || |.| ||           .|.||                   ....|.||      |.|||.| |    |..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Kinase Trad.AA Trio 2684-2938 57 2e-242 630.06 In-house 1-258 (258) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-258/258
Sequence Identity: 57% (149 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFY
||...||||||||.|..|.||||....|.||....|..|||..||...|||||||....||||||.|..|||||||.|||.||..||......|..|..|
YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFIPYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLMRWGSYCESEVKTY

IRDIMEALQYLHNCRVAHLDIKPENLLIDLRIP-VPRVKLIDLEDAVQISGH--FHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF
.....||..|||||...||||||||.... ... .|..|..|..||.|...|  ...||..|||||.|||.|||.|||.|||||||||||||||||.|||
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPF

LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
.|||..|||.|.||.|||||..|||.||..|..||...||||...||.|..||||||.
YDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF

Kinase Trad.AA DAPK 2686-2938 41 4.2e-104 287.6 In-house 1-264 (264) Show / Hide
Range on Protein: 2686-2938
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

ELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKE-------QAAHEAALLQHLQ-HPQYITLHDTYESPTSYILILELMDDGRLLDYLMN--HDEL
   |.|||.|..|.||.|| | |. | ||. |  ...           || | |. .. ||  |.||. ||  |  |||||.   | | ||. .   . |
MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL

MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPEN-LLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVML
 || ..  .. | |.. |||  ...|||.||.| .| | .|| ...|.||   .  |     .    | ||. |||...  | || ||.|||||.||.||
CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML

SGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
|| |||| . | ||  |. .|  .|. ||| ..|  |.|||   |  | ..|.||. ||||||.
SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI

Kinase Trad.AA MLCK 2684-2938 37 8.7e-97 255.43 In-house 1-257 (257) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-257/257
Sequence Identity: 37% (98 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSK-KMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLM-NHDELMEEKVA
|  . |.|||.|.|| .|| |.| | .|.||.   | |.||   .|   .  |.||  | .|| .|.... ..|.|. . | |...     ..| |. |.
YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI

FYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFH-IHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF
.|.| | |.....|  ...|||.|||| ..       ..|.||   | .. ..   .  . | |||.||||..  ||...||.||.||..|..||| |||
HYMRQICEGVHHMHWQNIVHLDLKPENIMC-QTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPF

LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
. .. .||  ||  ..  |  | | ..|. |.|||  .| .| ..|.||..|||||||
MGDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL

Kinase Trad.AA CAMK 2689-2938 20 3.1e-96 310.6 In-house 1-425 (425) Show / Hide
Range on Protein: 2689-2938
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

EIGRGRFSIVKKCIHKATR------------KDVAVKFVSKK-----------------------------MKKKEQAAHEAALLQHLQ-------HPQY
..|||.|..||.|||| |             . ||.|...||                              |....  .| .....||       ||  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLHDTYESPTS-------------------YILIL---ELMDDG----RLLDYLMNH---------------DELMEEKVAFYIRDIMEALQYLHNCRV
| |...||.|.                    .....   |... |    .|.||.  |                 . |. ...|.| | .|..|.|.. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHLDIKPENLLIDLRIPVP--------------RVKLIDLEDAVQISG------------------------HFHIHHLLGNPEFAA-PEVIQG------
.|.|.||||.|.| . .                 .|.||   | .. .                            .   | ||..| |||..|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------IPVSLGTDIWSIGVLTYVMLSGVSPFLDE-------------SKEETCINVCRVDFSFPHEYFCG------------VSNA--------ARD
         ...  .|.||.||..|.||.| .|| ..             . .|.. .... ...||..|| .            .|.         ..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FINVILQEDFRRRPTAATCLQHPWL
.|. .|| |  .|.|.. ||.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM

Kinase Trad.AA DAPK 2684-2938 41 4.4e-88 254.14 In-house 1-264 (264) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMK-------KKEQAAHEAALLQHLQ-HPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDEL
|    ||| | |..||||  | | |. | ||. |          . |    |   |. .. ||  ||||| ||  |  .|||||   | | |.|   . |
YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECL

MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVML
 ||  . .|  | ......|  ...|.|.||||  | |  .| ||.|.||   | .|     .  ..| ||| |||..   | .| || ||||| ||..|
NEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILL

SGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
|| |||| . |.||  |. .| . |  |||   |. | |||   |  | ..| | . |||||| 
SGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI

Kinase Trad.AA DRAK 2688-2938 36 4.3e-79 245.31 In-house 3-259 (259) Show / Hide
Range on Protein: 2688-2938
Range on HMM: 3-259/259
Sequence Identity: 36% (93 aa)

NEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKK---EQAAHEAALLQHLQH-PQYITLHDTYESPTSYILILELMDDGRLLD--YLMNHDELMEEKVA
 | |||.| .| ||||| | .. | ||. |  . .   .   || | |   |  |. | ||. ||  .  ||.||.   | . .   . . . . |. | 
KERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKDVQ

FYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFL
  .|.|.|...|||.  ..||| || | |     |   .|..|   .  |     .  . | |.. |||. .  |... ||.|||||||||||...|||.
RCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISPFV

DESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
 . | ||  |.  .  ... | | ..|. |.|||  ..  .   |.||  ||.||||
GDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL

Kinase Trad.AA S_TKc 2684-2938 29 1.7e-73 251.42 SMART 1-231 (231) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-231/231
Sequence Identity: 29% (81 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDD--GRLLDYLMNHDE------L
|. |..||.| |. |.||.|| | . ||.| ..      |..  | ..|.. .||  ..|.|.... ... ...|..|   | |.||. ..        .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSL-GTDIWSIGVLTYVML
 |  ..||.. | .||.|.|. .. | |.||||.|.|      ..|..|   | |.      ... | |.. ||||.   . .    |.||.|.. | ||
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQ-------HPWL
.|  ||     ... .....             |  |.|||. .|| | ..||||  .||       |||.
CGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Trad.AA Pkinase 2684-2938 29 1.5e-67 235.5 Pfam 1-293 (293) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQ---AAH--EAALLQHLQHPQYITLHDTYESPTSYILILELMDDG----RLLDYLM--NH
|. .  ||.| |. |.||.|| |.| |||| ..|. .|...   ...  |......|.||  ..|.|..|..... ...|... |     | ||..  .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DEL--MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVP--RVKLIDLEDAVQ--ISGHFHIHHLLGNPEFAAPEVIQ-GIPVSLGTDIWS
  .   |. . ||.. | ..|.|.|.... | |.||||.||| . ...  .||..|   | |  .      ... | |...|||||. | . .   |.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGVLTYVMLSGVSPFLDE------SKEETCINVCRVDFSFPHEYFCGVS-----------------NAARDFINVILQEDFRRRPTAATCLQHPWL
.|.. | ||.|  || ..      .. .   .. . ...|. .. | .|                  ...|||. .|. |  .||||. .|||||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase Trad.AA CAMK-Unique 2684-2938 20 2.5e-56 184.39 In-house 1-363 (363) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-363/363
Sequence Identity: 20% (76 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSK---KMKKKEQ------------------AAHEAALLQHLQHPQYITLHDT----YESPT-------
|. .. || | |..|..|. ..|.|  |.| | |   . ||. |                  .  |..... . ||  | | |.    .. ..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------SYILILELMDDGRLLDYLMN--------------------HDELME--EKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIP-----
         . ...|. ..| |.|...                        . |    ..|... . .|. |.|.  . | |.|.||...  . .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------VPRVKLIDLEDAVQISGHFHIH---HLLGNPEFAAP--------------EVIQ----GIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKE-
          ..||.|   ......    |      | |...||              |||     . ..|   ||||.||..| ||.| .||  |... 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ETCINVCRVDF-SFPHEYFCG---VSNAARDFINVILQEDFRRRPTAATCLQHPWL
       |.  . |  |. .|. ... |   .|..| ||.   .. |   | .|.  |.|.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

