Gene IfkB (Slime mold)

IfkB

Species: Slime mold
Alias: DDB0185219, IfkB, DdisK119
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
IfkB.AA Protein None 1358 None Fasta, JSON
IfkB.kin_dom Protein Kinase Domain None 356 None Fasta, JSON

Protein domain

Protein domains of IfkB.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IfkB.AA STE-Unique 1-582 67 0.0 1376.05 In-house 5-616 (616) Show / Hide 
Range on Protein: 1-582
Range on HMM: 5-616/616
Sequence Identity: 67% (416 aa)

MIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASEDWFMQS
|||.|.||.|....|| ||...|||.|..|...|.|||||.|....|......||||..|.||..|....||||||||||||||||||||||||||||||
MIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGGCDSFQSLEEGNEDLSGDLETDASEDWFMQS

SINSRSIISRDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKK
||||||||||||||||||||||||| ||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||||
SINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKK

ISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDD--NNNNNDSNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDI
||||||||||||||||||||||||||||||||||||||||||||||||||||||||  |||||| |||||||||||||||||||||||||||||||||||
ISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDI

INNSGSFDDNENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGG---------IAEEE
||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||.....|.||||...||...|...|.         ..|.|
INNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKEQNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETE

AFRLLRQIVEGLNHIHSQQ--IIHRDLKPANIFIDNEQ-----NVKIGDFGLATSGAPVSKSDDLNSSTSNAANNINLSSSTNSTAQQTPMWDLNDENLS
......||.|||...|||.  ||||||||.|||.....     .|||.|||.||...|.....|.||..|| ..|||..||||||||||||||||..|..
VIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYT

MTGGVGTPFYCCPEILEKN---TKHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILR--DLRDNLKFPPG-------FESTKPDQTQIIRSLLSRDPTQR
|....|||.|.|||.....   ...|.||||..|||...|.||........|.....  .........|.       .....|.|.|.|...|.|.|..|
MKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHR

PSTKQLLESGLL
||..|||....|
PSAHQLLHHFWL
Kinase IfkB.AA GCN2 250-582 34 5.8e-166 557.66 In-house 75-511 (511) Show / Hide 
Range on Protein: 250-582
Range on HMM: 75-511/511
Sequence Identity: 34% (151 aa)

DSYSDDDNNNNNDSNNNYHSDNESDSFSGSISMSDGNGSGYEATDDED-------IINNSGS--------------------------------------
|. . .|.||..|.|||||||.||..|||...|........|....|.       ...|...                                      
DEPMVTDTNNDDDTNNNYHSDDESECFSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDD

-------------------------------FDDNENDDDDEEDDDDEYDEEDDD------------------YETFDFQDKSRVVSNNSKLSTSSSRKK
                               .||||...............||..                  ......|||........| .......|
HYSYCHSDCEFDDDVFDIDWDIESNNVRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCK

PPKETHTLYIQMEYCSKKTLKTLIDN-VGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVS-------KSDDL
.|||.|.||||||||..|||...||| . .....|..|..|||.||||.||||..|||||||.|||.|...|||||||||||.....|       |....
KPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQ

NSSTSNAANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSL-GIIFFEMCFQ-FQTQMERSNILRDLRDNLKFP
.||.....|.|......|....|...||..||....||.||||||.|||..   ..||..||||||| |||||||... |.|||||..||..|| ...||
ASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ---KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-SCEFP

PGFES----TKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
..|..    ...||...||..|..||..|||..|||....|
QDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase IfkB.AA PEK 227-582 19 1.7e-128 433.15 In-house 1-655 (655) Show / Hide 
Range on Protein: 227-582
Range on HMM: 1-655/655
Sequence Identity: 19% (131 aa)

EQSSSDSENGEN-GMKSRIIENASDSYSDDDNNNNNDSN--------------NNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNS---------
 .  .    |.  |.  . .. ... |      . |...              ...|....   ..   ...  |  .|..  .|. ....         
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

-------------------------------------------------------------GSFDDNENDDDDEEDDDD---------------------
                                                             ............|..|..                     
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

--------------------------------------------------------------------------EYDEEDDDYETFDFQD----------
                                                                          ||...||..|..|.|.          
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

------------------------KSRVVSNNSKLSTSSSRKKPPKET-------HTLYIQMEYCSKKTLKTLIDNVG----------------------
                        .|.  ..... .|.....|....        |.||||||||.||||...||| |                      
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIM

----------------------GIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN-----VKIGDFGLATSGAPVSKSDDLN--------
                      ........|..|||.||||.||||..|||||||.|||.|....     ||||||||||. ...|. ...|        
NQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQ-SQKNYNQQDQSY

--SSTSNAANNINLSSSTNSTAQQTPMWDLND-----------ENLSMTGGVGTPFYCCPEILEKN---TKHYGTKVDMYSLGIIFFEMCFQFQTQM-ER
  ..  ......| ... ..| |.|.|| .|.           |....||||||..|..|| |...   ..||..||||||||||||||...|.|.| ||
WKYVANDNCQWWNTNQQNSPTGQDTHMW-SNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMER

SNILRDLRD------NLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
...|.||||      .  .|. |... |.| ..|. .||.||.||||..|.|.....
VKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase IfkB.AA STE 1-582 12 1.2e-61 211.09 In-house 6-359 (359) Show / Hide 
Range on Protein: 1-582
Range on HMM: 6-359/359
Sequence Identity: 12% (85 aa)

MIGKGGFGVVVKSRNKLDC---------------RYYAIKKIKTKGYTDSNQE------------PLTNKLLREVTTLSRLH--HQFVVRYYQAWIEKSC
.||||.||.|.| .|. .|               ...|||... .  . .. |               ...|.|. ......  |...|.|| . . .. 
KIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGH

DSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSLLSNN
.                                                                                                   
N---------------------------------------------------------------------------------------------------

KSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNDSNNNYHSDN
                                                                                                    
----------------------------------------------------------------------------------------------------

ESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDDNENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCS
                                                                                      |. ..|.| |||..
-------------------------------------------------------------------------------------HKNDDELWICMEYMD

KKTLKTLIDNVGGIA--------------EEEAFRLLRQIVEG-LNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNAAN
  .|  .|....|.               |..  . .|||..| |...||..|||||.|||||..     ||. |||.... .. . .. . |     .|
GGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S-----NN

NINLSSSTNSTAQQTPMWDLNDENLSMTGG------VGTPFYCCPEILEKNT----KHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILRDLRDNLK---
 |.                    . . |..      |||| .  ||....|.    |.|.||.|..|||.   ||.      .. ..    .. . .   
-II--------------------DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

------------FPPGFEST--------------------KPDQTQIIRSLLSRDPTQRPSTKQLLE--SGLL
             || ....                     |.  . |.  | .|| .||...|||.     .
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase IfkB.AA Pkinase 363-582 26 9.1e-49 173.13 Pfam 75-293 (293) Show / Hide 
Range on Protein: 363-582
Range on HMM: 75-293/293
Sequence Identity: 26% (69 aa)

LYIQMEYCSKK----TLKTLID--NVGGI--AEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNV----KIGDFGLATSGAPVSKSDDLNSS
.|. |||| .      |...|   . |..   |.|. . ..||..||...||. ||||||||.||.|||. ..    ||.|||||               
IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------

TSNAANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQ---FQTQ------MERSNILRDLRDN
                          .  |  ||. .|||.|. ||..    ..||.||||.|.|.|..||..    |. .       ..  | |...  
--------------------------Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPP

LKFPPGFESTK------------------PDQTQIIRSLLSRDPTQRPSTKQLLESGLL
|.|.   ....                  ..  ..|...| .||..||. .|.|..  .
LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase IfkB.AA S_TKc 1-582 12 2.4e-48 167.86 SMART 6-231 (231) Show / Hide 
Range on Protein: 1-582
Range on HMM: 6-231/231
Sequence Identity: 12% (78 aa)

MIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASEDWFMQS
 ||||.||.| | |.| . |..|||.||                                                                        
KIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------------------------------------------

SINSRSIISRDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKK
                                                                                                    
----------------------------------------------------------------------------------------------------

ISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNDSNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIIN
                                                                                                    
----------------------------------------------------------------------------------------------------

NSGSFDDNENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSK--KTLKTLIDNVGG------IAEEEAFR
                      .      .     .   .|       .           . ||. ||||.    .|...|.. |.      . | .| .
----------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

LLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNAANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFY
...||...|...||..||||||||.||..|.  ..||.|||||.                                               |  .|||.|
YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------------------------TTFCGTPWY

CCPEILEKNTKHYGT-KVDMYSLGIIFFEMCF---QFQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLE-------SGL
. ||.|     .||. |.|..|.|.|..||.     |.   .   ... ..             |.  ..|| .| .||..||.  ..|.          
MAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F
Kinase IfkB.AA CAMKL 2-517 12 8.3e-48 150.56 In-house 7-225 (297) Show / Hide 
Range on Protein: 2-517
Range on HMM: 7-225/297
Sequence Identity: 12% (68 aa)

IGKGGFGVVVKSRN-KLDCRYYAIKKIKTKGYT-DSNQEPL---------TNKLLREVTTLSRLH---HQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGD
.|||.||.|   .. ..  . .||| |. |. . | . .             .. ||.  ...|.   |. ... |. .  ...                
LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEH----------------

LETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTS
                                                                                                    
----------------------------------------------------------------------------------------------------

TSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNDSNNNYHSDNESDSFSGSISMSDGNG
                                                                                                    
----------------------------------------------------------------------------------------------------

SGYEATDDEDIINNSGSFDDNENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPK-ETHTLYIQMEYCSKKT--LKTLIDNVGG
                                                                      . ||  .|. |||||     |   |.. |.
----------------------------------------------------------------------DIETKKIYLVMEYCSGGEMDLFDYIVKHGH

----IAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQ--NVKIGDFGLATS---GAPVSKSDDLNSSTSNAANNINLSSSTNSTAQQTPMWD
    . |.|| |. ||||...|..||. |.|||.|| || .|. .  |.|| |||...    .                                     
RRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-------------------------------------

LNDENLSMTGGVGTPFYCCPEILEK-NTKHYGTKVDMYSLGII
 . ..  ..   |.| |..|||... |....| |||. |.|.|
IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVI
Kinase IfkB.AA CAMK 1-517 11 1.2e-45 144.67 In-house 1-323 (425) Show / Hide 
Range on Protein: 1-517
Range on HMM: 1-323/425
Sequence Identity: 11% (73 aa)

MIGKGGFGVVVKSRNKLDC------------RYYAIKKIKTKGYTDSN----------------------QEPLTNKLLREVTTLSR-------LHHQFV
 .|.|.||.| . ..|..             . .||| |..|  .|..                      ..    ...||.  ...       |.|  .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSS
.. |...  ... .                                                                                      
IKLYEVYEDPHYFK-NT-----------------------------------------------------------------------------------

NTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NNDSNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDDNENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKE
                                                                                                   .
--------------------------------------------------------------------------------------------------ND

--THT---------LYIQM---EYCSKK----TLKTLIDNVGG---------------IAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQ-
  | .         .|. |   ||||       |   |   |.               . |.|| |. |||.......||. |.|||||| || .|.   
YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNND

----------------NVKIGDFGLATSGAP---------VSKSDDLNSSTSNAANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCC-PEILE
                |.|| |||.|.   |         .     . ..                   |   |.  .|.  |.  .||| |.. ||.|.
DSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN-------------------Q---WTTPTEGQKMKTFCGTPEYMAAPEVLN

KN------------TKHYGTKVDMYSLGII
..             . || |.|| |.|.|
GKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase IfkB.AA ULK 68-582 10 1.9e-33 116.08 In-house 118-324 (324) Show / Hide 
Range on Protein: 68-582
Range on HMM: 118-324/324
Sequence Identity: 10% (59 aa)

EKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSL
|                                                                                                   
E---------------------------------------------------------------------------------------------------

LSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNDSNNNY
                                                                                                    
----------------------------------------------------------------------------------------------------

HSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDDNENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQM
                                                                                                    
----------------------------------------------------------------------------------------------------

EYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN------------VKIGDFGLATSGAPVSKSDDLNSSTSNAA
             . . . |.||   ..||..|. ..|...|||||.||.|| | | |             .||.|||.| .    ....... .. |  
-------------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVN--

NNINLSSSTNSTAQQTPMWDLNDENLSMTGGV---GTPFYCCPEILEKN--TKHYG-TKVDMYSLGIIFFEMCF-Q--FQTQMERSNILR--DLRDN---
                       |           ||| | .|.||...   |.|.  |.|..|||.||.|| . .  |...  .. .|.  .| .|   
-----------------------E-------KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKE

---------LKFPP--GFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
         ..||.        |.  ..|| .| .|...| |  ....  ..
QQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase IfkB.AA PEK 484-582 34 8.6e-33 105.95 In-house 646-758 (758) Show / Hide 
Range on Protein: 484-582
Range on HMM: 646-758/758
Sequence Identity: 34% (39 aa)

TGGVGTPFYCCPEILEKN--------TK------HYGTKVDMYSLGIIFFEMCFQ-FQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPT
|..|||. | .|| .  .        |       .|  ||| ||||.||||. .  | |||||  ...||| |...|. | .  |..   |  ..| .|.
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLR-NGQWPKWFTQKYPQEYEFIQQMMSMNPD

QRPSTKQLLESGLL
.||...|.... . 
ERPTADQISMHDFF
Kinase IfkB.AA PEK 2-223 16 4.4e-25 83.71 In-house 7-343 (655) Show / Hide 
Range on Protein: 2-223
Range on HMM: 7-343/655
Sequence Identity: 16% (60 aa)

IGKGGF-GVVVKSRNKLDCRYYAIKKIKTKGYTDS-----------NQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIE-------KSCDSFQSLEEGNE
.||||| |.|.| .|||| .|||||.|| .  ...           .  ..  | ||||.||.||.|. .|||..||||        . |.. .|.. ..
LGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQLDSSTD

DLSGD----------------------------------------------------LETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGANNTA
. .|.                                                    .| . ... . .|. .| .                        
WPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPN-----------------------

GGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSLL--------------------------------------------------------------
     ..| .|  .  ..| |..   ..|.....||                                                                
-----IENQFSINF-GTENENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYS

--------SNNKSKILNTSKSTSTNTSTSTS----TSNTNKNKKISKKKKSKLSPLMKPKNKKNKNN
        ....||....  ..... ...|.    ..| | | . . ...|. .  |. ....|||.
DQDDEHEQNDCQSKQCDSKNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNK
Kinase IfkB.AA PEK 343-470 26 5.3e-25 79.42 In-house 396-559 (758) Show / Hide 
Range on Protein: 343-470
Range on HMM: 396-559/758
Sequence Identity: 26% (46 aa)

NNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLL---RQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN-------------
|| ..... . .. ..   ..||||..| |.||| .. |   . . ...  |    ||.||.| |||  .|||||||.|||   .               
NNNNNKNWKMHPTGNC--IYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSS

-----------VKIGDFGLAT-----------------SGAPVSKSDDLNSSTSNAANNINLSSSTNSTAQQ
           .|||||||.|                 |  |.      |.  .  .. || .       ||
FEENSDGGHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPI------NTHITPIDQIININQQPQQQQQQ
Kinase IfkB.AA GCN2 2-206 19 2.1e-23 78.54 In-house 7-274 (511) Show / Hide 
Range on Protein: 2-206
Range on HMM: 7-274/511
Sequence Identity: 19% (55 aa)

IGKGGFGVVVK-SRNKLDCRYYAIKKIKTKGYTDSNQEPLTNK--LLREVTTLSRLHHQFVVRYYQAWIE-----------------------KSCDSFQ
.|||||| ||| .||..| |||||||.. .    ..|. |. |   .|||..|.||||| ||||||||||                       . ...| 
LGKGGFGQVVKNVRNMHDGRYYAIKKWPIN----WKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESECFS

SLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNS---------------------------------------NVGGANNTAGGGDSV
.  | .  ..   | . .|.   .|..|.|.  .. . ..   . .                                       .|   .. ... .  
GQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWDIESNNVR

SNANSNKSMIVGNNNKKLTLSSSNTSS------SSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKK
.   .. .    ..|  . . ......      ...  .. ...    .|..| . ... . ...|| .......|
DMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQ----NKKKSQQQDKMCQNQHKNKVHYKCMNCK
Kinase IfkB.AA NEK 358-435 31 8.8e-22 73.77 In-house 76-170 (286) Show / Hide 
Range on Protein: 358-435
Range on HMM: 76-170/286
Sequence Identity: 31% (30 aa)

KETHTLYIQMEYCS-KKTLKTL---IDNVG----GIAEEEAFRLLRQIVEGLNHIHSQ-----QIIHRDLKPANIFIDNEQN----VKIGDFGLA
.. ..|.| ||||  . .|  .   | .       . ||.  . . |.. .|...|..      |.|||.||.|||.... |    |||||||..
EQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase IfkB.AA HRI 1-68 52 2.5e-20 67.84 In-house 6-69 (613) Show / Hide 
Range on Protein: 1-68
Range on HMM: 6-69/613
Sequence Identity: 52% (36 aa)

MIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIE
 |||||.| | | |.|||  .||||||| |. |         |..||| .|  | |  .||| |||||
IIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCS----CMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase IfkB.AA HRI 484-582 40 2.2e-19 64.41 In-house 518-613 (613) Show / Hide 
Range on Protein: 484-582
Range on HMM: 518-613/613
Sequence Identity: 40% (40 aa)

TGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
| .|||  |  || |.  .  |  | ||||.|.| ||.   | | ||| ..|  .|   . |       | |   |  |  |   ||||  ||| | | 
TSRVGTCTYASPEQLDGSQ--YDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTG-QIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase IfkB.AA PEK 2-68 44 8.9e-18 54.82 In-house 7-76 (758) Show / Hide 
Range on Protein: 2-68
Range on HMM: 7-76/758
Sequence Identity: 44% (31 aa)

IGKGGFGVVVKSRNKLDCRYYAIKKIKTKG---YTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIE
.|.|||||| .. ||.|  .||||.|  .        | |   .| .||| ||  | |   |||. || |
LGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase IfkB.AA HRI 387-435 49 1.5e-16 54.24 In-house 432-484 (613) Show / Hide 
Range on Protein: 387-435
Range on HMM: 432-484/613
Sequence Identity: 49% (26 aa)

EEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN----VKIGDFGLA
| .. ..  |||||.. ||   |.|||.|| |||     .    |||||||||
EKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLA
Kinase IfkB.AA TyrKc 1-582 8 2.1e-11 -38.12 SMART 6-280 (280) Show / Hide 
Range on Protein: 1-582
Range on HMM: 6-280/280
Sequence Identity: 8% (54 aa)

MIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRL--HHQFVVRYYQAWIEK--------------------SCDSFQSLE
..| | ||.|.| . |   .  |.|..|               ..||   ...|  ||. .|| | . ...                    .....    
KLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

EGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSLLSNNKSKILNT
...                                                                                                 
RPK-------------------------------------------------------------------------------------------------

SKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNDSNNNYHSDNESDSFSG
                                                                                                    
----------------------------------------------------------------------------------------------------

SISMSDGNGSGYEATDDEDIINNSGSFDDNENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTL
                                                                                                    
----------------------------------------------------------------------------------------------------

IDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPV-SKSDDLNSSTSNAANNINLSSSTNSTAQQTPMWDLN
      .  ..      || .| ...||...|||||   |. ..... |||.||||.  .    ..                                 .
------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------------------------------ES

DENLSMTGGVGTP-----FYCCPEILEKNTKHYGTKVDMYSLGIIFFEM---CFQFQTQ-----MERSNILRDLRDNLKFPPGFE--------STKPDQT
..  ..... |.        . || .  |.. . || | .| |.  .|.   . |         |. . .......    |.  .         ..   .
KDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ

QIIRSLLSRDPTQRPSTKQLLESGLL
 |...   .|| .||. ...    ..
-IMKQCWHEDPEDRPTFSEI--HECF
Kinase IfkB.AA NEK 1-71 31 4.4e-10 32.11 In-house 6-80 (286) Show / Hide 
Range on Protein: 1-71
Range on HMM: 6-80/286
Sequence Identity: 31% (25 aa)

MIGKGGFGVVVKSRNKLDCRY-----YAIKKIKTKGYTDSNQEPLTNKLL-REVTTLSRLHHQFVVRYYQAWIEKS--C
.||.| ||.| | | | | .      |..|||.... .. ...    ...  ||  |..|.|. .|.|| ..||.   |
KIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQ----NAQNNEVRILKQLKHPNIVKYYDSFIEEQNNC
Kinase IfkB.AA ULK 1-63 28 2e-09 29.66 In-house 6-81 (324) Show / Hide 
Range on Protein: 1-63
Range on HMM: 6-81/324
Sequence Identity: 28% (22 aa)

MIGKGGFG-VVVKSRNKLD---CRYYAIKKIKTKGYTDSNQEP----LTNKLLREVTTLSRLH---HQF--VVRYY
..||| || .| | ||| .     |.|.|.|  |.  ....|     . ..| .|. ..  |.   |..  .|..|
CLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLY
Kinase IfkB.AA Pkinase 2-70 28 4e-09 33.35 Pfam 7-73 (293) Show / Hide 
Range on Protein: 2-70
Range on HMM: 7-73/293
Sequence Identity: 28% (20 aa)

IGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKS
||.|.||.| | ..| ... .|.|.|| ..  .. .. ...   .|.  . ||.| ..||.| .. .|.
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKD
Kinase IfkB.AA NEK 557-582 42 7.5e-08 24.16 In-house 261-286 (286) Show / Hide 
Range on Protein: 557-582
Range on HMM: 261-286/286
Sequence Identity: 42% (11 aa)

QIIRSLLSRDPTQRPSTKQLLESGLL
..|...| .||.||||..|.||  ..
NLISQMLQKDPEQRPSCNQILEMPFI
Kinase IfkB.AA Pkinase_Tyr 110-435 5 1e-06 23.32 Pfam 102-158 (270) Show / Hide 
Range on Protein: 110-435
Range on HMM: 102-158/270
Sequence Identity: 5% (19 aa)

RDSYSGLSTSNSNVGGANNTAGGGDSVSNANSNKSMIVGNNNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKL
|                                                                                                   
R---------------------------------------------------------------------------------------------------

SPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNDSNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDDNE
                                                                                                    
----------------------------------------------------------------------------------------------------

NDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQI
                                                                      .. . .  ..     .|| .|... .|...
----------------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNC

IHRDLKPANIFIDNEQNVKIGDFGLA
|||||   |. ....  |||.|||||
IHRDLAARNCLVTENNVVKICDFGLA
Kinase IfkB.AA NEK 487-522 47 3e-06 18.41 In-house 185-218 (286) Show / Hide 
Range on Protein: 487-522
Range on HMM: 185-218/286
Sequence Identity: 47% (17 aa)

VGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMC
|||| | .||...   | |. |.|. ||| . .|||
VGTPYYMSPEVCQ--NKPYNNKSDIWSLGCVLYEMC
Kinase IfkB.AA CAMK 559-582 33 7.8e-05 10.72 In-house 402-425 (425) Show / Hide 
Range on Protein: 559-582
Range on HMM: 402-425/425
Sequence Identity: 33% (8 aa)

IRSLLSRDPTQRPSTKQLLESGLL
||..| .||..|.. .| |.   .
IRKMLQVDPEKRMTIEQCLNHPWM
Kinase IfkB.AA CAMKL 557-582 26 0.000132 10.45 In-house 272-297 (297) Show / Hide 
Range on Protein: 557-582
Range on HMM: 272-297/297
Sequence Identity: 26% (7 aa)

QIIRSLLSRDPTQRPSTKQLLESGLL
..||..| ..|..||. .|...   .
DLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase IfkB.AA Pkinase_Tyr 1-63 24 0.109284 6.34 Pfam 6-70 (270) Show / Hide 
Range on Protein: 1-63
Range on HMM: 6-70/270
Sequence Identity: 24% (18 aa)

MIGKGGFGVVVKSRNKLDCRYY----------AIKKIKTKGYTDS-NQEPLTNKLLREVTTLSRL-HHQFVVRYY
..|.| ||.|.|      ....          |.|..   |.... |   .  ...||. ... | ||. .||.|
KLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLY
HGTP_anticodon IfkB.AA HGTP_anticodon 1027-1119 15 1e-06 27.81 Pfam 1-95 (95) Show / Hide 
Range on Protein: 1027-1119
Range on HMM: 1-95/95
Sequence Identity: 15% (15 aa)

EVFVCSLGS---SLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENGIPWVVILREKAFQIGKLKVKQIETRQERTVARKDLVDFFLKSR
.|.|  ..     .. . . ....|. |||....  .. ..    . .. . |||..... ..  . |...|.  .|..  |... ..|.. .|..
QVVVIPVNEKAEKHMDYAQKLYQELRDAGIRVEVDDRRNERIGKKFRDWDLIGIPYMIVVGDRELENGTVTVRDRDTGEQYTMSIDEFVEW-IKEL