Gene Sky1 (Slime mold)

Sky1

Species: Slime mold
Alias: Sky1, DDB0230135, SRPK1, DdisK072
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
Sky1.AA Protein None 656 None Fasta, JSON
Sky1.kin_dom Protein Kinase Domain None 514 None Fasta, JSON

Protein domain

Protein domains of Sky1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Sky1.AA SRPK 135-648 38 0.0 973.95 In-house 1-554 (554) Show / Hide 
Range on Protein: 135-648
Range on HMM: 1-554/554
Sequence Identity: 38% (227 aa)

YQVVDKLGWGHFSTVWLCNDKDTPITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGYKQVALKIVRSARTYSETAEDEIKILNAISKYN-----------
|.|..|||||||||||||.|                                 ......||.|||.||..|.|||.||||.|....|..           
YHVIRKLGWGHFSTVWLCWD---------------------------------MQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKE

-------------AQDKCVARLLDHFTHRGPNGRHYCMVFELLGNNLLDLIKHHRYRGMPITLVKTLMKQTLIALDYIHTKCKIIHTDLKPENVLLEKSF
             .....|..|||||.||||||.|||||||.||.|||..|||..|.|||...||....|.||.|||.|.||.|||||.|||||||....
YYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNGNHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQ

DFFTSNDYIWSEKYGYFKNRTSSSNKQSQQQQQPQQQQSQQNINDYSDDSDDSHSDYSDSEDELKNKGNKKSSNRDR-DNNKNKNIKKDDNKSSVNEINN
|........|.|.........|||..|...|.|.|.||.....|................|.....|........|. |||...|....|||...|..||
DYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQTQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDNEDNNQEDNDNEQDNKNNQNQENN

ISKENTDNKDLNSSEENKKEEEQQQNKKE-------------------------------------------EPTTTTTTATATATTTTTTGTEEFKFV-
...|.......|....|.|..||...|||                                           ...|...... ..........||.... 
MENEQEEKENTNKQKKNQKKKEQHKDKKEQECQNVQKQNNDPNFESQNDSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESECES

------NGISYKFKKNNELFNENHYPRAQLVDLGNACWTDKHFTDDIQTRQYRAPEAIVKAKWGTPVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDH
      .|......||.......|.......|||||||...|||.||||||||.||.|..|...||.||||.|||||||||||.||.|.||......|||
EDMQEQAGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDH

LALMIELLGKPPRFIFAGGDESRVYFTHKGDLRKIPDLSDQWPLFSVLTEKYKFSIQEAKDFEAFLLPMLNYLPEKRATAKDCLNHTWL
.|..|||.||.|..... |..|| .|..||.||.||.|. .|||..||.|||..|..|||.||.||.|||.|.||||||||.||.|.||
IAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLK-PWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase Sky1.AA CMGC 135-648 14 1.2e-108 358.26 In-house 1-513 (513) Show / Hide 
Range on Protein: 135-648
Range on HMM: 1-513/513
Sequence Identity: 14% (99 aa)

YQVVDKLGWGHFSTVWLCNDKDTPITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGY--------KQVALKIVRSARTYSETAE-------------DEI
|....|.|.|....|. | ||.|   ..                          .          ..||.|.....  | |.|              .||
YEIIKKIGEGTYGVVYKCRDKRTNQKKD--------------------------N-GQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREI

KILNAIS-----------KYNAQDKC-VARLLDHFTHRGPNGR-------------HYCMVFELLGNNLLDLIKHHR--YRG------------------
|||  ..           . .....  . .|.|.|.|....|              | ..|||.....|...||...  |.|                  
KILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRP

------MPITLVKTLMKQTLIALD--YIHTKCK-IIHTDLKPENVLLEKSFDFFTSNDYIWSEKYGYFKNRTSSSNKQSQQQQQPQQQQSQQNINDYSDD
      ..| ...  |.| | .|.  |.| ... |||.||||||.|. .  . .|.. . |  .    .                               
PHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM-M-W-KS----E-------------------------------

SDDSHSDYSDSEDELKNKGNKKSSNRDRDNNKNKNIKKDDNKSSVNEINNISKENTDNKDLNSSEENKKEEEQQQNKKEEPTTTTTTATATATTTTTTGT
                                                                                                    
----------------------------------------------------------------------------------------------------

EEFKFVNGISYKFKKNNELFNENHYPRAQLVDLGNACWTDKH------------------------FTDDIQTRQYRAPEAIVKAK----------WGTP
           . . |..    ..  |  . | |.|.|...|                        .|....|| ||||| .. .|          ..||
-----------D-W-NPC----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTP

VDIWSAACMAFELATG--------DHLFKPKSGK-----GFEKSDDHLALMIELLGKPPRFIFAGGD-------ESRVYFTHKGDLRKIPDLS-------
.|.||..|. .|. ||        . ||...|..       ..  |.|......||.|.  ..  |.        .. ...... .. .....       
IDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTM

-----------------DQWPLFSVLTEKYKFSIQ--------------------------------EAKDFEAFLLPMLNYLPEKRATAKDCLNHTWL
                  .|. .  ........                                  . ...  .|  || | |.|| ||...|.| ..
TNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase Sky1.AA S_TKc 135-648 14 7.6e-56 192.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 135-648
Range on HMM: 1-231/231
Sequence Identity: 14% (76 aa)

YQVVDKLGWGHFSTVWLCNDKDTPITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGYKQVALKIVRSARTYSETAEDEIKILNAISKYNAQDKCVARLLD
|....|.| | |..|..| .|.                                   ..||.||..      |... ||.||        . . . .|.|
YEILRKIGKGAFGKVYKCRHKK---------------------------------TGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYD

HFTHRGPNGRHYCMVFELLGN---NLLDLIKHHRYRG----MPITLVKTLMKQTLIALDYIHTKCKIIHTDLKPENVLLEKSF----DFFTSNDYIWSEK
.| .      |..||.|....   .|.|.||.....|    .|   .. .|.|.. ||.|.| . .||| ||||||.|| .      ||  .  .     
VFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-----

YGYFKNRTSSSNKQSQQQQQPQQQQSQQNINDYSDDSDDSHSDYSDSEDELKNKGNKKSSNRDRDNNKNKNIKKDDNKSSVNEINNISKENTDNKDLNSS
                                                                                                    
----------------------------------------------------------------------------------------------------

EENKKEEEQQQNKKEEPTTTTTTATATATTTTTTGTEEFKFVNGISYKFKKNNELFNENHYPRAQLVDLGNACWTDKHFTDDIQTRQYRAPEAIVKAKWG
                                                                               |  . |. |.||| .   ..|
-------------------------------------------------------------------------------TTFCGTPWYMAPEVL---GYG

T-PVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDHLALMIELLGKPPRFIFAGGDESRVYFTHKGDLRKIPDLSDQWPLFSVLTEKYKFSIQEAKDFE
. ..|.||  |. .|...|  .|             ....|....|                                                  ... 
KCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG-------------------------------------------------SPEAK

AFLLPMLNYLPEKRATAKDCLN-------HTWL
 |.  .|.. |||| || ..|.       | |.
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Sky1.AA CLK 192-570 20 1.3e-49 146.48 In-house 26-266 (350) Show / Hide 
Range on Protein: 192-570
Range on HMM: 26-266/350
Sequence Identity: 20% (81 aa)

KQVALKIVRSARTYSETAEDEIK-ILNAISKY-NAQDKCV---ARLLDHFTH-RGPNGRHYCMVFELLGNNLLDLIKHHR------YRGMPITLVKTLMK
|.|||||.|..  | | |  ||. |. .| .  ... |      ...| | .  |    | |.||||.| .. |..|  .      |.. ||  .. . .
KYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIYDFMKSNNSKMPNKYIPYPIDHIRHMAY

QTLIALDYIHTKCKIIHTDLKPENVLLEKS-FDFFTSNDYIWSEKYGYFKNRTSSSNKQSQQQQQPQQQQSQQNINDYSDDSDDSHSDYSDSEDELKNKG
| . |.   | . |..|||||||| ....| |                            .. ..  . .....||                        
QLCEAVKFLH-DMKLTHTDLKPENICFVDSRF----------------------------THFDCTFKYNHKKKIN------------------------

NKKSSNRDRDNNKNKNIKKDDNKSSVNEINNISKENTDNKDLNSSEENKKEEEQQQNKKEEPTTTTTTATATATTTTTTGTEEFKFVNGISYKFKKNNEL
                                                                                            |.. ||  
--------------------------------------------------------------------------------------------KKS-NNCV

FNENHY--PRAQLVDLGNAC---WTDKHFTDDIQTRQYRAPEAIVKAKWGTPVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDHLALMIELLGKP
  . |   .   ..| |.|      . | .. ..||.||||| |    | .| |.|| .|  ||| ||. ||      . ... .|||.| ...| |
CHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLF-----QTHDNR-EHLAMMERIMGMP
Kinase Sky1.AA Pkinase 135-648 15 1.5e-45 162.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 135-648
Range on HMM: 1-293/293
Sequence Identity: 15% (80 aa)

YQVVDKLGWGHFSTVWLCNDKDTPITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGYKQVALKIVRSARTYSETAED-----EIKILNAISKYNAQDKCV
|... |.| | |..|..| .|.|..                                 .||.||..  .. |.  .      ||.|.. ..      ...
YHIGRKIGSGSFGCVYKCHHKGTGK---------------------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNI

ARLLDHFTHRGPNGRHYCMVFELLGN-----NLLDLIKHHRYRGM--PITLVKTLMKQTLIALDYIHTKCKIIHTDLKPENVLLEKSFDFFTSNDYIWSE
 ||.| |.     ..|..||.|....      | |.|. .|....  .   .|  |.|.| .|.|.|  ..||| ||||||.|. .  .  .        
VRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDA--------

KYGYFKNRTSSSNKQSQQQQQPQQQQSQQNINDYSDDSDDSHSDYSDSEDELKNKGNKKSSNRDRDNNKNKNIKKDDNKSSVNEINNISKENTDNKDLNS
                                                                                                    
----------------------------------------------------------------------------------------------------

SEENKKEEEQQQNKKEEPTTTTTTATATATTTTTTGTEEFKFVNGISYKFKKNNELFNENHYPRAQLVDLGNAC---WTDKHFTDDIQ-TRQYRAPEAIV
                                                               .  . | | |.   .  .. ....  |. |.||| | 
---------------------------------------------------------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR

-KAKWGTPVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDHLALMIELLGKPPRFIFAGGDESRVYFTHKGDLRKIPDLSDQWPLFSVLTEKYKFSIQE
   ..|..||.||. |. .|...|  .|.  .. . .. .|..... . .|.|..| .   .. . .|  .    .              .   .| .  
GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------F-HWTF-HNW

AKDFEAFLLPMLNYLPEKRATAKDCLNHTWL
 ...  |.  .|.. |.|| ||...|.| |.
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Sky1.AA DYRK 194-306 36 5.6e-32 112.56 In-house 27-137 (320) Show / Hide 
Range on Protein: 194-306
Range on HMM: 27-137/320
Sequence Identity: 36% (42 aa)

VALKIVRSARTYSETAEDEIKILNAISKY-NAQDKCVARLLDHFTHRGPNGRHYCMVFELLGNNLLDLIKHHRYRGM-PITLVKTLMKQTLIALDYIHTK
||.||.|.   .  .| .|||||  ...  . . . . ...|.|.||.    | |.|||||  || ...| .. .|  .. ||..  .| | .|...|..
VAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRN----HLCIVFELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKN

CKIIHTDLKPENVLL
 .||| ||||||..|
ENIIHCDLKPENIML
Kinase Sky1.AA DYRK2 192-306 36 1.2e-27 86.72 In-house 25-135 (318) Show / Hide 
Range on Protein: 192-306
Range on HMM: 25-135/318
Sequence Identity: 36% (42 aa)

KQVALKIVRSARTYSETAEDEIKILNAISKYNAQDKC-VARLLDHFTHRGPNGRHYCMVFELLGNNLLDLIKHHRYRGMPITLVKTLMKQTLIALDYIHT
. ||.|..|    . ..|  ||.|| .|.. . .    . ..|| |. |.    | |..||||. || ..|| . . |    ||    .. | .|.  | 
QHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLH-

KCKIIHTDLKPENVLL
| .||| ||||||.||
KNNIIHCDLKPENILL
Kinase Sky1.AA CAMKL 135-531 12 1.7e-24 74.97 In-house 1-222 (297) Show / Hide 
Range on Protein: 135-531
Range on HMM: 1-222/297
Sequence Identity: 12% (53 aa)

YQVVDKLGWGHFSTVWLCND-KDTPITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGYKQVALKIVRSARTYSETAED----------------EIKILN
|.... || |.|..| |. . . |                                  ..|| ||.   ..  ..  .                ||.|. 
YRIGKTLGKGSFGKVKLATHIRTT---------------------------------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMK

AISKYNAQDKCVARLLDHFTHRGP---NGRHYCMVFELLGNN---LLDLIKHHRYRG--MPITLVKTLMKQTLIALDYIHTKCKIIHTDLKPENVLLEKS
 ..  . . . . .|..... .     .  ....| |. ..    |.| |. |..|.  ||    . . .| . |..|.| .. |.| |.||||.|| ..
MLN--IGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDEN

F-------DFFTSNDYI-WSEKYGYFKNRTSSSNKQSQQQQQPQQQQSQQNINDYSDDSDDSHSDYSDSEDELKNKGNKKSSNRDRDNNKNKNIKKDDNK
        ||  || |.                                                                                   
GNNNIKIIDFGFSNMYRPC---------------------------------------------------------------------------------

SSVNEINNISKENTDNKDLNSSEENKKEEEQQQNKKEEPTTTTTTATATATTTTTTGTEEFKFVNGISYKFKKNNELFNENHYPRAQLVDLGNACWTDKH
                                                                                              ..... 
---------------------------------------------------------------------------------------------IFGPGQK

FTDDIQTRQYRAPEAIVK--A-KWGTPVDIWSA
..    .  | ||| . .      | .|||||.
LKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSC
Kinase Sky1.AA DYRK2 489-648 26 2.6e-23 72.39 In-house 145-318 (318) Show / Hide 
Range on Protein: 489-648
Range on HMM: 145-318/318
Sequence Identity: 26% (48 aa)

LVDLGNACWTDK-HFTDDIQTRQYRAPEAIVKAKWGTPVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDHLALMIELLGKPPRFIFAGG-----DESR
..| |  |  .  ..  .||.| |||||.|.  | |...|.||  | . || ||  ||    |   |  .| .|.|.|.||.||. .|           .
VIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PG---ENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRK

VYFT-------------HKGDLRKIPDLSDQWPLFSVLTEKYKFSIQ--EAKDFEAFLLPMLNYLPEKRATAKDCLNHTWL
..|.             |. .. |.   .         . . | ...  | ..|  |..  .   |..| |... |.| |.
YFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGK-RRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase Sky1.AA CAMK 140-311 16 1e-22 69.37 In-house 1-217 (425) Show / Hide 
Range on Protein: 140-311
Range on HMM: 1-217/425
Sequence Identity: 16% (40 aa)

KLGWGHFSTVWLCNDKDTP-ITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGY-----KQVALKIVRSA----------------------------RTY
.|| | |..| || .| |.  . . .                                ..|| ||.                               | .
TLGRGSFGKVKLCIHKNTTGKERV-H--------------------------HIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPK

SET-AEDEIKILNAISKYN--AQDKCVARLLDHFTHRGP--------NGRH--------YCMVF---ELLGNN-----LLDLIKHHRY------------
..   . ||.|.. ... .   . ... .|....  .          . ..        ..||.   |.  .      |.| |. |..            
DRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVE

-RGMPITLVKTLMKQTLIALDYIHTKCKIIHTDLKPENVLLEKSFD
 . ..   ......| . |..|.| .  |.| ||||||.|| ...|
RGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNND
Kinase Sky1.AA YAK 194-308 32 2e-22 72.65 In-house 271-385 (347) Show / Hide 
Range on Protein: 194-308
Range on HMM: 271-385/347
Sequence Identity: 32% (39 aa)

VALKIVRSARTYSETAEDEIKILNAI-SKYNAQDKC----VARLLDHFTHRGPNGRHYCMVFELLGNNLLDLIKHHRYRGMPITLVKTLMKQTLIALDYI
.| |.. .   |   |  ||.||     .    .|     . |..| | |.     | |.|||.| ||| ...|  ...|. . |...  || | ..  .
FAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHK----NHFCLVFEMLSNNLYEYLKQNKFCGFSFQLIRQWTKQILDGM-CV

HTKCKIIHTDLKPENVLLEK
    .||| ||||||..| |
LENKQIIHCDLKPENIMLCK
Kinase Sky1.AA DYRK 489-648 24 1.1e-20 74.17 In-house 148-320 (320) Show / Hide 
Range on Protein: 489-648
Range on HMM: 148-320/320
Sequence Identity: 24% (44 aa)

LVDLGNACWTDKHFTDDIQTRQYRAPEAIVKAKWGTPVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDHLALMIELLGKPPRFIFAGG--DESRVYFT
..| | .|  .....  || | ||||| |.  . ....|.||  |   || ||  ||  ..        | ||...|.||.||. ..  |     . .|.
VIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGEN------EYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFD

H------------KG------DLRKIPDLSDQWPLFSVLTEKYKFSIQEAKDFEAFLLPMLNYLPEKRATAKDCLNHTWL
             .        ....|.. .|  . .    ....  .. ..|  |.. .|.. |.|| |... |.| |.
CFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase Sky1.AA DYRK1 192-306 36 2.3e-20 67.83 In-house 25-137 (321) Show / Hide 
Range on Protein: 192-306
Range on HMM: 25-137/321
Sequence Identity: 36% (43 aa)

KQVALKIVRSARTYSETAEDEIKILNAISKYNAQDK-CVARLLDHFTHRGPNGRHYCMVFELLGNNLLDLIKHHRYRGMPITLVKTLMKQTLIALDYIHT
..||.||..  ... . |  ||..|  . |  ...|  . .|  || .|     | |.|||||  || ||..   .||. . |.. . .| . || .. |
EYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMST

-KCKIIHTDLKPENVLL
   .||| ||||||.||
PELDIIHCDLKPENILL
Kinase Sky1.AA DyrkP 196-306 37 4.8e-13 38.63 In-house 29-139 (323) Show / Hide 
Range on Protein: 196-306
Range on HMM: 29-139/323
Sequence Identity: 37% (44 aa)

LKIVRSARTYSETAEDEIKILNAISKYN--AQDKCVARLLDHFTHRGPNGRHYCMVFELLGNNLLDLIKHHR----YRGMPITLVKTLMKQTLIALDYIH
.||.   . | . . ||||.|  |  ||    .| | |  | | |.     |  .. ||| .|| .  |  |     |   .  .. . .| ||||||||
MKIIENNKDYFDQSIDEIKLLRYI-NYNGDVDEKNVLRYYDYFYHK----EHLFIITELLKDNLYEFYKFNRENEQQRYFTVGRLQKITQQILIALDYIH

TKCKIIHTDLKPENVLL
   ..|| ||||||.|.
S-LRLIHCDLKPENILM
Kinase Sky1.AA DyrkP 488-588 32 6.9e-13 38.1 In-house 148-242 (323) Show / Hide 
Range on Protein: 488-588
Range on HMM: 148-242/323
Sequence Identity: 32% (33 aa)

QLVDLGNACWTDKHFTDDIQTRQYRAPEAIVKAKWGTPVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDHLALMIELLGKPPRFIFAGGDESRVYFTH
...| | .|.   |    .| | ||||| |.  |.   .|.||  |.  || ||  ||.    .|       || .| ..|  | ...  |   . .||.
KIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGL------LARVIGIIGPFPEWMMQEGRLVQNFFTR

K
|
K
Kinase Sky1.AA DYRK1 488-590 29 1.5e-12 39.88 In-house 146-242 (321) Show / Hide 
Range on Protein: 488-590
Range on HMM: 146-242/321
Sequence Identity: 29% (30 aa)

QLVDLGNACWTDKHFTDDIQTRQYRAPEAIVKAKWGTPVDIWSAACMAFELATGDHLFKPKSGKGFEKSDDHLALMIELLGKPPRFIFAGGDESRVYFTH
...| | .| ...     || | ||.|| ..  .. . .|.||  |.  |. ||. ||   ||       | .  ..| || ||. .   .  .. ||..
KIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SG---SNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEK

KGD
. |
DPD
Kinase Sky1.AA YAK 485-538 38 6.9e-08 22.46 In-house 145-198 (347) Show / Hide 
Range on Protein: 485-538
Range on HMM: 145-198/347
Sequence Identity: 38% (21 aa)

PRAQLVDLGNACWTDKHFTDDIQTRQYRAPEAIVKAKWGTPVDIWSAACMAFEL
|  ...| | .| . |  .  || | ||.|| ||     | .| ||  |   ||
PEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL
Kinase Sky1.AA CAMK 628-648 57 1.8e-07 19.35 In-house 405-425 (425) Show / Hide 
Range on Protein: 628-648
Range on HMM: 405-425/425
Sequence Identity: 57% (12 aa)

MLNYLPEKRATAKDCLNHTWL
||.. ||||.|...|||| |.
MLQVDPEKRMTIEQCLNHPWM
Kinase Sky1.AA CAMKL 628-648 47 1e-06 17.03 In-house 277-297 (297) Show / Hide 
Range on Protein: 628-648
Range on HMM: 277-297/297
Sequence Identity: 47% (10 aa)

MLNYLPEKRATAKDCLNHTWL
||.  ||||.|... .|| |.
MLQVNPEKRPTIHQIMNHPWM
Kinase Sky1.AA CLK 628-648 52 3.4e-05 10.74 In-house 330-350 (350) Show / Hide 
Range on Protein: 628-648
Range on HMM: 330-350/350
Sequence Identity: 52% (11 aa)

MLNYLPEKRATAKDCLNHTWL
|| | | || |.|| | |.. 
MLEYDPSKRITCKDALQHPFF
Kinase Sky1.AA CLK 135-154 45 5.8e-05 10.04 In-house 1-20 (350) Show / Hide 
Range on Protein: 135-154
Range on HMM: 1-20/350
Sequence Identity: 45% (9 aa)

YQVVDKLGWGHFSTVWLCND
| .|..|| | |..|  |.|
YEIVCTLGEGTFGKVVECWD
Kinase Sky1.AA TyrKc 135-506 9 0.000592 -158.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 135-506
Range on HMM: 1-280/280
Sequence Identity: 9% (43 aa)

YQVVDKLGWGHFSTVWLCNDKDTPITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGYKQVALKIVRSARTYSETAEDEIKILNAI-SKYNAQDKCVARLL
 .  .||| |.| .|...  |                                     ||| | ...     |   .|..|.  .      . ... ||.
ITLGKKLGEGAFGEVYKGTWK------------------------------------IQVAVKMLKEDA--REDFMREARIMCKLGG----HHPNIVRLY

DHFTHRGPNG---RHYCMVFELLGN-NLLDLIKHHRYRGMPITLVKTLMKQTLIALDYIHTKCKIIHTDLKPENVLLEKSF----------DFFTSN---
   |. | |      ...|.|.  . .|.| .. || .  .       . |     .|.| | ..|| ||   |.|. . .           . ..    
GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQ

----DYIW-----SEK-----------------------------------------YGY-----FKNRTSSSNKQSQQQQQPQQQ----QSQQNINDYS
    ||.      ..|                                         |        .|.    . ..     . .               
GESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------

DDSDDSHSDYSDSEDELKNKGNKKSSNRDRDNNKNKNIKKDDNKSSVNEINNISKENTDNKDLNSSEENKKEEEQQQNKKEEPTTTTTTATATATTTTTT
                                                                                                    
----------------------------------------------------------------------------------------------------

GTEEFKFVNGISYKFKKNNELFNENHYPRAQLVDLGNACWTD--------KHFTDDI
                     |       . . ..   ||          .   ...
---------------------F---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Sky1.AA DYRK 135-157 34 0.005243 7.41 In-house 1-23 (320) Show / Hide 
Range on Protein: 135-157
Range on HMM: 1-23/320
Sequence Identity: 34% (8 aa)

YQVVDKLGWGHFSTVWLCNDKDT
|.... .| | |. |  | |. |
YEILEYIGKGSFGQVVKCWDHKT
Kinase Sky1.AA DyrkP 635-648 50 0.006468 4.67 In-house 310-323 (323) Show / Hide 
Range on Protein: 635-648
Range on HMM: 310-323/323
Sequence Identity: 50% (7 aa)

KRATAKDCLNHTWL
.| |||. |.| |.
RRPTAKEALQHPWF
Kinase Sky1.AA DYRK1 614-648 28 0.00743 5.29 In-house 287-321 (321) Show / Hide 
Range on Protein: 614-648
Range on HMM: 287-321/321
Sequence Identity: 28% (10 aa)

SIQEAKDFEAFLLPMLNYLPEKRATAKDCLNHTWL
|... . |.  .. ||.| |..| |  . | | ..
SVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase Sky1.AA DyrkP 135-157 43 0.010902 3.91 In-house 1-23 (323) Show / Hide 
Range on Protein: 135-157
Range on HMM: 1-23/323
Sequence Identity: 43% (10 aa)

YQVVDKLGWGHFSTVWLCNDKDT
||... ||   ||    | || |
YQIMEYLGSAAFSKAIQCQDKQT