Kinase Trad.AA Ciliate-E2 2684-2938 21 4.1e-52 177.18 In-house 1-365 (365) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YTELNEIGRGRFSIVKKCIHKATRK------------------DVAVKFVSKKMKKK---EQAAHEAALLQ----------------HLQHPQYITLHDT
|  .. ||.| |..|.|| .. ..|                   |..|.. .|..||   ||   |  ...                .|.||  | ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--SPTSYILILELMDDGRLLDYL------------------MNHDELMEEKVA--------FYIRDIMEALQYLHNCR-VAHLDIKPENLLIDLRIPV
..  . ... |..|. . | |.||.                  ...   . ....        |||. |..||.|||.   . | ||||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PRVKLIDLEDAVQIS------------GHFHIHH---------------------LLGNPEFAAPEVIQGIP---------VSLGTDIWSIGVLTYVMLS
  .|.||.  . ...            . .   .                     ..|.|.. |||...| .          .   ||||.||. | ||.
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GVSPFLDESKEETCINVCRVDFSFPHEY------------FCGVSNAARDFINV----ILQEDFRRRPT-AATCLQHPWL
|  ||      .  |  | .||..|.              .  .|. . |.|.     .|| |   |.| .  .|.|||.
GKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase Trad.AA RSK 2684-2938 26 1.4e-49 171.01 In-house 1-278 (278) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-278/278
Sequence Identity: 26% (75 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAA-----HEAALLQHLQ-HPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDE---
  .| ..| | .....||.|..|..  |.| ..|.. .. | .      |   |.. | ||  .|||.... ..   ||.|..  | |.. | ..     
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPV-PRVKLIDLEDAVQ--ISGHFHIHHLLGNPEFAAPEVIQ-GI-PV--SLGTDIWSIG
..|. ..||.. |  |...||   . | |.|||| | | .     ..||.|   . |  ..  .  .   .  |..|||..  .  ..  .   |.|| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VLTYVMLSGVSPFLD---ESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPT-----AATCLQHPWL
|| | ||.| .||     ....|.  .... .||....    .|..|.|.|.  |. |  .|..     |.  .||||.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase Trad.AA CAMKL 2684-2812 27 1.2e-34 107.93 In-house 1-161 (297) Show / Hide
Range on Protein: 2684-2812
Range on HMM: 1-161/297
Sequence Identity: 27% (44 aa)

YTELNEIGRGRFSIVKKCIH-KATRKDVAVKFVSKKMKKKEQAAH----------------EAALLQHLQ---HPQYITLHDTYESPTS------YILIL
|. . ..|.| |. || ..| . |.. ||.|.. || ..... ..                |......|.   ||  | |....| |.       . |..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELMDDGR--LLDYLMNHDE----LMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLID
|. . |   |.||. .| .    . |.   .| | |..|..|.|.....| ||||||.|.|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLD

Kinase Trad.AA CAMKL 2842-2938 31 5.8e-22 66.75 In-house 195-297 (297) Show / Hide
Range on Protein: 2842-2938
Range on HMM: 195-297/297
Sequence Identity: 31% (35 aa)

GNPEFAAPEVIQG--IPVS-LGTDIWSIGVLTYVMLSGVSPFLDES---------KEETCINVCRVDF-SFPHEYFCGVSNAARDFINVILQEDFRRRPT
| |...|||..||   |     .||||.||. |.|. |  || |..         ...  |...   .  ..|     ||  .||.|  .|| .  .|||
GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYH-----VS-DCRDLIRKMLQVNPEKRPT

AATCLQHPWL
.   ..|||.
IHQIMNHPWM

Kinase Trad.AA TyrKc 2684-2938 21 1e-09 -65.49 SMART 1-280 (280) Show / Hide
Range on Protein: 2684-2938
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHL--QHPQYITLHDTYESP-------TSYILILELMDDGRLLDYLMNHDE
 | . ..|.| | .| |.. |    .|||| . |. . .|   .|| .. .|  .||  . |.    ..         . ...|.|. | |.||| .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVK-MLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKL------IDLEDA-------VQIS------GH--FHIHHLLGNPEFAAPEVI
 |  ..   .  .| .  .|||  .. | |.   | |.. .    .||        |..|          ..      |.  . |  .       |||.|
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-------APECI

QGIPVSLGTDIWSIGVLTYVMLS-GVSPFLD-----ESKEETCINVCRVDFSFPHEY-----FCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL
.    .  .|.|| ||. . ... | .|  .      | .|   .| . .   . ..     | . . .  . .    .||   ||| ...  |  .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase Trad.AA Pkinase_Tyr 2684-2772 26 3.3e-05 18.27 Pfam 1-101 (270) Show / Hide
Range on Protein: 2684-2772
Range on HMM: 1-101/270
Sequence Identity: 26% (27 aa)

YTELNEIGRGRFSIVKKCIHK----ATRKDVAVKFVSKKMKKKE--QAA--HEAALLQHL-QHPQYITLHDTYE-----SPTSYILILELMDDGRLLDYL
 | . ..|.| |  |.|.. |     |. .|||| .  .  ...  ...  .||... .| .||  . |.         .  ......|.|  | |||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL

MNH
 .|
RKH