Gene GSK-3 (Slime mold)

GSK-3

Species: Slime mold
Alias: GSK3, GSK-3, DDB0185150, gskA, DdisK068
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
GSK-3.AA Protein None 467 None Fasta, JSON
GSK-3.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of GSK-3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GSK-3.AA GSK 56-339 57 1.5e-220 681.18 In-house 1-328 (328) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-328/328
Sequence Identity: 57% (187 aa)

YITEGVIGNGSFGVVTQAIVA----DTKEV----VAIKKVLQDQRYK-NRELQIMKML---NHINIVSLKNSFYTS--DNDE--VYLN-LVLEYVPDTVY
| .  |||.||||||.||..     .|||.    ||||||.||.||| ||||||||||   .| |||.||..||..  ..||  ||.| ||.||.| |.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RVSRHYSMSKQPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKILIK--GETNVSYICSRHYRAPELIFGSTNYTTTI
.| |||...||..|.|..||| ||..|...|.||.|||||||||||.|.| .| .||.|||||||.|..  .|.|.||||||.|||||||||.||||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DVWSLGCVLAELLLGQPLFPGENGIDQLVEIIKVLGTPTKEQIHAMNPYYTSFKFP-----EIKANPWPR-------------------VFKAKDVPAE-
||||.|||.||.|.|||||||....||||||||.|||||||||..||| |. ||||     .||..||..                   .||..  ... 
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

SIDLISKILLYDPSSRLKPVEICAHPFF
.||||||.| |||..||.| |.||||||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GSK-3.AA CMGC 56-339 22 2.2e-125 414.29 In-house 1-513 (513) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-513/513
Sequence Identity: 22% (114 aa)

YITEGVIGNGSFGVVTQAIV--------------ADTKEVVAIKKVLQDQRYKN----------------RELQIMKMLN-----------------HIN
|   ..|| |..||| ...                .|.|.|||||. ... |..                ||..|.|.||                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVSLKNSFYTSDND-------------EVYLNLVLEYVPDTVYRVSRHYS------------------------MSKQPVPNIFVKLYIYQLCRSIN--Y
||.|...||....|             ...|.|| ||.. . |.. ....                         ...  ..  .. |.||..|...  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHSLG--ICHRDIKPQNLLLDTSTST-------------------LKLCDFGSAKILIKG----------------------ETNVSYICSRHYRAPELI
.|| .  |.|||.||.|.|..  .                     ||.||||.|... .                       ... .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGS---------TNYTTTIDVWSLGCVLAELLLG--------QPLFPGENG-----------IDQLVEIIKVLGTPT---------------KEQIHAMN
.|.         ..|||.||.||.||..||...|        .|||||...           |||| .|.|||||||               .|..  |.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PYYTSFK---------------------------FPEIKANPWPRVFKAKD---------------------------------VPAESIDLISKILLYD
.... .|                           ||... .|| ..|. ..                                  . . |||..|.| ||
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PSSRLKPVEICAHPFF
|. |... ....||.|
PDKRITAEQALQHPYF
Kinase GSK-3.AA S_TKc 56-339 28 6.7e-89 302.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-231/231
Sequence Identity: 28% (86 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQDQRYKNRELQIMKMLNHINIVSLKNSFYTSDNDEVYLNLVLEYVPD---TVYRVSRHYSMSK--QP
|    .|| |.||.| ...  .|...||||..    .   ||.||.|. .| ||| |. .|..      .| .|.||..    ..... ...   .  .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

VPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKILIKGETNVSYICSRHYRAPELIFGSTNYTT-TIDVWSLGCVLAELL
 |   .. |.||.|. ..|.||.||.|||.||.|.|||.   ..|.||||.|..|       ... ...|.|||..     |..  .|.||.||.|.|.|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGQPLFPGENGIDQLVEIIKVLGTPTKEQIHAMNPYYTSFKFPEIKANPWPRVFKAKDVPAESIDLISKILLYDPSSRLKPVEICA-------HPFF
 |.|.||      |. ...|..|                                    . | .|.|.|.| .||. |.   |. .       ||.|
CGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GSK-3.AA Pkinase 56-339 31 1.8e-88 304.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQDQRYKNR--------ELQIMKMLNHINIVSLKNSFYTSDNDEVYLNLVLEYVPDTVYRVSRHY---
| ....|| ||||.| ...  .| ..||.|..  . . ..         |.||||.||| ||| |. .|..  .|..|  .|.||.. ..| |   .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIY--MVMEYCEGGLY-VMDLFDYI

-SMSKQPV--PNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTL----KLCDFGSAKI--LIKGETNVSYICSRHYRAPELIFGSTNYTTT
  ... ..  .   .| |.||..| ..|.|| ||.|||.||.|.|.| .. ..    |.||||.||   . ... . .. ....|.|||.| |.. |.. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDVWSLGCVLAELLLGQPLFPGE----NGIDQLVEIIKVLGTPTKEQIHAMNPYYTSFKFPEIKANPWPRVFKAKDVPAESIDLISKILLYDPSSRLKPV
.|.||.||.|.|.|.|.|.|||.    | .||.. | ...|.|.....   .. ...| |.  .  . ...|  . .. | .|.|...| .||..|. . 
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF--HNWSEECKDFIKWCLCKDPKKRPTAE

EICAHPFF
.|. ||.|
QILQHPWF
Kinase GSK-3.AA CDK 56-339 30 3.8e-80 256.1 In-house 1-284 (284) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-284/284
Sequence Identity: 30% (99 aa)

YITEGVIGNGSFGVVTQAIVADTK-----EVVAIKKVL--------QDQRYKN---RELQIMKMLNHINIVSLKNSFYTSDND-------EVYLNLVLEY
|     || |..|||  |.  .|.     ..||.||.          .        ||  ..| | | |||.|.  ..|.. |       |  | .| ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VPDTVYRVSRHYSMSKQPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTS----TLKLCDFGSAKIL-I------KGETNVSYICSRHYR
..   . . .             .| |..|| | ..|.|| .| |||.||||.|..   .    .||. ||| |..  |      .  |  . .  . ||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELIFGSTNYT--TTIDVWSLGCVLAELLL---GQPLFPGENGIDQLVEIIKVLGTPTKEQIHAM--NPYYTSFKFPEIKANPWPRVFKAKDVPAESID
|||| .||..|.  |.||.||.||..||...   ..|||||.. ||||  |....|||| ..   .   |.|                           |
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------D

LISKILLYDPSSRLKPVEICAHPFF
|..| | |||. |..  .   ||.|
LLNKMLCYDPKKRISAEQALQHPYF
Kinase GSK-3.AA RCK 56-339 29 1.3e-79 252.26 In-house 1-298 (298) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-298/298
Sequence Identity: 29% (92 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQDQRYKN-------RELQIMKMLN-HINIVSLKNSFYTSDNDEVYLNLVLEYVPDTVYRVSRHYSMS
|..   .| |..|.|. |.  .|.|.|||||    |....       ||.. .. || | ||. ||  .. .|. .  | .|.||.   .|   ...  .
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQ--LYFVFEYMDMNLYQMMKDFKER

KQPVPNIF--VKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTS--------TSTLKLCDFGSAKILIKGETNVSYICSRHYRAPELIFGSTNYTTTID
....| .   .| ..||.. .....|. |. |||.|| |...  |        . ..|..|||...       .  |. .| |||||..  .|.|.. .|
RKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMD

VWSLGCVLAELLLGQPLFPGENGIDQLVEIIKVLGTPTKE-----QIHAMNPYYTSFKFPEIKANPWPRVFKAKDVPAESIDLISKILLYDPSSRLKPVE
.|..||. .||   .||||| . |||. .|.||.|||.|.     . .|     . |.||  |..| . ..     . . |.|. | | .||. |  . .
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQ---MNFNFPQCKGMPLKQLIPN--CSQDCIELMEKMLQWDPQKRITAQQ

ICAHPFF
.. ||.|
ALQHPYF
Kinase GSK-3.AA CDC2 56-339 31 1.7e-74 228.25 In-house 1-301 (301) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-301/301
Sequence Identity: 31% (96 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQDQRYKN--------RELQIMKMLN-HINIVSLKNSFYTSDNDEVYLNLVLEYVPDTVYRVSRHYSM
|     || |..|||....  .|...||.||.  .|            ||. ..| |. | |||.|.  ..        | .| ||.     .  . .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLYMVFEYLDMDLKKYMDMSIP

SKQPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKIL---IKGETNVSYICSRHYRAPELIFGSTNYTTTIDVWSLGC
.....| ..|| |.||... ... |. .| |||.||||.|.|.. . .|. ||| |.     |. .|    .  . |||||. .|.  |.|..|.||.||
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGC

VLAEL---LLGQPLFPGENGIDQLVEIIKVLGTPTKEQIHAM--NPYYTSFKFPEIKANPWPRVFKA-------KDVPAESIDLISKILLYDPSSRLKPV
..||.       |||.|.  ||||  | ..||||. .    .  .|.| . .||. |..   ....          .. | |||....| |||. |..  
IFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAK

EICAHPFF
|. .||.|
EALQHPYF
Kinase GSK-3.AA CDKL 56-339 36 8.5e-69 234.34 In-house 1-286 (286) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-286/286
Sequence Identity: 36% (108 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQ---DQRYK---NRELQIMKMLNHINIVSLKNSFYTSDNDEVYLNLVLEYVPDTVYRVSRHYSMSKQ
| . |..| || |||      .| ..||||| .    |.  |    ||. . |.| | |||.|.  |    . . .  || ||.  ||  .  .     .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRR--KRKLH--LVFEYCDHTVLHELEE---YPN

PVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKILI-KGETNVSYICSRHYRAPELIFGSTNYTTTIDVWSLGCVLAEL
 |.   |. |..|....||. |.  . |||||| |.|.  . ...|||||| |..|  .||    |   | ||||||  | | | . .|.|..|||.||.
GVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEM

LLGQPLFPGENGIDQLVEIIKVLG--TPTKEQIHAMNPYYTSFKFPEIKANPWPRVFKAKDVP-AESIDLISKILLYDPSSRLKPVEICAHPFF
. ||||.||.. ||||  |.|.||  .|  ..|  .||..   |||||. .. |   .  ..  ....|.. | |  ||. |.   .   ||.|
IDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIE-HMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GSK-3.AA MAPK 56-339 28 8.6e-67 228.21 In-house 1-328 (328) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-328/328
Sequence Identity: 28% (96 aa)

YITEGVIGNGSFGVVTQAIVAD------TKEVVAIKKV---LQDQRYKN---RELQIMKML-NHINIVSLKNSFYTS-----DN----DEVYLNLVLEYV
|     || |..|||  ||         ... |||||.    |.. .     ||. ..... .| ||..|.. |. .     ..    ...|  .| |. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY--IVMELM

PDTVYRVSRHYSMSKQPVPNIFVKLYIYQLCRS--INYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKILIKGETNV---------------SYIC
    ... .       |  .. ..  .||..|   . |||| .. |||.|| |.|.. .  .||.|||| | ..   ..                  |. 
ETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVA

SRHYRAPELIFG--STNYTTTIDVWSLGCVLAELLL-GQPLFPGENGIDQLVEIIKVLGTPTKEQIHAMN-P--YYTSFK----FPEIKANPWPRVFKAK
 | |||||....  ...||...|.||.|| .||.|  ..|||||.. |||.  |..|||||..| |  .  .  ... ..    .|  .. ||  .|.  
TRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNA

D--VPAESIDLISKILLYDPSSRLKPVEICAHPFF
.  .  . |||..| |  ||. |.   |  .||.|
NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase GSK-3.AA CDK-Unclassified 56-278 30 1.2e-58 191.5 In-house 1-262 (324) Show / Hide 
Range on Protein: 56-278
Range on HMM: 1-262/324
Sequence Identity: 30% (82 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQDQ-------------RYK---NRELQIMKMLNHINIVSLKNSFYTSDNDE-----VYLN----LVL
| .  ..| | || |  ||  .|   |||||.   .             . |   .||. ... .|| ||  .   .|  | .        |.    .|.
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYVPDTVYRV--SRHYSMSKQPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTST----STLKLCDFGSAKILI------------K-GETN
||.|.| | .  .  |. |..      .. .  |.  .|.|.|. .| ||||||||....  .      ||. |||.|                . .   
EYMPYTWYNQLHNNRYNLSMCQ-----IRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQY

VSYICSRHYRAPELIFGSTNYTTTIDVWSLGCVLAELLLGQPLFPGENGIDQLVEIIKVLGTPTKEQ
.. .  | |||||| |||  |.| .|.||.||..||.. | |.|.| . |.|.  |.|.||||. ..
STQVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDM
Kinase GSK-3.AA ERK7 56-339 31 2.8e-57 194.35 In-house 1-292 (292) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-292/292
Sequence Identity: 31% (95 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQ------DQRYKNRELQIMKMLN-HINIVSLKNSFYTSDNDEVYLNLVLEYVPDTVYRVSRHYSMSK
|  .  .| | .|.|  |.   ||.|||.||.        |     ||  ... .. | ||..| | .  . .  .|  || |.       | |. .. |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIY--LVFEFMETDLHAVIRKGNILK

QPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKILIKGE-------TNVSYICSRHYRAPELIFGSTNYTTTIDVWSL
    .| ..  .||| | | |.||  . |||.|| |.||| |  ..|.|||| |  . . |           |.  | |||||   ||..||  .| ||.
----DIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLD-SECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCVLAELLLGQPLFPGENGIDQLVEIIKVLGTPTKEQIHAMNPYYTSFKFPEIKANPWPRVFKA--KDVPAESIDLISKILLYDPSSRLKPVEICAHPFF
||.|.|.| |.|.|||   ..|.  |..... ||.| |.|... | .    ...    .. ...  .. . . |||. ..| . |  ||   .  .||. 
GCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN-QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase GSK-3.AA Ciliate-E2 56-339 20 9.9e-56 189.78 In-house 1-365 (365) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-365/365
Sequence Identity: 20% (80 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIK----------------------KVL--QDQRYKNRELQIMK----------------MLNHINIVSLKNS
|.   .||.|.||.| .. |  ... .|||                      |..  .. .....|..||.                 ||| ||. .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYTSDNDEVYLNLVLEYVPD-TVYRVSRHYSMSKQPVPN-------IFVKLYIYQLCR---------------SINYIHSLG-ICHRDIKPQNLLLDTST
|..  .|. .. ||.||.   . .   .. . ...  ..         .| ...|...                ..|.|| . |.||||||.|.|.    
FQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

STLKLCDFGSAKILIKGETNVSY--------------------------------ICSRHYRAPELIFGSTN--------YTTTIDVWSLGCVLAELLLG
  .|..||| .|.. . . | ..                                ... .| ||| . |  .        |.. .|.||||..| |.| |
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

QPLFPGENGIDQLVEIIKVLGTPTKEQIHAMNPYYTSFKFPEIKANPWPRVFK---AKDVPAESIDLISK----ILLYDPSSRLK-PVEICAHPFF
.| |                     .||.  .  . .... .  ..    ..|    |... | .|||.|    .| .||. |.  . .|  ||.|
KPPF--------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GSK-3.AA TyrKc 56-339 22 4.5e-13 -11.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 56-339
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YITEGVIGNGSFGVVTQAIVADTKEVVAIKKVLQDQRYKN--RELQIMKML--NHINIVSLKNSFYTSD-----NDEVYLNLVLEYVP----DTVYRVSR
   . ..|.| ||.| ...     . ||.|..  |   .   ||..||..|  .| ||| |     |..      .| .. .|.||.|    .   | .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLM-IVMEYMPHGDLKDYLRKHR

HYSMSKQPVPNIFVKLYIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFGSAKILIKG----ETNVSYICSR--HYR--------APELIFG
.       ...     . .| ..  .|.|| .. |||.   | |..    | | .||| .. .  .    |    |  .   . .        ||| |  
PK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

STN-YTTTIDVWSLGCVLAELL-LGQPLFPGE----NGIDQLVEIIKVLGTPTKEQI----HAMNPYYTSFKFPEIKANPWPRVFKAKDVPAESIDLISK
 .. .||  |||| | .. |.. .||.  ||.       ....| .|  . . . .                            |     |.|  .....
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F--VCCPDEMYQIMKQ

ILLYDPSSRLKPVEICAHPFF
   .||..|    ||  | .|
CWHEDPEDRPTFSEI--HECF
Kinase GSK-3.AA Pkinase_Tyr 56-112 30 7.4e-07 23.85 Pfam 1-69 (270) Show / Hide 
Range on Protein: 56-112
Range on HMM: 1-69/270
Sequence Identity: 30% (21 aa)

YITEGVIGNGSFGVVTQAIVA----DTKEVVAIKKVLQDQRYKN-------RELQIMKML-NHINIVSL
 .   ..| |.||.| ...      .||  ||.|.. ..   ..       ||..||| | .| |||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase GSK-3.AA CDK-Unclassified 313-339 33 0.013537 4.2 In-house 298-324 (324) Show / Hide 
Range on Protein: 313-339
Range on HMM: 298-324/324
Sequence Identity: 33% (9 aa)

IDLISKILLYDPSSRLKPVEICAHPFF
.....  . |.|  |.|  ||  || |
NNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase GSK-3.AA Pkinase_Tyr 222-249 42 0.570229 3.91 Pfam 182-208 (270) Show / Hide 
Range on Protein: 222-249
Range on HMM: 182-208/270
Sequence Identity: 42% (12 aa)

APELIFGSTNYTTTIDVWSLGCVLAELL
||| |. .  .||  |||| | .. |..
APECINYGK-FTTKSDVWSFGVLMWEIF
Kinase GSK-3.AA Pkinase_Tyr 159-200 30 4.953579 0.73 Pfam 116-156 (270) Show / Hide 
Range on Protein: 159-200
Range on HMM: 116-156/270
Sequence Identity: 30% (13 aa)

YIYQLCRSINYIHSLGICHRDIKPQNLLLDTSTSTLKLCDFG
. .| ..  .| .| .. |||.   | |.. .  . | ||||
MCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFG