Gene ZAK (Human)

ZAK

Species: Human
Alias: MLTK, LOC51784, ZAK, mlklak, MLK7, LOC51776, AZK, MLT, MRK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2q31.1,

Classification

Group: TKL
Family: MLK
Subfamily: ZAK

Sequence

Name Sequence Type Origin Length Description Download
ZAK.NA RNA Sugen Kinome 3867 None Fasta, JSON
ZAK.AA Protein Sugen Kinome 800 None Fasta, JSON
ZAK.kin_dom Protein Kinase Domain Sugen Kinome 244 None Fasta, JSON

Protein domain

Protein domains of ZAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZAK.AA ZAK 16-259 70 1.1e-215 722.81 In-house 1-257 (257) Show / Hide 
Range on Protein: 16-259
Range on HMM: 1-257/257
Sequence Identity: 70% (180 aa)

LQFFENCGGGSFGSVYRAKWISQD---KEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPN-YGIVTEYASLGSLYDYINSNRSEEMD-------M
.|||..||.|.|||||||.|||||   .|.||||..||||||||||...|||||||||...|||| |.||||||..|||||||.||||.|||       |
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFKIEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGNSM

DHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVI-QSLPVSETCDTYSYGVVLWEMLTR
||||.|||..|||||||||.||.|.||||||||||||...||.||||||.|| ||.|.||||.||||||||||.| ||.||.||||..||||||||||||
DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEMLTR

EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISI
|||.|..|..|..|..|.||.|||||.||||.|..|.||||..|.|.||...||.||
EVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase ZAK.AA MLK 16-260 45 1.5e-144 486.48 In-house 1-291 (291) Show / Hide 
Range on Protein: 16-260
Range on HMM: 1-291/291
Sequence Identity: 45% (132 aa)

LQFFENCGGGSFGSVYRAKWISQD---KEVAVKKLL--------------KIEKEAEILSVLSHRN----IIQFYGVILEPPN-YGIVTEYASLGSLYDY
.|| | .| ||||.|....|  .|   |.||||.                ..|.|...|..|||.|    |||||||.|.||. ..||.||.. ||||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

INSNRSEEM------------DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAA------DGVLKICDFGASR-FHNH-TTHMSLVGTFPWM
....||..|            |.||.|.||...|.||||||..||...|||||||.|..|..      .|.|||||||.|| .|.. |..||  ||. ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEVI---QSLPVSETCDTYSYGVVLWEMLTREVPFK-GLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISIL
|||||   .. ..|| || .|.|||||||||||||.| .......|| |.....|..|||.||.....|..|||..|..|||||.||...|
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase ZAK.AA TKL 22-260 28 1.9e-104 353.29 In-house 1-364 (364) Show / Hide 
Range on Protein: 22-260
Range on HMM: 1-364/364
Sequence Identity: 28% (106 aa)

CGGGSFGSVYRAKWISQD--------KEVAVKKL-----------------------------------LKIEKEAEILSVLSHRNIIQFYGVILEPPN-
 | |.|| ||..||  ..        |.|||||.                                    ..|.|. ..| |.| ||.||.|. ..||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP-----VKVIHRDLKSRNVVIAADGV--------------
            ..||.||.. |||..|..        ..... || |.|.||.|||.. |      ..|||||||.|. .  ..               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

LKICDFGASRFH---------------------NHTTHMSLVGTFPWMAPEVIQSL----------------PVSETCDTYSYGVVLWEMLTREVPFKGL
.|||||| |||.                     |..|.|. .||. ||||||..                  . || || ||.|.||||.|||..|....
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

EGLQVA---------WLVVEKNERLTIP------------SSCPRSFAELLHQCWEADAKKRPSFKQIISIL
   ..          ..|..|..|..||            ..||.|...|. .||..|..|||||..|...|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ZAK.AA LZK 13-260 42 8e-79 265.38 In-house 1-241 (241) Show / Hide 
Range on Protein: 13-260
Range on HMM: 1-241/241
Sequence Identity: 42% (107 aa)

FDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEI--LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTW
  .||     | |. | |.| ..  . ..|||||  . .|| .|  |  | | |||.| ||    | | |. || . | ||.   . |  ..    .  |
ISELQWL---GSGAQGAVFRGWF--RNETVAVKK-VRDLKETDIKHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERR--TITPQLMVDW

ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHT--THMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKG
 ...|.||||||.    |.||||||| |. |... |.|||||| |.  |    | ||  ||  |||||||.  |.||  | .|.|||||||||.|.|.| 
SKQIAQGMHYLHQH---KIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKD

LEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISIL
 .   . | |     .| .||.||  |  |. |||..    ||||.|| . .
VDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase ZAK.AA Dicty4 16-262 36 2.3e-76 254.21 In-house 1-277 (277) Show / Hide 
Range on Protein: 16-262
Range on HMM: 1-277/277
Sequence Identity: 36% (103 aa)

LQFFENCGGGSFGSVYRAKWISQDKEVAVKKL--LKIE----------KEAEILSVLSHRNIIQFYGVIL----EPPNYGIVTEYASLGSLYDYINS---
... .  |.||||.||...|    ||||||||  ...           ||..|.. ..| ||..|.|  .    .|.   ||||| . |.||  ...   
INIEQRIGKGSFGEVYKGTW--RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

NRSEEMDMD--HIMT---WATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR----FHNHTT-HMSLVGTFPWMAPEVIQSLPVSET
   ..  .|   |      | |.|.|| .||   || .||||||| |  . .. . |.|||| |.      .|..  |. .||  |||||| .. |  | 
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

CDTYSYGVVLWEMLTREVPFK--GLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISI--LES
 | ||.| ||||.|||. |.   . .  |.. .|..| .|. ||..|| |...|.  ||. | ..||||..||..  ||.
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase ZAK.AA TKL-Unique 18-260 34 2.7e-76 259.78 In-house 1-290 (290) Show / Hide 
Range on Protein: 18-260
Range on HMM: 1-290/290
Sequence Identity: 34% (100 aa)

FFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------I-----EKEAEILSVLS-HRNIIQFYGVIL----EPPNYGIVTEYASLGSLYDYINS-----
|..  |.|..|.||..||    ..||.|.. .      .     |.|  ....|  | || ...|.       |||. ||.|| ..|||||...      
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---NRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAAD-----GVLKICDFGASRFHNHTTHMSLV-----------GTFPWMAPEV
   |.. ...|  ... | |.|.||.||| . |  .|||||||.|. .  .        |||||| |.| .  . |..            |.| ||||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

IQS--LPVSETCDTYSYGVVLWEMLTREV------PFKGLEGLQVAWLVVE--KNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISIL
. .     || .| ||.|.||||..||..      |..|..  |.. .| .  .| |..||..|| .. .|. |||  |  .|||| .||. |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase ZAK.AA Pkinase_Tyr 16-260 31 2.5e-68 232.06 Pfam 1-270 (270) Show / Hide 
Range on Protein: 16-260
Range on HMM: 1-270/270
Sequence Identity: 31% (85 aa)

LQFFENCGGGSFGSVYRAKWI----SQDKEVAVKKL-----------LKIEKEAEILSVL-SHRNIIQFYGVIL--EPP-NYGIVTEYASLGSLYDYINS
..| .  | |.||.||...|     ... .||||.|            .  .||.|.. | .| ||...|||..  . | .. ||.||. .|.|.||  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N--RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFH----NH-TTHMSLVGTFPWMAPEVIQSLPVSETCDT
.    .  .| ..  .....|||| ||.     . |||||  ||. .. ..| |||||| .| .    .  ... .     .|||||.|.    ..  | 
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSYGVVLWEMLTRE-VP-FKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISIL
.|.||..||..|.   | ..|.   .|  .. |...|. .|  ||    .|. |||..|...||.|..|...|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ZAK.AA TyrKc 16-260 28 2e-67 231.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-260
Range on HMM: 1-280/280
Sequence Identity: 28% (81 aa)

LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL-----KIEKEAEILSVL--SHRNIIQFYGVILEP-------PNYGIVTEYASLGSLYDYINSNRSEE
... .  | | || ||...|.    .||||.|       . .||.|.. |  .| ||...|||....       . . ||.||...|.| ||. ..| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

MDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHT-------THMSL----VGT--FP--WMAPEVIQSLPVSET
  |..   .....|.|| |||     ..|||||  ||. ...... ||.||| ||.. .           .      |   .|  |||||.|.    .. 
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDTYSYGVVLWEMLTREVPFKGL-----EGLQVAWLVVEKNERLTIPSS--------CPRSFAELLHQCWEADAKKRPSFKQIISIL
 | .|.||..||..|.  .            | .   |.. .|. .| .        ||    ..  |||..|...||.|..|....
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ZAK.AA DRK 23-262 36 1.8e-64 217.26 In-house 8-258 (258) Show / Hide 
Range on Protein: 23-262
Range on HMM: 8-258/258
Sequence Identity: 36% (93 aa)

GGGSFGSVYRAKWISQDKEVAVKKL--LKIE---------KEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWA
| |..| |.|  |     .||||.|  . |.         .|..... | | ||.|| |  ..||   |..|| ..||||  |  . | |||   ..  .
GRGNYGEVFRGTW--RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYN-ILHDESIEMDWPLMKQMM

TDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR----FHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFK
 |.|||| |||   |. .||||||| |  .      |. ||| |        |.. |  .||  | ||||  . .  |  | ||...||||..||. |. 
FDCAKGMIYLHCCNPI-IIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYF

GLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILES
|   .||   |    .|. .|  ||  .. |.  ||. |   |||. ... .||.
GMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase ZAK.AA Pkinase 16-260 25 1.3e-63 222.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-260
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK--IEK----------EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLG----SLYDYINSNRS
... .  | ||||.||......  |.||||.. |  ...          |..|.  |.| ||...|..  ..... .|.||.  |    .|.|||   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EEM--DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVL----KICDFGASR---FHNHTTHMSLVGTFPWMAPEVIQ-SLPVSETCDT
  .  .....  ... ...|. |.| .   ..||||||. |. |  .|..    |||||| ..     | .  ....|| ..||||||. . . .  .| 
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSYGVVLWEMLTREVPFKGL------EGLQVAWLVVEKNERLTIPSSCP-------------------RSFAELLHQCWEADAKKRPSFKQIISI--L
.|.|..|.|||... ||.|       . .|.  .. ..  .  .| .|.                   ... ...  |.. | ||||...||     .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ZAK.AA LRRK 16-262 27 1.8e-62 213.85 In-house 1-351 (351) Show / Hide 
Range on Protein: 16-262
Range on HMM: 1-351/351
Sequence Identity: 27% (97 aa)

LQFFENCGGGSFG-SVYRAKWISQ--------------------------DKEVAVKKLLKI--------------------------------------
| . |  | |.|| .||||||..|                          ...||.||....                                      
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

----EKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNR-SE------EMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNV
     .|. |.| | | ||.. .|. ..|  . .|.|||..|.||... ... ..      ...   .   |...|||| |||   | ..||||||| |.
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

VIAADG------------VLKICDFGASR--FHNHTT-HMSLVGTFPWMAPEVIQ---SLPVSETCDTYSYGVVLWEMLTRE-VPFKGLE---GLQVAWL
 .                . ||.||| ||  .  |..  . .||.. |||||...       .|  |.||.|..||| |||.  || ...    .|   .
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

VVE---KNERLTIPSS-CPR-----SFAELLHQCWEADAKKRPSFKQIISILES
. .   .  | |||.. ||.     .. .|. .||..| ||||.| ||...|..
IEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase ZAK.AA Dicty5 51-264 38 1.4e-58 200.26 In-house 44-260 (260) Show / Hide 
Range on Protein: 51-264
Range on HMM: 44-260/260
Sequence Identity: 38% (85 aa)

EKEAEILSVLS--HRNIIQFYGVILEPPNY-GIVTEYASLGSLYDYINSNRS---EEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAAD
..|  |.|.    | |.| .||      .|  .|||| . ||| .| |  |      .    ..  | |.|..| .||    . .||||||| |. |  .
YREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHS---MNIIHRDLKSMNFLITEN

GVLKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW
   || ||| |||     || . |||  |||.|. .. |  ..|| ||.|.|||||.||  |.. .     . . | | || |||  || ... |   ||
WKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIP-VMVMKGERPTIPKDCPTEISNLIKKCW

EADAKKRPSFKQIISILESMS
    ..||||| |. ..||..
QQKPHNRPSFKEICKYFESII
Kinase ZAK.AA S_TKc 16-263 25 7.5e-56 192.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-263
Range on HMM: 1-231/231
Sequence Identity: 25% (66 aa)

LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL-KIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASL--GSLYDYINSNRSEE----MDMDHIM
 .. .  | |.||.||...... ...||.|..  .|..| .||.   | ||...|.|. .  .. .|.||..   |.|.||| .....     ..  |. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

TWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSE-TCDTYSYGVVLWEMLTREVPFK
 ..  ..... |.|     ..||||||  |. .    ..|||||| .|.      ....||  .|||||.   . .   || .| |..|.|||... || 
FYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

GLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIIS------ILESM
    .|. . ..            .... ... .|.. | .|||.  ..        . . .
---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ZAK.AA MLK 146-260 48 7e-49 159.58 In-house 166-280 (280) Show / Hide 
Range on Protein: 146-260
Range on HMM: 166-280/280
Sequence Identity: 48% (56 aa)

VLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEA
.||| |||  |   .|| ||  ||. |||||||..   |.  |  ||||.|||.||.|||..|  .| ||. |  .   | |||.||  .| |.. ||. 
QLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQ

DAKKRPSFKQIISIL
|  |||.|..|.  |
DPHKRPKFSEILQQL
Kinase ZAK.AA MLK 16-141 36 6e-31 99.34 In-house 1-136 (280) Show / Hide 
Range on Protein: 16-141
Range on HMM: 1-136/280
Sequence Identity: 36% (51 aa)

LQFFENCGGGSFGSVYRAKWISQDKEV----------AVKK---LLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM
|.  |  | | || |||| |  . . |          ...    . .. .|| ..  |.| |||.  || ||.|. ..| ||.  |||   .        
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK---RI

DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVI
  . .  ||. .|.||.||| |||| .||||||| |. |
PPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI
Sam7 ZAK.AA sam7 339-408 26 1e-13 46.64 In-house 1-70 (70) Show / Hide 
Range on Protein: 339-408
Range on HMM: 1-70/70
Sequence Identity: 26% (20 aa)

WTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNI-----TGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLT
||..||. |.. .  .     . . |.. |....|     .|. |. ..||||..||| . ||  .. ..|... 
WTFEDVCEWLEWIGME-----NFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM ZAK.AA SAM 336-410 34 1.8e-10 42.06 SMART 1-67 (67) Show / Hide 
Range on Protein: 336-410
Range on HMM: 1-67/67
Sequence Identity: 34% (26 aa)

IGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLE-EEDLKDMGIVSKGHIIHFKSAIEKLTHD
   ||..||  | . .         |. |.. |..|.|.|. ||.|. .||||.||| . ||   . .||.|. ..
VD-WTPEDVCDWLESIG--------MCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 ZAK.AA SAM_2 361-408 29 4.2e-09 34.1 Pfam 18-71 (71) Show / Hide 
Range on Protein: 361-408
Range on HMM: 18-71/71
Sequence Identity: 29% (16 aa)

M-SVYASLFKENNITG-KRL-LLLEEEDL--K-DMGIVSKGHIIHFKSAIEKLT
|   |.  |....||| . | . ....||  | .||| ..||  .  ..|... 
MCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM_1 ZAK.AA SAM_1 337-408 25 2.5e-08 32.52 Pfam 1-66 (66) Show / Hide 
Range on Protein: 337-408
Range on HMM: 1-66/66
Sequence Identity: 25% (19 aa)

GAWTEDDVYCWVQQLVRKGDSSAEMSVYASLF-KENNITGKRLLLLEEEDLKD-MGIVSKGHIIHFKSAIEKLT
. |. .||  | .           |. |.. | . . |... ||.. .|||.. ||. . ||     ..|..| 
DYWHFEDVCEWLES--------IGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK