Gene Erk2 (Slime mold)

Erk2

Species: Slime mold
Alias: DDB0191457, Erk2, DdisK070, erkB, dagC
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
Erk2.AA Protein None 369 None Fasta, JSON
Erk2.kin_dom Protein Kinase Domain None 291 None Fasta, JSON

Protein domain

Protein domains of Erk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk2.AA ERK7 14-304 70 5.4e-218 730.49 In-house 1-292 (292) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-292/292
Sequence Identity: 70% (205 aa)

YEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKADNDRDIYLVFEHMETDLHAVIR-AKILEEI
||.....|||||||||||.||.|||.||||||||||.|.|||||||||||||||.|.|.|||.|.|||.||||||||||||.|||||||||| ..||..|
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

HKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTKGVDMWSIGCILGEL
||||..||||.|.|||||.||.|||.||||.||.|||.|||.||||||||...|...|.||.|||||||||||||||||||..||||||||||||||||.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

LGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITAEEALAHPFV
| .|.||||.|||||...|.|....|..||||||.| .| .|||... .....|..|.|... ||.||||.||.|||.||.|||.||.||.|
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase Erk2.AA MAPK 14-304 47 3.6e-186 624.76 In-house 1-328 (328) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-328/328
Sequence Identity: 47% (155 aa)

YEVLQKIGKGAYGIVWKAIDKK------TKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKAD-----ND----RDIYLVFEHMET
|. |..||.||||.|..||||.      ....||.|||...|||.|...||.|||..|...|.||||||||......     |.    .|||.|.| |||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHAVIR-AKILEEIHKQYTIYQLLKA--LKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESI--AEANP------VLTEYVATRWYRAP
|||..|.  ..|...|.|| .||.|..  |||.|||||.|||.||||.|.|..|..|..|||||||| . ..    ...|       .||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EILLG--STKYTKGVDMWSIGCILGELLG-EKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIK-SPFAGTMLESL---PPSNPRSLSDMYPS----ASVD
||.|.  ...|||.|||||.|||..|.|.  | .|||.....|. ||.||.| || |.|. |. |. | ....||   |. .......|.|     |. .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLKKLLQFNPDKRITAEEALAHPFV
|.|||.|.|.|.||||||.||||.||..
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk2.AA ERK 14-304 46 1.8e-151 509.53 In-house 1-307 (307) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-307/307
Sequence Identity: 46% (145 aa)

YEVLQKIGKGAYGIVWKAIDKK-----TKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKAD---NDRDIYLVFEHMETDLHAVIR
|. ...||.||||.| .||||.     | |.|| |||..|| .. .. || ||| .|  ..||||||.|..... .   .  |||.|.| |||||| .|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

AK-ILEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLAR----SITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTKGV
 .  |.. | || .||.| .|||.|||||.|||.||||.|.|| |  |..||||||    |. . ..  . .. .||||||||||||||.|  .|||| .
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE--CNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DMWSIGCILGELLGEKAMFPGNSTMNQLDLIIEVTGRP-SAEDIEAIKSPFAGTMLESLPP--SNPRSLSDMYPSAS--VDALDLLKKLLQFNPDKRITA
|.||.|||. |.|| | .|||.....|...|....| | | ||.. |.|. |  .. .||     |.......|.|.   .|.|||.|.|.|.||||||.
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITV

EEALAHPFV
||.|.||. 
EECLEHPYF
Kinase Erk2.AA CMGC 14-304 26 6.9e-145 479.57 In-house 1-513 (513) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-513/513
Sequence Identity: 26% (135 aa)

YEVLQKIGKGAYGIVWKAID--------------KKTKQTVALKKIFDAFQNATDAQ----------RTFREIMFLQELH----------------GHEN
||...|||.|.||.|.|..|              ..|.. ||.|||. .| . ..|.          |..|||..|..|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKLLNVIKADN---------------DRDIYLVFEHMETDLHAVIRA----------KILEEIH------------KQYTI------YQLLKALK--YM
|.||..... .|               ....|||||.|..||. .|.           . |.| |            ..| .      ||.|..||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VLHRDIKPSNLLLNSECLV--------------------KVADFGLARSITS-LESIAEANP--------------VLTEYVATRWYRAPEILL
||..  ..|||.||.|.|.|..| .                    |..||||||.. .  . ... .|               .|.||.|||||||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GS---------TKYTKGVDMWSIGCILGELLGE--------KAMFP-----------GNSTMNQLDLIIEVTGRP----------------SAEDIEAIK
|.         ..||...||||.|||..|..          | .||           |.|. .||..|..| | |                . |... ||
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------SPFAGTMLES---LPPSNPRSLSDMYPS-----------------------------------ASVDALDLLKKLLQFNP
                    |.|| . ..|   .|. .|.......|                                    .. .|.|||||.||..|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRITAEEALAHPFV
|||||||.||.||. 
DKRITAEQALQHPYF
Kinase Erk2.AA p38 14-304 42 9.1e-117 394.22 In-house 1-289 (289) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-289/289
Sequence Identity: 42% (126 aa)

YEVLQKIGKGAYGIVWKAIDKKTKQT---VALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKA-----DNDRDIYLVFEHMETDLHAVIR
|. || .|.|||| | ||.|..|.|    || ||..  || . .| ||.||.  |. .. |||.|.||.|        .. .|.|.| . |..||. ...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR-HENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK

AKILEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTKGVDMWSI
 . | . | |. .||.|..||| |||.. ||| ||||. .| .| ... ||||||         ..   .|.||||||||||||.|   .||. ||.||.
CQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSV

GCILGELLGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITAEEALAHPFV
|||. ||. ... |||.  ..||  |..|.| |..| .. |.|  | . ..|.|.   | ...... |.. |.||| |.|.  ||||||||||..||. 
GCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Erk2.AA CDK 14-304 35 1.1e-109 352.11 In-house 1-284 (284) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-284/284
Sequence Identity: 35% (115 aa)

YEVLQKIGKGAYGIVWKAIDKKTK-----QTVALKKIFDAF---QNATDAQR--TFREIMFLQELHGHENIIKLLNVIKADN---------DRDIYLVFE
|| |.||| |.||.| ||.||.|.     | ||||||       ... .     . |||  |.||  |.||.||. |.  .|         .. .|.|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

HMETDLHAVIRAKILEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECL-----VKVADFGLARSITS-LESIAEANPVLTEYVATRWYRAPE
.|..||  ...         .  ..|||..| |.|| ...|||.||.|.|.|.        .|.|||||||   . ..   | | ..|  | |.||||||
YMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPE

ILLGSTKYT--KGVDMWSIGCILGELLG---EKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKS-PFAGTMLESLPPSNPRSLSDMYPSASVDALDLLK
.||||..|.   ..||||.|||..|..     |..|||.|  .||..|... | |. ..   ... |                             ||| 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLN

KLLQFNPDKRITAEEALAHPFV
|.|...|.|||.||.|| ||. 
KMLCYDPKKRISAEQALQHPYF
Kinase Erk2.AA ERK5 14-304 43 1.2e-109 370.55 In-house 1-295 (295) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-295/295
Sequence Identity: 43% (130 aa)

YEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKADND----RDIYLVFEHMETDLHAVIRAKI-
|... ||| ||||.|  |. .|. | ||.|||  ||   | |.|||||.  |.  . |.||| . ....        .|.| ||. || ||| .| .   
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFR-HDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQP

LEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTKGVDMWSIGCI
.   |  | .||.|. |||||||.|.|||.|||||| |  | .|. |||.|| .. . | ..    .|||||||||||||... |  ||. .|.||.|||
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTF-SPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCI

LGELLGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLES-LPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITAEEALAHPFV
.||... . ||||   ..||.||..| | |..  |.|. .      . . .|.  |. .. .|| |   ||||| ..| | | .|||. .|| |||.
FGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase Erk2.AA ERK1 14-304 50 7.89999999999e-108 364.54 In-house 1-289 (289) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-289/289
Sequence Identity: 50% (149 aa)

YEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKA---DNDRDIYLVFEHMETDLHAVIRAKILE
|  || ||.||||.|  |.|. .|| ||.|||   |   |  ||| |||  |.  . |||||.. ..|.|   .. ||.|.| . |||||  ..... | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFK-HENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

EIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTKGVDMWSIGCILG
  |  | .||.|. |||.|||||||||.||||||||  | .|. |||||| |.  |   .    |||||||||||||||.| |  ||| .|.||.|||| 
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPE--HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA

ELLGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITAEEALAHPFV
|.|  . .|||   . || .|. | | || .|.. |    |   |.|||  .  ..  ..| |   ||||| |.| |||.|||| |||||||..
EMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Erk2.AA S_TKc 14-304 31 4e-105 356.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-231/231
Sequence Identity: 31% (98 aa)

YEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKADNDRDIYLVFEHMET---DLHAVIRAKI--
||.|.||||||.| |.|...|||.. ||.|.|          ... |||  |..  .|.||.||. |.      ..|.|.|....   ||. .|. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTK-GVDM
     . | | .. .||...||.|.|| ...|||.||.|.||..   .|..|||||| .             | .. |.||.|||.|    .|.|  .|.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GYGKCKCDW

WSIGCILGELLGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITAEEALA--
||.|||| |.|  .  ||      |....... |                                     | .|.|...|.||..|.||.|| |||.  
WSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----HPFV
     ||..
WDIKCHPWF
Kinase Erk2.AA RCK 14-304 36 8.7e-98 310.86 In-house 1-298 (298) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-298/298
Sequence Identity: 36% (114 aa)

YEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKADNDRDIYLVFEHMETDLHAVIRA-----KI
| .. ..|.|.|| | ||..|.|.. || ||    | .  ....  ||| .|  |. |.|||||. ||. ....  |.|||.|...|   ..      | 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMN-LREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

LEEIH---KQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNS---------ECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKY
| |.    | . .||.|..|..||. .  |||.|| |.....           ..|.|||||.|.| |       .|  |.|| ||||||||.|| .|.|
LPENQRSIKNI-MYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRS-------KPPYTDYVSTRWYRAPECLLRCTYY

TKGVDMWSIGCILGELLGEKAMFPGNSTMNQLDLIIEVTGRPSAED-IEAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITA
.. .|.|..|||  ||   ...|||.| . |.  |..| | |. .|  ...|   | .|   .|.. . .|.   |..| |...|..|.|| .|.|||||
NSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYK--LASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITA

EEALAHPFV
..|| ||. 
QQALQHPYF
Kinase Erk2.AA Pkinase 14-304 30 8.8e-94 322.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-304
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

YEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFR--EIMFLQELHGHENIIKLLNVIKADNDRDIYLVFEHMET-----DLHAVIR-
|....|||.|..| |.|...|.| ..||.|.|    ..    |. .|  ||  ...| .|.||..|. .     ...||.|.|..|      ||...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

--AKIL--EEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLV----KVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYT
   . .  .| . .  .||.|..|.|.|| ...|||.||.|.|..... .    |..|||||. .         |. .| .. |.||.|||...|...|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KGVDMWSIGCILGELLGEKAMFPGN----STMNQLDLIIEVTGRPSAEDIEAI--KSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDK
. |||||.|||| |.|  .  |||     . ..|. .| .. |.|  .|..    .|.|  ..    .    . ..   . .| ...|..|..|...| |
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPKK

RITAEEALAHPFV
|.|||..| ||..
RPTAEQILQHPWF
Kinase Erk2.AA MAPK-Unclassified 14-162 44 2.3e-65 223.48 In-house 1-159 (575) Show / Hide 
Range on Protein: 14-162
Range on HMM: 1-159/575
Sequence Identity: 44% (71 aa)

YEVLQKIGKGAYGIVWKAIDKKT-KQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKADNDRD-----IYLVFEHMET---DLHAVI
||. . || ||||.| .|.|||. .| || ||.  .|.| ||. |. |||  | .|  |.|||.. ... .. .       ||.| . |.|   ||| .|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLN-HPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQII

RAKI--LEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSI
.  .  ....| || .||.|. |||.|||...||| ||||||.|  |.|...|||..|||
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI
Kinase Erk2.AA MAPK-Unclassified 175-304 30 2.3e-50 173.64 In-house 405-575 (575) Show / Hide 
Range on Protein: 175-304
Range on HMM: 405-575/575
Sequence Identity: 30% (53 aa)

LTEYVATRWYRAPEILLGSTKYTKGVDMWSIGCILGELLGE-----------KAMFPGNS--------------------TMNQLDLIIEVTGRPSAEDI
.|.||.|||||||||.| .  |.. ||.||||||..|..             . .||| .                       |. .|... |.|  ||.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

EAIKSPFAGTMLESLPPSNPRSLSDMYPSASV----------DALDLLKKLLQFNPDKRITAEEALAHPFV
  |... |   ..|. . .|   .|.....            ...|...|.||||| |||||..|| ||..
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk2.AA TyrKc 14-307 20 4.5e-15 21.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-307
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIF-DAFQNATDAQRTFREIMFLQEL-HGHENIIKLLNVIKAD-----NDRDIYLVFEHMET-DLHAVIR
 . ..|.| ||.|.|.|.. |   ..|| |..  ||       .   ||.  . .|   |.||..|. |.  .      .  ...|.|.|.  ||.  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

AKI--LEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSL-------ESIAEANPVLTEY-VATRWYRAPEILLGSTK
..   |   .. .  .|  .   | || |. |||.   | |....  ||..||||.| |..        . .  .    . . .  ||. ||| .    |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YTKGVDMWSIGCILGELLGEKAMFPGN-----STMNQLDLIIEVTGRPSAEDI--EAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFN
.|   | || |  . |..   .. . .      .  ..   ..  .|.   .   . .                    .   . .. .  .. |.  ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-------------------F---VCCPDEMYQIMKQCWHED

PDKRITAEEALAHPFVTQF
|..| | .|      . .|
PEDRPTFSEI-----HECF
Kinase Erk2.AA Pkinase_Tyr 14-162 30 3.6e-14 48.61 Pfam 1-161 (270) Show / Hide 
Range on Protein: 14-162
Range on HMM: 1-161/270
Sequence Identity: 30% (50 aa)

YEVLQKIGKGAYGIVWKAIDK----KTKQTVALKKIFDAFQNATDA----QRTFREIMFLQELHGHENIIKLLNVIKADNDR-DIYLVFEHMET-DLHAV
 . ..|.|.||.| |.|.. |    .||..|| |..     .|..     .  .||.  . .|  |.||..|. |.  . .   ||.|.|.|.  ||.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IRAK-----ILEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSI
 |..      |   ..    .|  |.. | .| |  |||.   | |....  ||..|||||| |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI