Gene ULK1 (Human)

ULK1

Species: Human
Alias: FLJ38455, Unc51.1, ULK1, UNC51, ATG1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12q24.3,

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
ULK1.NA RNA Sugen Kinome 5239 None Fasta, JSON
ULK1.AA Protein Sugen Kinome 1050 None Fasta, JSON
ULK1.kin_dom Protein Kinase Domain Sugen Kinome 263 None Fasta, JSON

Protein domain

Protein domains of ULK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ULK1.AA ULK 16-278 33 9.60000000001e-125 420.72 In-house 1-324 (324) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-324/324
Sequence Identity: 33% (111 aa)

FSRKDLIGHGAFA-VVFKGRHREKH--DLEVAVKCINKKNLAKSQT---------LLGKEIKILKELK---HEN--IVALYDFQEMA--NSVYLVMEYCN
.. .. .|.|.|. .|.|||. ...  .  ||.|.|.||.. |..          || .||.|.|.||   |.|  || |||..| .  | .|..|||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLADYLHAMRTLSEDT----------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR----ANPNSIRVKIADFGFARYLQSNMMAATLC
|||| .|..  ..|.| |          .. |..||. ... ||...|||||.||||||..|. . .    ..| ....||||||||. ...|.|....|
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMC

----------GSPMYMAPEVIMSQ-----HYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLR-------------LFYEKNKTLVPTIPR---ETSAPL
          |.|.||||.....|     .|| |.|.||.|.| |..|.|| ||... ..|.              ..|.||. . . .|.     |  .
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

RQLLLALLQRNHKDRMDFDEFFHHPFL
..|.  .||.. |||....|.|.||..
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase ULK1.AA ULK 16-278 33 1.8e-120 406.56 In-house 1-329 (329) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-329/329
Sequence Identity: 33% (111 aa)

FSRKDLIGHGAFAVVFKGRHREKH---DLEVAVKCINKKNLAKSQTL---------LGKEIKILKELK--------HENIVALYDFQEMA--NSVYLVME
.. .. .|.|.|..|.|||. ...   .  ||.| | |. . ... .         | .||||.|.||        |.||| |||..| .  | .|..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGGDLADYLHAMRTLSEDT----------IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR----ANPNSIRVKIADFGFARYLQSN----
||||||| .|..  ..|.|||          .. |..||. ... ||...|||||.||||||..|. . .    ..| ....||||||||. ....    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ

--MMAAT----LCGSPMYMAPEVIMSQ-----HYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLR-LFYEKNKTLVPTIP----------------RET
  ||...    |||.|.||||.....|     .|| |.|.||.|.| |..|.|| ||.|. ..|.  ....|.. . |..|                   
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
|  ...|.  .||.. |||....|.|.||..
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase ULK1.AA S_TKc 16-278 34 2.9e-98 333.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNG--GDLADYLHAMRT----
.   ..||.|||..|.|.||..  . .||.|.|.          . .||.|||. .|.||| |||. .  ...|.|||||.|  ||| ||.. ...    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG-KADLWS
  ..| ..| ...||. |.  .||.|||||||||.||||..           ..||.|||.|| |       |.||.| ||||||.   .|.. |.| ||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

IGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFH-------HPFL
.| |.| .|.|. ||.     .. . ..| .          | ......  .||.. ..|.   | ..       ||..
CGCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ULK1.AA AGC 16-278 20 2.2e-84 217.29 In-house 1-395 (395) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-395/395
Sequence Identity: 20% (85 aa)

FSRKDLIGHGAFAVVFKGRHREKH-----DLEVAVKCINKKN---------LAKSQTL--------LGKEIKILKELK----------HENIVA-LYDFQ
|  . .|| |.|  |.  |.....     .   |.|...||          ... .|         . .| .||....          | .||  |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EMANS--VYLVMEYCN---------GG-DLADYLHAM-R--TLSEDTIRLFLQQ-------IAGAMRLLHS-KGIIHRD-LKPQNILLSNPAGRRANPNS
.  .   .|.||||..         || .|  .|. . .  ...|...| .. .       |. |.  ||| .|||||| ||| |||| .          
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---------

IRVKIADFGFARYLQSNM---------------------------------------------------MAATLCG--SPMYMAPEVIMSQHYDGKADLW
  .|..|||..  . ...                                                   .. |.||  .| |||||..    |.  .| |
GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWW

S--IGTIVYQCLTGKAPFQASSPQ-------DLRLFYEKNK------TLVPTIP----------RETSAPLRQLLLALLQRNHKDRMD----------FD
|   | . |. |||. ||.. .||       .    ..| .      .  ...|          |. |  .. |.  ||... ..|            ..
SFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAE

EFFHHPFL
|   ||. 
EIKNHPWF
Kinase ULK1.AA CAMK 21-278 21 4.8e-84 270.59 In-house 1-425 (425) Show / Hide 
Range on Protein: 21-278
Range on HMM: 1-425/425
Sequence Identity: 21% (95 aa)

LIGHGAFAVVFKGRHREKHDLE-----------VAVKCINKKNLAK---------------------------SQTLLGKEIKILKE-------LKHENI
 .|.|.|..|....|..   .|           ||.| |.|| | .                           ..  . .||.|.|        |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VALYDFQEMANS-------------------VYLVM---EYCNGG----DLADYLHAM---------------RTLSEDTIRLFLQQIAGAMRLLHSKGI
. ||.. | ..                    .|.||   ||| ||    || ||. .                . ..|.  | . .||. |.. .||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPQNILL-SN-------------PAGRRANPNSIR-VKIADFGFARYLQS------------------------NMMAATLCGSPMYMA-PEVIM
.|||||| |||| .|             .       ..   .||.|||||.....                        . .  | ||.| ||| |||. 
VHRDLKPENILLDDNNDDSDPVEHDEIFD-------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

S--------------QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQ----------DLRLFYEKNKTLVPT-IPRETSA--------------------
.              . |. |.| ||.| | | .|.|. ||.... .          ...  .|| ..   . .| . |                     
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHF

---PLRQLLLALLQRNHKDRMDFDEFFHHPFL
     ..|.  .||.. ..||  ..   ||..
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase ULK1.AA Pkinase 16-278 31 3.4e-81 280.85 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQT-----LLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGG----DLADYLH-
. ..  || |.|..|.|..|.   . .||||.|.|..  ...      |   ||.|.|.|.|.||| |||. |  ...|.|||||.||    ||.||.. 
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-AMRTL--SEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARY--LQSNMMAATLCGSPMYMAPEVIM-SQHYD
 . ...  ||.... .. ||. ..  .||.|||||||||.|||..|     |     .|||.|||.|.   . .|  . |.||.| |||||||. .|.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

GKADLWSIGTIVYQCLTGKAPFQAS----SPQDLRLFYEKNKTLVPTIPRETS---------------------APLRQLLLALLQRNHKDRMDFDEFFH
 |.| ||.| |.|. |.|. ||. .    .  | .  .....   .  .....                      ......  .|... |.|  ... ..
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPFL
||..
HPWF
Kinase ULK1.AA CAMKL 16-278 29 6.7e-79 251.39 In-house 1-297 (297) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-297/297
Sequence Identity: 29% (92 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGK--------------EIKILKELK---HENIVALYDFQEMANS------VYLVM
.   . .|.|.|..|  ..|.     .||.| |.|| . . .  . .              ||.|.| |.   |.||. ||.  |  .       .||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCNGGD--LADYLHAM----RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQS-----NMMAATL
||| ||.  | ||. .     . ..|.  | . .||  |.  .||.||.|||.|| ||||..   .        .||.||||. . .      . .  | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-------NIKIIDFGFSNMYRPCIFGPGQKLKTF

CGSPMYMAPEVIMS--QHYD-GKADLWSIGTIVYQCLTGKAPFQASSPQ-----DLRLFYEKNKTLVPTIPRE--TSAPLRQLLLALLQRNHKDRMDFDE
|||| |||||.. .  ..||  |.| ||.| | |  ..|. || . . .     .  ..|.|....   .|     | ..|.|.  .||.| ..|.  ..
CGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQ

FFHHPFL
   ||..
IMNHPWM
Kinase ULK1.AA Ciliate-E2 16-278 23 2.8e-77 263.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLE-----------------VAVKCINKKNLAKSQ-TLLGKEIKILKELK----------------HENIVALYDF
.    .|| |.|..|.|......  ..                 |..| ...|.. |.|   . .||.|..|..                | ||. .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

QE--MANSVYLVMEYCNGGDLADYLHAMRTLS-----------EDTIRLFLQQIAG---------------AMRLLHSKG-IIHRDLKPQNILLSNPAGR
 .    |..|||||||.|||| ||.  ... .           |  |. . .||.                |.. ||||. |||||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

RANPNSIRVKIADFGFARYLQSN--------------------------------MMAATLCGSPMYMAPEVIMSQH---------YDGKADLWSIGTIV
        .||.|||...... .                                .|. |.||.|.|||||.....          || |.|.||.| | 
--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRE------------------TSAPLRQLLLA----LLQRNHKDRMD-FDEFFHHPFL
|..|.|| ||           ....|     .| .                   |    .|.      .||.. . |.. ... . ||..
YEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase ULK1.AA CAMK1 14-790 10 3.4e-75 218.03 In-house 1-211 (276) Show / Hide 
Range on Protein: 14-790
Range on HMM: 1-211/276
Sequence Identity: 10% (80 aa)

FEFSRKDLIGHGAFAVVFKGRHREK--HDLEVAVKCIN-KKNLAKSQ----TLLGKEIKILK---ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADY
.||  .. || |||..|... |.|.   . ..|.|||. ||...|.     ..| .|| |.|   ...|.||...|...|  | .|||||...||.| | 
YEF--GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

LHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGR----RANPNSIRVKIADFGFARYLQSNM-MAATLCGSPMYMAPEVIMS---
       .|.  |.  .||..|   .||||| ||||||.|.|....       |         ||||| .... ..  .  | ||.| |.||||.     
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRS--------IADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKD

QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSY
..|| . |.|||| | |                                                                                   
KPYDKACDMWSIGVITYIL---------------------------------------------------------------------------------

PSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGL
                                                                                                    
----------------------------------------------------------------------------------------------------

ESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPPAHAEHGGVLARKMS
                                                                                                    
----------------------------------------------------------------------------------------------------

LGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHG
                                                                                                    
----------------------------------------------------------------------------------------------------

LQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFST
                                                                                                    
----------------------------------------------------------------------------------------------------

SRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLV
                                                                                             |.
---------------------------------------------------------------------------------------------LC
Kinase ULK1.AA STE 16-278 22 1.6e-72 247.21 In-house 1-359 (359) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-359/359
Sequence Identity: 22% (86 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLE--------------VAVKCINKKNLA----------------KSQTLLGKEIKILKELK--HENIVALYDFQE
. . . ||.||| .|.|..........              .|.| .|..|                  . .  . |||||.|...  |.|||  |.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

MA-------NSVYLVMEYCNGGDLADYLHAM----RTLS----------EDTIRLFLQQIAGA-MRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRV
         ......|||..|| | | ..      ..|.          |. |. ...||  . . .|||..|||||.||.||||              |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------------V

KIADFGFARYLQSNM-----------------MAATLCGSPMYMAPEVIMS------QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNK-
|..|||..  |...|                 .  |..|.| .||||||.       ..|| |.| ||.|  .   .||| |.   .|    .   .|. 
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

------------TLVPTIPRETS-------------------APLRQLLLALLQRNHKDRMDFDEFFH--HPFL
               |..| ..|                    .... .   ||.. ..| . ..  .  |||.
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase ULK1.AA Ciliate-E2-Unclassified 16-278 24 1.4e-65 224.2 In-house 1-352 (352) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-352/352
Sequence Identity: 24% (89 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLG-----------KEIK-------------ILKELKHENIVALYDFQEMANSVYLV
.     ||.|.|..|.| .|...  .  | | ..|..  |..  .            ...|             ||. ..|..|| ...  .  . .|.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCNGGDLADYL--------------HAMRT---LSEDTIR-----LFLQQIAGAMRLLHSKG-IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGF
||||.|||| .|.              | |..   ..|  ..      .. ||  .   ||.|. |||||.||.|||..|  .        ..||.|||.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK------NYYIKIIDFGI

ARYLQSN----------------MMAATLCGSPMYM----APEVIMSQHYDGK----ADLWSIGTIVYQCLTGKAPFQASSPQD----------------
....|.|                .|. | ||.|.||    ||||...|.||..    .| || | | |..|.|. ||.. .  .                
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ

LRLFYEKNKTLVPT-----IPRETSAPLRQLLL----ALLQRNHKDRMDFDEFFHHPFL
|.    .... .|      ||   |     ..      .|. | . |..|.. . ||..
LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase ULK1.AA RSK 18-278 29 6.2e-59 202.11 In-house 1-278 (278) Show / Hide 
Range on Protein: 18-278
Range on HMM: 1-278/278
Sequence Identity: 29% (85 aa)

RKDL--IGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQT---LLGKEIKILKELK-HENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRT--
 |.|  .| |.. .. | .|. ... . |.| ..|. ....|.      .|..||.. . | .|| |..  .    .||.||||.||.| . |   ..  
LKVLGQGGYGKVFLCRKCTHH-DTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-LSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARY-LQS-NMMAATLCGSPMYMAPEVIM---SQH-YDGKA
 .|||. .  . .|. |.. ||..||||||||| |||. .      . |. ..|. ||||...   . | .. | |..  |||||...    |  .|  .
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDD-----ES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKAC

DLWSIGTIVYQCLTGKAPFQA---SSPQDLRLFYEKNKTLVPTIP--RETSAPLRQLLLALLQRNHKDRMD-----FDEFFHHPFL
|.|| | . |  |||. |||.   ......    .|.| . .|.|   . |.. . |. ..|.|. ..|        .|   ||..
DWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK-FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase ULK1.AA Pkinase_Tyr 16-206 31 3.5e-39 133.33 Pfam 1-199 (270) Show / Hide 
Range on Protein: 16-206
Range on HMM: 1-199/270
Sequence Identity: 31% (67 aa)

FSRKDLIGHGAFAVVFKGRHR---EKHDLEVAVKCINKKNLAKSQ---TLLGKEIKILKEL-KHENIVALYDFQE-MANS--VYLVMEYCNGGDLADYLH
 .    .|.||| .|.||. .   ......||||.. | .  ..|     . .|.||.|.| .|.||| ||        .  .|.||||. .||| |||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AM----RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYL----QS-NMMAATLCGSPMYMAPEVIMSQ
.     . |.  ..  . .||| .|  |.||..|||||   |.|...         .  |||.||| ||..    .   .   .       ||||.|.  
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---------NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYG

HYDGKADLWS
 .  | | ||
KFTTKSDVWS
Kinase ULK1.AA TyrKc 16-278 25 9.7e-29 102.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-280/280
Sequence Identity: 25% (77 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKEL--KHENIVALYDFQEMA-------NSVYLVMEYCNGGDLADYLHA
 . .. .|.||| .|.||. .    ..||||....      .  . .|..|...|  .|.|||.||               ...||||. .||| |||..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MRT-LSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSN--------MMAATLCGSPM------YMAPE
 |  |. ..   |  |||  |. ||||..|||||   |.|....          .|||.||| .|.. .         .  ..  ..         ||||
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VIMSQHYDGKADLWSIGTIVYQCLT-GKAPFQA-----SSPQDLRLFYEKNKTLVPTIPRE--------TSAPLRQLLLALLQRNHKDRMDFDEFFHHPF
.|.   .  | | || |   .  .| |. |         |.|... . .. . .   .| .         .. . |. .   ... .||  | |   | .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM--PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

L
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F
DUF3543 ULK1.AA DUF3543 833-1049 21 3.5e-71 247.57 Pfam 1-275 (275) Show / Hide 
Range on Protein: 833-1049
Range on HMM: 1-275/275
Sequence Identity: 21% (60 aa)

ETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGG--PEYQLQESVV----------ADQISLLSREWGFAEQLVLYLKVAELLSSGLQSAIDQ
.|.|..|||.... |.. . . . |...|. |..... ..   ..|.|....|           .... .. .|...|.|||| |  .||..... | ..
QTSMDDEHTRTVQKLEECATRSDCVYGFAEVKYKQLIPLMPSVSTYGLGDANVQGRDDSMHQDDGLTPDAIVTWKSEEALVLYVKALSLLAKSMDIASAW

IRA--------------GKLCL-SSTVKQVVRRLNELYKASVVSCQGLSLRL---QRFFLDKQRLLDR-----------------IHSITAERLIFSHAV
..               ..||. |....|||....| .. ... |. . |.|   |... .... ...                 .. .|||.|....|.
WYRKNRGEDFNMTRDSSNQLCPTSNRINQVVQWIRERFNECLEKCEFVRLKLQEAQKRLPEDHPSHPKNHSNESSSSGSSNDVVVSSGVTAEKLMYDRAL

QMVQSAALDEMFQ-HREGCVPRYHKALLLLEGLQHML----------SDQADIENVTKCKLCIERRLSALLTGIC
.|...||..|.|. ...||...||.|. .||.|..             |. |...| |.. .|..|||.|   ..
EMSRTAAINELFGEDLPGCEIAYHTAIWMLEALLENDEDEDKDENDGLDDEDKQMVEKYIVSIRKRLSVLRKKMY