Gene Prp4 (Slime mold)

Prp4

Species: Slime mold
Alias: Prp4, DdisK065, DDB0216281
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
Prp4.AA Protein None 811 None Fasta, JSON
Prp4.kin_dom Protein Kinase Domain None 314 None Fasta, JSON

Protein domain

Protein domains of Prp4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Prp4.AA PRP4 490-808 58 3.1e-246 824.32 In-house 1-320 (320) Show / Hide 
Range on Protein: 490-808
Range on HMM: 1-320/320
Sequence Identity: 58% (188 aa)

YQIFSPIGSGVFSTVVSAK-ETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSMSLHQLIKKYGKD
|......|.||||.|.... .|..||.|.||||||...||..||.|.|||||....||..|.|.||..|..|||.|.|.|.|||.|||.|....||||||
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

IGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKNTIKIVDFGSAGEIHESEITPYLVSRFYRAPEIILGHKYDYSIDVWSVGCCLAEFFT
.||.|.|||.||.||||||||.|...|||||||||||.|||.|||.|..|||||..|||.|||||||||||||||||.||.|||.||.|||||.|.|..|
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYT

GKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKSEFVSNHFNENLVFMKQEIDNIEKTVRKVPHDITKPTKDILQFLLPKNVSIPDQDMKKLIQLKDLIEKC
||..|||||||.|..|||.|.|....||..|..|..|||..|..||.||.|..............||||||.|.|...|..||...|||..|.|||..||
GKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEVDKVTEREKVTVMTYIKPTKDIYQELIECNQRIPEDQMKKVHQFKDLLDKC

TILDPEKRITPFEALNHEFL
..|||.||||..||| | |.
LMLDPKKRITCNEALKHPFI
Kinase Prp4.AA DYRK 490-808 41 1.7e-169 569.42 In-house 1-320 (320) Show / Hide 
Range on Protein: 490-808
Range on HMM: 1-320/320
Sequence Identity: 41% (137 aa)

YQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSMSLHQLIKKYGKDI
|.|...||.|.|. || .. .||||.| ||||||....||....||.||.....    ...|.||..|.|.|..|||||||||..||.|....|..... 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ--DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQG

GLSLNAVRVYAKQLFLALKHIKNS-KILHADIKPDNIVVNE--AKNTIKIVDFGSAGEIHESEITPYLVSRFYRAPEIILGHKYDYSIDVWSVGCCLAEF
..|||.||..|.|....||..... .|.|.|.||.||....   |.|||..||||....|. .|..|..||||||||.|||..|.|.||.||.||.|||.
FFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAEL

FTGKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKS--EFVSNHFNENLVFMKQEIDNIEKTVRKVPHDIT---KPTKDILQFLLPKNVS-IPDQDMKKLIQ
|||. ||||....|.....||..|...|.|..|.  ... ..|..   ||..|.|. .|. .. .|..|   .|||.  | ..|.. . .| .. .. .|
FTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQ

LKDLIEKCTILDPEKRITPFEALNHEFL
.||.|.|| ..||.||||| .||.| ..
FKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase Prp4.AA CMGC 490-808 20 2.7e-105 347.08 In-house 1-513 (513) Show / Hide 
Range on Protein: 490-808
Range on HMM: 1-513/513
Sequence Identity: 20% (105 aa)

YQIFSPIGSGVFSTVVSAKE--------------TKTNEDVVIKIIRNRPSMHRSGL-------------KEIEILQKISNTPTSSN----------QKS
|.| ..||.| ...|....               ..||| | ||.|.|.. ... ..              ||.||......    |          .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

HCIQMKDHFNYRN-----------------HLCIVFEPMSMSLHQLIKKYGK-DIG------------------------LSLNAVRVYAKQLFLALK--
......|.| ..|                 ||..||| | ..|.|.||.. . . |                        ... ..| |..|.. .||  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

HIKNSK--ILHADIKPDNIVVNEAKNT-------------------IKIVDFGSAGEIHES-----------------------EITPYLVSRFYRAPEI
..   .  |.| |.|| || .|. .                     .|| |||.|  .|.                         .|.| |.|.||||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILG----------HKYDYSIDVWSVGCCLAEFFTG--------KFLFPGKTN-----------NDMIRLFMEYRGAFSKKMLKKSEFVS-NHFNENLVFM
.||          ..|...||.||||| .|| .||        | ||||...            |.. . ..  | .. .|..|.. .. | |...   .
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFN-FCKHEEEW

KQEIDNIEKTVRKVPH-------DITKPTKDILQF--LLPKNVSIPDQDMKKL-------------------------------------IQLKDLIEKC
 . |.. .   .  ..       ....  .  .|    .|.   .| .....                                       |. ||..|.
PNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKM

TILDPEKRITPFEALNHEFL
 ..||.||||. .||.|...
LQYDPDKRITAEQALQHPYF
Kinase Prp4.AA S_TKc 490-808 24 2.2e-79 270.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 490-808
Range on HMM: 1-231/231
Sequence Identity: 24% (82 aa)

YQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSM---SLHQLIKKYG
|.|  .||.| |..|  ....||.. | ||||.      .. ..||.||.|         .  . ....|.|   .||..|.| ..    .|...|||.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

K---DIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKNTIKIVDFGSAGEIHESEITPYLVSRFYRAPEIILGHKYDY-SIDVWSVGCC
.   . ...   .| |..|...||... . .|.| |.||.|| ..|   .||| |||.| ..     | . ....|.|||..   .|.. ..|.||.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LAEFFTGKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKSEFVSNHFNENLVFMKQEIDNIEKTVRKVPHDITKPTKDILQFLLPKNVSIPDQDMKKLIQLK
|.|...|. .||  . . |... .                                                                         ..|
LYEMLCGYPPFP--QMQMMFKKIG-----------------------------------------------------------------------SPEAK

DLIEKCTILDPEKRITPFEALN-------HEFL
|.|.||   |||||.|  |||.       |...
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Prp4.AA DYRK2 490-727 40 2.6e-72 234.4 In-house 1-240 (318) Show / Hide 
Range on Protein: 490-727
Range on HMM: 1-240/318
Sequence Identity: 40% (98 aa)

YQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSMSLHQLIKKYGKDI
| | . ||.| |  || .   ||.. | ||.|||.   |.  . ||.||..|.      .  . |. |.| | .|||.||.|| .||.|  .|||  .  
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRR--QDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQ-

GLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEA-KNTIKIVDFGSAGEIHESEITPYLVSRFYRAPEIILGHKYDYSIDVWSVGCCLAEFFT
|.||. ||  |...  .|.  .  .| |.| || ||. ... ...||..||||    |.  |  |  ||||||||.|||.||. .|| || || .|| .|
GFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYT

GKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKS----EFVSNHF
|. ||||   || . ..||  |. .||.....     |  . |
GYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYF
Kinase Prp4.AA DYRK1 490-808 33 1.2e-58 201.2 In-house 1-321 (321) Show / Hide 
Range on Protein: 490-808
Range on HMM: 1-321/321
Sequence Identity: 33% (110 aa)

YQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSMSLHQLIKKYGKDI
|.| |.|| | |  || | .... | | ||||.|. .     . || .|  . .  .  ..| . ...| || .|||||.||| .|  |  |..   .  
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDK--EMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRN-THFR

GLSLNAVRVYAKQLFLALKHIKNS--KILHADIKPDNIVVNEAK-NTIKIVDFGSAGEIHESEITPYLVSRFYRAPEIILGHKYDYSIDVWSVGCCLAEF
| ||| .| .|.|.  ||  .     .|.| |.||.||..  .|   |||.||||. .  .  |  |. |||||.||..|| .|| .||.||.|| | | 
GVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEM

FTGKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKSEFVSNHFNENLVFMKQEIDNIEKTVRKVPHDITKPTKDILQFLL----PKNVSIPDQDMKKLIQLK
 ||  || |.   | .   .|  |   |.|. ..     .| | .      .   .   ..  .  |.  ..||         .    |   ..   . |
HTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYF-EKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFK

DLIEKCTILDPEKRITPFEALNHEFL
|||..  . ||..||||..|| |.|.
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase Prp4.AA HIPK 490-808 30 2.6e-57 178.8 In-house 1-329 (329) Show / Hide 
Range on Protein: 490-808
Range on HMM: 1-329/329
Sequence Identity: 30% (103 aa)

YQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSMSLHQLIKKYGKDI
| .   .| | |  || .    ||| | |||..| |.  | |  |..||...|.    . .  | . . . |. .|| |.||| .   |..  |.  |  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQE---NADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQN-KFM

GLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKNT---IKIVDFGSAGEIHESEITPYLVSRFYRAPEIILGHKYDYSIDVWSVGCCLAEF
 | |...|   .|   ||...|.  ..|||.||.||   . .     .|..|||||  . .    .|| ||.||||||||| ..  ..|.|| || .|| 
PLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAEL

FTGKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKSEFVSNHF--NENLVFMKQEIDNIEKTVRKVPHDITKPTKDILQFL--LPKNVSIPDQDMKKLI---
| |  |.||  . | || . .  .   . .|..       |   ... |    . .|| .  ..     .  | |.  |   |...   | . . .    
FLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEK

----QLKDLIEKCTILDPEKRITPFEALNHEFL
    .  ..  |   .|..||||| |||||.| 
IDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase Prp4.AA Pkinase 490-707 26 8.5e-50 176.55 Pfam 1-229 (293) Show / Hide 
Range on Protein: 490-707
Range on HMM: 1-229/293
Sequence Identity: 26% (64 aa)

YQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLK------EIEILQKISNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSM-----SL
|.| ..|||| |..|  ... .|.. |..|||. | . . . ..      ||.|.....    . |     ....| | ...|...|.| . .     .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN----HPN----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDL

HQLIK--KYGKDIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKNT---IKIVDFGSAG---EIHESEITPYLVSRFYRAPEIIL-GHK
. .|.  ..|. . .| . .. |..|.. .|... . .|.| |.||.|| ...  ..   .|| |||.|    . . |  | . ....|.|||.|. | .
FDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YDYSIDVWSVGCCLAEFFTGKFLFPGK----TNNDMIRLFME
|....|.||.|| |.|...|...|||.    . .|.. .. .
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICR
Kinase Prp4.AA YAK 490-727 34 8.3e-47 156.84 In-house 1-239 (347) Show / Hide 
Range on Protein: 490-727
Range on HMM: 1-239/347
Sequence Identity: 34% (83 aa)

YQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQKS---HCIQMKDHFNYRNHLCIVFEPMSMSLHQLIKKYG
| .    | | |  ||  .   ||| . .|.| ||.     .  || || .. |     | |    | . | | | ..||.|.|||  |..|  ..|   
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQIL-RVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQ-N

KDIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNE-AKNTIKIVDFGSAGEIHESEITPYLVSRFYRAPEIILGHKYDYSIDVWSVGCCLAE
|  |.| . .|.. ||   ..   .|..| | | || ||      |  |||.||||. .   . .. |  .|.||.||||..  |  ||| || || .||
KFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQ-EKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE

FFTGKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKSEFVSNHF
 | |  .|||    . |    . .| .   |. .  |    |
LFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase Prp4.AA GSK 568-704 38 6.8e-45 134.68 In-house 89-230 (328) Show / Hide 
Range on Protein: 568-704
Range on HMM: 89-230/328
Sequence Identity: 38% (54 aa)

CIVFEPMSMSLHQLIKKY-GKDIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKNTIKIVDFGSAGEIHE---SEITPYLVSRFYRAPE
|.|.| | . |.|.|..|   .  .... ...|. |.| .|...   .| | ||||.||.|.. . . || |||||  . .   .. ..| .||.|||||
CLVMEYMPQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPE

IILG-HKYDYSIDVWSVGCCLAEFFTGKFLFPGKTNNDMIRL
 |.|  .|. .|||||.||..|| ..|. ||||.. .|....
LIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVE
Kinase Prp4.AA STE 490-690 21 4.9e-33 114.04 In-house 34-298 (359) Show / Hide 
Range on Protein: 490-690
Range on HMM: 34-298/359
Sequence Identity: 21% (61 aa)

YQIFSPIGSGVFSTVVSAKETK---------------TNEDVVIKIIRNRP------------------SMHRSGLKEIEILQKISNTPTSSNQKSHC--
... . ||.| | ||. |.  |               |.| . ||... ..                  . . . ||||.|..| ..          .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH--------M-HPN

-IQMKDHFNY-------RNHLCIVFEPMS-MSLHQLIK-KYGKDIGLS----------LNAVRVYAKQLFLA-LKHIKNSKILHADIKPDNIVVNEAKNT
 ..  ... .       ...|.|. | |.  || ..|| |||.  .|.           . ......|.  . |... . .| | ||||.|| .      
IVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------

IKIVDFGSAGEIHES------------------EITPYLVSRFYRAPEIILG------HKYDYSIDVWSVGCCLAEFFTGK
.|..||| .| . .|                  . .    .  . |||.|..      ..||.. |.||.||.. |  |||
VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase Prp4.AA CLK 490-625 33 2.9e-30 87.37 In-house 1-145 (350) Show / Hide 
Range on Protein: 490-625
Range on HMM: 1-145/350
Sequence Identity: 33% (49 aa)

YQIFSPIGSGVFSTVVSAKETKT-NEDVVIKIIRNRPSMHRSGLKEIE-ILQKISNTPTSSNQKS-HCIQMKDHFNY-RNHLCIVFEPMSMSLHQLIKKY
| | .  |.|.|..||  . .|  .  |..|||||          ||. |..|| ..  . |..  ||..| | |.|  .| ||||| .  |.  ..|. 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G-----KDIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNI
.     | |.. ....|. |.||  |.|     |. | | || ||
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENI
Kinase Prp4.AA CLK 634-695 46 4.5e-17 47.06 In-house 186-249 (350) Show / Hide 
Range on Protein: 634-695
Range on HMM: 186-249/350
Sequence Identity: 46% (30 aa)

IKIVDFGSAG-EIHESEITPYLVS-RFYRAPEIILGHKYDYSIDVWSVGCCLAEFFTGKFLFPG
|...|||||     . |  . .|| | |||||.|||  . .  ||||.|| | |  ||  ||..
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQT
Kinase Prp4.AA TyrKc 490-808 19 1.8e-10 -53.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 490-808
Range on HMM: 1-280/280
Sequence Identity: 19% (67 aa)

YQIFSPIGSGVFSTVVSAKETKTNEDVVIKIIRNRPSMHRSGLKEIEILQKI-SNTPTSSNQKSHCIQMKDHFNYRNHLCIVFEPMSM-SLHQLIKKYGK
 .    .|.| | .|. .. .   ..| .| ...    ..  ..|..|. |.  . |   .    |.| .  | |   |.||.| |.  .|.. ..|...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

DIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKNTIKIVDFGSAGEIHES----EITPYLV------SR-----FYRAPEIILGHKYDY
.  |..     .. |      ..   .. | |.   |. |.| . |.|| ||| . .|..     | . | .      ..        ||| |  .|.  
K--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

SIDVWSVGCCLAEFFT-GKFLFPG-----KTNNDMIRLFMEY-RGAFSKKMLKKSEFVSNHFNENLVFMKQEIDNIEKTVRKVPHDITKPTKDILQFLLP
  |||| | |. | || |.   ||     ..| ..|.. ..  |    .  .   . .|                                         
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MS-----------------------------------------

KNVSIPDQDMKKLIQLKDLIEKCTILDPEKRITPFEALNHEFL
   .           . .....|   |||.| | |... ||..
---F-----VCCPDEMYQIMKQCWHEDPEDRPT-FSEI-HECF
Kinase Prp4.AA CLK 779-808 53 7.7e-10 24.93 In-house 321-350 (350) Show / Hide 
Range on Protein: 779-808
Range on HMM: 321-350/350
Sequence Identity: 53% (16 aa)

IQLKDLIEKCTILDPEKRITPFEALNHEFL
.|| |||.|. . || ||||  .|| |.| 
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase Prp4.AA STE 781-808 43 5.5e-08 24.41 In-house 330-359 (359) Show / Hide 
Range on Protein: 781-808
Range on HMM: 330-359/359
Sequence Identity: 43% (13 aa)

LKDLIEKCTILDPEKRITPFEALN--HEFL
.|| |.|| . ||.|| |. . |.  |.|.
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Prp4.AA Pkinase 781-808 39 2.8e-07 26.82 Pfam 266-293 (293) Show / Hide 
Range on Protein: 781-808
Range on HMM: 266-293/293
Sequence Identity: 39% (11 aa)

LKDLIEKCTILDPEKRITPFEALNHEFL
.||.|..|  .||.||.|. ..|.|...
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Prp4.AA DYRK2 792-808 47 6.9e-07 18.08 In-house 302-318 (318) Show / Hide 
Range on Protein: 792-808
Range on HMM: 302-318/318
Sequence Identity: 47% (8 aa)

DPEKRITPFEALNHEFL
||..|.|| .||.|...
DPSERMTPSQALKHPWI
Kinase Prp4.AA GSK 783-808 53 1e-06 15.4 In-house 303-328 (328) Show / Hide 
Range on Protein: 783-808
Range on HMM: 303-328/328
Sequence Identity: 53% (14 aa)

DLIEKCTILDPEKRITPFEALNHEFL
||| || . ||.||..| ||. |.| 
DLISKCLVYDPKKRLSPLEACAHPFF
Kinase Prp4.AA GSK 490-519 31 2e-05 11.91 In-house 167-204 (328) Show / Hide 
Range on Protein: 490-519
Range on HMM: 167-204/328
Sequence Identity: 31% (12 aa)

YQIFSPIGSGVFSTVVSAKET----KTNED----VVIK
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YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIK
Kinase Prp4.AA YAK 791-808 38 0.001796 7.22 In-house 330-347 (347) Show / Hide 
Range on Protein: 791-808
Range on HMM: 330-347/347
Sequence Identity: 38% (7 aa)

LDPEKRITPFEALNHEFL
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LNPRERWKPMQAMQHPFI