Gene DDB0229841 (Slime mold)
DDB0229841
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0229841.AA | Protein | None | 442 | None | Fasta, JSON |
| DDB0229841.kin_dom | Protein Kinase Domain | None | 324 | None | Fasta, JSON |
Protein domains of DDB0229841.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DDB0229841.AA | Dicty1 | 74-397 | 65 | 9.69999999999e-263 | 879.13 | In-house | 1-327 (327) | Show / Hide |
Range on Protein: 74-397 Range on HMM: 1-327/327 Sequence Identity: 65% (213 aa) IDPNTIVDCGTNGIMFIAFNFETQKRVILKKLSKRMFDNELNGHRIIRNLIFQNLFQGGKHISTYQSIFKRKCSDSYQPPLTSILNSIISSNDNPQQHST ||||||||||||||||.||||.||.|||.||.|..||.|.|.||...||..||..||...|.||.||||||||||.|||||||||||||.||.|.|||.. IDPNTIVDCGTNGIMFRAFNFDTQRRVIIKKISVFMFKNHLMGHMMLRNCHFQRHFQHHPHVSTFQSIFKRKCSDNYQPPLTSILNSIINSNNNNQQHLI LIQQKDDEDFYFESIQPQYSLLNLISN-NMLDQDDICQLFYEILMGLKFMHSAGVIHRDLDPENSIFVDENFNIKFTEFNNCFLLDTDPTFLFNKEYITN |||||||.|||||.||||..|...|.| .||||...|...|..||..|||||||||||||||||.||||.|..||.|||..||..|..|.|.|||.|.|| LIQQKDDDDFYFEYIQPQFTLYQMIHNDKMLDQYQCCYFLYQLLMTIKFMHSAGVIHRDLDPENTIFVDQNYCIKLTEFYFCFPTDCPPDFFFNKDYDTN TYSYRAPETIWGDSLYTEATDVWGAGVLFAELLLGKRLFRSFNSKEHLKSIYKLIGAPKASEGAYVVKGELLFFLMEYNRKNSFQPTF--NNTFIGCNQI ...||||||||....||.|.|||..||.|||..|||||||..|...||.|||||||.|...|..|||.|...||.||||||..|||.| ...|.||||. PWPYRAPETIWMNKEYTFACDVWNIGVIFAEMILGKRLFRTQNFQDHLISIYKLIGNPTYDECKYVVNGFAIFFYMEYNRKSTFQPHFGIKRRFKGCNQD QIDLLKNMLCWDPRDRYSVNEILESPY ||.||..|||||||.|...|.||..|| QIELLQGMLCWDPRKRWPINQILQHPY |
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| Kinase | DDB0229841.AA | CMGC | 74-398 | 17 | 3.9e-58 | 189.21 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 74-398
Range on HMM: 1-513/513
Sequence Identity: 17% (91 aa)
IDPNTIVDCGTNGIMFIAFN--------------FETQKRVILKKLSKRMFDNELNG---------HRIIRNLIFQNLFQ----------------GGKH
. . .|| |. . ... ||...| .||.... . | |..| . . .. ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN
ISTYQSIFKRKCSDSYQPPLTSILNSIISSNDNPQQHSTLIQQKDDEDFYFESIQPQYSLLNLISNN----------MLDQDD------------ICQLF
| . . ||..| ||..... ..| |.| .....|. ...|...| || |.. |. ..
IVKLYDIFYHKNSDGNEYEDKHI-----------------ISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFM
------YEILMGLK--FMHSAG--VIHRDLDPENSIFVDEN-------------------FNIKFTEFNNCFLLDTDPTFLF----------------NK
| || ||| ..||.. .||||| ||| . ... ...| | .. ... . | |.
IHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNR
EYI--TNTYSYRAPETIWGDSLYT---------EATDVWGAGVLFAELLLG--------KRLFRSFNS-----------KEHLKSIYKLIGAPK------
| | ||||| . |.. || .. |.|..| |||...| | || .. ..|. | |..| |
PYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKG
---------ASEGAYVVKGELLFFLMEYN----------------------RKNSFQPTFNNTFIG----------------------------------
| ...| . .... .. ....| | .
KRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRK
-CNQIQIDLLKNMLCWDPRDRYSVNEILESPYF
|.. |||||.||..|| .| .. ..|. |||
CCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
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| Kinase | DDB0229841.AA | nmo | 197-398 | 31 | 3.2e-33 | 99.04 | In-house | 93-292 (292) | Show / Hide |
Range on Protein: 197-398 Range on HMM: 93-292/292 Sequence Identity: 31% (64 aa) LISNNMLDQDDICQLFYEILMGLKFMHSAGVIHRDLDPENSIFVDENFNIKFTEFNNCFLLDTDPTFLFNKEYITNTYSYRAPETIWGDSLYTEATDVWG ..| | | . | || |||..|||...|||. | | . |. | .| .| . | .| .| | ||||| . | ||.| |.| IVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGN-LLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQ-Y-YRAPEILMGARHYTSAVDIWS AGVLFAELLLGKRLFRSFNSKEHLKSIYKLIGAPKASEGAYVVKGELLFFLMEYNRKNSFQPTFNNTF-IGCNQIQIDLLKNMLCWDPRDRYSVNEILES | .||||| . || . . |. | |.| | . | | | . .. ..| .. . . ..||. || .|| | |... |. VGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAH PYF || PYL |
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| Kinase | DDB0229841.AA | Ciliate-E2-Unclassified | 196-398 | 22 | 1.9e-27 | 92.28 | In-house | 128-352 (352) | Show / Hide |
Range on Protein: 196-398 Range on HMM: 128-352/352 Sequence Identity: 22% (53 aa) NLISNNMLDQDDIC-----QLFYEILMGLKFMHSAG-VIHRDLDPENSIFVDEN---FNIKFTEFNNCFLLDTDPT----------FLFNKEYITN--TY |. ...... .. ..|..|| ||...|. . .||||. ||| |..|.| ..|| . | .. ..... .. .... |. |. NMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPEN-ILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTP SYR----APETIWGDSLYT---EATDVWGAGVLFAELLLGKRLFRSFNSKEHLKSIYKLIGAPKASEGAYVVKGELLFFLMEYNRKNSFQPTFNN--TFI .| ||| . | .. .. |.|. ||.. |.| |.. | . |...| ..|.. | | . .. . . || ..| |.. NYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N-NA---------YRKQLYQNIKQKNIQFPKFPWQQIPK GCNQIQIDLLK----NMLCWDPRDRYSVNEILESPYF . .. ..|... || ..| |.. ..||. |.| HWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | DDB0229841.AA | Ciliate-E2 | 193-398 | 18 | 9.8e-26 | 85.31 | In-house | 120-365 (365) | Show / Hide |
Range on Protein: 193-398
Range on HMM: 120-365/365
Sequence Identity: 18% (55 aa)
SLLNLISNN------------MLDQDDICQLFYEIL---------------MGLKFMHSAG-VIHRDLDPENSIFVDENFNIKFTEFNNCFLLDTDPT--
.|. .| || .. |......|| .|...|| . .||||. ||| .| || . | .. .|.|
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNR
--------FLFNKEYITNTYS-------------------YRAPETIWGDSL--------YTEATDVWGAGVLFAELLLGKRLFRSFNSKEHLKSIYKLI
..| | ... |.. | ||| . | . |... |.| .||.. |.| ||. |
THKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------
GAPKASEGAYVVKGELLFFLMEYNRKNSFQPTFNNT---------------FIGCNQIQIDLLKN----MLCWDPRDRYS-VNEILESPYF
.. . . |.. . . | .||.|. ||. || |.. ..||. |.|
----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | DDB0229841.AA | ERK5 | 213-398 | 33 | 4.9e-25 | 88.55 | In-house | 110-295 (295) | Show / Hide |
Range on Protein: 213-398 Range on HMM: 110-295/295 Sequence Identity: 33% (64 aa) YEILMGLKFMHSAGVIHRDLDPENSIFVDENFNIKFTEFNNCFLLDT---DPTFLFNKEYITNTYSYRAPETIWGDSLYTEATDVWGAGVLFAELLLGKR | || |||.|||| |||||| | | . | || .| .| | | | .| ||. | ||||| . || | ||| | .| |.. . YQILRGLKYMHSAQVIHRDLKPSN-LLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVA-TRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQ LFRSFNSKEHLKSIYKLIGAPKASEGAYVVKGELLFFLMEYNRKNSFQPTFNNTFIGCNQIQIDLLKNMLCWDPRDRYSVNEILESPYF .| | . |. | . .| | .. | . . . | | .. . . . .||| || ..| .| .||. | |. MFPGKNYIHQLQLIMMVLGMP-PPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL |
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| Kinase | DDB0229841.AA | S_TKc | 74-398 | 16 | 1.7e-22 | 81.98 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 74-398
Range on HMM: 1-231/231
Sequence Identity: 16% (57 aa)
IDPNTIVDCGTNGIMFIAFNFETQKRVILKKLSKRMFDNELNGHRIIRNLIFQNLFQGGKHISTYQSIFKRKCSDSYQPPLTSILNSIISSNDNPQQHST
. .. |. | . . . .|...| .|... .|.. | .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------------------EHIRREIQILKK---HHPN
LIQQKDDEDFYFESIQ------PQ--YSLLNLISNNM-------LDQDDICQLFYEILMGLKFMHSAGVIHRDLDPENSIFVDENFNIKFTEFNNCFLLD
... .| . ... .. .|. .| .. .. ... ..|.|. .|...|| |.||||| ||| |..|| .|| . | . .|
IVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPEN-ILLDE--HIKICDFGLARQL-
TDPTFLFNKEYITNTYSYRAPETIWGDSLYTE-ATDVWGAGVLFAELLLGKRLFRSFNSKEHLKSIYKLIGAPKASEGAYVVKGELLFFLMEYNRKNSFQ
. | |.||| . |. . |.| |....|.| |. .|. ... ..|.||
---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-----------------------------
PTFNNTFIGCNQIQIDLLKNMLCWDPRDRYSVNEILE-------SPYF
. .|.....|..||..|... |.|. |.|
----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | DDB0229841.AA | MAPK | 276-398 | 28 | 4.1e-22 | 73.08 | In-house | 197-328 (328) | Show / Hide |
Range on Protein: 276-398 Range on HMM: 197-328/328 Sequence Identity: 28% (38 aa) YRAPETIWGD--SLYTEATDVWGAGVLFAELLL-GKRLFRSFNSKEHLKSIYKLIGAPKASEGAYVV-KGELLFFLMEYN-RKNSFQPTFNNTFIG---- ||||| . . ||.| |.| .| |||.| .| ||. .. . .. | ...| |. .. . .. .. .. . .. . | . YRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFN CNQIQIDLLKNMLCWDPRDRYSVNEILESPYF .| ||||. || .|| .|..| | |. ||| ANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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| Kinase | DDB0229841.AA | Pkinase | 273-398 | 25 | 3.7e-18 | 65.27 | Pfam | 174-293 (293) | Show / Hide |
Range on Protein: 273-398 Range on HMM: 174-293/293 Sequence Identity: 25% (33 aa) TYSYRAPETIWGDSLYTEATDVWGAGVLFAELLLGKRLFRSF----NSKEHLKSIYKLIGAPKASEGAYVVKGELLFFLMEYNRKNSFQPTFNNTFIGCN |. |.||| | |.. |. . |.|..|....|.|.|. .|.. | .... |.. |.| .. . . . | .. . . . ||. . TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----F-HWTFHNWS QIQIDLLKNMLCWDPRDRYSVNEILESPYF . .|..|..||.|| .|.. .||..|.| EECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | DDB0229841.AA | JNK | 193-312 | 34 | 1.4e-16 | 58.17 | In-house | 91-208 (309) | Show / Hide |
Range on Protein: 193-312 Range on HMM: 91-208/309 Sequence Identity: 34% (42 aa) SLLNLISN--NMLDQDDICQLFYEILMGLKFMHSAGVIHRDLDPENSIFVDENFNIKFTEFNNCFLLDTDPTFLFNKEYITNTYSYRAPETIWGDS-LYT .| ..| . || . . ||| .. | |..||.|.||||| |.| | | . .| | . | ... . |. | ||||| | | |. NLCQVIHSTFMELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSN-IVVNQDCTLKICDFG---HARTEDPTFMMTPYVVTRY-YRAPEVICGMMDNYK EATDVWGAGVLFAELLLGKRLFR | |.| | .||.. .. ||. ENVDIWSVGCIMAEMIRHHVLFP |
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| Kinase | DDB0229841.AA | ERK | 276-398 | 33 | 1.5e-14 | 50.8 | In-house | 182-307 (307) | Show / Hide |
Range on Protein: 276-398 Range on HMM: 182-307/307 Sequence Identity: 33% (43 aa) YRAPETIWGDSLYTEATDVWGAGVLFAELLLGKRLFRSFNSKEHLKSIYKLIGAP-KASEGAYVVKGELLFFLMEYNR----KNSFQPTFNNTFIGCNQI ||||| . . ||.|.|.| .|. |||.| .| ||. .. ... | ..|| | . | ... .. ... . ... | |. || YRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNAN--CNPQ QIDLLKNMLCWDPRDRYSVNEILESPYF ||||. || .|| .|..| | || ||| AIDLLEKMLVFDPDKRITVEECLEHPYF |
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| Kinase | DDB0229841.AA | MAPK | 191-243 | 46 | 4.7e-12 | 37.76 | In-house | 99-153 (328) | Show / Hide |
Range on Protein: 191-243 Range on HMM: 99-153/328 Sequence Identity: 46% (26 aa) QYSLLNLIS-NNMLDQDDICQLFYEILMG--LKFMHSAGVIHRDLDPENSIFVDEN . | ..| ...|. | |. ..| || | ||..|||.|||||| |.| | |.|| ETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSN-ILVNEN |
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| Kinase | DDB0229841.AA | p38 | 181-236 | 44 | 3.8e-11 | 34.04 | In-house | 81-136 (289) | Show / Hide |
Range on Protein: 181-236 Range on HMM: 81-136/289 Sequence Identity: 44% (25 aa) EDFYFESIQPQYSLLNLISNNMLDQDDICQLFYEILMGLKFMHSAGVIHRDLDPEN .|.|. . . .| |.. | | | | | || |||. ||||.||||| | | QDVYMVTHFMGADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSN |
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| Kinase | DDB0229841.AA | p38 | 276-332 | 36 | 4.4e-10 | 30.36 | In-house | 169-225 (289) | Show / Hide |
Range on Protein: 276-332 Range on HMM: 169-225/289 Sequence Identity: 36% (21 aa) YRAPETIWGDSLYTEATDVWGAGVLFAELLLGKRLFRSFNSKEHLKSIYKLIGAPKA ||||| . ||.. |.| | |||. |. ||. . . |. | |..| |.. YRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDE |
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| Kinase | DDB0229841.AA | Pkinase | 193-247 | 37 | 9e-09 | 32.1 | Pfam | 90-152 (293) | Show / Hide |
Range on Protein: 193-247 Range on HMM: 90-152/293 Sequence Identity: 37% (24 aa) SLLNLIS---NNML--DQDDICQLFYEILMGLKFMHSAGVIHRDLDPENSIFVDENFNI----K .| .|| .. . . .... .|.|| ||...|| |.||||| ||| |..|.| .| | DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN-ILIDNNGHIDACVK |
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| Kinase | DDB0229841.AA | ERK | 206-236 | 68 | 1.1e-08 | 28.66 | In-house | 107-138 (307) | Show / Hide |
Range on Protein: 206-236 Range on HMM: 107-138/307 Sequence Identity: 68% (22 aa) DDICQLF-YEILMGLKFMHSAGVIHRDLDPEN ||.|| | | || |||..|||.|||||| | | DDHCQYFMYQILCGLKYIHSANVIHRDLKPSN |
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| Kinase | DDB0229841.AA | JNK | 373-398 | 50 | 7.9e-07 | 21.52 | In-house | 284-309 (309) | Show / Hide |
Range on Protein: 373-398 Range on HMM: 284-309/309 Sequence Identity: 50% (13 aa) DLLKNMLCWDPRDRYSVNEILESPYF ||| .|| .| ||.|| ..|. || DLLFRMLVINPDDRISVDDALQHPYI |
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| Kinase | DDB0229841.AA | p38 | 360-398 | 43 | 2e-06 | 17.66 | In-house | 251-289 (289) | Show / Hide |
Range on Protein: 360-398 Range on HMM: 251-289/289 Sequence Identity: 43% (17 aa) FNNTFIGCNQIQIDLLKNMLCWDPRDRYSVNEILESPYF | . |.| | |||| || || | .. | .. ||| FHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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| Kinase | DDB0229841.AA | TyrKc | 74-396 | 17 | 5e-05 | -141.31 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 74-396 Range on HMM: 1-280/280 Sequence Identity: 17% (63 aa) IDPNTIVDCGTNGIMFIAFNFETQKRVILKKLS---KRMFDNELNGHRIIRNL--IFQNLFQGGKHISTYQSIFKRKCSDS-----YQPPLTSI------ | . . .| |. . . | |.| ...| .|. || ..| .|. . . |... | .|| . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREA---RIMCKLGGHHPNIVR-----------LYGVCTQQGRNFMYIEPLMIVMEYMPH --LNSIISSNDNPQQHSTLIQQKDDEDFYFESIQPQYSLLNLISNNMLDQDDICQLFYEILMGLKFMHSAGVIHRDLDPENSIFVDENFNIKFTEFNNCF |.. . .. . | .| .. . | | . || ..||||| | . |.||. .| . | . GDLKDYLRKHRPK----------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN-CLVGENHTVKISDFGLSR LLDTD---PTFLFNKEYITNTY--SYR--------APETIWGDSLYTEATDVWGAGVLFAELL-LGKRLFRS-----FNSKE---HLKSIYKLIGAPK-- .. | .|.|.. . . . |||.| .. .|...||| ||. |.. .|. . .| ..|. | . | DIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY --ASEGAYVVKGELLFFLMEYNRKNSFQPTFNNTFIGCNQIQIDLLKNMLCWDPRDRYSVNEILESP . | .| . .. | || || . .|| | PMS-------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | DDB0229841.AA | nmo | 74-136 | 26 | 0.067656 | 0.92 | In-house | 1-62 (292) | Show / Hide |
Range on Protein: 74-136 Range on HMM: 1-62/292 Sequence Identity: 26% (17 aa) IDPNTIVDCGTNGIMFIAFNFETQKRVILKKLSKRMFDNELNGHRIIRNLIFQNLFQGGKHIS |.|. . | |... ||| |||. . .| | . |. | | |. ..| IQPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPN-VFQNLVSCKRVFRELKMLCFFKHDNVLS |
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