Gene Akt1 (Slime mold)

Akt1

Species: Slime mold
Alias: AktPKB, pkfC, DK1, PKB, Akt1, DdisK002, DDB0191195, pkbA
External Links: DictyBase Link ,
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
Akt1.AA Protein None 444 None Fasta, JSON
Akt1.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of Akt1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH Akt1.AA PH 6-100 35 4e-25 93.22 Pfam 1-92 (92) Show / Hide 
Range on Protein: 6-100
Range on HMM: 1-92/92
Sequence Identity: 35% (34 aa)

IKHEGFLTKEGGGFKSWKKRWFILKGGDLSYYKTKGELVPLGVIHLNTSGHIKNSDRKKRVNGFEVQTPSR-TYFLCSETEEERAKWIEILINERE
...||.|.| | ..||||||||.|... |.||| ..   | |.| |..   ..  .. || ..|.. | .| ||... |.|||.  |.. .     
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH Akt1.AA PH 6-102 30 8.7e-23 82.94 SMART 1-82 (82) Show / Hide 
Range on Protein: 6-102
Range on HMM: 1-82/82
Sequence Identity: 30% (30 aa)

IKHEGFLTKEGGGFKSWKKRWFILKGGDLSYYKTKGELVPLGVIHLNTSGHIKNSDRKKRVNGFEVQTPSRTYFLCSETEEERAKWIEILINERELL
. .||.|.| .  . .||||||.|... |.||| |    | |.|.|..   ..  .      .||. . .|||... |.|||. .|.. . .  . .
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P------CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN
Kinase Akt1.AA Akt 120-374 60 6.7e-200 644.79 In-house 1-264 (264) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-264/264
Sequence Identity: 60% (159 aa)

FELLNLVGKGSFGKVIQVRKKDTGEVY-AMKVLSKKHIVEHNEVEHTLSERNILQKINHPFLVNLNYSFQTEDKLYFILDYVNGGELFYHLQKDKKFTED
|..|.. ||||||||..|.||||...| |||||.|..|...|.||||. ||||||..||||.|||.|||||.|||||..||.||||||||||....|.||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RVRYYGAEIVLALEHLHLSGVIYRD-LKPENLLLTNEGHICMTDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQGNGYGKQVDWWS-FGSLLYEMLTGL
| |.|.|||.||.|||| ...|||| |||||.|. ..||||.||||||||.... .||| ||||||||||||.|.|||..|.||||. .| ..|||..|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFYNQDVQEMYRKIMMEKLSFP--HFISPDARSLLEQLLERDPEKRLA----DPNLIKRHPFF
|||||||...|. ||..... ||  ..|||....|...||..||.|||     | . |||||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase Akt1.AA AGC 120-374 40 1.3e-197 516.83 In-house 1-395 (395) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-395/395
Sequence Identity: 40% (162 aa)

FELLNLVGKGSFGKVIQVRKK------DTGEVYAMKVLSKKH-IVEHN--EVEHTLSE------------RNILQKIN----------HPFLVN-LNYSF
||.| ..||||||||..||||      |||..||||||.||| ||. .  .||||..|            ||||.|.|          |||.|. | |||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEDK--LYFILD----YVN-----GG-ELFYHLQ---KDKKFTEDRVRYYGAE-------IVLALEHLHL-SGVIYRD-LKPENLLLTNEGHICMTDFG
|..|.  |||...    |||     || |||.|||   | ..|.|.|.|.| ||       ||||||.||   |.|.|| |||||.||...|||. ||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEGLLTP-------------------------------------------------TDKTGTFCG--TPEYLAPEVLQGNGYGKQVDWWS--FGSLLY
|||||   .                                                 .|.| ||||  ||||.|||.|    |||..||||  .| |.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGLPPFYNQDVQ----------EMYRKIM------MEKLSFP----------HFISPDARSLLEQLLERDPEKRLA---------DPNLIKRHPFF
|||||.||||....|          ||. |||      ..|. ||           ..||.|..|...||..||||||          . . ||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Akt1.AA SGK 120-374 52 1.5e-177 553.32 In-house 1-283 (283) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-283/283
Sequence Identity: 52% (149 aa)

FELLNLVGKGSFGKVIQVRKKDT------------------GEVYAMKVLSKKHIV-------EHNEVEHTLSER-NILQKINHPFLVNLNYSFQTEDKL
|..|...|||||||| ||..||.                  . .||||||.|.||.         .|. |...|| .||....|||.||| |.|||..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFILDYVNGGELFYHLQKDKKFTEDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHICMTDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQG
|| .|||||||.|||||. |.| |||.| | ||||.|||.|| . .|||||||||.||  .||.|.|||||||||  | .|.| ||||||||||||||..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKT-NDTTFTFCGTPEYLAPEVLRK

NGYGKQVDWWSFGSLLYEMLTGLPPFYNQDVQEMYRKIMMEKLSFPHFISPDARSLLEQLLERDPEKRLADP---NLIKRHPFF
 .... ||||. |..||||..||||||....|.|| .|. ..| .|...|.||..|...||..||.|||        ||.||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase Akt1.AA AktR 120-374 48 2.4e-136 459.25 In-house 1-268 (268) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-268/268
Sequence Identity: 48% (129 aa)

FELLNLVGKGSFGKVIQVRKK-DTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQ-KINHPFLVNLNYSFQTEDKLYFILDYVNGGELFYHLQKDKKFTE
|..... ||| ||||. |.|| |....||||...||.|.| |  .||. ||||.. ..||||.|.| |.|||..||.||..|. |||||.||.|.|||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DRVRYYGAEIVLALEHLHLS-GVIYRDLKPENLLLTNEGHICMTDFGLCK-EGLLTPTDKTGTFCGTPEYLAPEVLQG-NGYGKQVDWWSFGSLLYEMLT
...| | |.|.||||.||    .|||||||||.||  .||.. ||||| | ..    ..|. .|||||||.|||...   |..|.||||.|| ..|||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GLPPFYNQDVQEMYRKIMMEK-LSFPHF--ISPDARSLLE-QLLERDPEKRLA----DPNLIKRHPFF
|.||||... ..|. ||  .  ..||    .|. ...|.. .|| ..|.|||     ..  ||.||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase Akt1.AA RSK 123-374 48 4.1e-135 455.16 In-house 1-278 (278) Show / Hide 
Range on Protein: 123-374
Range on HMM: 1-278/278
Sequence Identity: 48% (135 aa)

LNLVGKGSFGKVIQVRKK---DTGEVYAMKVLSKKHIVEHNE-VEHTLSERNILQKIN-HPFLVNLNYSFQTEDKLYFILDYVNGGELFYHLQKDKK---
| . |.|..||| ..||.   ||| .||||||.|. || ..  ..||. |||||. .. |||.|.|.|.||||.||| |..|..|||||.|||| |    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTN---EGHICMTDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQ----GNGYGKQVDWWSFGS
|.||....| ||||||.||||  |.|.||||||| |...   ||||  ||||.||.. .  . .| |||.| ||.|||.|     ..|..|..||||.| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMLTGLPPFYN---QDVQEMYRKIMMEK--LSFP--HFISPDARSLLEQLLERDPEKRLA----DPNLIKRHPFF
|.|||||| |||..   .. .|  ..|.  |  |..|  ...|..|..|. ..|.|||.|||     | . ||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Akt1.AA RSK-Unclassified 120-374 44 6.2e-131 413.73 In-house 1-283 (283) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-283/283
Sequence Identity: 44% (125 aa)

FELLNLVGKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQKINHPFLVNLNYSFQTEDKLYFILDYVNGGELFYHLQ--KDKKFTE
|.   |.|.|.||||  ||||||  .||||||.|. .. || .   . |.||.   |||| | |..||||.|.|| ...|  ||..| |||  |.|.|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHICMTDFGLCKEG--------------------LLTPTDKTGTFCGTPEYLAPEVLQGNGYG
|.||.| .|...|||.||. ..|||||||.| .|  |||. .|||.| ...                     .    .|  |||| ||||||.....| .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KQVDWWSFGSLLYEMLTGLPPFYNQDVQEMYRKIMMEKLSFP--HFISPDARSLLEQLLERDPEKRLA----DPNLIKRHPFF
| ||||  | ..|||| |.||.|     |..  |  ....||   .|| ..|.|.  ||.| | |||     | . |||||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase Akt1.AA PKA 120-374 46 1.5e-128 433.37 In-house 1-263 (263) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-263/263
Sequence Identity: 46% (124 aa)

FELLNLVGKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQKINHPFLVN-LNYSFQTEDKLYFILDYVNGGELFYHLQKDKKFTED
||.....|.||||.| ..|.|..|. ||||.|.|  ||  . |||...|.|||| |.|||.|. . ..||....||....||.|||.|..|.| ..|...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RVRYYGA-EIVLALEHLHLSGVIYRDLKPENLLLTNEGHICMTDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQGN-GYGKQVDWWSFGSLLYEMLTGL
  . | | .|||||| ||    |||||||||.|. ..||| .||||  |.   . .  | | ||||||||||..|.  |.|| ||||..| | ||||.| 
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK---VDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGY

PPFYNQ--DVQEMYRKIMMEKLSFPHFISPDA---RSLLEQLLERDPEKRL----ADPNLIKRHPFF
||||.   |. ..|.||   |. || ....||   ..|...||..|..||.    .. | ||.|..|
PPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase Akt1.AA PKC 120-374 46 8.3e-123 399.96 In-house 1-262 (262) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-262/262
Sequence Identity: 46% (123 aa)

FELLNLVGKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLSERNIL-QKINHPFLVNLNYSFQTEDKLYFILDYVNGGELFYHLQKDKKFTED
|..|   ||||||||. ...|.| |.||.||| |  |..   || |. |. .| .  .||||..|  .|||.|.|.|.. ||||| | .| |. ..| | 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHICMTDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQGNGYGKQVDWWSFGSLLYEMLTGLPP
. | |.|||..||  ||  |.|||||| .| ||. |||| ..|||.|||...   |.| ||||||.|.|||.||.  ||| ||||.|| |.|||. | .|
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNG-DTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSP

FYNQDVQEMYRKIMMEKLSFPHFISPDARSLLEQLLERDPEKRLAD-------PNLIKRHPFF
|  .|  |. . ||... ..|  .| .| |.........|||||          . |..||||
FHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase Akt1.AA p70 120-374 43 1.4e-117 396.88 In-house 1-299 (299) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-299/299
Sequence Identity: 43% (131 aa)

FELLNLVGKGSFGKVIQVRKKD---TGEVYAMKVLSKKHIVEHN-EVEHTL-------------------------SERNILQKINHPFLVNLNYSFQTE
|||| ..||| .||| ||||     || .|||||| |  ||      .||                           |||||  ..|||.. | |.|||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

DKLYFILDYVNGGELFYHLQKDKKFTEDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHICMTDFGLCKEGLLTPTD---------KTGTFCG
 ||| ||.|  |||||.|| .   . || ...| .||..||||||  |.||||||||| .|   ||.  |||||||| .   .           | ||||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TPEYLAPEVLQGNGYGKQVDWWSFGSLLYEMLTGLPPFYNQDVQEMYRKIMMEK--LSFPHFISPDARSLLEQLLERDPEKRLA----DPNLIKRHPFF
|.|| |||.| . |... ||||| | |.| |||| |||     ..   ||.  |  |. |   ....| |. .|| |.| .|.     |   |..||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase Akt1.AA RSK 120-374 42 5.8e-111 374.95 In-house 1-271 (271) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-271/271
Sequence Identity: 42% (117 aa)

FELLNLVGKGSFGKVIQVRKK---DTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQKINHPFLVNLNYSFQTEDKLYFILDYVNGGELFYHLQKDKKFT
.||.   |.|||.||  ..|.   ||.  ||||.. |. ..       .  ||.||  ..||| | |.|.||.| |.| |.|   ||.|| .|.| | |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNE----GHICMTDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQGNGYGKQVDWWSFGSLLYEM
|. |. | ||| ||.|.||  |...||||||| |.  |    |||  .|||. |. |.  . .. |||.| .|.|||||   |... .|||||| |.|||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LTGLPPFYNQDVQEMYRKIMMEKLSF-------PHFISPDARSLLEQLLERDPEKRLAD----PNLIKRHPFF
||| .||.|.. ...  .|   ||         ..|||. | .|| ..|.|||..||       . ||.||.|
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase Akt1.AA S_TKc 120-374 40 1.5e-110 374.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-231/231
Sequence Identity: 40% (108 aa)

FELLNLVGKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQKINHPFLVNLNYSFQTEDKLYFILDYVNG--GELFYHLQKDKK---
.|.|...|||.|||| ..|.|.||...|.|...          ||...|..||.| .||..|.| ..||. |.||....|..|  |.|| ...| ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTEDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHICMTDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQGNGYGK-QVDWWSFGSLLY
   |.| ..|.| ..|..|||..|  |.|.|||||||.||..  ||  .||||...          ||||||.|.|||||   ||||  .||||.| .||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLTGLPPFYNQDVQEMYRKIMMEKLSFPHFISPDARSLLEQLLERDPEKRLADPNLIK------RHPFF
|||.| |||.  ..|.|..||.          ||.|.......|..|||||.    . .       ||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Akt1.AA Pkinase 120-374 33 5.5e-100 343.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

FELLNLVGKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTL-SERNILQKINHPFLVNLNYSFQTEDKLYFILDYVNGG----ELFYHLQ--KD
....  .|.||||.| . ..|.||...|.|...|.|. .  ...|.. ||  |....|||. | | ..|...|..|....|..||    .|| ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KKF--TEDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHI----CMTDFGLCK--EGLLTPTDKTGTFCGTPEYLAPEVLQ-GNGYGKQVDWW
..|  .|. .. |  .|. .||..|  |.|.|||||||.|. |.|||    . .||||.|  .  . .   . ||||||.|.||||.. |..||. ||.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGSLLYEMLTGLPPFYNQ------DVQEMYRKIMMEKLSFPHFIS---------------------PDARSLLEQLLERDPEKRLADPNLIKRHPFF
|.| .|||||.| |||...      | ..|...||. .|.|. . .                     ........ .|..||.||.  .  |. ||.|
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-AEQILQHPWF
Kinase Akt1.AA S_TK_X 375-438 39 1.5e-27 98.75 SMART 1-79 (79) Show / Hide 
Range on Protein: 375-438
Range on HMM: 1-79/79
Sequence Identity: 39% (31 aa)

RSIDWEQLFQ--KNIPPPFIPNVK----GSADTSQIDPVFTDEAPSLTMAGECALNPQQQKD---------FEGFTYVA
|.|||..|..  |.|.|||.|..|    .  |||. || ||.|.|.||.. ....| ..|..         |.|||||.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase Akt1.AA TyrKc 120-371 20 2.1e-15 26.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 120-371
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FELLNLVGKGSFGKVIQVRKKDTGEVYAMKVLSKKHIVEHNEVEHTLSERNILQKI--NHPFLVNLNYSFQTE-------DKLYFILDYVNGGELFYHLQ
 .|.   | | ||.| . . |   .  | |.| . .      .|  ..| .|. |.  .|| .|.|     ..       . |. .. |. .| |  .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KDKK-FTEDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHICMTDFGLCKEGLLT-------PTDKT-----GTFCGTPEYLAPEVLQGNGYG
| .. .. .   ..   |    |.||  ..| |||   | |.......  .||||....           . ..     | .      .|||... . . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KQVDWWSFGSLLYEMLT-GLPPFYN-----QDVQEMYRKIMME-KLSFPHF--------ISPDARSLLEQLLERDPEKRLADPNLIKRH
 . | |||| ...|..| | .| ..      . ||......    .  |.          ...  .. .|  ..|||.|    ..... 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Akt1.AA Pkinase_C 394-440 42 2.4e-14 53.7 Pfam 1-46 (46) Show / Hide 
Range on Protein: 394-440
Range on HMM: 1-46/46
Sequence Identity: 42% (20 aa)

NVKGSADTSQIDPVFTDEAPSLTMAGECALNPQQQKDFEGFTYVAES
.||.  |||  || ||||.|..|.  .. . ...|  |.|||||...
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase Akt1.AA Pkinase_Tyr 120-331 24 5.6e-12 41.19 Pfam 1-228 (270) Show / Hide 
Range on Protein: 120-331
Range on HMM: 1-228/270
Sequence Identity: 24% (57 aa)

FELLNLVGKGSFGKVIQVRKK----DTGEVYAMKVLSKKHIVEHNE--VEHTLSERNILQKI-NHPFLVNLNYSFQ-TEDK--LYFILDYVNGGELFYHL
 ...   |.|.||.| . . |    .|.   | |.|  |.   | .   |  ..| .|. .. .|| .|.|       ..   .| .. |. .| |  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QK----DKKFTEDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHICMTDFGLCKEGLLTP---TDKTGTFCGTPEYLAPEVLQGNGYGKQVDW
.|    ....|  .   . ..|  ..|.|.  . | |||   | |.|.....  .||||..    .    . ..|.       .|||... . .  . | 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDV

WSFGSLLYEMLT-GLPP-FYNQDVQEMYRKI
|||| |..|..| |  | ... . .|.|..|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI