Gene IreA (Slime mold)

IreA

Species: Slime mold
Alias: DDB0231217, DdisK091, IreA
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IreA.AA Protein None 984 None Fasta, JSON
IreA.kin_dom Protein Kinase Domain None 277 None Fasta, JSON

Protein domain

Protein domains of IreA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IreA.AA IRE 578-851 47 3.9e-164 551.56 In-house 1-292 (292) Show / Hide 
Range on Protein: 578-851
Range on HMM: 1-292/292
Sequence Identity: 47% (142 aa)

NKILGTGSCGTIVYEGKMEGRK-VAVKRMLSQFVKFADREVSILI--HSDEHTNVVRYYAKEEDDEFIYLAISFCQKSLDMYVQQTLSLQISPTDSPSIQ
|.|||.|..||.|..|...||. ||||.|...|..|..||...||  .||.|.||.|||..||||.|.|||...||.||..||.|........       
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFIN-------

SSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDP--------NNRVKISDMGLGKLLDNDDQSLTF-----TSDSH
||||..|.|..|||||||..|.....|.| ....||.||||.||||||.||||.||..        |||..|||.||.| |.....|.|.     .....
SSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTW

GWQPAEYLNG--TNRNTKKVDIFSLGCVVYYLLT-GAHPFG-HRYNREKNVLKGKFDIDQIKHLPDIH-----QLVHSMIQFEPEKRPDIGECINHPFF
||.|.|.|..  ..|.||.|||||.|||.||..| |.|||| ....|..|.||||...||.||....|     .|.|.||...|.|||.|.||.|||||
GWHPPEMLQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
Kinase IreA.AA Ciliate-E2 575-851 20 2e-50 171.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 575-851
Range on HMM: 1-365/365
Sequence Identity: 20% (80 aa)

IITNKILGTGSCG-----TIVYEGKME-------------------GRKVAVKRMLSQFVKFADREVSIL--IH-------------SDEHTNVVRYY-A
.. .|..|.|. |     .   ..|..                   . ..|.|.|  . ...  .| .|.  |.             .. | |....| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KEE-DDEFIYLAISFCQK-SLDMYVQ--QTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFK---------------GLEHLHS
 .| ||. |||   .||  .|  | .  .. .... .                        . . ... |... ....               .||.|||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE--------------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS

LN-IVHRDIKPHNVLIDPNNRVKISDMGLGKLLDNDDQ---------SLTFTS-----------------------DSHGWQPAEYLNGTNRNT------
 | |.|||||| |.|.     .||.|.|| | .|.| |          ..| .                        . | .. | ||| . ..      
KNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKG

--KKVDIFSLGCVVYYLLTGAHPFGHRYNREKNVLKGKFDID----------------QIKHLPDI-HQLVHS----MIQFEPEKRPD-IGECINHPFF
  .|.||.|||.. |..|.| .||      ... ...|.|..                  |....   .|       |.| .||||.. . ...|||.|
YDYKCDIWSLGVILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase IreA.AA Pkinase 575-851 22 1.4e-44 158.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 575-851
Range on HMM: 1-293/293
Sequence Identity: 22% (72 aa)

IITNKILGTGSCGTIVYEGKMEGRK--VAVKRMLSQFVKFADR-------EVSILIHSDEHTNVVRYYAKEEDDEFIYLAISFCQK-----SLDMYVQQT
. . ...| || |.  |...  |    ||||..  .  |   .       |..|. .   | |.||.|   ||.  ||.   .|..     .|  |..  
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

LSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQII--IDNKTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNNRV----KISDMGLGKL--LDNDDQ
                             ..  .   ..  | .......|||..|| .|.|||.|| |.||| |. .    ||.| || |.  . |.  
----------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-

SLTFTSDSHGWQPAEYLNGTNRNTKKVDIFSLGCVVYYLLTGAHPFGHR--------YNREKNVLKGKFDIDQIKHL--------------------PDI
  ||.  . .. . | ..| .  ..|||..|.||..|..|.|  || ..        . . ......... |  .                      .. 
MTTFCG-TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

HQLVHSMIQFEPEKRPDIGECINHPFF
 ... ..... |.||| . .. .||.|
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase IreA.AA CAMK 580-851 16 3.4e-41 130.03 In-house 1-425 (425) Show / Hide 
Range on Protein: 580-851
Range on HMM: 1-425/425
Sequence Identity: 16% (76 aa)

ILGTGSCGTIVYEGKME-G-------------RKVAVKRML------------------------------SQFV-KFADREVSILIHSDE------HTN
.||.|| | .|....                 .|||.| .                               ...  |.  ||..|. .  .      | |
TLGRGSFG-KVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VVRYYAKEED-------------------DEFIYLAI---SFCQKS------LDMYVQQ--------TLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQ
... |   ||                   |...|.      .|.        .|. |..                                         
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ------------------------------FD

IIIDN------KTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPN-----------------NRVKISDMGLGKLLDN--------------------
|. ..       .....  .  .....||.||||||.|| |.|.| |                 | .||.| |. . .|                     
IV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWT

---DDQSLTFTSDSHGWQP-AEYLNG-------------TNRNTKKVDIFSLGCVVYYLLTGAHPFGHR---------------YNREKNVLKGKFDID-
   ..| ..    . .  .  | |||                 ..|.|. |.|.. | .|.|  || .                |.  ....|||.| . 
TPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPP

-QIKHLP---------------------DIHQLVHSMIQFEPEKRPDIGECINHPFF
 ......                     .  .|. .| | .||||. | .| |||..
PYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IreA.AA S_TKc 575-851 22 5.9e-41 143.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 575-851
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

IITNKILGTGSCGTIVYEGKMEG--RKVAVKRMLSQFVKFADREVSILIHSDEHTNVVRYYAKEEDDEFIYLAISFCQK---SLDMYVQQTLSLQISPTD
    ...| |. |. || ..  .  |.||.|..     . . ||..|| .   | |.|..|   .| ...|.   .|     .|  | ..  .       
YEILRKIGKGAFGK-VYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR-------

SPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNNRVKISDMGLGKLLDNDDQSLTFTSDSHGWQPAEYL
                  . ... .    .. .. .....||..||..|.|||.|| |.|.|   ..||.| || ..|       |    .  . . | |
------------------HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL

NGTNRNTK-KVDIFSLGCVVYYLLTGAHPFGHRYNREKNVLKGKFDIDQIKHLPDIHQLVHSMIQFEPEKRPDIGECIN-------HPFF
      .| |.|. |.||..| .|.|  ||   ...  ....           |.  ...  . |..||||| . |. .       ||.|
----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IreA.AA Ciliate-E2-Unclassified 575-851 18 2.6e-40 137.53 In-house 1-352 (352) Show / Hide 
Range on Protein: 575-851
Range on HMM: 1-352/352
Sequence Identity: 18% (68 aa)

IITNKILGTGSCGTIVYEGKMEGRKVA-------VKRMLS-QFVKFADREVSILIHSDE---------------------HTNVVRYYAKEEDDEFIYLA
 . .|..|.|. | .||. . .  | .       .... . . ... |... ....  .                     | ..|...  ..|.. ||. 
YKIIKQIGQGGFG-KVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

ISFC-QKSLDMYVQQTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTK-----QMILELFKGLEHLHSLN-IVHRDIKPHNVLIDPNN---R
  .| ...|  | ..  ....       .        .  ..|.....|. ....|     ... .. .|||.||. | |.|||||| |.|.| |.   .
MEYCEGGDLWQYIKKRKKQKQ-------K-------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYY

VKISDMGLGKLLDND---------------DQSLTFTSDSHGWQ----PAEYLNGTNRNT---KKVDIFSLGCVVYYLLTGAHPFGHRY-----------
.||.| |. | ....               .| .. .. . . .    . |.| | | ..   .|.||.|||.. |..|.| .||. .            
IKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQW

-------NREKNVLKGKFDIDQIK------HLPDIH-----QLVHSMIQFEPEKRPDIGECINHPFF
       . ..| ........  .      |...       .| ..|..  |.||... . .|||.|
INNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IreA.AA STE 576-851 15 7e-34 117.05 In-house 1-359 (359) Show / Hide 
Range on Protein: 576-851
Range on HMM: 1-359/359
Sequence Identity: 15% (61 aa)

ITN-KILGTGSCGTIVYEGKME----------------GRKVAVKRML--------------------SQFVKFADREVSILIHSDE-HTNVVRYYAKEE
 .. ...| |..|| ..  ...                |. .|.|.|                     .. ..   .|..|. ...  | |.|.||  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD-------EFIYLAISFCQ-KSLDMYVQQTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKG-LEHLHSLNIVHRDIKPHNV
..       . ....  ..   |||  .... . . . . .                    .. .  .  . .. .. || |..|||..|.|||||| |.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ----------------H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANI

LIDPNNRVKISDMGLGKLLDN-----------------DDQSLTFTSDSHGWQPAEYLNGTNRNTK------KVDIFSLGCVVYYLLTGAHPFGHRYNRE
|.     ||..| |. . |..                 . .. ||.     |   | ... ... .      |.|| ||||..  ..|| .|.   .. .
LL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMR

KNVLKGKF---------------DIDQIKHL---------------------PDIHQLVHSMIQFEPEKRPDIGECIN--HPFF
   .. .                .. ....                      |. .. .    | .|.|||.  . ..  |||.
AMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase IreA.AA TKL 581-849 16 1.4e-32 114.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 581-849
Range on HMM: 1-364/364
Sequence Identity: 16% (66 aa)

LGTGSCGTIVYEGKMEG----------RKVAVKRMLSQFVKF----------------------------ADREVSILIHSDE-HTNVVRYYA--KEEDD
.| |. | .|| ||  |          . ||||.. |. ...                              .|. |...|   | |.|....  .....
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

EF-----------IYLAISFC-QKSLDMYVQQTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKGLEHLHSLN--------IV
             ...   .|   ||  |..                                      ... ...|.  .|...||| |        |.
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPII

HRDIKPHNVLIDPNNR--------------VKISDMGLGKLLDNDDQ-------------------SLTFTSDSHGWQPAEYLNGTNRNTKKV-------
|||.|..|.|.| |..              .||.|.|| . .... .                    .     . .| . | |.|.. .|.||       
HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK

--------DIFSLGCVVYYLLTGAHPFG-HR--------------YNREKNVLKGKFD---------IDQIKHLPDIHQLVHSMIQFEPEKRPDIGECIN
        |..| | | . .||. .|.  .               . . .. |.   .          .    .|.. .|     . .|||||   |.. 
GFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK

HP
. 
RL
Kinase IreA.AA CMGC 575-748 17 6.2e-21 64.69 In-house 232-486 (513) Show / Hide 
Range on Protein: 575-748
Range on HMM: 232-486/513
Sequence Identity: 17% (48 aa)

IITNKILGTGSCGTIVYEGKM----------------EGRKVAVKRMLSQFVKFAD---------------REVSILIHS----------------DEHT
    | .| |. | .||...                  ...||.|.. ..| .  .               ||..|| |                 . | 
YEIIKKIGEGTYG-VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NVVR----YYAKEED-------------DEFIYLAISFCQKSLDMYVQQ-----------TLSLQI-------SPTDSPSIQSSNNNGNGNNGNNNNNNQ
|.|.    .| |..|             .. .||   .....|  | ..            ||          .|                     .| .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP--------------------PHNIK

IIIDNKTKQMILELFKGLE--HLHSLN--IVHRDIKPHNVLIDPNNRV--------------------KISDMGLGKLLD
 ..    . ..  ...||.  ..|| .  |.|||.|| |.||..|...                    || | || . ..
YFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYH
Kinase IreA.AA ULK 575-757 21 2.5e-20 67.71 In-house 1-206 (329) Show / Hide 
Range on Protein: 575-757
Range on HMM: 1-206/329
Sequence Identity: 21% (50 aa)

IITNKILGTGSCGTIVYEGK---ME---GRKVAVKRMLSQ-FVKFA------------DREVSILIHSD-------EHTNVVRYYAKEEDDEF--IYLAI
.. |..|| || |  ||.|.    .   . |||.| ...| . ..             ..|. |.   .        | |.|..|   |.. .  ||.  
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

SFCQK-SLDMYVQ--------QTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNN---
 .|.   |. | .        . .                            .....  ....| .  .  |. .||. ||.|||||| |.||. ..   
EYCNGGDLEQYIKKNKKLPEDT-E----------------------------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT

---------RVKISDMGLGKLLDND----DQSLTFT
         ..||.| |..| .|||    .. .|..
DSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCV
Kinase IreA.AA ULK 575-757 21 2.1e-17 58.34 In-house 1-198 (324) Show / Hide 
Range on Protein: 575-757
Range on HMM: 1-198/324
Sequence Identity: 21% (49 aa)

IITNKILGTGSCGTIVYEG---KME--GRKVAVKRMLSQ-FVKFADR------------EVSILIHSDE--HTN--VVRYYAKEEDD--EFIYLAISFCQ
.. |..|| || |  ||.|   | .  . .||.| .  . . |.  .            |..|.   .|  | |  .|..|   |..   .||.   .|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

K-SLDMYVQQT------LSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNN---------
   |. | ..       .                            .....  ....| .  .  |. .||. ||.|||||| | ||  ..         
GGDLEQYIKKNKKLPETE----------------------------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVH

---RVKISDMGLGKLLDNDDQSLTFT
   ..||.| |..| .||.... . .
PNGVLKIADFGFAKHVDNNNMEQQMC
Kinase IreA.AA CAMKL 769-851 27 6.4e-16 47.14 In-house 205-297 (297) Show / Hide 
Range on Protein: 769-851
Range on HMM: 205-297/297
Sequence Identity: 27% (26 aa)

LNG--TNRNTKKVDIFSLGCVVYYLLTGAHPFGHRYNR---------EKNVLKGKFDIDQIKHLPDIHQLVHSMIQFEPEKRPDIGECINHPFF
..|  .  . .|||| |.| . | ...|. ||    .          .. . .| . ..  .|..| ..| ..| |  ||||| | .  |||..
FQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase IreA.AA ULK 775-851 22 1.9e-14 47.7 In-house 229-324 (324) Show / Hide 
Range on Protein: 775-851
Range on HMM: 229-324/324
Sequence Identity: 22% (22 aa)

NTKKVDIFSLGCVVYYLLTGAHPFGHRYNREKN----------------VLKGKFDID---QIKHL-PDIHQLVHSMIQFEPEKRPDIGECINHPFF
...|.||.||||. |..|.|  ||  . ... .                . . .....   ..... |....|   |.|.....| .. | .|||.|
YDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase IreA.AA CAMKL 709-744 47 6.1e-14 40.73 In-house 139-176 (297) Show / Hide 
Range on Protein: 709-744
Range on HMM: 139-176/297
Sequence Identity: 47% (18 aa)

GLEHLHSLNIVHRDIKPHNVLIDPNN--RVKISDMGLG
.....||..|||||||| |.|.| |.   .||.| |..
AVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase IreA.AA TyrKc 575-851 21 3.7e-13 -9.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 575-851
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

IITNKILGTGSCGTIVYEGKMEGRKVAVKRML-SQFVKFADREVSILIHS-DEHTNVVRYYAKEEDD-------EFIYLAISFCQK-SLDMYVQQTLSLQ
|  .|.|| |  | .||.|..  ..|||| .  .  ..   || .|. .   .| |.|| |.   ..       | ...   .. . .|. | . .    
ITLGKKLGEGAFG-EVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

ISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNNRVKISDMGLGKLLDND------DQSLTFTS
                             .   .  .. .   .| |.||| |..|||.   |.|.. |..||||| || . ...|      ..  . ..
-----------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE

--DSHG-----WQPAEYLNGTNRN--TKKVDIFSLGCVVYYLLT-GAHPFGH-----RYNRE-KNVLKGKFDIDQIKH---------LPDIHQLVHSMIQ
  ....     | . | .   | .  | | |..| | . . ..| |. |          |.|  . .|  .  .| ..          ....|.  .  .
HKGGKTMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

FEPEKRPDIGECINHPFF
..||.||   |.  | .|
EDPEDRPTFSEI--HECF
Kinase IreA.AA ULK 775-851 23 4.2e-12 38.61 In-house 233-329 (329) Show / Hide 
Range on Protein: 775-851
Range on HMM: 233-329/329
Sequence Identity: 23% (23 aa)

NTKKVDIFSLGCVVYYLLTGAHPFGHRYNREKN-----VLKGK------------FDID----QIKHLPDIHQLVHSMIQFEPEKRPDIGECINHPFF
...|.||.||||. |..|.|  ||    ... .      |. .            ....    ...  |....|   |.|.....| .. | .|||.|
YDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase IreA.AA CMGC 827-851 36 5.6e-08 21.32 In-house 489-513 (513) Show / Hide 
Range on Protein: 827-851
Range on HMM: 489-513/513
Sequence Identity: 36% (9 aa)

LVHSMIQFEPEKRPDIGECINHPFF
|.  | |..|.||. . .. .||.|
LLKKMLQYDPDKRITAEQALQHPYF
Kinase IreA.AA Pkinase_Tyr 575-752 26 2.2e-07 25.66 Pfam 1-166 (270) Show / Hide 
Range on Protein: 575-752
Range on HMM: 1-166/270
Sequence Identity: 26% (52 aa)

IITNKILGTGSCGTIVYEGKME------GRKVAVKRM-----LSQ--FVKFADREVSILIHSDEHTNVVRYYAKEE-DDEF--IYLAISFCQK-SLDMYV
|. .| || |. |. ||.|..       . .|||| .      .|    .|   |..|. .   | |.||.|.    ..|   ||.   .... .|. | 
ITFGKKLGEGAFGE-VYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QQTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTKQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNNRVKISDMGLGKLLDNDDQ
..                             ...| .      || ..  ||.|.|.| |..|||.   |.|.. || |||.| || ... |||.
RKHR---------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
Kinase IreA.AA CMGC 776-820 21 0.002243 5.92 In-house 313-365 (513) Show / Hide 
Range on Protein: 776-820
Range on HMM: 313-365/513
Sequence Identity: 21% (13 aa)

TKKVDIFSLGCVVYYLLTGAHPFGHRYNRE-----KNVLK-----------GKFDIDQIKH
|...|. |.||. . ..||          .     |   .           || .|||...
TTPIDMWSVGCIFAEMYTGYQ--------SLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFK
Ribonuc_2-5A IreA.AA Ribonuc_2-5A 856-984 38 1.6e-43 155.71 Pfam 1-136 (137) Show / Hide 
Range on Protein: 856-984
Range on HMM: 1-136/137
Sequence Identity: 38% (53 aa)

KKLSFLVAASDYLEFEKPT--SPLNLEIDSHVDLVTDGSGDWWLKIDQVLIDNIGRY-RK---YNGKSIRDLLRVIRNKFNHYRDL-SPEEQTCLGILPD
|.|.||  .||..|.|     ||.  . ...   |. |.|||  |||....|..|.| ||   |.| |.|||||..||| .||... ..| .  || |||
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVV-GFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPD

GFFNYFDLKFPQLFIVTYLFILK-NLKNDQYFVQYYY
||..||. .||.|.. .| .. . .... . | .||.
GFLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYK
PUG IreA.AA PUG 916-971 33 3.7e-13 50.95 SMART 1-66 (66) Show / Hide 
Range on Protein: 916-971
Range on HMM: 1-66/66
Sequence Identity: 33% (22 aa)

KSIRDLLRVIRNKFNHYRDL--------SPEEQTCLGILPDGFFNYFDLKFPQLFI--VTYLFILK
 |.|||||..||. .|.|..         .. .. .| .|.|| .|| ..||.| |   . .|..|
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK