Gene ClkA (Slime mold)

ClkA

Species: Slime mold
Alias: ClkA, DDB0230105, DdisK057
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
ClkA.AA Protein None 932 None Fasta, JSON
ClkA.kin_dom Protein Kinase Domain None 330 None Fasta, JSON

Protein domain

Protein domains of ClkA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ClkA.AA CLK 590-920 46 8.8e-236 715.56 In-house 1-350 (350) Show / Hide 
Range on Protein: 590-920
Range on HMM: 1-350/350
Sequence Identity: 46% (163 aa)

YKVLCTVGSGTFSTVVECWDTNSSG-QVAIKIVRSAKKYTEDALVEID-ILRNLEKTGNSNGKYLSHCIRLLDSFLF-KDHICLVFKRYGLSLYEFLKKN
|...||.|.|||..||||||..... .||.||.|...||.|.| |||. |..........|.||..||....|.| . ..|||.||..||||.|.|.|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

R------YRPLPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILLESSRFTYFDNSIPLQFKNSIDTTSNNSVDHYCHLVDTDIVVIDFGGAT---FE
.      |.|.|...|.....||..|....|...|.|||||||||....||||.||.......|..|...|||.|.||.|...|.|.|||||.||   |.
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

NTHHTAIVCSRPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLFDTHNNVQHLAMMEKVMG-PFPNSM--SNV----SKKYFNDYGTLNRPQNSDEI
..||..||..|.||.||.|||.|||.|||.|..||||.|||.|.|||.||.|..||||||..|| |.|..|  ...    ..|||..........|||..
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

KSMERVEGLKQLKEYFHPCHDSFFDLASRLLEYQPSKRISASDALSHPFL
..||....|||......|.|...|||....|||.|||||...|||.||| 
YVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase ClkA.AA CMGC 590-920 18 8.4e-107 352.11 In-house 1-513 (513) Show / Hide 
Range on Protein: 590-920
Range on HMM: 1-513/513
Sequence Identity: 18% (100 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQ--------------VAIKIVRSAKKYTEDAL-------------VEIDILRNLEKTGNSNG---------KYLS
|...  .|.||...|..|.|... ..              ||||...... |.|.|.              || ||..| |...  .         |   
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

HCIRLLDSFLFKD-----------------HICLVFKRYGLSLYEFLKKNR--YRP-----LPLSQ------------IQNIS------KQLLTAIY--S
....|.|.| .|.                 |..|||   . .||...|.|.  |..     |.  .            |....      .|.|...    
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

MHKLS--LVHTDLKPENILLES-----------SRFTYFDNSIPLQFKNSIDTTSNNSVDHYCHLVDTDIVVIDFGGATFENTH----------------
.|.     .|.||||||||. .           |                  .. . ...    ...  . ..||| |.....|                
CHSHWGNIIHRDLKPENILINHNCELITRMMWKS------------------ED-W-NPC----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVN

--------HTAIVCSRPYRPPEIILG----------MGWSYPCDIWGVGCILVELYLG--------YTLFDTHNN-----------VQHLAMMEKVMGPF
        .|  |..| ||.|||.||          |....|.|.|.||||. |.|.|        ..|| .|..           . .|... ||.|..
KDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTP

PNSMSNV----------SKKYFNDYGTLNRPQNSDEI----------------------KSMERVEGLKQLKEYFHP-----------------------
. .| .           .....|  . ......   .                      . . .   .|.|.  ...                       
T-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHK

---------CHDSFFDLASRLLEYQPSKRISASDALSHPFL
         |.. ..|| ...|.| |.|||.|..||.||..
FNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase ClkA.AA S_TKc 590-920 21 2.3e-69 237.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 590-920
Range on HMM: 1-231/231
Sequence Identity: 21% (74 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSNGKYLSHCIRLLDSFLFKDHICLVFKRYGL---SLYEFLKKN
|..| ..|.|.|..|  |.....  .|||||..      |... ||.||..             . ..|.|.|   ||...|.   .    .|....||.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

RYRP----LPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILLESSRFTYFDNSIPLQFKNSIDTTSNNSVDHYCHLVDTDIVVIDFGGATFENTHHT
....    .|  ... . .|.. |.  .|..  .| ||||||||| .                                    | ..||| |..     |
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------------------------HIKICDFGLARQL----T

AIVCSRPYRPPEIILGMGWSY-PCDIWGVGCILVELYLGYTLFDTHNNVQHLAMMEKVMGPFPNSMSNVSKKYFNDYGTLNRPQNSDEIKSMERVEGLKQ
 .. .. |..||..   |... .||.| .|||| |.. ||..|.     |. .|..|..                                         
TFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------------------------------------

LKEYFHPCHDSFFDLASRLLEYQPSKRISASDALS-------HPFL
         ... |. ...|.. |.||..| .||        ||..
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ClkA.AA Pkinase 590-920 21 3.1e-56 197.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 590-920
Range on HMM: 1-293/293
Sequence Identity: 21% (76 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTED---ALV--EIDILRNLEKTGNSNGKYLSHCIRLLDSFLFKDHICLVFKRYGL-----SL
|... ..|||.|..| .| . ... .||.||..  ..  .    ..   || |...| .      ..    .||.|.|  ||||..|.   .      .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-----HPNI---VRLYDWFEDKDHIYMVMEYCEGGLYVMDL

YEFLKKNRYRPL--PLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILLESSRFTYFDNSIPLQFKNSIDTTSNNSVDHYCHLVDTDIVVIDFGGA---
.....  |....  .  ..... .|.| ... .|. . .| ||||||||.  .. .  .                            .. ..||| |   
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA----------------------------CVKICDFGLAKQF

-TFENTHHTAIVCSRPYRPPEIIL-GMGWSYPCDIWGVGCILVELYLGYTLFDTH----NNVQHLAMMEKVMG-------PFPNSMSNVSKKYFNDYGTL
 .  |.  | ......|..||.|. | ......|.|..|||| |...|...|. |    | . ...|....||       | ..|.|. .  .. .    
DY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--

NRPQNSDEIKSMERVEGLKQLKEYFHPCHDSFFDLASRLLEYQPSKRISASDALSHPFL
                  . ...  |  .... |. ...|.. |.||..| ..| ||..
------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ClkA.AA DYRK 590-733 37 4.6e-48 166.0 In-house 1-145 (320) Show / Hide 
Range on Protein: 590-733
Range on HMM: 1-145/320
Sequence Identity: 37% (56 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSNGKYLSHCIRLLDSFLFKDHICLVFKRYGLSLYEFLKKNRYR
|..|   |.|.|. || |||..    |||||.|. |..   |. || ||. | .  ... ||  ||....|.| .. | |.||  .  .||||||.|. .
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKY--HCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQ

PL-PLSQIQNISKQLLTAIYSMHKL-SLVHTDLKPENILLES--SRFT
.. .|. .. . .|.||..  .||. ...| |||||||.| .  .. |
GFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKST
Kinase ClkA.AA SRPK 590-728 32 6.1e-42 104.6 In-house 248-411 (554) Show / Hide 
Range on Protein: 590-728
Range on HMM: 248-411/554
Sequence Identity: 32% (53 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSN--------------------GKYLSHCIRLLDSFLFK----
| |    | | ||||  |||.    .||.|||.||. ||| |. || .|  . |. ..                      .. .|...|||.| ..    
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

DHICLVFKRYGLSLYEFLKKNRYRPLPLSQIQNISKQLLTAIYSMHKL-SLVHTDLKPENILLE
 |.|.||   | .|..  |...|. .|.... .|..|.|..   .|   .  |||.||||.||.
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLC
Kinase ClkA.AA Ciliate-E2 590-920 16 5.1e-40 135.05 In-house 1-365 (365) Show / Hide 
Range on Protein: 590-920
Range on HMM: 1-365/365
Sequence Identity: 16% (74 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIK-----------------IVRSAKKYTEDALVEIDILRNLEKTGNSNG----------KYLSH--CIRLLD
||..   |.|.|..| .| . .   |.|||                      | . .. . .|    .. .. |. .          . |.|   |.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

SFL--FKDHICLVFKRY-GLSLYEFLKKN----------RYRPLPLSQIQNISKQLLT---------------AIYSMHKLS-LVHTDLKPENILLESSR
.|    ...| ||.  . | .|....|.|             .. . .|..|.||.|                |. ..|.    .| |.||||||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

FTYFDNSIPLQFKNSIDTTSNNSVDHYCHLVDTDIVVIDFGGATFENT----------------------------------HHTAIVCSRPYRPPEIIL
                                  | .|||| ... ..                                   .  |... .| .|||. 
----------------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILN

GMG---------WSYPCDIWGVGCILVELYLGYTLFDTHNNVQHLAMMEKVMGPFPNSMSNVSKKYFNDYGTLNRPQNSDEIKSMERVEGLKQLKE----
| .         ..| |||| .|.|| |.  |.. |                                                      ..| |.    
GKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------------------------------------QQQIKQCKID

------------------YFHPCHDSFFDLASR----LLEYQPSKRIS-ASDALSHPFL
                   .. . ..  || ..    .|...|.|||. ....| ||..
FPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase ClkA.AA DYRK2 590-727 35 1.9e-38 122.42 In-house 1-135 (318) Show / Hide 
Range on Protein: 590-727
Range on HMM: 1-135/318
Sequence Identity: 35% (49 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSNGKYLSHCIRLLDSFLFKDHICLVFKRYGLSLYEFLKKNRYR
| .|   |.| |  ||.| |      ||||..|  |.. . |..|| ||  . .    |    . |...||.| |  |.|..|  ....|||..||| . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDN---TMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQ

PLPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILL
 . |. .    ...|...   ||  ..| |||||||||
GFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILL
Kinase ClkA.AA HIPK 590-727 40 6.4e-38 116.67 In-house 1-134 (329) Show / Hide 
Range on Protein: 590-727
Range on HMM: 1-134/329
Sequence Identity: 40% (56 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSNGKYLSHCIRLLDSFLFKDHICLVFKRYGLSLYEFLKKNRYR
| ||   | |||  || ||    .  ||||| .    |     .|. ||. | .    .     | .| .. |  | |.||||      ||.|.|.|.. 
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE----YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFM

PLPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILL
||||  |  | .| |||.  . .|.|.| |||||||.|
PLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIML
Kinase ClkA.AA DYRK 768-920 30 7.8e-35 122.05 In-house 148-320 (320) Show / Hide 
Range on Protein: 768-920
Range on HMM: 148-320/320
Sequence Identity: 30% (53 aa)

VIDFGGATFENTHHTAIVCSRPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLFDTHNNVQHLAMMEKVMGPFPNSMSNVS-----KKYFN------
||||| ..||. . .  . || || ||.|||.  .|. |.| .||||.||..|. ||   |..  ||..  |.|..|. | . .     .|.|.      
VIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCE

-------DY---GTLNRPQNSDEIKSMERVEGLKQLKEYFHPCHDSFF-DLASRLLEYQPSKRISASDALSHPFL
       ..    . ..... . .  ..|. | . .. ... |.|. | |.  ..|.. |.|||..|.|| ||..
CDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase ClkA.AA YAK 590-727 36 1.5e-32 107.57 In-house 245-383 (347) Show / Hide 
Range on Protein: 590-727
Range on HMM: 245-383/347
Sequence Identity: 36% (51 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSNGKY-LSHCIRLLDSFLFKDHICLVFKRYGLSLYEFLKKNRY
|.||   | |||  || |        .|.|.. .   |   |  || ||| | .    |.|    | .|..|.| .| | ||||    ..|||.|| |..
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RPLPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILL
. .  . |.   || | ..       ..| |||||||.|
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIML
Kinase ClkA.AA DYRK2 768-920 33 5e-27 84.65 In-house 145-318 (318) Show / Hide 
Range on Protein: 768-920
Range on HMM: 145-318/318
Sequence Identity: 33% (58 aa)

VIDFGGATFENT--HHTAIVCSRPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLFDTHNNVQHLAMMEKVMGPFPNSMSNVS-------KKYFND-
|||||  .||.    .| |  || || ||.|||.  . . |.|  |||..||| || ||   | .  .|.|  |.|  | .. ...       .||| . 
VIDFGSSCFEHQYRIYTYI-QSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNS

-----------YGTLNRPQNSDEIKSMERVEGLKQLKEYFHPCHDSFF-DLASRLLEYQPSKRISASDALSHPFL
            ..   | .    . . |. | |..|.... | | .| |  .| .|  ||.|...|.|| ||..
HCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase ClkA.AA DYRK1 590-727 34 2.5e-25 85.56 In-house 1-137 (321) Show / Hide 
Range on Protein: 590-727
Range on HMM: 1-137/321
Sequence Identity: 34% (48 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSNGKYLSHCIRLLDSFLFKDHICLVFKRYGLSLYEFLKKNRYR
|..   .| | |  ||  .|.    .|||||..  | . . |..|| .|  |      . ||  . ..|   | |..|.||||      ||. |.   .|
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLL-ELMNKHDKEMKY--YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFR

PLPLSQIQNISKQLLTAIY--SMHKLSLVHTDLKPENILL
   |  .. . .|..||..  |   |...| |||||||||
GVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL
Kinase ClkA.AA PRP4 590-726 35 7.1e-24 84.31 In-house 1-138 (320) Show / Hide 
Range on Protein: 590-726
Range on HMM: 1-138/320
Sequence Identity: 35% (49 aa)

YKVLCTVGSGTFSTVVECWDTNSSG-QVAIKIVRSAKKYTEDALVEIDILRNLEKT-GNSNGKYLSHCIRLLDSFLFKDHICLVFKRYGLSLYEFLKKN-
|.|   .|.| ||.|. | |.     .|||||.|.        | |. ||. |  .   .| |.  ||.|. ..| .. |.||||     .| | |||  
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKF--HCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYG

RYRPLPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENIL
.   | |  .   ..||. |   . |.  .| |.|| |||
KDVGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL
Kinase ClkA.AA DYRK1 766-856 35 4.7e-15 48.86 In-house 145-238 (321) Show / Hide 
Range on Protein: 766-856
Range on HMM: 145-238/321
Sequence Identity: 35% (33 aa)

IVVIDFGGATFENTHHTAIVCSRPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLFDTHNNVQHLAMMEKVMGPFPNSM---SNVSKKYFN
| .|||| .   .      . || || ||..||. ..   |.| .||||||.  |  ||   | |  .  .  |.|  |. |   .  ..|||.
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase ClkA.AA SRPK 901-920 50 1.3e-11 24.64 In-house 535-554 (554) Show / Hide 
Range on Protein: 901-920
Range on HMM: 535-554/554
Sequence Identity: 50% (10 aa)

LEYQPSKRISASDALSHPFL
|.| |.||..|...| ||.|
LHYNPEKRATAKECLQHPWL
Kinase ClkA.AA YAK 765-824 40 3e-11 34.09 In-house 146-205 (347) Show / Hide 
Range on Protein: 765-824
Range on HMM: 146-205/347
Sequence Identity: 40% (24 aa)

DIVVIDFGGATFENTHHTAIVCSRPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLF
.| .|||| .  |    .  . .| || ||||..|  .   | |  |||..||.||  .|
EIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIF
Kinase ClkA.AA PRP4 787-847 44 5.4e-11 36.55 In-house 168-228 (320) Show / Hide 
Range on Protein: 787-847
Range on HMM: 168-228/320
Sequence Identity: 44% (27 aa)

SRPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLFDTHNNVQHLAMMEKVMGPFPNSM
|| || ||||.|.   |  |.| ||| | ||| |  .|.   | . | ..  . | .|| |
SRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKM
Kinase ClkA.AA HIPK 768-825 42 7.3e-09 23.53 In-house 146-204 (329) Show / Hide 
Range on Protein: 768-825
Range on HMM: 146-204/329
Sequence Identity: 42% (25 aa)

VIDFGGAT-FENTHHTAIVCSRPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLFD
||||| |  . ..   . . || || ||||||.      |.|  ||.. ||.||  |..
VIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYP
Kinase ClkA.AA SRPK 788-827 47 9.5e-09 17.07 In-house 416-455 (554) Show / Hide 
Range on Protein: 788-827
Range on HMM: 416-455/554
Sequence Identity: 47% (19 aa)

RPYRPPEIILGMGWSYPCDIWGVGCILVELYLGYTLFDTH
| || || |.| |...| ||| . | . ||  |  ||..|
RQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPH
Kinase ClkA.AA TyrKc 590-920 15 5.1e-08 -93.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 590-920
Range on HMM: 1-280/280
Sequence Identity: 15% (56 aa)

YKVLCTVGSGTFSTVVECWDTNSSGQVAIKIVRSAKKYTEDALVEIDILRNLEKTGNSNGKYLSHCIRLLDSFLFK-------DHICLVFKRYGL-SLYE
 . . . |.| | .|...  .    |||.| ... .   || . |. |...|       |.   . .||.   . .       . ...|.    . .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKL-------GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLKKNRYRPLPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILLESSRFTYFDNSIPLQFKNSIDTTSNNSVDHYCHLVDTDIVVI-DFGGATFENTH
.|.|.| . |....  ... |        |.  ..| ||   |.|. . .                                  .| | ||| . .   .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------------------------TVKISDFGLSRDIYDD

------HTAIV-----CSR---PYR--PPEIILGMGWSYPCDIWGVGCILVEL-------YLG-----YTLFDTHNNVQHLAMMEKVMGPFPNSMSNVSK
      .  ..     ...   |.|  .|| |     .   |.|  |  . |.       | |      . .. ...|..  .|..   .    ||    
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS----

KYFNDYGTLNRPQNSDEIKSMERVEGLKQLKEYFHPCHDSFFDLASRLLEYQPSKRISASDALSHPFL
                                 |  |.|  ... ..  ...|..| . |.   | ..
---------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase ClkA.AA YAK 851-920 30 6.3e-08 22.61 In-house 283-347 (347) Show / Hide 
Range on Protein: 851-920
Range on HMM: 283-347/347
Sequence Identity: 30% (21 aa)

SKKYFNDYGTLNRPQNSDEIKSMERVEGLKQLKEYFHPCHDSFFDLASRLLEYQPSKRISASDALSHPFL
||.||. | .||   |    |   | .     .  .    | | |..  ||.  | .| ... |  |||.
SKTYFQ-YKCLNDIKNYMYFKQFMRNQDDTKNNRHR----DCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase ClkA.AA DYRK1 893-920 46 3.9e-07 20.56 In-house 294-321 (321) Show / Hide 
Range on Protein: 893-920
Range on HMM: 294-321/321
Sequence Identity: 46% (13 aa)

FFDLASRLLEYQPSKRISASDALSHPFL
| ||  |.|.|.| .||.  .|| |.|.
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase ClkA.AA PRP4 905-920 56 8e-06 17.31 In-house 305-320 (320) Show / Hide 
Range on Protein: 905-920
Range on HMM: 305-320/320
Sequence Identity: 56% (9 aa)

PSKRISASDALSHPFL
|.|||.  .|| |||.
PKKRITCNEALKHPFI
Kinase ClkA.AA HIPK 892-920 31 6e-05 10.98 In-house 301-329 (329) Show / Hide 
Range on Protein: 892-920
Range on HMM: 301-329/329
Sequence Identity: 31% (9 aa)

SFFDLASRLLEYQPSKRISASDALSHPFL
.| ..  ...  .. |||. ..|| ||| 
EFVHVLKKMCTWDAHKRITPCEALNHPFV