Gene MARK-C (Slime mold)

MARK-C

Species: Slime mold
Alias: MARK-C, DDB0216323, mrkC, DdisK036
External Links: DictyBase Link ,
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MARK-C.AA Protein None 773 None Fasta, JSON
MARK-C.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of MARK-C.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MARK-C.AA MARK 46-300 47 2.2e-157 517.85 In-house 1-262 (262) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-262/262
Sequence Identity: 47% (125 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSG-KQKETCFREIDIMKLLDHPNIVKLLDVVDKREEEGT-TYLIVEYVSGGELFDYIVAR--E
|...||.| |...||||.....|...||||.....||.  .... ..|||.|||.||||||.||..|.. ...|.. .||| ||.|||||.|||.|.   
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIE-QDTEQHQIYLIMEYASGGELYDYIKAHPNG

YIKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNG--DIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDIWSLGVIMYAV
...|.|||..|||..||..||| . |||||.||||.|.|.||  .|||.|||.|. |.||..|..|||.| |.||||.. ..| ||.||||||||..|. 
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LCGNLPWEGDS--QAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKNHPWT
.||..|..||.  . |. .. ..|.|. |.|.|.|. ....|....||..|.||.|. .||| 
VCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MARK-C.AA CAMKL 46-300 44 1.2e-148 477.54 In-house 1-297 (297) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-297/297
Sequence Identity: 44% (133 aa)

YEVGKTLGNGTFGKVKLGTNICT-KENVAIKFIKNNKLSGKQKET-------------CFREIDIMKLLD---HPNIVKLLDVVD----KREEEGTTYLI
|..||||| |.||||||.|.| | .| ||||.|. .|.. ... .              .||| |||.|.   ||||.||..|..    ..|  .  ||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

VEYVSGGE--LFDYIVAREY----IKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGD--IKISDFGLSNNIQP-----GKLLESFCGSPLY
 ||.||||  ||||||....    ..|.|||..|||..||..||| . |||||.||||.|||.||.  |||.|||.|| ..|     |..|. ||||| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

AAPEILKA--EKYLGPPVDIWSLGVIMYAVLCGNLPWEGD--------SQAEISFNSVHGNYEDP--THLSAEAVHILRRMIVPNPKDRATIQELKNHPW
.||||..   ..| ||.|||||.|||.|| .||.||...|         . .       | |..|   |.| .. ...|.| ..||..|.||....||||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

T
 
M
Kinase MARK-C.AA AMPK 46-300 50 7.50000000001e-134 399.72 In-house 1-254 (254) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-254/254
Sequence Identity: 50% (129 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQ-KETCFREIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSGGELFDYIVAREYIK
| .|||.| |||||||.|| | |.| |||| .   |. ... .|   |||.|.||. ||.|..| .|.   | .   ....||||||||||||| .. ..
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVI--IETPTDIFMVMEYVSGGELFDYIVKHGRLQ

EKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDIWSLGVIMYAVLCGNL
|.||..|| |.||..|||| . |||||||||||||| |  ||| ||||||  . |..|   |||| |||||.    .| || ||||| |||.|| ||| |
EREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYL

PWEGDSQAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKNHPWT
| . .....   . . | |. |..|| ||  ....|  ..|  |.||....|||| 
PFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MARK-C.AA CAMK 51-300 28 1.8e-129 419.66 In-house 1-425 (425) Show / Hide 
Range on Protein: 51-300
Range on HMM: 1-425/425
Sequence Identity: 28% (123 aa)

TLGNGTFGKVKLGTNICTK------------ENVAIKFIKNNKLS--------------------------GKQKETCFREIDIMKL-------LDHPNI
||| |.||||||.... |.            . ||||.|. .||.                          .| ..  .|||.|||.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLLDVVDKRE---------EEGT--------TYLIV---EYVSGGEL----FDYIVAREY---------------IKEKEARKFFRQMISAIEYCHANL
.||..| . ..            .         |..    ||.|||||    |||||....               ..|.|||..|||..||..||| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPENLLLDSN-----------------GDIKISDFGLSNNIQP------------------------GKLLESFCGSPLYAA-PEILKA-----
||||||||||.|||.|                 ..|||.|||..| ..|                        |.... |||.| |.| ||.|.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------EKYLGPPVDIWSLGVIMYAVLCGNLPWEGD-------------SQAEISFNSVHGNYE-DPTH-----------------------LSAEAV
        ..| ||..|.||.|||.|. ||| .|..||             .. |.  .   |.|. .| .                       .|.|. 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

HILRRMIVPNPKDRATIQELKNHPWT
. .|.| ...|..|.||.. .|||| 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MARK-C.AA NuaK 46-300 46 1.9e-124 329.22 In-house 1-252 (252) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-252/252
Sequence Identity: 46% (118 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQKETCFR-EIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSGGELFDYIVAREYIK
||. |||| ||.|||||.|.. |   |||| || .|   .|     | || ||  |.||.|..   |   ..      .. || |||||.|||  .. . 
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDK---IVIVMEYASGGELYDYISECKSLP

EKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDIWSLGVIMYAVLCGNL
|.|||.|||| .||. ||| . |.||||| || ||| |...|| ||||||  . .|.|. |||||||| |||   . | || || |||||..|.   | .
EREARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTM

PWEGDSQAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKNHPWT
| .|.   ..     .|.| .|.. | .|    | |   ||. |||| .  .|.| 
PFDGHDFKHLVKQISQGAYYEPCKPS-DACMLIRWMLMVNPRRRATIYDICHHWWV
Kinase MARK-C.AA QIK 46-300 40 1.6e-107 363.53 In-house 1-272 (272) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-272/272
Sequence Identity: 40% (112 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQKETCFREIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSGGELFDYIVAREY---
|....|.| | |. |||.... ||. |||| |   .|  .  . |.||. |||.|.||.|.||..|    | .   |.. || |.||.|||...      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVM---ETDDMMYIVTEYCSNGEMFDYLCKHGRKGV

-----------------IKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGP
                 ..|.|||. | |..||..|||   ||||||| ||.|||.| .||| |||.||  ..|.||...|||| |||||... ..| ||
KMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGP

PVDIWSLGVIMYAVLCGNLPWEGDSQAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKNHPWT
 |||||.||..|.  || ||  |..  .     . | .  |  .| .  |. |.| | .|. | ||.  ..|.|.
KVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MARK-C.AA S_TKc 46-300 37 2.7e-102 347.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-231/231
Sequence Identity: 37% (102 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQKETCFREIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSG--GELFDYIVAREY-
||.....| |.||||...... |.. |||| ||         |.  |||.|.|  .|||||||.|| .     .  |.. ||..|  |.|||||. | . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----IKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDIWSLGVIMY
     . | .||....|...|.|||| . |.||||||||.|||.   |||.||||.  .       .|||.| | |||.|   .| ....|.||.|.|.|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

AVLCGNLPWEGDSQAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKN-------HPWT
  |||  |..   | .  |. .          | || ...|.. . .|..| |. |. .       ||| 
EMLCGYPPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MARK-C.AA Pkinase 46-300 32 1.4e-98 338.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQKETCFR--EIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSGG----ELFDYIV-
|..|...| |.||.|...... | . ||.| ||  . . ....| .|  || ||| |.|||||.|.|..     ..  |.. ||. ||    .|||||  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYIST

-AREYI--KEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDI----KISDFGLSNN--IQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDI
 ..  .   |.|......|.....||||.. |.||||||||.|.|.||.|    ||.||||.    . ..  . .|||.| |.|||...  .| ||.||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGVIMYAVLCGNLPWEGD------SQAEISFNSVHGNYEDPTHLS---------------------AEAVHILRRMIVPNPKDRATIQELKNHPWT
||.|.|.| .|||..|. |.      .| .. ..  .. .. .   .                      |. ....... ..||.| |......||| 
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MARK-C.AA CAMK1 46-300 38 1.8e-95 278.01 In-house 1-276 (276) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-276/276
Sequence Identity: 38% (108 aa)

YEVGKTLGNGTFGKVKLGTNICT---KENVAIKFIK-NNKLSGKQK---ETCFREIDIMKL---LDHPNIVKLLDVVDKREEEGTTYLIVEYVSGGELFD
||.||..|.|.|..|.|.|.. |   ....||| |. .  ...|     |   .||.|||    .|||||.|. ..    |..   ||..|.|.||||||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWY---ESDNHFYLVMELVTGGELFD

YIVAREYIKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSN-GD--IK--ISDFGLSNNIQPGK-LLESFCGSPLYAAPEILKA---EKYLGPP
 || ...  ||.||.  .| .||.||.|.. ||||||||||||. ..  |  ||  |.|||||  . ..  |..  ||.| | |||.|.    . | . .
RIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPY-DKA

VDIWSLGVIMYAVLCGNLPWEGDS-QAEISFNSVHGNYEDPTH----LSAE-AVHILRRMIVPNPKDRATIQELKNHPWT
.|.|| ||| |  |||  |  ... ..|.      . || |.      | . | . .. |....|| | |...  |||| 
CDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MARK-C.AA BRSK 46-300 46 1.9e-89 303.48 In-house 1-254 (254) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-254/254
Sequence Identity: 46% (119 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLS--GKQKETCFREIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSGGELFDYIVAREYI
| ..|||| |. |.||||.   | . |||| |   |||          ||| |||| |||.. |. ||    |     ||| |.||||||||| | .   
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVY---ENKKYLYLILEHVSGGELFDYLVKKGRL

KEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDIWSLGVIMYAVLCGN
. ||||||||| |||...||.  | ||||||||||||    ||| |||.      . .|.  |||| || ||. . ||| |   |.|| |||.|| | | 
TPKEARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGA

LPWEGDSQAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKNHPWT
||   |   .       | .  |    . .   || ||  .|. | ...| . ||| 
LPFDDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase MARK-C.AA Ciliate-E2 46-300 25 5.6e-85 288.63 In-house 1-365 (365) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNK-------------------LSGKQKETCFREIDIMK----------------LLDHPNIVKLLD
|.. | .|.|.||.|...... .....|||.|. .|                   .. .|.|  ..||.||.                .|.||||.|. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VVDKRE--EEGTTYLIVEYVSGGELFDYIV------------AREYIKEKEARKFFRQMIS---------------AIEYCHANL-IVHRDLKPENLLLD
.    .   . . ||. ||..||.|||||             . .|..|||......| ..               |.||.| .  |.|||.||||.|. 
CF---QEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

SNGDIKISDFGLSNNIQPG--------------------------------KLLESFCGSPLYAAPEILKAEKYLG--------PPVDIWSLGVIMYAVL
    |||.||||| ....                                  .  ..||.| | |||||. .|| .          .||||||||.|  |
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

CGNLPWEGDSQAEISFNSVHGNYE--------------DPTHLSAEAVHILRR----MIVPNPKDRAT-IQELKNHPWT
.|..|.    | .|  . .  . .              .. ..| |. .....    |.. .|. | | .....|||| 
FGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MARK-C.AA SNRK 46-300 42 1.8e-82 269.83 In-house 1-254 (254) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-254/254
Sequence Identity: 42% (110 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQKETCFREIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSGGELFDYIVAREY-IK
|.. ||||.| |  |||   . | | ||.| |   |.    |   |.|.  |||  |||||.| .|.|        |||.|   |....|||.  |  ..
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTK---LYLILELGDGYDMYDYIMKHEKGLC

EKEARKFFRQMISAIEYCHANLIVHRDLKPENLL-LDSNGDIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDIWSLGVIMYAVLCGN
|. |||.|.|.. ||.|||   .||||||||| .  .  | .|. ||| ||  .||. || .|||  |.|||||  ..|  | |||||||||.| ..|| 
EDLARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQ

LPWEGDSQAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKNHPWT
.|..    .|     .   |  | |.|.|   .. .|.| .|| ||.. |...|.| 
APFQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MARK-C.AA Pkinase_Tyr 46-193 33 6.5e-21 71.45 Pfam 1-158 (270) Show / Hide 
Range on Protein: 46-193
Range on HMM: 1-158/270
Sequence Identity: 33% (54 aa)

YEVGKTLGNGTFGKVKLGTNI----CTKENVAIKFIKNNKLSGKQ--KETCFREIDIMKLL-DHPNIVKLLDVVDKREEEGT--TYLIVEYVSGGELFDY
 . ||.|| | ||.|..||       ||  ||.| . ... . .|  .|  .||. ||| | .|||||.|. |.   ....    |...||. .| | ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT--DQGEPNQIYIVMEYMPHGDLLDY

IVA----REYIKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLS
  .    .. .. |.  .. .|  .. || ... ..||||   | |...|. .||.||||.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase MARK-C.AA TyrKc 46-307 26 1.1e-19 72.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-280/280
Sequence Identity: 26% (80 aa)

YEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQKETCFREIDIMKLL--DHPNIVKLLDVVDKREEE----GTTYLIVEYVSGGELFDYIVA
 . ||.||.| ||.| .|| .   ..||.| .|...     .|   ||. ||. |  .|||||.|. |. . ..     .  ....||...| | ||. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

REY-IKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLSNNIQPG-------KLLES-F--CG---SPL-YAAPEILKAEKYLG
..  .. |.  .|  |  .  || | . ..||||   | |...|. .|||||||| .|  .       .   .    .|    |.   ||| ..  |.  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-T

PPVDIWSLGVIMYAVL-CGNLPWEG-----DSQAEISFNSVHGNYEDPTHL---------SAEAVHILRRMIVPNPKDRATIQELKNHPWTNIDYQEI
.  |.|| || |. ..  |  |..|      | .|.  .  .|.. .. .          ..|   | ..    .|.|| | .|.         ....
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---------HECF
KA1 MARK-C.AA KA1 727-773 43 2.1e-24 85.03 Pfam 1-48 (48) Show / Hide 
Range on Protein: 727-773
Range on HMM: 1-48/48
Sequence Identity: 43% (21 aa)

EDNSVKFQIEIVKIC-NLDLTGIQLKRLSGDTWKYKDICTELVESMKL
|...|||.|...|.. .|.| |...||.||..| |||.||.....|.|
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL