DDB0216331

Species: Slime mold
Alias: DdisK084, DDB0216331
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: Dicty8

Sequence

Name Sequence Type Origin Length Description Download
DDB0216331.AA Protein None 942 None Fasta, JSON
DDB0216331.kin_dom Protein Kinase Domain None 614 None Fasta, JSON

Protein domain

Protein domains of DDB0216331.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0216331.AA Dicty8 4-617 92 0.0 1849.18 In-house 1-618 (618) Show / Hide
Range on Protein: 4-617
Range on HMM: 1-618/618
Sequence Identity: 92% (573 aa)

YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFL

KNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKD
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKD

NNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNT

VNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
VNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSN

STFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDLKSENIFLSESQKIKI
|||||||||||||||||||||||||||||||||||||||||||||||||||||||.|.|.||.||||||.||||||.||..|.||||||||.||||||||
STFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKIPQKQFYEWIYQICYGVQSIHRNHMIHRDLKSENIFISESQKIKI

GDFGLAKKYENS----MSGVAGTYYYLSPEILLNKNYSRPADIFSLGCIFYEMYTLNLLPLTKRSFGQELIEGKFDRKAFKQEFDDSDEPIADLILDMLN
|||||||.||..    .|.|.|||.|.|||||.||||.||.|||||||||||||||||||...|.|||..|...|||..|||||||..|.||||||||.|
GDFGLAKQYEHHTGSIHSEVVGTYCYSSPEILNNKNYDRPTDIFSLGCIFYEMYTLNLLPHNRRYFGQDMINDRFDRMQFKQEFDDKYEKIADLILDMIN

LDQNLRPTIDLILQNKLF
..||.|||||.|.|||||
KNQNFRPTIDSIIQNKLF

Kinase DDB0216331.AA Ciliate-E2 4-617 11 4.2e-48 163.21 In-house 1-365 (365) Show / Hide
Range on Protein: 4-617
Range on HMM: 1-365/365
Sequence Identity: 11% (82 aa)

YEVVKLIGVGGEA-----KALLVKRI------------------NSDKLYVMKQRMFFLLEEAN--EGLCEAMS-----------LAKIQSPYIVRFEEV
|...|.|| |. .     |  .|..                   .  |.| ||. .   .|. .  . ..  .            | ....|.|... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLDNNSNMFSLCIVMEYCEGGDLMD-------NLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNN
| ..  .  .. .|||||.||||.|       . .. |.                                                             
FQEK--DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE-------------------------------------------------------------

NNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSN
                                                                                                    
----------------------------------------------------------------------------------------------------

DSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTS
                                                                                                    
----------------------------------------------------------------------------------------------------

KTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLP
                                                                                        .. ..   ... 
------------------------------------------------------------------------------------K-D-KYFTEKEIKYIM

RKLFY-------TWIYQICLGVQSIHKNH-LVHLDLKSENIFLSESQKIKIGDFGLAKKYENS--------MSG--------------------------
.....        .| .|.|.....|...  .| |.| |||..     ||| ||||.||| ..        ...                          
KQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNT

VAGTYYYLSPEILLNKN---------YSRPADIFSLGCIFYEMYTLNLLPLTKRSFGQELIEG-KFD-RKAFKQ-----------EFDDSDEPIADLILD
..||..|..|||| .|.         |.  .||.|||.|.||| . ..         |. |.  |.| .....|           .... ..   |||  
ICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK

----MLNLDQNLRPT-IDLILQNKLF
    ||. |.. |.| .. ||... |
FGKRMLQKDPEKRITGWEQILNHPWF

Kinase DDB0216331.AA Ciliate-E2-Unclassified 4-617 11 4.5e-47 161.32 In-house 1-352 (352) Show / Hide
Range on Protein: 4-617
Range on HMM: 1-352/352
Sequence Identity: 11% (83 aa)

YEVVKLIGVGGEAKALLVKRINSDKLY-----VMKQRMFFLLEEAN--------EGLCEAM-------------SLAKIQSPYIVRFEEVFLDNNSNMFS
|...| || || .|  ...... . .|      .|....  .   |        . ... .             .|  ...|.||.....| | .     
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ----N

LCIVMEYCEGGDLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYE
..|||||||||||.. . || . .                                                                            
IYIVMEYCEGGDLWQYIKKRKKQK----------------------------------------------------------------------------

NFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDY
                                                                                                    
----------------------------------------------------------------------------------------------------

SSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMT
                                                                                                    
----------------------------------------------------------------------------------------------------

WWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFY-----TWIYQIC
                                                            .     . ||   .|. .  ... .        ....||.
------------------------------------------------------------Q-----K-GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQIL

LGVQSIHKNH-LVHLDLKSENIFLSESQ---KIKIGDFGLAKKYENS------------------MSGVAGTYYYL----SPEILLNKNYSRP----ADI
.| ...|...  .| |.| |||......   .||| |||..|||...                  |. ..||..|.    .||.| ..||. .    .||
QGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDI

FSLGCIFYEMYTLNLLPLTKRSFGQ---------------ELIEGKFDRKAFKQEFD------DSDEPIADLIL----DMLNLDQNLRPTIDLILQNKLF
.|||.|.||| . . .|   ..  |               .|.. ..... ....|.      ....  .|.|      ||. ..| |.|.. ||.  .|
WSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF





Kinase DDB0216331.AA CAMK 59-552 9 7.3e-43 135.49 In-house 98-327 (425) Show / Hide
Range on Protein: 59-552
Range on HMM: 98-327/425
Sequence Identity: 9% (55 aa)

PYIVRFEEVFLD-----------NNSN--MFS----LCIVM---EYCEGGDLMDNLFKRISDS--------FLKNSGLNNNQNNNNNNNNNLNSIVNNNI
| |... ||. |           . |.  . .    ...||   |||.||.| | || .| .                                      
PNIIKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ----------------------------

LNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLN
                                                                                                    
----------------------------------------------------------------------------------------------------

SQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRS
                                                                                                    
----------------------------------------------------------------------------------------------------

TTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQ
                                                                                                    
----------------------------------------------------------------------------------------------------

SPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFYT-------WIYQICLGVQSIHKNHLVHLDLKSENIFLSESQ-----------------KIKIGDF
                          . .  . ..        .. ||| .|. .|... ||.||| ||| |...                  .||| ||
--------------------------FDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF

GLAKKYEN--------------------------SMSGVAGTYYYLS-PEILLNKN--------------YSRPADIFSLGCIFYEM
|.|.|..                            |. . || .| . ||.|. |               |....|. |.|.| | |
GFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM

Kinase DDB0216331.AA CMGC 4-554 9 9.7e-40 127.64 In-house 1-330 (513) Show / Hide
Range on Protein: 4-554
Range on HMM: 1-330/513
Sequence Identity: 9% (64 aa)

YEVVKLIGVGGEAKALLVKR--------------INSDKLYVMKQRM--FFLLEEAN----------EGLCEAMSLAKIQ-----------------SPY
||..| || |  ..    .               ....... .|  .  |   |.|             | | . | ...                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRFEEVFLDNNSN-------------MFSLCIVMEYCEG--GDLMDNLFK-------------------RISDSFLKNSGLNNNQNNNNNNNNNLNSIV
||.  ..| ..||.             . .|..|.||..    ....|  .                   |                             
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRR----------------------------

NNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNEST
                                                                                                    
----------------------------------------------------------------------------------------------------

NNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGC
                                                                                                    
----------------------------------------------------------------------------------------------------

QIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQ
                                                                                                    
----------------------------------------------------------------------------------------------------

QLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFYTWI------YQICLGVQ--SIHKNH--LVHLDLKSENIFLSESQK----------------
                                 |  .    .      |||. |.    .|..    .| ||| ||| ...  .                
---------------------------------PPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ

----IKIGDFGLAKKYENS------------------------MSGVAGTYYYLSPEILLN----------KNYSRPADIFSLGCIFYEMYT
    .||.|||||..|..                         ..    | .| .|||||.          ..|. | |. |.||||.||||
KNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYT

Kinase DDB0216331.AA Pkinase 467-617 28 2.6e-39 140.06 Pfam 113-293 (293) Show / Hide
Range on Protein: 467-617
Range on HMM: 113-293/293
Sequence Identity: 28% (52 aa)

WIYQICLGVQSIHKNHLVHLDLKSENIFLSESQKI----KIGDFGLAK---KYENSMSGVAGTYYYLSPEILL-NKNYSRPADIFSLGCIFYEMYTLNLL
..|||. |.. .|..  .| |||.|||....   |    ||.||||||      |||....||..|..||... .. |....|..|.|||.|||..   .
YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRP

PLTKRS------FGQELIEGKFDRKAFKQEFDDSD-------------------EPIADLILDMLNLDQNLRPTIDLILQNKLF
|    .        ...|. . ...   ... ...                   |.  |.| ..|..| . |||.. ||| . |
PFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase DDB0216331.AA ULK 53-617 10 3.2e-35 120.45 In-house 64-329 (329) Show / Hide
Range on Protein: 53-617
Range on HMM: 64-329/329
Sequence Identity: 10% (68 aa)

LAKI----QSPY----IVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRIS---DSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQST
. |.    ....    ||.. ..| . |.    . |.||||.||||.. . |.     |  .                                      
MKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYIIMEYCNGGDLEQYIKKNKKLPEDT-E--------------------------------------

TNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSI
                                                                                                    
----------------------------------------------------------------------------------------------------

SSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTS
                                                                                                    
----------------------------------------------------------------------------------------------------

PQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESS
                                                                                                    
----------------------------------------------------------------------------------------------------

LNINGNNNNNNCSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDLKSENIFLSESQK------------IKIGDFGLAKKYENS------MSGVA---
             .  .|. .     ..||. | . .||.  .| |.| .|| ... |             .||.|||.||. .|.      |       
-------------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEK

---GTYYYLSPEILL----NKNYS-RPADIFSLGCIFYEMYTLNLLPLTKRSFGQE-LIEGKFDRK---------AFKQEFDDS------DEPIADLILD
   || .| .|.||     .|.|.   .||.||||||||| .    . .   . |  .|  |  ..          .. .|...       . . |||  
RLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRR

MLNLDQNLRPTIDLILQNKLF
||  |.. | ... ......|
MLQYDEKDRISWEELFNHPWF

Kinase DDB0216331.AA ULK 56-617 11 5.4e-35 121.63 In-house 70-324 (324) Show / Hide
Range on Protein: 56-617
Range on HMM: 70-324/324
Sequence Identity: 11% (70 aa)

IQSPY--IVRFEEVFLDNNS-NMFSLCIVMEYCEGGDLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSS
...|.  ||.. ..| . |. |   ..|.||||.|||| . . |.   .. .                                                
LKHPNHHIVKLYDWFETSNHNN---IYIIMEYCNGGDLEQYIKKNKKLPE-T-E----------------------------------------------

IASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNND
                                                                                                    
----------------------------------------------------------------------------------------------------

LINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQ
                                                                                                    
----------------------------------------------------------------------------------------------------

PPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

CSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDLKSENIFLSESQK------------IKIGDFGLAKKYEN-SMSGVA-----------GTYYYLSP
  .  .|. .     ..||| | . .||.  .| |.| .|| ... |             .||.|||.||. .| .|.              || .| .|
--EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAP

EILL----NKNYS-RPADIFSLGCIFYEMYTLNLLPLTKRSFG-Q----ELIEG----KFDRKAFKQEFDDSD------EPIADLILDMLNLDQNLRPTI
.||     .|.|.   .||.||||||||| .    . .      .    .||.     ..  |  . .|.. .      . . |||  ||  |.. | ..
QILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISW

DLILQNKLF
. |.....|
EEIFNHPWF

Kinase DDB0216331.AA NEK 467-556 39 2.5e-29 100.67 In-house 119-223 (286) Show / Hide
Range on Protein: 467-556
Range on HMM: 119-223/286
Sequence Identity: 39% (41 aa)

WIYQICLGVQSIHKN-----HLVHLDLKSENIFLSESQK----IKIGDFGLAKKYENS--MSG--VAGTYYYLSPEILLNKNYSRPADIFSLGCIFYEMY
| .|.||... .|..     . .| |.|. ||||. . .    .||||||..|  ...  |    . || ||.|||.. || |.  .|| ||||. ||| 
WFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMC

TL--N
||  .
TLKPK

Kinase DDB0216331.AA NEK1 467-555 40 1.8e-27 92.46 In-house 109-217 (276) Show / Hide
Range on Protein: 467-555
Range on HMM: 109-217/276
Sequence Identity: 40% (44 aa)

WIYQICLGVQSIHKNHLVHLDLKSENIFLS--ESQ---------------KIKIGDFGLAKKYENSM---SGVAGTYYYLSPEILLNKNYSRPADIFSLG
|  ||||... ||.    | |.|| ||||.  ..                ..|.|||| |.   ..|   . ..|| |||||||  || |    || |||
WFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLG

CIFYEMYTL
|. ||  ||
CVLYELCTL

Kinase DDB0216331.AA NEK4 467-555 45 8e-25 86.17 In-house 107-198 (257) Show / Hide
Range on Protein: 467-555
Range on HMM: 107-198/257
Sequence Identity: 45% (42 aa)

WIYQICLGVQSIHKNHLVHLDLKSENIFLSESQKIKIGDFGLAKKYENSM---SGVAGTYYYLSPEILLNKNYSRPADIFSLGCIFYEMYTL
|  || .. | .|. | .| |||  ||||     |||||||...  .|.    . . || ||.|||.  |. |    || ||||  ||| ||
WFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

Kinase DDB0216331.AA S_TKc 4-617 9 3.8e-19 70.86 SMART 1-231 (231) Show / Hide
Range on Protein: 4-617
Range on HMM: 1-231/231
Sequence Identity: 9% (60 aa)

YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFL
||....|| |. .|  ... ....... .|.                                                                     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

KNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKD
                                                                                                    
----------------------------------------------------------------------------------------------------

NNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNT
                                                                                                    
----------------------------------------------------------------------------------------------------

VNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSN
                                                                                                    
----------------------------------------------------------------------------------------------------

STFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNN--------NN--NNCSTLLK----------LPRKLFYTWIYQICLGVQSIHKNHL
          .  .  |....     . | .   ...  .   ..        ..   .  ...|          .|      ..||||.... .|... 
---------EHIRREIQILKK-----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI

VHLDLKSENIFLSESQKIKIGDFGLAKKYENSMSGVAGTYYYLSPEILLNKNYSR-PADIFSLGCIFYEMYTLNLLPLTKRSFGQELIEGKFDRKAFKQE
.| ||| |||.|.|   |||.|||||...    . . || .|..||.|    |.. ..|. |.|||.|||..    |       |....           
IHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG--------

FDDSDEPIADLILDMLNLDQNLRPTIDLILQ-------NKLF
    ...  |.|  .|. | . |||.  .||          |
----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase DDB0216331.AA NEK 4-92 34 7.1e-18 59.85 In-house 1-96 (286) Show / Hide
Range on Protein: 4-92
Range on HMM: 1-96/286
Sequence Identity: 34% (34 aa)

YEVVKLIGVGGEAKALLVKRINSDKL-----YVMKQRMFFLL--EEANEGL-CEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCE-GGDLMD
||..| || |   |. .|.|..  |      ||.|.  .  .  .|  . .  |.  |.....|.||.. . |.....|  .||||||||| ||||..
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNN--CLCIVMEYCEGGGDLYQ

Kinase DDB0216331.AA Pkinase 4-92 24 7.8e-15 53.54 Pfam 1-93 (293) Show / Hide
Range on Protein: 4-92
Range on HMM: 1-93/293
Sequence Identity: 24% (24 aa)

YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLC-------EAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGG----DLMD
|.... || |. ..  . ..... |....|.   . ....... .       |.  ......|.|||. ..| | ....    .||||||||    ||.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI---IKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIY---MVMEYCEGGLYVMDLFD





Kinase DDB0216331.AA NEK1 4-91 41 6.6e-14 44.77 In-house 1-88 (276) Show / Hide
Range on Protein: 4-91
Range on HMM: 1-88/276
Sequence Identity: 41% (37 aa)

YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLL--EEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLM
|.. | || |   ||.|||.  . ..||.|   .     .|  | . |.  |||   | ||.. | |  | . .  | ||||||.|||||
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGI--LYIVMEYCDGGDLM

Kinase DDB0216331.AA NEK4 4-94 35 6.5e-13 42.87 In-house 1-91 (257) Show / Hide
Range on Protein: 4-94
Range on HMM: 1-91/257
Sequence Identity: 35% (33 aa)

YEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFL---LEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNL
|. .| .| |      ||.     | |||| .|| .    .|  . . ||  | . . | || . | .   |  .  |.||| .||||||   |
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMK-KMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQF--LYIVMGFCEGGDLYRKL

Kinase DDB0216331.AA Pkinase_Tyr 49-510 7 2e-12 42.74 Pfam 53-159 (270) Show / Hide
Range on Protein: 49-510
Range on HMM: 53-159/270
Sequence Identity: 7% (36 aa)

EAMSLAKI-QSPYIVRFEEVFL-DNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNS
||  . .. . | |||.  | . .  .|  ...|||||...||| | | |.                                                 
EAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHR------------------------------------------------

SGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESS
                                                                                                    
----------------------------------------------------------------------------------------------------

SFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIP
                                                                                                    
----------------------------------------------------------------------------------------------------

LNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKDKKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNING
                                                                                                    
----------------------------------------------------------------------------------------------------

NNNNNNCSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDLKSENIFLSESQKIKIGDFGLAK
       .   .|. |    . .||. | .  . ....| ||   |. ..|. ..||.|||||.
-------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR

Kinase DDB0216331.AA TyrKc 4-616 10 5.8e-12 -29.26 SMART 1-280 (280) Show / Hide
Range on Protein: 4-616
Range on HMM: 1-280/280
Sequence Identity: 10% (68 aa)

YEVVKLIGVG-------GEAKALLV--KRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKI--QSPYIVRFEEVFLDNNSNMF----SLCIVMEYCEGG
 .  | .| |       |..| . |  | ...|.                . . ||  . |.  . | |||.  | ..   | |     |.|||||...|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHG

DLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSET
|| | | |.  .                                                                                        
DLKDYLRKHRPK----------------------------------------------------------------------------------------

LKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISS
                                                                                                    
----------------------------------------------------------------------------------------------------

PGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIKTESIGCQIRSTTSPCTSGPTSPQMIPLNIVEQPPQSTSTSKTDSSPTGADVKKTKMTWWKTYKSSKKD
                                                                                                    
----------------------------------------------------------------------------------------------------

KKQTICSNACESFSNSTFFNDPSSHSQPQHQQLHSSPQQLPQSPRLKPNIESSLNINGNNNNNNCSTLLKLPRKLFYTWIYQICLGVQSIHKNHLVHLDL
                                                                      |. | .  . .||. | . .|.....| ||
----------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDL

KSENIFLSESQKIKIGDFGLAKKYENS----------MS----GVA--GTYYYLSPEILLNKNYSRPADIFSLGCIFYEMYTLNLLPLTK-----RSFGQ
   |. ..| . .||.||||... ..           ..    |      .  ..|| .  . ..   |..| |   .|..|.   |         |  |
AARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS-NQ

ELIEGKFDRKAFKQEFDD-------SDEPIADLILDMLNLDQNLRPTIDLILQNKL
|.||   ...  .|  .|         . . .....  . | . |||   |   ..
EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF

Kinase DDB0216331.AA CAMK 586-617 33 2.4e-05 12.42 In-house 387-425 (425) Show / Hide
Range on Protein: 586-617
Range on HMM: 387-425/425
Sequence Identity: 33% (13 aa)

SDE-------PIADLILDMLNLDQNLRPTIDLILQNKLF
|||          |||  ||. | . |.||. .|. . .
SDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase DDB0216331.AA NEK 592-617 34 0.001441 8.89 In-house 261-286 (286) Show / Hide
Range on Protein: 592-617
Range on HMM: 261-286/286
Sequence Identity: 34% (9 aa)

DLILDMLNLDQNLRPTIDLILQNKLF
.||  ||. |  .||... ||.. . 
NLISQMLQKDPEQRPSCNQILEMPFI

Kinase DDB0216331.AA CMGC 592-617 38 0.01604 3.06 In-house 488-513 (513) Show / Hide
Range on Protein: 592-617
Range on HMM: 488-513/513
Sequence Identity: 38% (10 aa)

DLILDMLNLDQNLRPTIDLILQNKLF
||.  || .| . |.|.. .||   |
DLLKKMLQYDPDKRITAEQALQHPYF

Acetyltransf_1 DDB0216331.AA Acetyltransf_1 868-917 29 2e-07 23.95 Pfam 25-78 (78) Show / Hide
Range on Protein: 868-917
Range on HMM: 25-78/78
Sequence Identity: 29% (16 aa)

IGVSKEYRDLGVGQYLLKPVIEWAEH--QRKTVKAVVFSQKQ--INFFSKLGLS
| |...||  |.|  |.. .||||..  . ... ..|... .  |.|. |.|  
IYVHPDYRGQGIGTRLMQHAIEWAREERGCHRIYLWVREHNHPAIRFYEKCGFK