Gene TRKA (Human)

TRKA

Species: Human
Alias: TRK, TRK1, TRKA, NTRK1, TRK-A, p140-TrkA, DKFZp781I14186, MTC
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q21-1q23.1,

Classification

Group: TK
Family: Trk

Sequence

Name Sequence Type Origin Length Description Download
TRKA.NA RNA Sugen Kinome 2663 None Fasta, JSON
TRKA.AA Protein Sugen Kinome 796 None Fasta, JSON
TRKA.kin_dom Protein Kinase Domain Sugen Kinome 275 None Fasta, JSON

Protein domain

Protein domains of TRKA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRCT TRKA.AA LRRCT 148-192 29 1.1e-12 49.39 SMART 1-55 (55) Show / Hide 
Range on Protein: 148-192
Range on HMM: 1-55/55
Sequence Identity: 29% (16 aa)

NPLHCSCALRWLQRWEEE-GLGGVPEQ--KLQCHGQG-----PLAHMP--NASCG
||..|.| |||.||| ..     |...   ..|....     ||.|..  ...|.
NPWNCDCHLRWFQRWLQQQHNRHVQDPQSDMRCASPEHMRGQPLFHYLHSDFKCP
IG TRKA.AA IG 200-283 19 2.4e-05 25.01 SMART 1-58 (58) Show / Hide 
Range on Protein: 200-283
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

VPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLN--RKNVTCWAENDVGRAEV--SVQVNVS
 |  .| .|..| |.| |.     |  |                     ||. ||. .    . . .| |.   | ..   .... |.
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set TRKA.AA I-set 264-282 42 0.006629 12.37 Pfam 74-92 (92) Show / Hide 
Range on Protein: 264-282
Range on HMM: 74-92/92
Sequence Identity: 42% (8 aa)

TCWAENDVGRAEVSVQVNV
|| |.| .| ||......|
TCVATNSFGEAECTAELTV
I-set TRKA.AA I-set 194-219 26 0.035667 9.89 Pfam 1-26 (92) Show / Hide 
Range on Protein: 194-219
Range on HMM: 1-26/92
Sequence Identity: 26% (7 aa)

PTLKVQVPNASVDVGDDVLLRCQVEG
|.   .  .. | .|... . |||.|
PKFTQKPKDVEVQEGETARFECQVTG
I-set TRKA.AA I-set 305-326 30 0.386017 6.38 Pfam 24-46 (92) Show / Hide 
Range on Protein: 305-326
Range on HMM: 24-46/92
Sequence Identity: 30% (7 aa)

VDGQPAPSLRWLFNGSVLNE-TS
|.|.| |.  |. .|. |.. ..
VTGDPPPQVSWFKDGQPLRPDSD
I-set TRKA.AA I-set 357-374 44 0.198526 7.36 Pfam 71-88 (92) Show / Hide 
Range on Protein: 357-374
Range on HMM: 71-88/92
Sequence Identity: 44% (8 aa)

GNYTLLAANPFGQASASI
| ||  | |.||.|....
GKYTCVATNSFGEAECTA
Kinase TRKA.AA Trk 510-781 76 3.8e-221 740.97 In-house 1-275 (275) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-275/275
Sequence Identity: 76% (210 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAK
||||||||||||||||||||.||.||||||.||||.||.|||.||.||||||||||.|||||||.|.||||...|||||||||.|||||..||.|||||.
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDAM

LLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYS-TDYYRVGGRTMLPIRWMPPESILYRKFTTE
..|.... .|||||...|.|..|.|.|.||||.|..||||||.|||||||||.|.|||||||||||.|| |||||||..|||||||||||||.|||||.|
CYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYE

SDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE-LERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL
|||||||||.||.|||||||||||||.|.|.||.|||. |||||.||.|||.||.||||||||||..|||.|...
SDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase TRKA.AA TyrKc 510-781 43 1.8e-141 477.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-280/280
Sequence Identity: 43% (134 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTML--QHQHIVRFFGVCTEG-------RPLLMVFEYMRHGDLNRF
|.|. .|||||||.|....          . |||| ||| .   |.|| |||.....|  .|..|||..||||..        ||..|.||| ||||. .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST-------DYYRV----GGRTML
||.|.|.              | . .||  . |.|.|| ||.  ...|||||.|||||| ...|||.|||.|||||.        ||||.    ||.|||
LRKHRPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ-----LSNTEAIDCITQGRELERPRA--------CPPEVYAIMRGCWQREPQQRHSIKD
|||||.||.| |.||||.||||||||..|||||||.||..      .||.|.| .. ||. ...|          ||.|.| ||. ||...| .| . ..
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

VHARL
.| ..
IHECF
Kinase TRKA.AA Pkinase_Tyr 510-781 45 2e-139 472.82 Pfam 1-270 (270) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-270/270
Sequence Identity: 45% (129 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA---RQDFQREAELLTML-QHQHIVRFFGVCT-EGRP--LLMVFEYMRHGDLNRFLR
|..  .|||||||.|......  .|...|. |||| ||| . .    |.|| |||.... | .|..|||. |||| .|.|  ...|.||| ||||  .||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYY-RVGGRTMLPIRWMPPESILY
.|              ..|| . .||  . |.|.|| ||.  ...|||||.|||||. ..||||.|||..||||..||| |..| ..|||.||.||.| |
KHR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY

RKFTTESDVWSFGVVLWEIFTYGKQP-WYQLSNTEAIDCI-TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL
.||||.||||||||..|||||||.|| .. .||.| .. |  .|. ...|. ||.|.| .|. ||. .|..| . ...| .|
GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TRKA.AA Musk 510-781 47 3.5e-123 408.99 In-house 1-282 (282) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-282/282
Sequence Identity: 47% (133 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
|.   ..|||||| || |    |.|... ..|||| ||. ||.   .|||||| ..    |. ||.  |||  |||. . ||||  |||| ||.|  | .
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

KLLAGGEDVA-------PGPLGLGQL--LAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESI
   .  .| .       |||..|  .  | .| |.|.|| ||    ||||||||||||..   .||| |||.|| ||. |||.  .    ||||||||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

LYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL
.| .||.|||||..||.||||| |. ||.| ..  | |  | ||  |  |  || .||..|| |||..|  | . ...|  .
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase TRKA.AA TK 510-781 27 8.99999999999e-123 413.65 In-house 1-486 (486) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-486/486
Sequence Identity: 27% (132 aa)

IVLKWELGEGAFG---KVFLAECHNLLP--------------------EQDKMLVAVKALKE-ASESARQDFQ-------------REAELLTMLQ----
|.|  .||||.||   .|...| ... |                    |. |. |||| ||| ...|... |.             .||| . |..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HQHIVRFFGVCTEG------------RPLLMVFEYMRHGD----LNRFLRSHGPDAKLLAGGED-----------------------------------
 |..|||..||||.|            .|...| ||| |||    |  .||.. |...  . . |                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------VAPGPLGLGQLLA-------------------VASQVAAGMVYLAGL------HFVHRDLATRNCLVGQGLV-----------VKIGDFGMS--
       .| ||.. .||                     . |.|.|| ||. .      .|||||||.||||||...|           .||.|||.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------RDIYSTDYYRVGG------------------------RTMLPIRWMPPESIL---------YRKFTTESDVWSFGVVLWEIFTYGKQPWYQ-LS
      ||||| |.|.. .                        ...||||||.||...         |.||||.||||||||..|||||||..|.|  .|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------TEAIDCITQG--------------RELERPRACP--------------PEVYAIMRGCWQREPQQRHSIKDVHARL
|         .| ......|               ....|  ||              .|.| .|. ||...|..| . ...| .|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TRKA.AA Ror 510-784 46 1e-115 390.76 In-house 1-278 (308) Show / Hide 
Range on Protein: 510-784
Range on HMM: 1-278/308
Sequence Identity: 46% (129 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
.    ||||..||||.  .   ... .  |.||.|..|. ||   .|||..|..|   |.|. ||   ||||   |..|.|||| ||||  || .. | .
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

