Gene Scy1 (Slime mold)
Scy1
Sequence
Protein domains of Scy1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Scy1.AA | SCY1 | 34-264 | 26 | 1.8e-101 | 343.43 | In-house | 1-337 (337) | Show / Hide |
Range on Protein: 34-264
Range on HMM: 1-337/337
Sequence Identity: 26% (88 aa)
WTLHSGTKKEDGSAVSIFSFDIK--------KNPS-KLEVAKNGFKRAKTTRHPNVLKYLDGLETETN--IYIVTEPIQLLDELLEDIRN----------
|..|.||||..|...|.|.||.| .... . |..|. .|| |..||||.|.|...||.... .|...|..| |...|....|
WKIHNGTKKYTGQECSVFVFDKKNIEKWHKDSWWEEICEFLKKQAKRLKRLRHPNILQYIHPLEESKDCMMYATEEIFQPLENVLKKWDNKKSCQTQKTQ
---------------------FENAISWGLYQEG--LSFLNNKCNLTHGNIQSSSIFVNKGGDWQIGG---------LDFVSDVKDINNSILRNHNDLI-
.|. ..||..| ||||.|.|...|.||. .||||||.|||.||| .|||.|... |......... .
DVDFGQNTQPQRPYHKKDWKLDELEVCWGIFQILDALSFLHNDCHMVHNNICPESIFVNKNGDWKIGGDDDDAGGWGMDFVCDIQNGNPQMPWFPCQEWR
------------PNKYKSPEIMKSQWQQIQQSPS-----------------YSIDSWMLGCLMYECYNGTMTKAEDIKNL-------------------D
.|||..|......|........ ...| ..||||....|||....... .|. |
EMDYISVSSTKPDNKYPPPCQPNPDWLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWWD
QIPKQLHQA----YQKSFAVKTESRLNPQKFLESPYF
.|||.|... |.. .......| .||.||...||
HIPKELQEHLGHCYCHLLHQDPTCRPDPQQFLQHCYF
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| S_TKc | Scy1.AA | S_TKc | 19-264 | 14 | 1.8e-07 | -67.41 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 19-264 Range on HMM: 1-231/231 Sequence Identity: 14% (41 aa) YNIGPIV----TGYVGKSIWTLHSGTKKEDGSAVSIFSFDIKKNPSKLEVAKNGFKRAKTTRHPNVLKYLDGLETETNIYIVTEPIQL----LDELLEDI | |. .. | | | ... .| | | . | ... . | .|||. |..| .. ...|.|.| . | ..... YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR RN------FENAISWGLYQE---GLSFLNNKCNLTHGNIQSSSIFVNKGGDWQIGGLDFVSDVKDINNSILRNHNDLIPNKYKSPEIMKSQWQQIQQSPS . | . . .. .| .. .. . | . . |.... |. . . . | .||.. . . GRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---------GYG Y-SIDSWMLGCLMYECYNGTM---TKAEDIKNLDQIPKQLHQAYQKSFAVKTESRLNPQKFLE-------SPYF . ..| | .||..||.. | . .. .|.. .... . .| . . | |. . |. |.| KCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Scy1.AA | Ciliate-E2-Unclassified | 77-264 | 17 | 2.7e-05 | 14.34 | In-house | 80-352 (352) | Show / Hide |
Range on Protein: 77-264
Range on HMM: 80-352/352
Sequence Identity: 17% (47 aa)
HPNVLKYLDGLETETNIYIVTEPIQ--LLDELLEDIRN-----------------F-ENAIS-----WGLYQ--EGLSFLNNKCNLTHGNIQSSSIFVNK
||...|... ... |||||.| .. | . ... . | |.... ..| .||..| | | | .|. . |....
HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDN
GG---DWQIGGLDFVSDVKDINNS---------ILRNHND---LIPNKYK----SPEIMKSQWQQIQQSPSYSIDSWMLGCLMYECYNGT----MTKAED
.| | .. . . .. ||. |..... . |. .||....| . . . |..| | ||...||. |. .. |.
NGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA--YKCDIWSLGVILYEMLFGYYPFYDNNCEQ
----------------IKNLDQ-------------IPKQLHQAYQ--------KSFAVKTESRLNPQKFLESPYF
... . |||.... .. | . .. ..|..... |. |.|
HQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | Scy1.AA | Ciliate-E2 | 77-264 | 15 | 3.5e-05 | 13.73 | In-house | 91-365 (365) | Show / Hide |
Range on Protein: 77-264 Range on HMM: 91-365/365 Sequence Identity: 15% (45 aa) HPNVLKYLDGLE--TETNIYIVTEPIQL--LDELLEDIRNF-------------ENA--ISWGLYQ--------------EGLSFLNNKCNLTHGNIQSS |||..|. . . ...|||.|.| .| | ..... . . . . |.. . | ..| .| .| | | .| . HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE SIFVNKGGDWQIGGLDFVSDVKDINNSIL--RNHNDLIPNK---------------------------YKSPEIMKSQW---QQIQQSPSYSIDSWMLGC |.. | . . ...| |. .. . .. .. | |..||| ... || |. .|..| | ||. NILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV LMYECYNGTMTKAEDIKNL------------------------DQIPKQLHQAYQK----SFAVKTESRLN-PQKFLESPYF ..||. | .... ...... . .| . .. | |.. ... |. |.| ILYEMLFGKPPF-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | Scy1.AA | Ciliate-E2c | 73-98 | 34 | 0.000106 | 12.5 | In-house | 69-94 (310) | Show / Hide |
Range on Protein: 73-98 Range on HMM: 69-94/310 Sequence Identity: 34% (9 aa) KTTRHPNVLKYLDGLETETNIYIVTE |.. ||...|. | |. .||...| KHMNHPHIIKFYDAKQTDKHIYLIME |
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| Kinase | Scy1.AA | ULK | 76-98 | 48 | 0.000116 | 12.29 | In-house | 76-100 (329) | Show / Hide |
Range on Protein: 76-98 Range on HMM: 76-100/329 Sequence Identity: 48% (12 aa) RHPNVLKYLDGLETE--TNIYIVTE .|||. |..| .|| .||||..| HHPNIVKLYDWFETSNHNNIYIIME |
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| Kinase | Scy1.AA | ULK | 73-98 | 39 | 0.000146 | 12.18 | In-house | 65-97 (324) | Show / Hide |
Range on Protein: 73-98 Range on HMM: 65-97/324 Sequence Identity: 39% (13 aa) KTTR---HPN--VLKYLDGLETE--TNIYIVTE |. ||| . |..| .|| .||||..| KKLKELKHPNHHIVKLYDWFETSNHNNIYIIME |
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| Kinase | Scy1.AA | Ciliate-E2a | 76-98 | 43 | 0.000201 | 8.96 | In-house | 57-79 (275) | Show / Hide |
Range on Protein: 76-98 Range on HMM: 57-79/275 Sequence Identity: 43% (10 aa) RHPNVLKYLDGLETETNIYIVTE .|||..| . |.|.|.|.|.| DHPNIIKLYEVYEDENNYYLVME |
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| HEAT | Scy1.AA | HEAT | 422-452 | 25 | 0.002703 | 15.27 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 422-452 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) LLKYFAALQKDQQAGVRCNTTICLGRITEYM .| .. . .|. . ||... |||.. |.. ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | Scy1.AA | HEAT | 461-491 | 19 | 7.001386 | 3.45 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 461-491 Range on HMM: 1-31/31 Sequence Identity: 19% (6 aa) LIPAFSTALKDPFVPSQNAAIQAFMFTISNY ..|.. ..|.|| . ||.... .... ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | Scy1.AA | HEAT | 500-530 | 16 | 0.005768 | 14.13 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 500-530 Range on HMM: 1-31/31 Sequence Identity: 16% (5 aa) VIPEVSRMLISPEKSIRTSAFTAINMFLQKI ..| . ..| .|. ..| .|. .. ..... ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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