Gene DDB0220701 (Slime mold)

DDB0220701

Species: Slime mold
Alias: DdisK007, DDB0220701
External Links: DictyBase Link ,
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
DDB0220701.AA Protein None 2102 None Fasta, JSON
DDB0220701.kin_dom Protein Kinase Domain None 325 None Fasta, JSON

Protein domain

Protein domains of DDB0220701.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PX DDB0220701.AA PX 34-114 30 1.1e-19 69.96 Pfam 33-120 (120) Show / Hide 
Range on Protein: 34-114
Range on HMM: 33-120/120
Sequence Identity: 30% (27 aa)

TN----RQWNIYRRYSQFHELDSEIKSAFPKIKLPKLPKKYIFKN--STNRELVEERKLLLQKYLKDLVKHEQIED-SDCLINWLVPQ
||      |...||||.||.| ...|. ||....|.|| | .|..  . ..| .|.|.  |..||. ...|  .   .....  | |.
TNPFQKKEWHVWRRYSDFHWLHKQLKRHFPMCIIPPLPPKHWFGRYNNFDEEFIEKRRQMLEQYLQRVCQHPELCNHCEVFHDFLHPD
PX DDB0220701.AA PX 5-114 19 4.1e-19 70.73 SMART 1-142 (142) Show / Hide 
Range on Protein: 5-114
Range on HMM: 1-142/142
Sequence Identity: 19% (28 aa)

LSILGDESRLDPTTF------NAFTVYMVNVTNLMTN--RQWNIYRRYSQFHELDSEIKSAFP----KIKLPKLPKKYIFKNS-----------------
 .|.   . ... |.      .  ..| ....    |  ..| .|||||.||.|.. .|  ||    ....|.|| | .| ..                 
DHIFI-ITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEKRMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFNN

TNRELVEERKLLLQKYLKDLVKHEQIED----SDCLINWLVPQ
 .....|.|.. |..||. |..|...      .....  . . 
FDEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS
PH DDB0220701.AA PH 125-222 34 3.4e-25 93.49 Pfam 1-92 (92) Show / Hide 
Range on Protein: 125-222
Range on HMM: 1-92/92
Sequence Identity: 34% (34 aa)

PDKSGYLIKEGHVIRSWKKRYFVLKDGLIYYFKHQSDQEPTGMIPVIGSQIKRIGETERKFSFQIIPKNETFFPTFSIQARDEQDCNDWIKAIELSQQ
. |.|.| | |  ..|||||.|||... .||.|. .  .| |.||. . |.... . .|...|||.  ..    |. .|| .|...|||..||.  . 
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR---RTYYFQAESEEEMNDWMQAIQSACR
PH DDB0220701.AA PH 125-224 26 9.5e-23 82.81 SMART 1-82 (82) Show / Hide 
Range on Protein: 125-224
Range on HMM: 1-82/82
Sequence Identity: 26% (26 aa)

PDKSGYLIKEGHVIRSWKKRYFVLKDGLIYYFKHQSDQEPTGMIPVIGSQIKRIGETERKFSFQIIPKNETFFPTFSIQARDEQDCNDWIKAIELSQQHF
. |.|.| | .    .||||.|||... .||.|     .| |.||. . ....        .|.|.  ..    |. .|...|.....|..||.  ... 
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDCTVRE-P------CFEIHH-DR----TYYFQCESEEEMQEWMQAIQKAIHNN
Kinase DDB0220701.AA MAST 1527-1851 55 1.4e-246 762.47 In-house 1-337 (337) Show / Hide 
Range on Protein: 1527-1851
Range on HMM: 1-337/337
Sequence Identity: 55% (190 aa)

FEIIKPISRGAFGRVYLAQKKKTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMVQNEFVVKLFYAFQS--TDKLYLVMEYLIGGDCASLLRALG-CFE
||.||.||.||.|.|||...|||.|..|.||... |||.||.|..|.||||||.|.||.||||.||.||.  ...|..||||..|||||||||..| |..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EHMAKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSKIGIIDDKKMEDSGNTNTN----THFNFSTSPTNTSMMDDSSTTGNPNGNG
|.|||.|||||||||||||...||||||||||||||..||||||||||||.|..|.......|..|||    .|||......|.......     ...||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQD-----FGING