KLL-AGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTT
      ..|      |  .  | .| |.|||| ||.  ||||||||.|||||| ...||| ||| .||||| ||||. .. ..|||||.||.|.| ||..
DHGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSE

ESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL
.||.||||||||||. || ||.|  || | |. | .   |. |  ||. .|. |  ||   |  |   ||.| ||...
DSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIHSRLRSW
Kinase TRKA.AA InsR 510-783 42 6e-110 370.52 In-house 1-278 (278) Show / Hide 
Range on Protein: 510-783
Range on HMM: 1-278/278
Sequence Identity: 42% (119 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKM--LVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP
|||  |.|.|.||.| .    ...|.       .|.| ..| ||   | .|  ||.      . |.|| .|||. | | . | | | .|||  .|||. |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

DAKLLAGGEDVAP---GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRK
...     . . .    .  |.|..  |.... || ||| . ||||||| |||.| . . |||||||| |||| .|||| ||. |||.|||.|||.   .
EEEF---NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

FTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI-TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA
||| ||||||||||||. | | ||   ||| .. . |   |  |..|  ||. ....|. |||  |. | . .|. . |. 
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase TRKA.AA UTK 510-781 36 6.4e-105 354.87 In-house 1-296 (296) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-296/296
Sequence Identity: 36% (110 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK--EASESARQ---DFQREAE---LLTMLQ-HQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
. |  .||.|||| |..|.  .  .   .|.||||...  .... ..    || .||    .. ... |....|. |||| . |...| |||. |||  .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG-------LVVKIGDFG---MSRDIY---------STDYY
||.|.|..         .|  | | |.|  |...|.|| ||.. .||||||| |||||..        .|.||.|||   |||...         ...||
LRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYY

RVGGRTMLPIRWMPPESILYR-KFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQG--RELERPRACPPEVYAIMRGCWQREPQQRHSIKDVH
.  .....||||| ||.. .. .||| |||||||||.|||.|.|..|.  .|| ...  .. |  . ...|..|| .|| .|. ||. .|| | ...|. 
MAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLV

ARL
...
QQM
Kinase TRKA.AA DDR 510-781 40 5.8e-96 325.11 In-house 1-306 (306) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-306/306
Sequence Identity: 40% (123 aa)

IVLKWELGEGAFGKVFLAECHNLL-----------PEQDKMLVAVKALKE-ASESARQDFQREAELLTMLQ-HQHIVRFFGVCTEGRPLLMVFEYMRH-G
 . .  .||| || | | |  ...              . .||||| |.. |.. ||.|| .|.  .  .  |  ||| .||||.  |..|. |||   |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNRFLRSHGPDAKLLAGGE---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG--MSRDIYSTDYYRVGG----
||| |.  | .  . | . .   . . .| .  .... .. |.|.|| ||. . ||||||||||||||  . .|| |||  |||  || ||||| |    
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR

-RTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVY-AIMRGCWQREPQQRHSIK
 |  .||||| .||||  |||| ||||.||| .||.|.  . ||. ||..   |. .     .||..  | .|..|| |.|   |  ||.|...|| | .
QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE

DVHARL
 .|  |
EIHKFL
Kinase TRKA.AA TK-Unique 510-781 35 1.5e-94 320.46 In-house 1-294 (294) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-294/294
Sequence Identity: 35% (105 aa)

IVLKWELGEGAFGKVFLAECHNLL-PEQDKMLVAVKALK-EASESARQDFQREAELLTMLQ-HQHIVRFFGVCTEGR-PLLMVFEYMRHGDLNRFLRSHG
.... ..|||||| |. .|  ..  .. ..  ||||.|| .|..  .||| .|....  |  |..||...|.||.   | ....||.. |.|  .||. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PD-----------AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG--LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIY-STDYYRVGGRTMLPI
|.            ..    ... . |. ...|.  | |.| || |||.   ..|||||..||.|.. ..|.||.||||.||.|  ..| . ... ..||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMPPESIL--YRKF-TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC-PPEVYAIMRGCWQREPQQRHSIKDVHARL
|||.|||..  .. . ||.||||||||..|||||.|..| ....... ..||..|  ...|  | ..|.| .|. |||.||..| |. ..  ||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TRKA.AA CTKB 510-783 42 5.4e-88 298.64 In-house 1-269 (269) Show / Hide 
Range on Protein: 510-783
Range on HMM: 1-269/269
Sequence Identity: 42% (119 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELL-TMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
||||  |||| || |.  |   ..|.|    ||.| |...|  |  || .|  .. |.   | |||  |.||   | ||| | |  |||   ||   |  
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVTPVAIKMLQDSSSEATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRPKT

KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTES
          |  |    |  .|  || || |.|..  |||||| ||||| |   | |||||.|||.|   ||   .   |||||| ||||    .|| |
--------SKPSALSPRRLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQS

DVWSFGVVLWEIFTYGKQPWYQ-LSNTEAIDCITQG-RELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA
||||.|.|.||| |..| |.   ..| | .  |. .   . .|. || |.|. |  ||  ||  | | |. | ..  
DVWSYGIVIWEIMTFAKMPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISFKELHEKTLL
Kinase TRKA.AA ALK 510-783 41 9.2e-88 297.87 In-house 1-273 (273) Show / Hide 
Range on Protein: 510-783
Range on HMM: 1-273/273
Sequence Identity: 41% (117 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
| |   || |||| |. ..   .     .| ||.| |.| .|.    ||  ||  .   .|| .||  |.| .  |.. | |||  ||. .|||   |  
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDI-YSTDYYRVGGRTMLPIRWMPPESILYRKF
. |       | .|    || ..  ||.|  ||   ||.||| | ||||    | | |.||.||||.||| | .|||| |||.|.|. |||||  .   |
ESL------QPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIF

TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA
|. .||||||| .||||  |  |    .|.| .. .|.|  .. || ||  || ||. ||| .|  | .  ..  ..|.
TSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase TRKA.AA S_TKc 510-790 21 6.1e-49 169.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 510-790
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRH--GDLNRFLRSHGPD
  .  ..|.||||||...  ..     .. .||.| .|       ....|| ..| . .| .||....|. .   | ||.||. .  ||| ......|. 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTT-
 .         . |.   .   .. |.. .. |.  ....||||   | |. .  ..||.|||..| .                 .|.|| .   .... 
GL---------RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKC

ESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPV
..|.||.|..|.| .. |. |..     . .. |            .||.  ..|.|.|..|..| .. .. .. .. .. | .
KCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TRKA.AA Pkinase 510-781 19 1.7e-44 158.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 510-781
Range on HMM: 1-293/293
Sequence Identity: 19% (61 aa)

IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD--FQR--EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG----DLNRFL
....  .|.|.||.|...  ..     .  .|||| .|  .|.  .|    |  |.... .|.| .|||......... . ||.||...|    || ...
YHIGRKIGSGSFGCVYKCHHKG-----TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RSHGPDAKLLAGGEDVAPGPL--GLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV----KIGDFGMSRDIYSTDYYRVGGRTMLP--IRW
.               . |..     ..  .. |.. |. |.    ..||||   |.|. .  ..    ||.||| .. ..   | . .  | .   ...
ST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWY

MPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQL----SNTEAIDCITQGRELERPRACP-----------------------PEVYAIMRGCWQ
|.|| |. ... ....|.||.|..|.| .. |. |...     .  . . .| . .. . .. .|                       .|   ....|..
MAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

REPQQRHSIKDVHAR--L
. |..| .....     .
KDPKKRPTAEQILQHPWF