Gene DDB0185113 (Slime mold)

DDB0185113

Species: Slime mold
Alias: DDB0185113, DdisK004, pkgA
External Links: DictyBase Link ,
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
DDB0185113.AA Protein None 1367 None Fasta, JSON
DDB0185113.kin_dom Protein Kinase Domain None 427 None Fasta, JSON

Protein domain

Protein domains of DDB0185113.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0185113.AA MAST 810-1236 41 2.1e-247 765.05 In-house 1-337 (337) Show / Hide 
Range on Protein: 810-1236
Range on HMM: 1-337/337
Sequence Identity: 41% (184 aa)

FEFIKPITKGGYGKVFLAKKIRTGDIYAIKRLKKSDMIKKNQLDHVKVERNILAYTSNPFVVKMYYSFQT--KEYYYLVMEYLQGGDCFSLLQMLG-SMD
|||||.|.||.||.|.|.|...|.|..|.|.....|.|.|||.|.|.||||||....|||||||.|||||  |.|...||||..||||.|||.|.| .|.
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ENMAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSKVGLLDRQTVVPPSYFSPTLSGKNNQSSSSSSVSNIGGSNTIGSNISSTNN
|.||||.||||||.||||||.||||||.||||.|||..||||||||||||||..|..|.....||.....||                            
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGK----------------------------

NNNNNNTTGATMVGGHVINTETPIPSNTAIPAKKEKKLLSLAQSKSLFSASSSPSIPSLNLLNSDKPISPMMMGVKGFIPPPPINQQPISNIPTTTTTTT
                        .........|........                                                     .....
------------------------NHFNEYHIQKNYQQFQQD-----------------------------------------------------FGING

TTTTGQQSQQQSQQQQQTTPPLPPHNIHRKLSCVGTPDYLAPEILLGIG-HGASADWFSLGVILYEFLCGVSPFNGSSVQE-TFQNILQ--RNISWPED-
.|...|..|||.|.|.|......|||||.. .|.|||||.|||..||.| .|...||.|.|.|.||||.|..||||....| .||||..  |.|.|||. 
NTNKNQIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEG

-------MSPEARDLIDKLLALDPRQRLGFNGAEEIKSHPFF
       |||||.|||.|||...|..|||.|||.|||.||||
DPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase DDB0185113.AA MAST 810-1236 44 1.3e-229 747.87 In-house 1-334 (334) Show / Hide 
Range on Protein: 810-1236
Range on HMM: 1-334/334
Sequence Identity: 44% (196 aa)

FEFIKPITKGGYGKVFLAKKIRTGDIYAIKRLKKSDMIKKNQLDHVKVERNILAYTSNPFVVKMYYSFQTKEYYYLVMEYLQGGDCFSLLQMLGSMDENM
|||||||.||.||||.|.|...|.|..|.|..||||||.||..|.|.|||||||...|||||||.||||||.|...||||..||||.|||.|.|..||.|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSKVGLLDRQTVVPPSYFSPTLSGKNNQSSSSSSVSNIGGSNTIGSNISSTNNNNN
|||.||||||.|||||||||||||.||||.|||..||||||||||||||. |........|..|..                                  
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI----------------------------------

NNNTTGATMVGGHVINTETPIPSNTAIPAKKEKKLLSLAQSKSLFSASSSPSIPSLNLLNSDKPISPMMMGVKGFIPPPPINQQPISNIPTTTTTTTTTT
                                                                       ......|.. |||..|..|........|.
-----------------------------------------------------------------------FNNSTDPMNKNQQDYSQFPGDFGINGNTN

TGQQSQQQSQQQQQTTPPLPPHNIHRKLSCVGTPDYLAPEILLGIG-HGASADWFSLGVILYEFLCGVSPFNGSSVQETFQNILQRN---ISWPED----
..|..|||.|.|.|... ..|||||....|.|||||.|||..|| | || . ||.|.|.|.||||.|..|||.....|.|||||.||   |.|||.    
KNQIQQQQEQPQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDIN

----MSPEARDLIDKLLALDPRQRLGFN-GAEEIKSHPFF
    |||||.|||.|||..|||.|||.| ||.|.|.||||
DDEAMSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase DDB0185113.AA AGC 810-1236 26 1.1e-190 498.56 In-house 1-395 (395) Show / Hide 
Range on Protein: 810-1236
Range on HMM: 1-395/395
Sequence Identity: 26% (144 aa)

FEFIKPITKGGYGKVFLAKKI------RTGDIYAIKRLKKSD---MIKKNQLDHVKVE------------RNILAYTS----------NPFVVK-MYYSF
|||.|.| ||..|||.|..|        ||..||.| |||..   ..|||...|...|            ||||.  .          .||.|| ..|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKEY--YYLVMEYLQ--------GGDCFSLLQMLG-----SMDENMAKMIIAE-------TVLALEYLHS-HGIVHRD-VKPDNLLIDKKGHIKLTDFG
|.|..   |.||||..        ||.| ..|.. |     ..||..|. ..||       .||||||||| .||.||| .||.|.|.|..|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKVGLLDRQTVVPPSY---------------------FSPTLSGKNNQSSSSSSVSNIGGSNTIGSNISSTNNNNNNNNTTGATMVGGHVINTETPIPS
|.|.|  |.  ... |.                       |.   .|| .|                                                 
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNN-MS-------------------------------------------------

NTAIPAKKEKKLLSLAQSKSLFSASSSPSIPSLNLLNSDKPISPMMMGVKGFIPPPPINQQPISNIPTTTTTTTTTTTGQQSQQQSQQQQQTTPPLPPHN
                                                                                        | . ...   ..
----------------------------------------------------------------------------------------Q-E-DDTTR-KK

IHRKLSCVG--TPDYLAPEILLGIGHGASADWFS--LGVILYEFLCGVSPFNGSSVQ----------ETFQNIL------QRNISWP----------EDM
 .|  . .|  ||.|.|||||    .| ..|| |  ||...||.|.| .||.| ..|          |.||.|.      . .. .|          . .
RDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWF

SPEARDLIDKLLALDPRQRLGFN-------GAEEIKSHPFF
||||.||| |||  ||..||| .       ||||||.||.|
SPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase DDB0185113.AA AktR 810-1236 25 2e-108 366.53 In-house 1-268 (268) Show / Hide 
Range on Protein: 810-1236
Range on HMM: 1-268/268
Sequence Identity: 25% (113 aa)

FEFIKPITKGGYGKVFLAKKI-RTGDIYAIKRLKKSDMIKKNQLDHVKVERNILA-YTSNPFVVKMYYSFQTKEYYYLVMEYLQGGDCFSLLQMLGSMDE
|...|.. ||..|||.|..|   ....||.| .||...|..|| .|.  ||||..   ..|| ||..|.|||||. ...||| .||. |. |.  . ..|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NMAKMIIAETVLALEYLHSH-GIVHRDVKPDNLLIDKKGHIKLTDFGLSKVGLLDRQTVVPPSYFSPTLSGKNNQSSSSSSVSNIGGSNTIGSNISSTNN
..|. ..|. .|||||||.|  |. || ||.|.|.|. ||.|.|||||||                                                  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

NNNNNNTTGATMVGGHVINTETPIPSNTAIPAKKEKKLLSLAQSKSLFSASSSPSIPSLNLLNSDKPISPMMMGVKGFIPPPPINQQPISNIPTTTTTTT
                                                                                                    
----------------------------------------------------------------------------------------------------

TTTTGQQSQQQSQQQQQTTPPLPPHN--IHRKLSCVGTPDYLAPEILLG-IGHGASADWFSLGVILYEFLCGVSPFNGSSVQETFQNILQRN---ISWPE
                     | . .    .  | .||| |.|||...   ||. |.|| ..|. .|| . |  ||. .. .. ||.|.  .   .  |.
---------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPS

DMSPEARDLID-KLLALDPRQRLG--FNGAEEIKSHPFF
. |....|||  |||  .|..|||   ||.|||||||.|
YFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase DDB0185113.AA RSK 813-1236 26 2.3e-106 359.66 In-house 1-278 (278) Show / Hide 
Range on Protein: 813-1236
Range on HMM: 1-278/278
Sequence Identity: 26% (117 aa)

IKPITKGGYGKVFLAKKI---RTGDIYAIKRLKKSDMIKKNQ-LDHVKVERNILAYTS-NPFVVKMYYSFQTKEYYYLVMEYLQGGDCFSLLQMLGS---
.|  ..|||||||| .|.    || ||| | |||. .....  . |.. |||||. .   ||.|. .|.|||... ||.|||. ||. |  ||  ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

MDENMAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDK---KGHIKLTDFGLSKVGLLDRQTVVPPSYFSPTLSGKNNQSSSSSSVSNIGGSNTIGSNI
..|. |....|| |||.|.||..||.||| ||.| | |     |||||||||..| .                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

SSTNNNNNNNNTTGATMVGGHVINTETPIPSNTAIPAKKEKKLLSLAQSKSLFSASSSPSIPSLNLLNSDKPISPMMMGVKGFIPPPPINQQPISNIPTT
                                                                                                    
----------------------------------------------------------------------------------------------------

TTTTTTTTTGQQSQQQSQQQQQTTPPLPPHNIHRKLSCVGTPDYLAPEILL----GIGHGASADWFSLGVILYEFLCGVSPFNG---SSVQETFQNILQR
                           ....  .  . ..| .|.|||.|     . ||....||.||||..|| | | .|| |   .. .|....|.. 
---------------------------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKG

N--ISWP--EDMSPEARDLIDKLLALDPRQRLG--FNGAEEIKSHPFF
.   . |  . .|.||.||| |.|  || .|||   ..|||||.||.|
KFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase DDB0185113.AA S_TKc 810-1236 23 7.50000000001e-104 352.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 810-1236
Range on HMM: 1-231/231
Sequence Identity: 23% (103 aa)

FEFIKPITKGGYGKVFLAKKIRTGDIYAIKRLKKSDMIKKNQLDHVKVERNILAYTSNPFVVKMYYSFQTKEYYYLVMEYLQG--GDCFSLLQMLGS---
.|....| ||..|||.......|| |.|||..|          .|.. |..||     |..||.|..||. ...|.||||. |  || |....  |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---MDENMAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSKVGLLDRQTVVPPSYFSPTLSGKNNQSSSSSSVSNIGGSNTIGSNI
   ..| .|. .......||||.|||||.|||.||.|.|.|.  |||..||||...                                            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

SSTNNNNNNNNTTGATMVGGHVINTETPIPSNTAIPAKKEKKLLSLAQSKSLFSASSSPSIPSLNLLNSDKPISPMMMGVKGFIPPPPINQQPISNIPTT
                                                                                                    
----------------------------------------------------------------------------------------------------

TTTTTTTTTGQQSQQQSQQQQQTTPPLPPHNIHRKLSCVGTPDYLAPEILLGIGHGA-SADWFSLGVILYEFLCGVSPFNGSSVQETFQNILQRNISWPE
                                    ...|||.|.|||.|   |.|  ..|| |.|.||||.|||  ||    .|..|..|.        
-----------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------

DMSPEARDLIDKLLALDPRQRLGFNGAEE----IKSHPFF
  ||||.|.|.|.|  ||..|..   | .    ||.||.|
--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0185113.AA NDR 810-959 54 4.5e-92 284.24 In-house 1-155 (350) Show / Hide 
Range on Protein: 810-959
Range on HMM: 1-155/350
Sequence Identity: 54% (84 aa)

FEFIKPITKGGYGKVFLAKKIRTGDIYAIKRLKKSDMIKKNQLDHVKVERNILAYTS--NPFVVKMYYSFQTKEYYYLVMEYLQGGDCFS---LLQMLGS
||.||.| ||..|.|.|..|  ||.|||.|...||.|..|||..||. || |.| ..  ||.|||.||||| | | ||||||. |||  .   ||.... 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

MDENMAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSKVGL
 .|..|.  |||.|.|.|..|. |..|||.||||.||||.||||||||||.. |.
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGM
Kinase DDB0185113.AA Akt 810-956 51 5.1e-76 242.47 In-house 1-149 (264) Show / Hide 
Range on Protein: 810-956
Range on HMM: 1-149/264
Sequence Identity: 51% (76 aa)

FEFIKPITKGGYGKVFLAKKIRTGDIY-AIKRLKKSDMIKKNQLDHVKVERNILAYTSNPFVVKMYYSFQTKEYYYLVMEYLQGGDCFSLLQMLGSMDEN
|.|.| . || .|||||.||  |...| |.| |||.  |.|||. |.| |||||  . .||.|...|||||... |.||.| .||. |..||  . ..|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MAKMIIAETVLALEYLHSHGIVHRD-VKPDNLLIDKKGHIKLTDFGLSK
 |.  .|| .||.|.|||..|. ||  || |.|.||.|||.||||||.|
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK
Kinase DDB0185113.AA MASTL 810-959 54 2.9e-70 239.72 In-house 1-151 (283) Show / Hide 
Range on Protein: 810-959
Range on HMM: 1-151/283
Sequence Identity: 54% (83 aa)

FEFIKPITKGGYGKVFLA-KKIRTGDIYAIKRLKKSDMIKKNQLDHVKVERNILAYTSNPFVVKMYYSFQTKEYYYLVMEYLQGGDCFSLLQMLGSMDEN
|  .||| .| .|||.|  |    . .||.| .||.||| ||    |  ||. ||    .|.| .||| |   | ||||||. |||  ||| | |  ||.
FVIVKPISRGAFGKVYLGYKNQKGKKLYAVKVMKKADMINKNMTHQVQAERDALALSKSQFCVHLYYSLQSASYVYLVMEYMIGGDVKSLLHMYGYFDEE

MAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSKVGL
||   |.| |.||.||| |||.|||.||||.||  .||||||||||||| .
MAIKYISEMVMALDYLHRHGIIHRDIKPDNMLISNEGHIKLTDFGLSKVTM
Kinase DDB0185113.AA SGK 810-956 39 1.4e-67 207.65 In-house 1-173 (283) Show / Hide 
Range on Protein: 810-956
Range on HMM: 1-173/283
Sequence Identity: 39% (69 aa)

FEFIKPITKGGYGKVFLAKKIRT------------------GDIYAIKRLKKSDMI-------KKNQLDHVKVER-NILAYTSNPFVVKMYYSFQTKEYY
|.|.| | ||..|||...|.  .                  ...||.| |.|   |       ||..  |.. || .||   . || |.  |.||||.. 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVMEYLQGGDCFSLLQMLGSMDENMAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSK
|.||.|..||. |. ||  ..  |  |.   || |.|||||||  |..|| ||.|.| | .||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase DDB0185113.AA PKA 810-956 48 6.4e-62 212.03 In-house 105-253 (263) Show / Hide 
Range on Protein: 810-956
Range on HMM: 105-253/263
Sequence Identity: 48% (72 aa)

FEFIKPITKGGYGKVFLAKKIRTGDIYAIKRLKKSDMIKKNQLDHVKVERNILAYTSNPFVV-KMYYSFQTKEYYYLVMEYLQGGDCFSLLQMLGSMDEN
||.|. . .| .|.| |...  .|..||.| |||.. .. .| .||. |.|||  ...||.| |||..||.  |.|.|||| .||. || |.  |. .. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MAKMIIA-ETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSK
.|| ..| . |||||||||. |..|| || |.||||.||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase DDB0185113.AA Pkinase 810-957 34 3.6e-55 194.4 Pfam 1-161 (293) Show / Hide 
Range on Protein: 810-957
Range on HMM: 1-161/293
Sequence Identity: 34% (56 aa)

FEFIKPITKGGYGKVFLAKKIRTGDIYAIKRLKKSDMIKKNQLDHVKV--ERNILAYTSNPFVVKMYYSFQTKEYYYLVMEYLQGG----DCFSLLQ--M
......| .|..|.|...... ||.|.|.|..||.  .|.... .     |  |..  . |..|..|..|..| ..|.||||..||    | |....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

LGSM--DENMAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHI----KLTDFGLSKV
 |..  .|. .|... ... .|||.||.||.|||.||.|.|||..|||    |..||||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ
Kinase DDB0185113.AA NDR 1138-1236 45 2e-51 156.55 In-house 240-350 (350) Show / Hide 
Range on Protein: 1138-1236
Range on HMM: 240-350/350
Sequence Identity: 45% (51 aa)

SCVGTPDYLAPEILLG-IGHGASADWFSLGVILYEFLCGVSPFNGSSVQETFQNILQRNISW-------PEDM--SPEARDLIDKLLALDPRQRLG-FN-
| ||||||.|||....  |.... || |||.|.||.|.|. ||.....|||...|..  . |       |...  |||| ||| .|.. || .||| .. 
STVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGK

GAEEIKSHPFF
|..||||||||
GVDEIKSHPFF
Kinase DDB0185113.AA Akt 1141-1236 46 5e-47 148.31 In-house 164-264 (264) Show / Hide 
Range on Protein: 1141-1236
Range on HMM: 164-264/264
Sequence Identity: 46% (47 aa)

GTPDYLAPEILLGIGHGASADWFS-LGVILYEFLCGVSPFNGSSVQETFQNILQRNISWP--EDMSPEARDLIDKLLALDPRQRLG--FNGAEEIKSHPF
||| |||||||.|.||. ..|| . ||...||..||  ||    ... |..|.. ..  |  .  |||..||| .||  || .|||  .|.|.|||.||.
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPW

F
|
F
Kinase DDB0185113.AA SGK 1141-1236 45 2.8e-44 134.33 In-house 187-283 (283) Show / Hide 
Range on Protein: 1141-1236
Range on HMM: 187-283/283
Sequence Identity: 45% (44 aa)

GTPDYLAPEILLGIGHGASADWFSLGVILYEFLCGVSPFNGSSVQETFQNILQRNISWPEDMSPEARDLIDKLLALDPRQRLGFN-GAEEIKSHPFF
||| |||||.|.. .|. . ||..|| .|||.. |  ||    .|. ..||.   .  |  ||..|.|||  ||. ||..||| . ...|||.||||
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase DDB0185113.AA PKA 1141-1236 40 3.1e-36 126.72 In-house 160-263 (263) Show / Hide 
Range on Protein: 1141-1236
Range on HMM: 160-263/263
Sequence Identity: 40% (42 aa)

GTPDYLAPEILLGI-GHGASADWFSLGVILYEFLCGVSPFNGS--SVQETFQNILQRNISWPEDMSPEA---RDLIDKLLALDPRQRLG--FNGAEEIKS
|||.||||||...  ||| | || .||.. ||.| |..||. .  .. .... |..  | .|. ... |   .|||.|||. |. .|.|   ||.. || 
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKN

HPFF
|..|
HKWF
Kinase DDB0185113.AA Pkinase 1140-1236 29 6.2e-34 121.06 Pfam 172-293 (293) Show / Hide 
Range on Protein: 1140-1236
Range on HMM: 172-293/293
Sequence Identity: 29% (37 aa)

VGTPDYLAPEILL-GIGHGASADWFSLGVILYEFLCGVSPFNGS------SVQETFQNILQRNISWPED---------------------MSPEARDLID
.|||.|.|||... | ..| ..|..|.|.||||.|||  || |.      . .. ...|... ......                     .|.|..|.|.
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

KLLALDPRQRLGFNGAEEIKSHPFF
..|..|| .|..   ||.|. ||.|
WCLCKDPKKRPT---AEQILQHPWF
Kinase DDB0185113.AA MASTL 1141-1236 34 2.4e-24 80.11 In-house 166-283 (283) Show / Hide 
Range on Protein: 1141-1236
Range on HMM: 166-283/283
Sequence Identity: 34% (42 aa)

GTPDYLAPEILLGIGHGASADWFS-LGVILYEFLCGVSPFNGSSVQETFQNILQRNISWP---EDMS---------------------PEARDLIDKLLA
||||||.|| ..  .||   ||.. ||| .|||. |. ||. .| .  ||||| |...||   | .|                      ....||..|| 
GTPDYLKPEQDYQQTHGQVVDWWASLGVCFYEFMKGIPPFCDESPCKVFQNILSRDLEWPMGDEQKSTTPYSSKLLKSCFETVASNPEVPVMCLIENLLQ

LDPRQRLGFNGAEEIKSHPFF
..||.|     | . ..| | 
MRPRDR---PSATDVQQHTFI
Kinase DDB0185113.AA Pkinase_Tyr 810-956 24 5.7e-11 37.79 Pfam 1-159 (270) Show / Hide 
Range on Protein: 810-956
Range on HMM: 1-159/270
Sequence Identity: 24% (39 aa)

FEFIKPITKGGYGKVFLAKKI----RTGDIYAIKRLKKSDMIKKN--QLDHVKVERNILAYT-SNPFVVKMYYSFQ-TKEY--YYLVMEYLQGGDCFSLL
 .|.| . .| .|.|....       |.   |.| | | .  ...  . |  . | .|.    ..| .|..|      .|   .|.|||| ..||  . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QM----LGSMDENMAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSK
.      .. .  .   . ..   ..|||.|....|||.   | |.......| .||||..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase DDB0185113.AA TyrKc 810-1236 11 6.5e-10 -62.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 810-1236
Range on HMM: 1-280/280
Sequence Identity: 11% (56 aa)

FEFIKPITKGGYGKVFLAKKIRTGDIYAIKRLKKSDMIKKNQLDHVKVERNILAYT--SNPFVVKMYYSFQTK-------EYYYLVMEYLQGGDCFSLLQ
 ...| .  | .|.|.... .      |.| ||..       .     | .|.     ..| .|..|    ..       | ...||||  .||. . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

MLGS-MDENMAKMIIAETVLALEYLHSHGIVHRDVKPDNLLIDKKGHIKLTDFGLSKVGLLD-RQTVVPPSYFSPTL--SGK-------------NNQSS
  .          .        |||||....|||    | |.......| .|||||. .  | .|  .  .| ...   .||             |    
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SSSS---------------------------VSNI--------GGSNTIGSN---ISSTNNNNNNNNTTGATMVGGHVINTETPIPSNTAIPAKKEKKLL
.. |                           .||.        |.   .  |   .|                                           
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------------

SLAQSKSLFSASSSPSIPSLNLLNSDKPISPMMMGVKGFIPPPPINQQPISNIPTTTTTTTTTTTGQQSQQQSQQQQQTTPPLPPHNIHRKLSCVGTPDY
                                                                                                    
----------------------------------------------------------------------------------------------------

LAPEILLGIGHGASADWFSLGVILYEFLCGVSPFNGSSVQETFQNILQRNISWPEDMSPEARDLIDKLLALDPRQRLGFNGAEEIKSHPFF
                                                   .    ...|  ... .  . || .|  |.       | .|
---------------------------------------------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase DDB0185113.AA Pkinase_C 1254-1341 14 3.7e-05 21.48 Pfam 1-46 (46) Show / Hide 
Range on Protein: 1254-1341
Range on HMM: 1-46/46
Sequence Identity: 14% (13 aa)

KIENLQDTSYFDPRKEIYKVSDDFAESCKPFVQNQNQNKESSTILTTSPPSTSSTTATATATTSNLDSITINQNTNANFDDFLYVNFQ
....  |||.|||  .  ...| .                                          |.  . .. ...| .| |||. 
QVKSPTDTSNFDPEFTDEPPMDTP-----------------------------------------PDWR-MSSGDQEPFRGFTYVNPD
Kinase DDB0185113.AA S_TK_X 1237-1339 16 0.000141 15.52 SMART 1-79 (79) Show / Hide 
Range on Protein: 1237-1339
Range on HMM: 1-79/79
Sequence Identity: 16% (20 aa)

KSINWKTILT----QEPYFKPKIE----NLQDTSYFD---PRKEIYKVSDDFAESCKPFVQNQNQNKESSTILTTSPPSTSSTTATATATTSNLDSITIN
..|.|....      || |||||     . .|||.||   .....                                              .. |.. .|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--------------------------------------------LTPDDPPLSN

QNTNAN---------FDDFLYVN
.. .           | .| ||.
SMWQNEMETEIPPDPFRGFTYVF