NTSLNSSQTNILSPYPQRKNTLKTPLKKPVKKVVGTPDYLSPEILLGTG-HGQTVDWWALGIILYEFLTGSPPFNDDTPEL-IFQHILHRDREMEWPEE-
||..|..|.....|..|..|..........|...|||||..||..||.| .|..||||..|||.||||.|.||||.||||  |||.|...|||.||||| 
NTNKNQIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEG

-------ISSEAKDLILKLLNPDPYKRLGANGAYEVKTHPFF
       .|.||.||| |||.|.|.||||||||.|.|.||||
DPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase DDB0220701.AA MAST 1527-1851 60 8.8e-230 748.46 In-house 1-334 (334) Show / Hide 
Range on Protein: 1527-1851
Range on HMM: 1-334/334
Sequence Identity: 60% (202 aa)

FEIIKPISRGAFGRVYLAQKKKTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMVQNEFVVKLFYAFQSTDKLYLVMEYLIGGDCASLLRALGCFEEHM
||.|||||.||.|.|||. .|||.|..|.||.|| |.|.||||..|.||||||||.||.||||.||.||....|..||||..||||||||...|.|.|.|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSKIGIIDDKKMEDSGNTNTNTHFNFSTSPTNTSMMDDSSTTGNPNGNGNTSLNSS
||.|||||||||||||...|||||||||||||| .||||||||||||.|..||..|...|.|..|. ||.||.|.|....|.|...|....||||..|..
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI-FNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQI

QTNILSPYPQRKNTLKTPLKKPVKKVVGTPDYLSPEILLGTG-HGQTVDWWALGIILYEFLTGSPPFNDDTPELIFQHILHRDR-EMEWPEE--------
|.....|..|..| .........|...|||||..||..||.| ||..||||..|||.||||.| |||||||||.|||.||.|.. |.||||.        
QQQQEQPQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEA

ISSEAKDLILKLLNPDPYKRLGAN-GAYEVKTHPFF
.|.||.||| |||.|||.|||||| ||.|||.||||
MSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase DDB0220701.AA AGC 1527-1851 31 1.1e-189 495.87 In-house 1-395 (395) Show / Hide 
Range on Protein: 1527-1851
Range on HMM: 1-395/395
Sequence Identity: 31% (140 aa)

FEIIKPISRGAFGRVYLAQKK------KTGDLYAIKVLKKLD---TIRKNMVNHVIVE------------RNILAMVQ----------NEFVVK-LFYAF
||..|.|..|.||.|||..||       ||..||.||||| .    ..|||| |...|            ||||....          . |.|| |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSTDK--LYLVMEYLI--------GGDCASLLRALG-----CFEEHMAKHYIAE-------TVLCLEYLHK-SAIVHRD-LKPDNMLIDGLGHIKLTDFG
|. |.  ||.||||..        ||.| ..|.  |     .|.| .|..|.||       .||.|||||.   |.||| |||.|.|.|  |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKIGIIDD----------KKMEDSGNTNTNTHFNFSTSPTNTSMMDDSSTTGNPNGNGNTSLNSSQTNILSPYPQRKNTLKTPLKKP------------
|.|.|. |.          | .. . ... . . |..  . |                                  .   ... ...             
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KSNMD--T-N----------------------------------K-CNPNNWQRNNMSQEDDTTRKKR

--VKKVVG--TPDYLSPEILLGTGHGQTVDWWA--LGIILYEFLTGSPPFNDDTPE----------LIFQHILHRDREMEWP--------------EEIS
   .  .|  ||.|..||||    .|...|||.  ||...||.||| |||..|.|.           .|| |........|.              ...|
DRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFS

SEAKDLILKLLNPDPYKRLGAN-------GAYEVKTHPFF
.|||||| |||..|| ||||..       || |.| ||.|
PEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase DDB0220701.AA NDR 1527-1851 41 3.4e-148 460.55 In-house 1-350 (350) Show / Hide 
Range on Protein: 1527-1851
Range on HMM: 1-350/350
Sequence Identity: 41% (145 aa)

FEIIKPISRGAFGRVYLAQKKKTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMVQ--NEFVVKLFYAFQSTDKLYLVMEYLIGGDCAS---LLRALGC
|||||.|..||||.|.|..||.||..||.|...| . ..|| |.||  || |.| ..  |..||||.|.||  . |||||||..|||  .   ||  ...
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FEEHMAKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSKIGII--------DDKKMEDSGNTNTNTHFNFSTSPTNTSMMDDSSTTG
|.|..|. ||||.|...|..||  ..|||.|||| |||  ||||||||||.. |.|         .|.|  .  | ..||..      .   ..|..  .
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPM-TTYSTFHWTHNSWYYQNMKEHRPQDFM--D

NPNGNGNTSLNSSQTNILSPYPQRKNTLKTPLKKPVK-----KVVGTPDYLSPEILLG-TGHGQTVDWWALGIILYEFLTGSPPFNDDTPELIFQHI---
| | |..... .. | . .      ..|. . .|  .     ..||||||. ||.... ||..||.||| || |.||.|.| |||..|||. ... |   
NWNSNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNW

---LHRDREMEWPEE-ISSEAKDLILKLLNPDPYKRLGANG--AYEVKTHPFF
   . ....   ||. .| ||.||| .|..||| .|||..|  . |.| ||||
KQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase DDB0220701.AA AktR 1527-1851 34 3.8e-111 375.56 In-house 1-268 (268) Show / Hide 
Range on Protein: 1527-1851
Range on HMM: 1-268/268
Sequence Identity: 34% (117 aa)

FEIIKPISRGAFGRVYLAQKK-KTGDLYAIKVLKKLDTIRKNMVNHVIVERNILA-MVQNEFVVKLFYAFQSTDKLYLVMEYLIGGDCASLLRALGCFEE
|...|.. .||||.|||.||| .....||.|..|| . |..|.  |.| ||||.. .... | |||.|.||. .||...|||  ||.  . |.  . |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

HMAKHYIAETVLCLEYLHKS-AIVHRDLKPDNMLIDGLGHIKLTDFGLSKIGIIDDKKMEDSGNTNTNTHFNFSTSPTNTSMMDDSSTTGNPNGNGNTSL
 .|. |.|. .|.|||||.   |. |||||.| |.|  ||.|.|||||||                                                  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

NSSQTNILSPYPQRKNTLKTPLKKPVK-K------VVGTPDYLSPEILLG-TGHGQTVDWWALGIILYEFLTGSPPFNDDTPELIFQHILHRD-REMEWP
                        ... .      ..||| |..||...   ||. .|||||.|| .|| .|| |||...  . .|| |.  .  . . |
----------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYP

EEISSEAKDLIL-KLLNPDPYKRLG--ANGAYEVKTHPFF
...||..||||  |||. .|.||||  .||. |.| ||.|
SYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase DDB0220701.AA S_TKc 1527-1851 30 1.2e-107 364.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 1527-1851
Range on HMM: 1-231/231
Sequence Identity: 30% (104 aa)

FEIIKPISRGAFGRVYLAQKKKTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMVQNEFVVKLFYAFQSTDKLYLVMEYLIG--GDCASLLRALGC---
.||...| .||||.||....|||| ..|||..|          .|.. |..|| . . ...|||...||. |.||.||||. |  ||  ....  |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FEEHMAKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSKIGIIDDKKMEDSGNTNTNTHFNFSTSPTNTSMMDDSSTTGNPNGN
   | | .|..|...... |||.|.  |.||||||.| |.|   |||..||||...                                            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

GNTSLNSSQTNILSPYPQRKNTLKTPLKKPVKKVVGTPDYLSPEILLGTGHGQ-TVDWWALGIILYEFLTGSPPFNDDTPELIFQHILHRDREMEWPEEI
                               . ..|||.|..||.|   |.|   .|||..|.||||.|.| |||   .....|..|.            
-------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------

SSEAKDLILKLLNPDPYKRLGANGAYE----VKTHPFF
|.||||.| |.|. || ||..|  | .    .| ||.|
SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0220701.AA RSK 1530-1851 33 2.1e-102 346.53 In-house 1-278 (278) Show / Hide 
Range on Protein: 1530-1851
Range on HMM: 1-278/278
Sequence Identity: 33% (115 aa)

IKPISRGAFGRVYLAQKK---KTGDLYAIKVLKKLDTIRKNM-VNHVIVERNILAMVQ-NEFVVKLFYAFQSTDKLYLVMEYLIGGDCASLLRALGC---
.|   .|..| |.| .|.   .|| .|| |||||   ....  . |.  |||||...|   |.|.|.||||  .||||.|||. ||.    |.  ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEHMAKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDG---LGHIKLTDFGLSKIGIIDDKKMEDSGNTNTNTHFNFSTSPTNTSMMDDSSTTGNPNGN
| |. |. |.|| || .|.||.  |.||||||.|.| |     |||||||||..|.. .|.... ..                                 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT---------------------------------

GNTSLNSSQTNILSPYPQRKNTLKTPLKKPVKKVVGTPDYLSPEILL----GTGHGQTVDWWALGIILYEFLTGSPPFND---DTPELIFQHILHRDREM
                                  ..| .|. ||.|     . ||.. .||| ||...|| ||| |||     .... |.. |.. .  .
---------------------------------FCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSL

EWP--EEISSEAKDLILKLLNPDPYKRLG--ANGAYEVKTHPFF
. |  ...| |||||| |.|  || ||||   ..| |.| ||.|
TMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase DDB0220701.AA MASTL 1527-1674 58 3.5e-79 269.36 In-house 1-149 (283) Show / Hide 
Range on Protein: 1527-1674
Range on HMM: 1-149/283
Sequence Identity: 58% (87 aa)

FEIIKPISRGAFGRVYLA-QKKKTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMVQNEFVVKLFYAFQSTDKLYLVMEYLIGGDCASLLRALGCFEEH
| |.|||||||||.|||  . .| . |||.||.|| | | |||.  |. ||. ||. . .|.| |.|  ||   .||||||.||||  |||   | | | 
FVIVKPISRGAFGKVYLGYKNQKGKKLYAVKVMKKADMINKNMTHQVQAERDALALSKSQFCVHLYYSLQSASYVYLVMEYMIGGDVKSLLHMYGYFDEE

MAKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSKI
||  ||.| |. |.|||.  |.|||.|||||||   ||||||||||||.
MAIKYISEMVMALDYLHRHGIIHRDIKPDNMLISNEGHIKLTDFGLSKV
Kinase DDB0220701.AA Akt 1527-1682 47 6.9e-71 225.82 In-house 236-394 (264) Show / Hide 
Range on Protein: 1527-1682
Range on HMM: 236-394/264
Sequence Identity: 47% (75 aa)

FEIIKPISRGAFGRVYLAQKKKTGDLY-AIKVLKKLDTIRKNMVNHVIVERNILAMVQNEFVVKLFYAFQSTDKLYLVMEYLIGGDCASLLRALGCFEEH
|...| . .|.||.|.|..||.|...| |.|||||   | || | |.. ||||| .... |.|.| |.||. ||||.||.|  ||.  ..|.  . | | 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MAKHYIAETVLCLEYLHKSAIVHRD-LKPDNMLIDGLGHIKLTDFGLSKIG-IIDDKKM
 |. |.|| .| .|.||.. |. || ||| | |.|  |||.||||||.| . | |. |.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKT
Kinase DDB0220701.AA SGK 1527-1681 38 5.5e-69 212.02 In-house 1-181 (283) Show / Hide 
Range on Protein: 1527-1681
Range on HMM: 1-181/283
Sequence Identity: 38% (70 aa)

FEIIKPISRGAFGRVYLAQKKKT------------------GDLYAIKVLKKLDTI-------RKNMVNHVIVER-NILAMVQNEFVVKLFYAFQSTDKL
|...| |  | ||.||....|..                  ...||.|||.|   |       .|. ..|.  || .||  .   | |.| |||| ..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVMEYLIGGDCASLLRALGCFEEHMAKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSKIGIIDDKK
|.||.|. ||.  . |.  ..| |. |. | || |. |||||.. |..|||||.| | |  ||..||||||.| || . ..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDT
Kinase DDB0220701.AA PKA 1527-1673 49 7.6e-59 201.81 In-house 93-241 (263) Show / Hide 
Range on Protein: 1527-1673
Range on HMM: 93-241/263
Sequence Identity: 49% (74 aa)

FEIIKPISRGAFGRVYLAQKKKTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMVQNEFVV-KLFYAFQSTDKLYLVMEYLIGGDCASLLRALGCFEEH
||||. . .| ||||.|...|..|. ||.|.||| . .| . | ||. |.|||  ... |.| |. . ||  ..||.||||  ||.  | ||. |.| . 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MAKHYIA-ETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSK
.|| |.| . || |||||.  |..||||| | |||  ||||.|||| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase DDB0220701.AA Akt 1752-1851 47 1.8e-47 149.8 In-house 162-264 (264) Show / Hide 
Range on Protein: 1752-1851
Range on HMM: 162-264/264
Sequence Identity: 47% (49 aa)

VVGTPDYLSPEILLGTGHGQTVDWWA-LGIILYEFLTGSPPFNDDTPELIFQHILHRDREMEWPEEISSEAKDLILKLLNPDPYKRLG--ANGAYEVKTH
. ||| ||.||||.|.||...||||. ||...||...| ||| ..  .  |..|.  . ..   . || |.|||| .||| || ||||   |.| |.| |
FCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRH

PFF
|.|
PWF
Kinase DDB0220701.AA SGK 1754-1851 44 1.2e-45 138.64 In-house 187-283 (283) Show / Hide 
Range on Protein: 1754-1851
Range on HMM: 187-283/283
Sequence Identity: 44% (44 aa)

GTPDYLSPEILLGTGHGQTVDWWALGIILYEFLTGSPPFNDDTPELIFQHILHRDREMEWPEEISSEAKDLILKLLNPDPYKRLGAN-GAYEVKTHPFF
||| || ||.|.. .|. ||||| ||..|||...| ||| .   .. .. |.. .  .  |  .|..|.|||  ||. || ||||.. .. |.| ||||
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQP--LQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase DDB0220701.AA Pkinase 1527-1673 36 6e-45 160.01 Pfam 1-160 (293) Show / Hide 
Range on Protein: 1527-1673
Range on HMM: 1-160/293
Sequence Identity: 36% (58 aa)

FEIIKPISRGAFGRVYLAQKKKTGDLYAIKVLKKLDTIRKNMVNHVIV--ERNILAMVQNEFVVKLFYAFQSTDKLYLVMEYLIGG----DCASLLR--A
..|...| .|.||.||....|.||...|.|..||  ......  . .   |  |..... ...|.|...|.. |..|.||||. ||    | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

LGCF--EEHMAKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHI----KLTDFGLSK
 |||  .|. .|.|. ...  |||.|.  |.||||||.| |||  |||    |..||||.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase DDB0220701.AA PKA 1754-1851 46 1.6e-40 140.96 In-house 160-263 (263) Show / Hide 
Range on Protein: 1754-1851
Range on HMM: 160-263/263
Sequence Identity: 46% (49 aa)

GTPDYLSPEILLGT-GHGQTVDWWALGIILYEFLTGSPPFNDD--TPELIFQHILHRDREMEWPEEISSEA---KDLILKLLNPDPYKRLG--ANGAYEV
|||.|| |||.... |||  ||||||||. ||.|.| |||.|.  .|  |.. |.  . . ..|....| |   |||| |||..|. ||.|   ||.  .
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKIC--NGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDI

KTHPFF
|.|..|
KNHKWF
Kinase DDB0220701.AA Pkinase 1752-1851 30 9.4e-36 127.5 Pfam 171-293 (293) Show / Hide 
Range on Protein: 1752-1851
Range on HMM: 171-293/293
Sequence Identity: 30% (38 aa)

VVGTPDYLSPEILL-GTGHGQTVDWWALGIILYEFLTGSPPFNDD------TPELIFQHILHRDREMEWPEEIS-------------------SEAKDLI
..|||.|..||... |...|. ||.|..|.||||.|.| ||| ..      ..  ... |.... . .||...|                   .|.||.|
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

LKLLNPDPYKRLGANGAYEVKTHPFF
 ..|..||.||..   | ... ||.|
KWCLCKDPKKRPT---AEQILQHPWF
Kinase DDB0220701.AA MASTL 1751-1851 38 4.6e-25 82.58 In-house 163-283 (283) Show / Hide 
Range on Protein: 1751-1851
Range on HMM: 163-283/283
Sequence Identity: 38% (48 aa)

KVVGTPDYLSPEILLGTGHGQTVDWWA-LGIILYEFLTGSPPFNDDTPELIFQHILHRDREMEWP---EEIS---------------------SEAKDLI
.. |||||| || ..  .||| ||||| ||. .|||..| |||.| .|.. || || ||  .|||   | .|                      ....||
DILGTPDYLKPEQDYQQTHGQVVDWWASLGVCFYEFMKGIPPFCDESPCKVFQNILSRD--LEWPMGDEQKSTTPYSSKLLKSCFETVASNPEVPVMCLI

LKLLNPDPYKRLGANGAYEVKTHPFF
 .||  .|  |  |    .|. | | 
ENLLQMRPRDRPSAT---DVQQHTFI
Kinase DDB0220701.AA TyrKc 1527-1851 18 4.5e-12 -27.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 1527-1851
Range on HMM: 1-280/280
Sequence Identity: 18% (65 aa)

FEIIKPISRGAFGRVYLAQKKKTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMV--QNEFVVKLFYAFQST-------DKLYLVMEYLIGGDCASLLR
 . .| . .||||.||... |      |.|.||.        .   . | .|. ..  ... .|.|. .  .        . |..||||  .||. . ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ALGCFEEHMAKHYIAETVLC-LEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSKIGIIDDKKMEDSGNTNTNTHFNFSTSPTNTSMMDDSSTTGNPN
. .    .  .....  . |  ||||.  ..||||   | |..  ...| .|||||. .  ||..                                   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----------------------------------

GNGNTSLNSSQTNILSPYPQRKNTLKT----PLK--KPVKKVVGTPDYLSPEILLGTGHGQTVDWWALGIILYEFLT-GSPPFND-----DTPELIFQHI
                    .| . ..      |   |..        ..|| .         | |. |. ..| .| | .|  .      ... .....
-------------------ESKDYYRKKEHKGGKTMLPIR-------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV

LHRDREMEWPEE--------ISSEAKDLILKLLNPDPYKRLGANGAYEVKTHPFF
 ...| |. |..         ..|  .....  . || .|   .       | .|
KQGYR-MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase DDB0220701.AA Pkinase_Tyr 1527-1673 25 1.7e-07 26.02 Pfam 1-159 (270) Show / Hide 
Range on Protein: 1527-1673
Range on HMM: 1-159/270
Sequence Identity: 25% (41 aa)

FEIIKPISRGAFGRVYLAQKK----KTGDLYAIKVLKKLDTIRKNMVNHVIVERNILAMV-QNEFVVKLFYAFQ-STDK--LYLVMEYLIGGDCASLLRA
 ...| . .||||.||..  |    .|.   |.|.||   . . |.    . | .|.    ... .|.|  .     .   .|.||||  .||  . ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----LGCFEEHMAKHYIAETVLCLEYLHKSAIVHRDLKPDNMLIDGLGHIKLTDFGLSK
     . .  ..  .. ..    .|||.   ..||||   | |..  ...| .||||..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR