Gene DPYK4 (Slime mold)

DPYK4

Species: Slime mold
Alias: DDB0229958, DPYK4, DdisK152
External Links: DictyBase Link ,
Annotation: Secondary Group: TKL, Secondary Family: CZAK

Classification

Group: STE
Family: Dicty3
Subfamily: NZAK

Sequence

Name Sequence Type Origin Length Description Download
DPYK4.AA Protein None 635 None Fasta, JSON
DPYK4.kin_dom Protein Kinase Domain None 236 None Fasta, JSON
DPYK4.kin_dom2 Protein Kinase Domain None 276 None Fasta, JSON

Protein domain

Protein domains of DPYK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DPYK4.AA NZAK 9-244 48 2.7e-146 492.33 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-244
Range on HMM: 1-329/329
Sequence Identity: 48% (158 aa)

WEEISSIGSCNSKSRVLKCRKKNGLIENEKVDIVAVKIINKKFFKRNETDILEKIRLFNIPRYYS----HAEDDNYIYIYMEYIE----------DKKQL
|||||.||.|...|||.||||||..|.||.||.|..|||.|..|...|||||||||.||||||||    |||||||..||||..|          |||||
WEEISFIGGCQFFSRVKKCRKKNTEIANEQVDKVHCKIITKCDFFYHETDILEKIRHFNIPRYYSACIKHAEDDNYHCIYMEWMEGGNLTQFLMNDKKQL

RFKESEIISMIADLTETLSFLHKHQILHRDIKPSNIILDKNGVLKLIDFGSSIIDQQQ-------------------------------------DDGDN
||||..||.||||..||.|.||||.|.|||||..|.|||.|..|||||||||||.||.                                     ....|
RFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLIDFGSSIIQQQYQFEQYLNETTNNNNNPNNNNNNNNNNNNNNNNNNNNNENNNN

IC-----------------------KESSFAITGTHTYMAPEVKKLHRSTKKSDVWSLGCTVLEIVGGNPK---------------KIFDGIPIIPNHVS
||                       |||.|||.|||.|||||.|..||...||||||.||||....|.||.               ..|..||.||.||.
ICDFGNNNDLNGSGSGISTYLSSNQKESKFAIGGTHHYMAPENKNNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVP

EIMVDFIKRCLIIDPNKR----SHMEELL
..|.|||..|..|||.||    |||.|.|
DKMKDFITQCWDIDPKKRPKDFSHMIEKL
Kinase DPYK4.AA Dicty3 13-244 31 7.89999999999e-125 414.23 In-house 1-351 (351) Show / Hide 
Range on Protein: 13-244
Range on HMM: 1-351/351
Sequence Identity: 31% (112 aa)

SSIGSCNSKSRVLKCRKKNGLIENEKVDIVAVKIINKKFFK-----RNETDILEKIRLFNIPRYYS--HAEDDN--YIYIYMEYIE--------------
.|||.|....||.||.|.|. |....|||...|||||..|.     |.|..|..|.|...|..||.  ...|.|  ..||||||||              
WSIGGCGNFGRVKKCHKNNCIINIKMVDICHIKIINKCDFNEVNNWRHEKIINKKMRHPCIVKYYGACYCCDNNNDNHYIYMEYIEGEIPISFVKTNNML

-DKKQLRFKESEIISMIADLTETLSFLHKH-QILHRDIKPSNIILDKNG--------------------------VLKLIDFGSSIID----QQQ-----
 ..|..||.|.||...|.||..||...||. .|.|||||. ||.||..                           ..|||||| |...    ...     
KKHKNNRFNEHEISKIICDLVKTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDIQCYYSNEINWKLIDFGLSKNISYYSNNNNNNNY

--------------------------------DDGDNIC---------KESSFAITGTHTYMAPEVKKLHR--STKKSDVWSLGCTVLEIVGGN---PKK
                                .....|.         |.....|.||..|||||.|. ..  ...|||.|||||||.|.||||   ...
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNNNVKIINNNIYSNKQYKQKCYSICGTIHYMAPEIKLNNQCCACRKSDIWSLGCTVWEMVGGNLCHCEQ

IFD-------------GIPIIPNHVSEIMVDFIKRCLIIDPNKRSHMEELL
 ..             .||.||.|||.....||..|..||||.|..|.||.
DINEMAFMVNDNKQNIWIPQIPDHVSNFCKNFIQHCWQIDPNHRWDMHELI
Kinase DPYK4.AA STE 9-249 23 1.7e-62 213.94 In-house 1-359 (359) Show / Hide 
Range on Protein: 9-249
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

WEEISSIGSCNSKSRVLKCRKKNGLIE--------NEKVDIVAVKIINKKFFK----------------RNETDILEKIRLFNIP--------RYYSHAE
|| |. ||. .. . ......||. |.        .|...|.|.|..|..  .                 .. .||. |.. .          .|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD-------NYIYIYMEYIE--------DKKQLRFK-------------ESEIISMIADLTET-LSFLHKHQILHRDIKPSNIILDKNGVLKLIDFGSSI
..       ....|.|||..        ..|  ..|             ||.|. .. .. .  |..||.|.| ||||||.|| |      ||.||| . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IDQQQDDGDNI-----------CKESSFAITGTHTYMAPEVKKLHRST------KKSDVWSLGCTVLEIVGGNPK----KIF------------------
  | .|...||           ... .  ..||  .||||| .  ...       |.|.||||||..| . |.|     . .                  
--QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-----DGIPIIPN-------------------HVSEIMVDFIKRCLIIDPNKRSHMEELLT--HRLI
     ...| .|.                   ..|. . |||..||..|||||   ..||   |  |
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase DPYK4.AA S_TKc 9-249 30 1.4e-44 155.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-249
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

WEEISSIGSCNSKSRVLKCRKKNGLIENEKVDIVAVKIINKKFFKRNETDILEKIRLFNIPRYYSHAEDDNYIYIYMEYIED---------KKQLR----
.| .  ||.    ..| |||.|.         |||.|||.     |.| .||.| .  || ..| . .| ...|. |||..          ||. |    
YEILRKIGKGAF-GKVYKCRHKK------TGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FKESEIISMIADLTETLSFLHKHQILHRDIKPSNIILDKNGVLKLIDFGSSIIDQQQDDGDNICKESSFAITGTHTYMAPEVKKLHRSTK-KSDVWSL
  | | .. .... . . | ..|.|.|.|||.||.|| ||.  ..|..|||.. .                 . ||  ||||||      .| |.|.||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GCTVLEIVGGNP-----KKIFDGIPIIPNHVSEIMVDFIKRCLIIDPNKRSHMEELLT-------HRLI
||.. | . | |     ...|. |       |. . |||..||  ||.||    |.|.       |  .
GCILYEMLCGYPPFPQMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DPYK4.AA Ciliate-E2 35-249 22 8.8e-43 144.67 In-house 43-365 (365) Show / Hide 
Range on Protein: 35-249
Range on HMM: 43-365/365
Sequence Identity: 22% (75 aa)

ENEKVDIVAVKIINKK--FFKRNETDILEKIR-----LFN------------IPRYYSHAE--DDNYIYIYMEYIEDK-------------------KQL
|  |. |.|.||..|.  ... .| .|. .|.     . |            | ..| . .  |||.||. |||.. .                   . .
EKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-K

RFKESEIISMIADLTE---------------TLSFLHKHQ-ILHRDIKPSNIILDKNGVLKLIDFG-SSIIDQQQDDGD-----NICKESS---------
.|.| ||. ... ...                | .||.   |.||||||.||..     .|.|||| | ..|......      ..... .         
YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGY

----------FAITGTHTYMAPEVKKL---------HRSTKKSDVWSLGCTVLEIVGGNP---KKIFDGIPIIP------------------NHVSEIMV
          . | ||  |||||. .          .. ..|.|.||||..  | . |.|   ..| ..   .|                  ...|. . 
MDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECK

DFIKR----CLIIDPNKRSH-MEELLTHRLI
|.||.    .|  ||.||   .|..| |  .
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase DPYK4.AA Pkinase 9-249 26 9e-35 124.03 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-249
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

WEEISSIGSCNSKSRVLKCRKKNGLIENEKVDIVAVKIINKKFFKR---------NETDILEKIRLFNIPRYYSHAEDDNYIYIYMEYI-------EDK-
.. .. ||| .. ..| ||..|.  .      |||||||.|.  |          .|  |. ...  || |.|   ||...||. |||        . . 
YHIGRKIGSGSF-GCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

-----KQLRF--KESEIISMIADLTETLSFLHKHQILHRDIKPSNIILDKNGVL----KLIDFGSS-IIDQQQDDGDNICKESSFAITGTHTYMAPEVKK
     .. .|   | |.....  . . | ..|.. |.|||.||.|| .|.||..    |..|||..  .|       .  ..    ..||  |||||| .
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYMAPEVIR

-LHRSTKKSDVWSLGCTVLEIVGG-------------NPKKIFDGIPIIPNHVS-------------------------EIMVDFIKRCLIIDPNKRSHM
     ..|.|.||.||.. | . |             ....... |   |.| .                         | . ||||.||  ||.||   
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

EELLTHRLI
|..| |  .
EQILQHPWF
Kinase DPYK4.AA Ciliate-E2-Unclassified 9-204 23 2.2e-34 116.66 In-house 1-268 (352) Show / Hide 
Range on Protein: 9-204
Range on HMM: 1-268/352
Sequence Identity: 23% (65 aa)

WEEISSIGSCNSKSRVLKCRKKNG-----LIENEKVDIVAVKIINKK---------FFKRNETDILE-----------KIRLFNIPRYYSHAEDDNYIYI
 . |  ||.  . . | ||..|.      . .. |. |...|.|..|          ..... .. .            .   .| ... . .|...|||
YKIIKQIGQ-GGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

YMEYIED------------------------KKQLRFKESEII-----SMIADLTETLSFLHKHQ-ILHRDIKPSNIILDKNG---VLKLIDFGSSIIDQ
 |||.|.                        |.. .| | ...      ..| . . |..||. . |.||||||.||..|.||    .|.||||.|.  |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QQ---DDGD------NICKESSFAITGTHTYM----APEVKKL-HRST---KKSDVWSLGCTVLEIVGGNP
|.   | ..      .. .. .  ..||  ||    |||| .  . ..   .|.|.||||.   |.. |..
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY
Kinase DPYK4.AA CAMK 42-194 19 2.2e-33 104.39 In-house 34-322 (425) Show / Hide 
Range on Protein: 42-194
Range on HMM: 34-322/425
Sequence Identity: 19% (57 aa)

VAVKIINKK---------------------------------FFKRNETDILEK-------IRLFNIPRYYSHAED-------------------DNYIY
||.|||.||                                  . |.| .|. |       ..  || . | . ||                   |...|
VAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMY

IYM---EYIEDK------------KQL--------------RFKESEIISMIADLTETLSFLHKHQILHRDIKPSNIILDKN-----------------G
. |   ||..              .                ||.|.|   ..  . . . ..|.| | |||.|| || ||.|                 .
MVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNN

VLKLIDFGSS--IIDQQ-------QDDGDNICKE---------SSFAITGTHTYMA-PEVKK--------------LHRSTKKSDVWSLGC
 .|.|||| .  ... .       ...|  . ..               ||  ||| ||| .                  ..|.|.||.|.
NIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV
Kinase DPYK4.AA TKL 42-247 17 1.1e-22 78.47 In-house 29-364 (364) Show / Hide 
Range on Protein: 42-247
Range on HMM: 29-364/364
Sequence Identity: 17% (59 aa)

VAVKIINKK--------------------------------FFKRNETDILEKIRLFNIPRYYSHAEDDNY-------------IYIYMEYIE--D-KKQ
||||.....                                ||...|. .. ..|  || ...  . . ..             ..| |||..  .   .
VAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHY

LRFKESEIISMIADLTETLSFLHKHQ--------ILHRDIKPSNIILDKNGV--------------LKLIDFGSSI-IDQQQDDGDNICKES--------
|    . ..... |    ...|| ..        |.|||.|..|| .|.|.               .|. ||| |  ..| ... |.  ..         
LH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNN

---SFAITGTHTYMAPEVKKLH----------------RSTKKSDVWSLGCTVLEIVGGNPKKIFDGIP------------------------IIP----
   .  . ||  .||||| . .                  ..|.||.| |    ||. . .   ....|                         ||    
RKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQ

--------NHVSEIMVDFIKRCLIIDPNKRSHMEELLTHR
        ... . | . ...|   ||.||  ..|.| . 
NHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase DPYK4.AA MLK 112-191 34 4.8e-14 45.24 In-house 137-221 (291) Show / Hide 
Range on Protein: 112-191
Range on HMM: 137-221/291
Sequence Identity: 34% (32 aa)

LSFLHKHQ---ILHRDIKPSNIILD------KNGVLKLIDFGSSIIDQQQDDGDNICKESSFAITGTHTYMAPEV---KKLHRSTKKSDVWS
...||...   | |||.|..|| .|      ..|.||  ||| |  | .| . .|      .   ||  .|||||   ..  . ..|.||||
MHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR-DWHQMC-TNM-----MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWS
Kinase DPYK4.AA TKL-Unique 85-193 23 3.7e-12 39.33 In-house 88-215 (290) Show / Hide 
Range on Protein: 85-193
Range on HMM: 88-215/290
Sequence Identity: 23% (31 aa)

MEYIED--------KKQLRFKESEIISMIADLTETLSFLHKHQ--ILHRDIKPSNIILDKN-----GVLKLIDFGSSIIDQQQDDGDNICK----ESSFA
.... .        .. . .  . ...|. |    . .||  .  |.|||.|.||. .| |        |..||| |..  . ... |. .    .... 
YDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRC

ITGTHTYMAPEVKKL--HRSTKKSDVWSLG
  |.  .||||| .      ..||||.| |
--GSFRWMAPEVLRMNFCQYSEKSDVYSFG
Kinase DPYK4.AA CAMK 215-249 34 1e-06 16.87 In-house 392-425 (425) Show / Hide 
Range on Protein: 215-249
Range on HMM: 392-425/425
Sequence Identity: 34% (12 aa)

PNHVSEIMVDFIKRCLIIDPNKRSHMEELLTHRLI
. .||.   |.|...|  ||.||   |. | |  .
H-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase DPYK4.AA Ciliate-E2-Unclassified 214-249 37 3e-06 17.87 In-house 313-352 (352) Show / Hide 
Range on Protein: 214-249
Range on HMM: 313-352/352
Sequence Identity: 37% (15 aa)

IPNHVSEIMVDFIK----RCLIIDPNKRSHMEELLTHRLI
|| |.|.   |||.    ..|  .||||  .|..| | ..
IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase DPYK4.AA CZAK 172-200 41 0.000618 10.36 In-house 188-216 (279) Show / Hide 
Range on Protein: 172-200
Range on HMM: 188-216/279
Sequence Identity: 41% (12 aa)

YMAPEVKKLHRSTKKSDVWSLGCTVLEIV
.||||. |    | |.|| | |  . .|.
WMAPECFKGENYTEKVDVYSFGMILWCII
Kinase DPYK4.AA MLK 214-247 29 0.000819 9.26 In-house 258-291 (291) Show / Hide 
Range on Protein: 214-247
Range on HMM: 258-291/291
Sequence Identity: 29% (10 aa)

IPNHVSEIMVDFIKRCLIIDPNKRSHMEELLTHR
||.  .|..  ..|.|   ||.||  . . ..| 
IPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase DPYK4.AA CZAK 120-135 56 0.044765 3.52 In-house 130-145 (279) Show / Hide 
Range on Protein: 120-135
Range on HMM: 130-145/279
Sequence Identity: 56% (9 aa)

ILHRDIKPSNIILDKN
|||||   .|| || .
ILHRDLSSRNILLDHS
Kinase DPYK4.AA Pkinase_Tyr 173-200 50 0.175891 5.64 Pfam 181-208 (270) Show / Hide 
Range on Protein: 173-200
Range on HMM: 181-208/270
Sequence Identity: 50% (14 aa)

MAPEVKKLHRSTKKSDVWSLGCTVLEIV
||||. .  . | |||||| | .  ||.
MAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase DPYK4.AA Pkinase_Tyr 86-125 14 2.934946 1.5 Pfam 96-137 (270) Show / Hide 
Range on Protein: 86-125
Range on HMM: 96-137/270
Sequence Identity: 14% (6 aa)

EYIEDK--KQLRFKESEIISMIADLTETLSFLHKHQILHRDI
.|  ..   . ... .....| ..  . ...|. ... |||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase DPYK4.AA NZAK 298-577 45 7.1e-186 623.79 In-house 1-329 (329) Show / Hide 
Range on Protein: 298-577
Range on HMM: 1-329/329
Sequence Identity: 45% (150 aa)

FNKDDTVGGDGFFSVVKKGYYNETEVAIKLIKKAHGENVTVCDTFYHEVLIISNLRHPNIVQFIAACIKFDNKEVNHCIVSEWMSGGNLSQFISNERKIL
.   ...||..|||.|||.....||.|.....|.|....|.||.||||..|....||.||.....||||.......|||..|||.||||.||..|..|.|
WEEISFIGGCQFFSRVKKCRKKNTEIANEQVDKVHCKIITKCDFFYHETDILEKIRHFNIPRYYSACIKHAEDDNYHCIYMEWMEGGNLTQFLMNDKKQL

EINPHLRVKILLDIAKGMLYSHRQGIIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDS----------------------------------DEIIAK
....|...|...|||..|.|.|...|||||..||||.|.|.|...|....|....|.|..                                  .|....
RFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLIDFGSSIIQQQYQFEQYLNETTNNNNNPNNNNNNNNNNNNNNNNNNNNNENNNN

VCDFG---------------LSSNQSESKKLRGGSIHYMAPENLNGSPINEKSDIYSFGLLVWQMFSYASPNTIYSPKEMASMVSDEKLNYRPQIPFNVP
.||||               |||||.|||...||..|||||||.|...||||||..|||..|||||.|..||||||||||||||||.|.||.|||||.||
ICDFGNNNDLNGSGSGISTYLSSNQKESKFAIGGTHHYMAPENKNNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVP

LKFKELITQCWDRNPLNRPKDFSEIIDKL
.|.|..||||||..|..||||||..|.||
DKMKDFITQCWDIDPKKRPKDFSHMIEKL
Kinase DPYK4.AA Dicty3 302-573 29 1.2e-141 470.7 In-house 1-351 (351) Show / Hide 
Range on Protein: 302-573
Range on HMM: 1-351/351
Sequence Identity: 29% (102 aa)

DTVGGDGFFSVVKKGYYNETEVAIKLIKKAHGENVTVCDTF-----YHEVLIISNLRHPNIVQFIAACIKFDNKEVNHCIVSEWMSGGNLSQF-----IS
...||.|.|..|||...|.....|| ....| .....||..     .||..| ...|||.||....||...||...||.|..|...|... .|     ..
WSIGGCGNFGRVKKCHKNNCIINIKMVDICHIKIINKCDFNEVNNWRHEKIINKKMRHPCIVKYYGACYCCDNNNDNHYIYMEYIEGEIPISFVKTNNML

NERKILEINPHLRVKILLDIAKGMLYSHRQG-IIHRDLTSNNVLLNFRKKKLLNNN-----SSNNDEQFYDSDEIIAKVCDFGLSSNQS-----------
...| ...|.|...||. |..|...| |... |||||....|..|........|||     |...|.|.|.|.||..|..|||||.|.|           
KKHKNNRFNEHEISKIICDLVKTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDIQCYYSNEINWKLIDFGLSKNISYYSNNNNNNNY

-------------------------------------------------ESKKLRGGSIHYMAPENLNGSPIN--EKSDIYSFGLLVWQMFSYASPNTIY
                                                 .......|.|||||||........  .||||.|.|..||.|..........
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNNNVKIINNNIYSNKQYKQKCYSICGTIHYMAPEIKLNNQCCACRKSDIWSLGCTVWEMVGGNLCHCEQ

SPKEMASMVSDEKLN-YRPQIPFNVPLKFKELITQCWDRNPLNRPKDFSEI
...|||.||.|.|.| ..||||..|....|..|..||...|..|......|
DINEMAFMVNDNKQNIWIPQIPDHVSNFCKNFIQHCWQIDPNHRWDMHELI
Kinase DPYK4.AA TKL 306-577 24 2.6e-71 243.24 In-house 2-364 (364) Show / Hide 
Range on Protein: 306-577
Range on HMM: 2-364/364
Sequence Identity: 24% (94 aa)

GDGFFSVVKKGYYNE----------TEVAIKLIKKAHGENVT------------------------VCDTFYHEVLIISNLRHPNIVQFIAACIKFDN--
| |.|..| ||...           ..||.| .|. .  . |                         ....  |....|.|||||||||...|.  ..  
GSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGC

-------KEVNHCIVSEWMSGGN-LSQFISNERKILEINPHLRVKILLDIAKGMLYSHRQG--------IIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQ
        . ..||| |...||. |....          .|.|... ||||.|| | | ..        ||||||.|.|.|.    .. ..|.| |    
VCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV----DENWTNVS-NYM--

FYDSDEIIAKVCDFGLSSNQSES----------------------KKLRGGSIHYMAPENLNGS----------------PINEKSDIYSFGLLVWQMFS
..  ... .|.|||||| . |.|                      .  ..|.. .|||| |.|.                . .||.|.||||.. | ...
YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT

YASPNT-IYSPKEM------ASMVSDEKLNYRPQIP------------FNVPLKFKELITQCWDRNPLNRPKDFSEIIDKL
   |   . .. ..      . .. . . ..|| ||             ..|  .|.|...||| .| .||  |.||...|
RCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPS-FQEILKRL
Kinase DPYK4.AA TKL-Unique 306-577 31 4.7e-69 235.74 In-house 6-290 (290) Show / Hide 
Range on Protein: 306-577
Range on HMM: 6-290/290
Sequence Identity: 31% (96 aa)

GDGFFSVVKKGYYNETEVAIKLIKKAHGENVTVCDTFYHEVLIISNLR-HPNIVQFIAACIKFDNKEVNHCIVSEWMSGGNLSQFIS-------NERKIL
| | ...|.|| .. ..|||| ...  . . .. ..|. || ....|. |||||.....|..   .. | |||.| ..||.|   ..       | .. .
GEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNC

EINPHLRVKILLDIAKGMLYSHRQG--IIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLSSNQSES--KKLRG----------GS
..|. .|||. .|||.|| | |. .  ||||||.| |.|..                ..  . |. .|.|||||| ..| .  .....          ||
KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD----------------NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGS

IHYMAPENLNG--SPINEKSDIYSFGLLVWQMFSYAS------PNTIYSPKEMASMVSDEKLNYRPQIPFNVPLKFKELITQCWDRNPLNRPKDFSEIID
. .|||| |..  . ..||||.||||  .| ...         |   ..... ..|| . . |||| || . |  ...||.|||...| .||  |.||| 
FRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPS-FDEIIH

KL
.|
RL
Kinase DPYK4.AA CZAK 296-577 37 4.9e-66 225.7 In-house 1-279 (279) Show / Hide 
Range on Protein: 296-577
Range on HMM: 1-279/279
Sequence Identity: 37% (110 aa)

LKFNKDDTVGGDGFFSVVKKGYYNETEVAIKLIKKAHGENVTVC---DTFYHEVLIISNLRHPNIVQFIAACIKFDNKEVNHCIVSEWMSGGNLSQFISN
||| .   . | |||  |.|.|  .. |||| | .    | .       |  || |.| |.|||.|||. ||   |.    |||| ||| || | ..   
LKFGQ---TIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSE-DGP-NHHCIVMEWMGGGSLRRLLTD

ERKILEINPHLRVKILLDIAKGMLYSHR----QGIIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLS---SNQSESKKLRGGSIH
    .. ||||. .. .|||.|| | |       |.||||.| |.||.          ||  |        ||.|. |||||     |        |.. 
HYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQD--------IICKINDFGLSREMMEQPFEMTQTMGCLC

YMAPENLNGSPINEKSDIYSFGLLVWQMFSYASPNTIYSPKEMASMVSDEKLNYRPQIPFNVPLKFK---ELITQCWDRNPLNRPKDFSEIIDKL
.||||   |    ||.|.||||...| .     |.    |  ||   . |  |||| .|   . . |   |||..||. ||  ||  |..|.. |
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYE--NYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPS-FKQILQHL
Kinase DPYK4.AA STE 299-568 17 2.2e-54 187.0 In-house 1-347 (359) Show / Hide 
Range on Protein: 299-568
Range on HMM: 1-347/359
Sequence Identity: 17% (67 aa)

NKDDTVGGDGFFSVVKKGYYN------ETE-----------VAIKLIKKAHGEN--------------VTVCDTFYHEVLIISNLR--HPNIVQFIAACI
 ..  . | | | .| |....      .|            .||| ... . .|               .  . . .|. | ....  |||||... ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KFDNK---EVNHCIVSEWMSGGNLSQFISNERKILEINP-----------HLRVKILLDIAKG-MLYSHRQGIIHRDLTSNNVLLNFRKKKLLNNNSSNN
| ...   . . .|. |.|.|| |...| .  .... ..           ..  .|. .| || . | |...|||||. . |.||               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

DEQFYDSDEIIAKVCDFGLSSNQSE-------------------SKKLRGGSIHYMAPENLNG------SPINEKSDIYSFGLLVWQMFSYASPNTIYSP
           .| ||||.... ..                     .   |.  .|||| ...      .. ..|.||.|.|.... |     |   ..|
-----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHP

KEMASMVSDEKLNYR------------PQIPF-------------------NVPLKFKELITQCWDRNPLNRPK
 ..  |  ...  ..            |..|                    ..  .||. | .| ...| .||.
MRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase DPYK4.AA MLK 299-577 26 3.4e-48 165.29 In-house 1-291 (291) Show / Hide 
Range on Protein: 299-577
Range on HMM: 1-291/291
Sequence Identity: 26% (83 aa)

NKDDTVGGDGFFSVVKKGYYNETE-----VAIKLIKKAHGENVTV----CDTFYHEVLIISNLRHPN----IVQFIAACIKFDNKEVNHCIVSEWMSGGN
 .  .. | | | .| ||..  ..     ||.| ..      . .     . |  |. . . |.|||    |.|| ..|..    . . |||.|...|| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQ---PPCHFCIVMEYCEGGS

LSQFISNERKILE-----------INPHLRVKILLDIAKGMLYSHRQG---IIHRDLTSNNVLLN-FRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLS
|. .. ..|.  .           . ... ... |..|.|| | | .    |||||| | |.|.                     | .. ..|.||||.|
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEIC---------------H-DMHHGTLKICDFGTS

SNQSES---KKLRGGSIHYMAPENL---NGSPINEKSDIYSFGLLVWQMFSYASPNT-IYSPKEMASMVSDEKLNYRPQIPFNVPLKFKELITQCWDRNP
   ...   .  . |.  .|||| .    ... .||.|..|.|.. |.|..   |   .|.| . | .|  ..|  || || . |  .|.|..|||. .|
RDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGL--RPPIPSTCPEHWKKLMKQCWNQDP

LNRPKDFSEIIDKL
 .||. |..|. .|
HKRPS-FRQIVQHL
Kinase DPYK4.AA Pkinase_Tyr 306-577 28 2.6e-45 154.07 Pfam 8-270 (270) Show / Hide 
Range on Protein: 306-577
Range on HMM: 8-270/270
Sequence Identity: 28% (83 aa)

GDGFFSVVKKGYYN------ETEVAIKLIKKAHGEN-VTVCDTFYHEVLIISNL-RHPNIVQFIAACI-KFDNKEVNHCIVSEWMSGGNLSQFISNE-RK
| | | .|.||...      ...||.| .|  . .      . | .|. | ..| .|||||.....|. . . .  ...|| | | .|.|  .  .    
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHRED

ILEINPHLRVKILLDIAKGMLYSHRQGIIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLSSNQ-------SESKKLRGGSIHYMA
   ....  ... ..||||| | .....|||||   |.|..                     .. ..|.|||||.            ... .   |  ||
KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT---------------------ENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMA

PENLNGSPINEKSDIYSFGLLVWQMFSYA-SPNT---IYSPKEMASMV-SDEKLNYRPQIPFNVPLKFKELITQCWDRNPLNRPKDFSEIIDKL
|| .| .  ..|||..||| | | .|.|  .| |   . |. |.  ..  |   .||  .| | | .  .|..|||. .| .||  ||||. .|
PECINYGKFTTKSDVWSFGVLMWEIFTYGEQP-TYPGM-SNEEVYEYIYED---GYRMPCPENCPDEIYDLMKQCWHYDPEDRP-TFSEIHEQL
Kinase DPYK4.AA TyrKc 298-577 25 2.5e-39 137.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 298-577
Range on HMM: 1-280/280
Sequence Identity: 25% (80 aa)

FNKDDTVGGDGFFSVVKKGYYNETEVAIKLIKKAHGENVTVCDTFYHEVLIISNL--RHPNIVQFIAACIK-FDNKEV----NHCIVSEWMSGGNLSQFI
  .... |  |.| .| || .. ..||.| .|. .         |..|  | ..|  .|||||.....|.. . |        ..|| | |..|.| ...
ITLGKKLGE-GAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

SNERKILEINPHLRVKILLDIAKGMLYSHRQGIIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLSSNQSES----------KK--
 . |.   ...   ... ..||.|| | |....|||||   |.|.. ..                     ..|..||||| .  .           .|  
RKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKE

---LRG-GSIHYMAPENLNGSPINEKSDIYSFGLLVWQMFSYASPNTIYSP-----KEMASMVSDEKLNYRPQIPFN--------VPLKFKELITQCWDR
    ..   |  |||| .| .  ..|||..||| . | .|.|    . |.      .. . .. . |  ||. .| |         | .  ....|||..
HKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQ--QPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

NPLNRPKDFSEIIDKL
.| .||  ||||....
DPEDRP-TFSEIHECF
Kinase DPYK4.AA Pkinase 306-567 22 2.5e-39 140.16 Pfam 8-282 (293) Show / Hide 
Range on Protein: 306-567
Range on HMM: 8-282/293
Sequence Identity: 22% (68 aa)

GDGFFSVVKKGYYNETE--VAIKLIKKAHGENVTVCDTFYH--EVLIISNLRHPNIVQFIAACIKFDNKEVNHCIVSEWMSGG----NLSQFIS--NERK
| | |..|.|..   |.  ||.| |||  .|.  .. |  .  |. |  .|.|||||... ..      . . ..| |.. ||     |. .||  ....
GSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGC

ILEINPHLRVKILLDIAKGMLYSHRQGIIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLS----SNQSESKKLRGGSIHYMAPEN
..   ..   .... |..|. | |..||||||| . |.|.. ..  .                  . |.|||||.       ..  . . |...||||| 
FY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA----------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

LN-GSPINEKSDIYSFGLLVWQMFS---YASPN----TIYSPKEMASMVSDEKLNYRPQIPFNVP-----------------LKFKELITQCWDRNPLNR
.. |...  |.|..|.|.....|..     .      . .....|  .. . .| .  . . ...                   .|..|. |....|  |
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

P
|
P
Kinase DPYK4.AA S_TKc 299-585 22 3e-38 134.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 299-585
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

NKDDTVGGDGFFSVVKKGYYNE--TEVAIKLIKKAHGENVTVCDTFYHEVLIISNLRHPNIVQFIAACIKFDNKEVNHCIVSEWMSG--GNLSQFISNER
 .   . | | |..|.|.. ..   .|||| ||          .... |. | .. .|||||... ..        . ..| | ..|  |.| ..| . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG

KILE---INPHLRVKILLDIAKGMLYSHRQGIIHRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLSSNQSESKKLRGGSIHYMAPEN
.      ...    ...  |.... | |..|||||||   |.||.                          |.|||||.       .   |. .||||| 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------------HIKICDFGLARQL----TTFCGTPWYMAPEV

LNGSPINE-KSDIYSFGLLVWQMFSYASPNTIYSPKEMASMVSDEKLNYRPQIPFNVPLKFKELITQCWDRNPLNRPKDFSEIIDKLKDINQIYF
|   . .  |.|..|.| ... |..   |     ...|  ..               .  .|..| .|....| .||       | ..  .  .|
L---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DPYK4.AA CAMK 306-507 18 5.3e-29 90.01 In-house 3-321 (425) Show / Hide 
Range on Protein: 306-507
Range on HMM: 3-321/425
Sequence Identity: 18% (60 aa)

GDGFFSVVKKGYYNETE--------------VAIKLIKKAHGENVT-------------------------VCDTFYHEVLIISN-------LRHPNIVQ
| | |..||...  .|               |||| |.|    . .                          .. ...|. | ..       |.||||..
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

FIAACIK-----------FDNK-----EVNHCIVS---EWMSGG----NLSQFISNERKILE------------INPHLRVKILLDIAKGMLYSHRQGII
.. .              . .|     . . ..|    | .|||     | ..|   ..  |            .. .   ..   |. .. | | ..|.
LYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIV

HRDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLSSNQSESKKLR--------------------------GGSIHYMA-PENLNG---
||||   |.||. ...   .     .|| | |..    |..|||..    ......                           |. .||| || |||   
HRDLKPENILLDDNNDDSDP-V-E-HDEIF-DWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------SPINEKSDIYSFG
            ....|.|. | |
CNMQNATDEEKPYYGPKCDMWSCG
Kinase DPYK4.AA Ciliate-E2 350-575 17 5.6e-29 96.61 In-house 87-361 (365) Show / Hide 
Range on Protein: 350-575
Range on HMM: 87-361/365
Sequence Identity: 17% (54 aa)

SNLRHPNIVQFIAACIKFDNKEVNHCIVSEWMSGGNLSQFIS----NERKILE----INPHLRVKILLDIAK---------------GMLYSHRQG-IIH
..| ||||.... . .  .... |  .| |  .||.| ..|     .. ...|    ..   . .|   |..               .. | | .. |||
EQLNHPNIIKMYECFQ--EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH

RDLTSNNVLLNFRKKKLLNNNSSNNDEQFYDSDEIIAKVCDFGLSSNQSES------KKLRG----------------------------GSIHYMAPEN
||.  .|.|.                           |..||||| .....      |....                            |. .|||||.
RDIKPENILF--------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI

LNGSP---------INEKSDIYSFGLLVWQMFSYASPNTIYSPKEMASMVSDEKLNYRPQ--------------IPFNVPLKFKELITQ----CWDRNPL
||| .          ..|.||.|.| .  .| .   |              . |......              ........ | || .    . ...| 
LNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPE

NRPKDFSEIID
.|. ....|..
KRITGWEQILN
Kinase DPYK4.AA Ciliate-E2-Unclassified 298-574 15 3.5e-20 66.74 In-house 1-347 (352) Show / Hide 
Range on Protein: 298-574
Range on HMM: 1-347/352
Sequence Identity: 15% (60 aa)

FNKDDTVGGDGFFSVVKKGYYNET-EV-----AIKLIKKAHGENVTVCDTFYHEVLIISNLRHPNIVQ----------------FIAACIKFDNKEVNHC
...  . |  | |..|.| . ... ..     ..| ....     ..   .  | ... |. . ...                 ||  ..  .... | .
YKIIKQIGQ-GGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

IVSEWMSGGNLSQFISN----------------------ERKIL---EINPHLRVKILLDIAKGMLYSHRQG-IIHRDLTSNNVLLNFRKKKLLNNNSSN
|| | . ||.|.|.|..                      |....   .       ...  | .|  | |... |||||.. .|.|..  .|         
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA------KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------

NDEQFYDSDEIIAKVCDFGLSS-----NQSESKKL--------------RGGSIHYM----APENLNGSPIN----EKSDIYSFGLLVWQMFSYASPNTI
             |..|||.|.     |... ..               . |.. ||    ||| | |   .    .|.||.|.| .  .|     |   
---------NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYD

YSPKE----------------MASMVSDEKLNYRPQIP----FNVPLKFKELIT----QCWDRNPLNRPKDFSEII
.. ..                . .   . ....... .     ... . |..|.    .. . || .|. .|..|.
NNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-TFEQIL