Gene FNIPK-A (Slime mold)

FNIPK-A

Species: Slime mold
Alias: fnkA, DdisK147, DDB0216322, FNIPK-A
External Links: DictyBase Link ,
Annotation:

Classification

Group: STE
Family: Dicty3
Subfamily: FNIPK

Sequence

Name Sequence Type Origin Length Description Download
FNIPK-A.AA Protein None 793 None Fasta, JSON
FNIPK-A.kin_dom Protein Kinase Domain None 348 None Fasta, JSON

Protein domain

Protein domains of FNIPK-A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase FNIPK-A.AA FNIPK 11-353 51 1.1e-245 822.42 In-house 1-425 (425) Show / Hide 
Range on Protein: 11-353
Range on HMM: 1-425/425
Sequence Identity: 51% (219 aa)

WEILSQLGTGAFGRVVKAKKINCDGTGIIIDICAIKIIKKS----VFTKNEIEILKQL-DHP---------LIVKYYGYGVGEIDDNIYIYMEYIDG-YP
|||.|.|..|.||||.|||||||...|.....|.||||||.    .|..|||||...| |..         .|.|||||...|||.|.||||||||| .|
WEIISTLKSGNFGRVCKAKKINCQFNGNRVNFCIIKIIKKKDKYYYFKWNEIEIHIKLRDCKEILEKIKHICIMKYYGYCCDEIDHNFYIYMEYIDGYIP

VSS-----ILRKQPKNQFPEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIMLVNDNTHSCDVNGNCSRNGGGSAKSANQSFFTEDCVCNVNGSGTD
.|.     .|.|.|.|||||||||....||...|..||.|.|.|||||.||||||.|||..||||...|||.......|..|..||||||||||||||||
ISYVKTNNLLKKHPHNQFPEDIISRCMCDLVKSLNCIHENGRHIIHRDIKCDNIMIVNDEFHSCDFDYNCSKDISYYSKDNNNNFFTEDCVCNVNGSGTD

ENCKSCKLKSKPIREIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSKKIKLIDFGLSKGCD---GDSKYYSLVG------------
|||||||||||||||||||||||||.................||.....|...||.|....|.|.|||||||.||   .|||.||..|            
ENCKSCKLKSKPIREIQGSCESCGSNNNNNNNNNNNNNNNNNNNNNNNNCNANNCNYNTNNKWKFIDFGLSKSCDHSNDDSKCYSQCGEVSITSTISTIL

--------------TSTHMPPEVALRNNTACR------------------KSDIWSLGCTIIEMAGGNLF--EKDIHGK-------------PKIPDHLS
              |.||||||..|.|...||                  |||||.||||.|||.||||.  |.||||.             ||||||||
SGSSSSQLSTPSTSTETHMPPEIKLQNGKCCRIAPEIRNQQKITSKGLSKKSDIWCLGCTMIEMVGGNLCHTENDIHGISFNNNNNKPNIWIPKIPDHLS

ASCKNFIQRCLTIDPNHRDDIINLI
..||||||.||.||||||.||.|||
NFCKNFIQHCLQIDPNHRWDINNLI
Kinase FNIPK-A.AA Dicty3 14-353 35 1.1e-153 511.04 In-house 1-351 (351) Show / Hide 
Range on Protein: 14-353
Range on HMM: 1-351/351
Sequence Identity: 35% (152 aa)

LSQLGTGAFGRVVKAKKINCDGTGIIIDICAIKIIKKSVFT-----KNEIEILKQLDHPLIVKYYG--YGVGEIDDNIYIYMEYIDG-YPVSS-----IL
 |..|.|.||||.|..|.||.......|||.||||.|. |.     ..| .|.| ..|| ||||||  |......||.|||||||.| .|.|.     .|
WSIGGCGNFGRVKKCHKNNCIINIKMVDICHIKIINKCDFNEVNNWRHEKIINKKMRHPCIVKYYGACYCCDNNNDNHYIYMEYIEGEIPISFVKTNNML

RKQPKNQFPEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIMLVNDNTHSCDVNGNCSRNGGGSAKSANQSFFTEDCVCNVNGSGTDENCKSCKLKS
.|...|.|.|..||||..||...|.|||.|. .|||||.|||||||.||..|.|..|                                           
KKHKNNRFNEHEISKIICDLVKTLNYIHKNC-HIIHRDIKCDNIMLDNDEQHQCNNN-------------------------------------------

KPIREIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSKKIKLIDFGLSKGCDGDS--------------------------------
                                ||..|||||.|.|.||.....|||||||||.....|                                
--------------------------------NNKMSSTCRDIQCYYSNEINWKLIDFGLSKNISYYSNNNNNNNYNNNNNNNNNNNNNNNNNNNNNNNN

--------------------------KYYSLVGTSTHMPPEVALRNNT-ACRKSDIWSLGCTIIEMAGGNLF--EKDIH-------------GKPKIPDH
                          |.||..||...|.||..|.|.. |||||||||||||..||.||||.  |.||.             ..|.||||
NNNNNNTNNNVKIINNNIYSNKQYKQKCYSICGTIHYMAPEIKLNNQCCACRKSDIWSLGCTVWEMVGGNLCHCEQDINEMAFMVNDNKQNIWIPQIPDH

LSASCKNFIQRCLTIDPNHRDDIINLI
.|..||||||.|..||||||.|...||
VSNFCKNFIQHCWQIDPNHRWDMHELI
Kinase FNIPK-A.AA STE 11-358 21 4.1e-83 282.42 In-house 1-359 (359) Show / Hide 
Range on Protein: 11-358
Range on HMM: 1-359/359
Sequence Identity: 21% (103 aa)

WEILSQLGTGAFGRVVKAKKI----NCDGTGII------IDICAIKIIK----------------------KSVFTKNEIEILKQLD--HPLIVKYYGYG
||.....| |||| |.||...    ..  || .       .|.|||...                      .    ..||.|.|...  || ||||||. 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

VGE-----IDDNIYIYMEYIDGYPVSSILR-KQPKNQ-----------FPEDIISKIVIDLALI-LSYIHDNERKIIHRDLKCDNIMLVNDNTHSCDVNG
. |      ||...|.|||.||  ...|.. |  ...           |||..|..|. ..    |.|.|..   |||||.|..||.|            
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------------

NCSRNGGGSAKSANQSFFTEDCVCNVNGSGTDENCKSCKLKSKPIREIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSKKIKLIDF
                                                                                              .||.||
----------------------------------------------------------------------------------------------VKLCDF

GLSKGCDG-----------------DSKYYSLVGTSTHMPPEVALR-----NNTACRKSDIWSLGCTIIEMAGGNLFEKDIH------------------
|...  .                  ..| ...|||  .| ||| ..     ..   .|.||||||||||||| |.    | |                  
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

--------GKPKIPD-------------------HLSASCKNFIQRCLTIDPNHRDDIINLIS--HNFI
        . |..||                   ..| ..|.||..||..|||.| .   |..  | ||
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase FNIPK-A.AA S_TKc 11-358 23 5.6e-49 169.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-358
Range on HMM: 1-231/231
Sequence Identity: 23% (84 aa)

WEILSQLGTGAFGRVVKAKKINCDGTGIIIDICAIKIIKKSVFTKNEIEILKQLDHPLIVKYYGYGVGEIDDNIYIYMEYIDG--YPVSSILRKQPK---
.||| ..| ||||.| |.....         |.||||||    ...||.|||. .|| |||.|.. .    |..|. |||.||    . ....|...   
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-NQFPEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIMLVNDNTHSCDVNGNCSRNGGGSAKSANQSFFTEDCVCNVNGSGTDENCKSCKLKSKPIR
  .|||  . ...  ... | |.|..  .||||||| .||.| .                                                        
RFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--------------------------------------------------------

EIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSKKIKLIDFGLSKGCDGDSKYYSLVGTSTHMPPEVALRNNTACR-KSDIWSLGCT
                                                ||..||||..        ....||   |.|||        . |.|.||.||.
-----------------------------------------------HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

IIEMAGGNL---FEKDIHGKPKIPDHLSASCKNFIQRCLTIDPNHRDDIINLIS-------HNFI
..||. |      .. .  | .     | ..|.||..||. ||..|  .  .         | ..
LYEMLCGYPPFPQMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FNIPK-A.AA Pkinase 11-358 19 1.4e-47 169.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-358
Range on HMM: 1-293/293
Sequence Identity: 19% (79 aa)

WEILSQLGTGAFGRVVKAKKINCDGTGIIIDICAIKIIKKSVFTK---------NEIEILKQLDHPLIVKYYGYGVGEIDDNIYIYMEYIDGY----PVS
..|....| |.||.| |.....         | |.|||||.   .         .||.|.| |.|| ||..|..     .|.||. ||| .|       .
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF

SILRKQPKNQF--PEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIMLV-NDNTHSCDVNGNCSRNGGGSAKSANQSFFTEDCVCNVNGSGTDENCK
.... . .. |  .|. . ...  ..  | |.|..  .||||||| .||... |... .                                         
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDA-----------------------------------------

SCKLKSKPIREIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSKKIKLIDFGLSKG--CDGDSKYYSLVGTSTHMPPEVALR-NNTA
                                                         ..|..||||.|      .| .....||.  |.||| .| ..  
---------------------------------------------------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-IRGGQYY

CRKSDIWSLGCTIIEMAG------GN----------LFEKDIHGKPKIPDHLS---------------------ASCKNFIQRCLTIDPNHRDDIINLIS
 .|.|.||.||...||.       |           ..... ..... .   .                      .|| || .||. ||. |  .  .  
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HNFI
| ..
HPWF
Kinase FNIPK-A.AA Ciliate-E2 11-358 18 7.8e-46 155.31 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-358
Range on HMM: 1-365/365
Sequence Identity: 18% (86 aa)

WEILSQLGTGAFGRVVKAKKINCDGT-----------------GIIIDICAIKIIKKS--VFTKNEIEILK----------------QLDHPLIVKYYGY
 ... ..|.|.|| | |.|... .                   .  | | |.||.||.   ..|.|| |..                ||.|| |.|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

GVGEIDDNIYIYMEYIDGYPVSSILRKQPKN---------QFPEDIISKIVIDLAL---------------ILSYIHDNERKIIHRDLKCDNIMLVNDNT
   . |.|||. |||..|    .......|.         .| |  |..|   ..                 | |.| . . |||||.| .||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

HSCDVNGNCSRNGGGSAKSANQSFFTEDCVCNVNGSGTDENCKSCKLKSKPIREIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSK
                                                                                                    
----------------------------------------------------------------------------------------------------

KIKLIDFGLSKGCDGD--------------------------------SKYYSLVGTSTHMPPEVALRNNTAC--------RKSDIWSLGCTIIEMAGGN
 ||.||||||| .| |                                  .....||   |.||.  . .            |.||||||... ||  |.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

L--FEKDIHGKPKIP------------------DHLSASCKNFIQR----CLTIDPNHRDD-IINLISHNFI
.  ... . .| ..|                  ...| .||..|..    .|  ||. | . .  .. | ..
PPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase FNIPK-A.AA Ciliate-E2-Unclassified 11-358 17 7.5e-40 135.92 In-house 1-352 (352) Show / Hide 
Range on Protein: 11-358
Range on HMM: 1-352/352
Sequence Identity: 17% (79 aa)

WEILSQLGTGAFGRVVKAKKINCDGTGIIIDICAIKIIKKSVFTK-----NEIEILKQLD-----------------HPLIVKYYGYGVGEIDDNIYIYM
 .|. |.|.|.|| | |..... .   ..  .. |.|.|.    .     ||.......                  || ..... . . . ..|||| |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYIDGYPVSSILRKQPK---------------NQFPEDIIS-----KIVIDLALILSYIHDNERKIIHRDLKCDNIMLVNDNTHSCDVNGNCSRNGGGSA
||..|   . ...|..|               ..|.|  ..     ..   . . |.|.| .  .|||||.|..||.. |..                  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGK-----------------

KSANQSFFTEDCVCNVNGSGTDENCKSCKLKSKPIREIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSKKIKLIDFGLSKGCD---
                                                                                   .||.||||.||  .   
---------------------------------------------------------------------------------NYYIKIIDFGISKKYQQNN

-------------GDSKYYSLVGTSTHM----PPEVALRNNTACR---KSDIWSLGCTIIEMAGGNL-------------------------FEKDIHGK
              . .... .||   |    .|||  ..|   .   |.||||||. . ||  |..                         ....|. |
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

-------PK--IPDHLSASCKNFIQ----RCLTIDPNHRDDIINLISHNFI
       |.  ||.|.| ..|.||.    ..|  .|| | ..  .. | ..
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase FNIPK-A.AA NZAK 11-146 35 3.5e-29 94.75 In-house 1-138 (329) Show / Hide 
Range on Protein: 11-146
Range on HMM: 1-138/329
Sequence Identity: 35% (49 aa)

WEILSQLGTGA-FGRVVKAKKINCDGTGIIIDICAIKIIKKSVFTKNEIEILKQLDHPLIVKYYG--YGVGEIDDNIYIYMEYIDGYPVSSILRKQPKN-
|| .| .| .  |.||.| .| |       .|. ..||| |  | ..|. || .. |. |..||      .| | ...||||...|   . .| .. |  
WEEISFIGGCQFFSRVKKCRKKNTEIANEQVDKVHCKIITKCDFFYHETDILEKIRHFNIPRYYSACIKHAEDDNYHCIYMEWMEGGNLTQFLMNDKKQL

QFPEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIML
.| |  | |.. |.|  .|| |   ..|||||.|  |..|
RFKEHRIIKMIADIAETMSYLH--KHHIIHRDIKSNNVIL
Kinase FNIPK-A.AA NEK 56-284 23 3.9e-29 99.98 In-house 53-195 (286) Show / Hide 
Range on Protein: 56-284
Range on HMM: 53-195/286
Sequence Identity: 23% (56 aa)

NEIEILKQLDHPLIVKYYGYGVGEIDDNIYIYMEYID-GYPVSSI---LRKQP--KNQFPEDIISKIVIDLALILSYIHDN---ERKIIHRDLKCDNIML
||. |||||.|| |||||   . | .. ..| ||| . |   .     . ||   .  |.|..| .. | ..| | |.||.    |||.|||.|. ||.|
NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFL

VNDNTHSCDVNGNCSRNGGGSAKSANQSFFTEDCVCNVNGSGTDENCKSCKLKSKPIREIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCI
 ..|. .                                                                                             
TKNNNDY---------------------------------------------------------------------------------------------

YSVSKKIKLIDFGLSKGCDGD-SKYYS-LVGTSTHMPPEV
    . .|. |||.||  . . .. |. .|||   | |||
----HNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEV
Kinase FNIPK-A.AA NZAK 275-353 30 4.1e-26 84.28 In-house 234-329 (329) Show / Hide 
Range on Protein: 275-353
Range on HMM: 234-329/329
Sequence Identity: 30% (30 aa)

GTSTHMPPEVALRNNTACRKSDIWSLGCTIIEMAGGNLF--------------EKDIHGKPKIPDHLSASCKNFIQRCLTIDPNHR----DDIINLI
|| . | ||. ..|  . .|||.||.|||...|.|.|.               .. . . | ||.|..   |.||..|. |||. |      .|.. 
GTHHYMAPEN-KNNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL
Kinase FNIPK-A.AA CAMK 16-156 20 1.2e-25 78.95 In-house 1-235 (425) Show / Hide 
Range on Protein: 16-156
Range on HMM: 1-235/425
Sequence Identity: 20% (49 aa)

QLGTGAFGRVVKAKKINCDGTGIII--------DICAIKIIKKS---------------------------------VFTKNEIEILKQ-------LDHP
.||.|.|| | ... .|   || .           .|||||.|.                                  . ..||||.|.       ||||
TLGRGSFGKVKLCIHKN--TTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHP

LIVKYYG-------------Y-----GVGEIDDNIYIYM---EYIDGY----PVSSILRKQPK-------------NQFPEDIISKIVIDLALILSYIHD
 |.| |              |      . . |...|. |   ||..|      . . ......               |.|.  ....  ..  . |.|.
NIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

NERKIIHRDLKCDNIMLVNDNTHS-------------CDV
.   |.|||||..||.|...|..|             ...
HN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI
Kinase FNIPK-A.AA CAMK 252-358 19 2.3e-20 61.68 In-house 234-425 (425) Show / Hide 
Range on Protein: 252-358
Range on HMM: 234-425/425
Sequence Identity: 19% (38 aa)

KIKLIDFGLSKGCDG------------------------DSKYYSLVGTSTHMP-PEVALR-------------NNTACRKSDIWSLGCTIIEMAGG---
.||.||||... .|.                        . |..  .||   |. ||| ..             .    .|.|.||.|.    |  |   
NIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP

--------------------NLFEKDIHGKPK-IPDH-----------------------LSASCKNFIQRCLTIDPNHRDDIINLISHNFI
                    .|||| . ||   .|..                       .|..||..|...|. ||..|  |    .| ..
FYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase FNIPK-A.AA STE11 57-152 38 1.8e-16 56.3 In-house 60-155 (303) Show / Hide 
Range on Protein: 57-152
Range on HMM: 60-155/303
Sequence Identity: 38% (38 aa)

EIEILKQLDHPLIVKYYGYGVGE-IDDNIYIYMEYIDGYPVSSILR-KQPKNQFPEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIMLVNDNTH
||...|.|.|. ||.|||  . .  .|...|.|||. |  .||.|| |. .  |.|  |.| . ..   |.| |..  .|||||.| .||.|  |...
EIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSH--GIIHRDIKGANILLDSDGNV
Kinase FNIPK-A.AA STE11-Unclassified 11-144 34 5.2e-15 49.69 In-house 1-138 (308) Show / Hide 
Range on Protein: 11-144
Range on HMM: 1-138/308
Sequence Identity: 34% (50 aa)

WEILSQLGTGAFGRVVKAKKINCDGTGIIIDICAIKIIKKS----VFTKN-------EIEILKQLDHPLIVKYYGYGVGEIDDNIYIYMEYIDGYPVSSI
|.  . .|.|.||.|.|.  .||. || .. .  |.| ...    .. |        |...||||.|. ||.|||  . .  |.|.|.|||. |  ..| 
WQKGEFIGKGSFGQVYKC--MNCN-TGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSM

LRKQPKNQFPEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNI
|.|. .  | |  |.| . ..   |.| | ..  |||||.| .||
LNKYGC--FDEMVIKKYTKQILEGLAYLHSHG--IIHRDIKGANI
Kinase FNIPK-A.AA TyrKc 11-358 15 1.1e-13 -1.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-358
Range on HMM: 1-280/280
Sequence Identity: 15% (63 aa)

WEILSQLGTGAFGRVVKAKKINCDGTGIIIDICAIKIIKKSVFTK---NEIEILKQL--DHPLIVKYYGYGVGE-----IDDNIYIYMEYIDGYPVSSIL
 . . .|| ||||.|.|.. .           .|.| .|..   .   .|..|...|  .|| ||. ||. . .      .. ..| ||| ..    . |
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RKQPKNQFPEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIMLVNDNTHSCDVNGNCSRNGGGSAKSANQSFFTEDCVCNVNGSGTDENCKSCKLKS
||  .. .. .   .. .. |   .|.|..  ..||||| . |... ...                                                  
RKHRPK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH--------------------------------------------------

KPIREIQGSCESCGSDLEQDSSSSSSSSSSTINNGQSSTCRLINCIYSVSKKIKLIDFGLSKGCDGD------SKYYSLVG-TSTH-------MPPEVAL
                                                    .|  |||||.  . |      ..||.  .  ...       |.||.  
---------------------------------------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

RNNTACRKSDIWSLGCTI-----------IE-----MAGGNLFEKDIHG-KPKIPDH--------LSASCKNFIQRCLTIDPNHRDDIINLISHNFI
. ..   |||.|| | ..            .     |    ..|.  .|  ...|..         ..   . ...|   ||. |    ..  | ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase FNIPK-A.AA STE11 253-308 33 5.2e-13 43.65 In-house 156-232 (303) Show / Hide 
Range on Protein: 253-308
Range on HMM: 156-232/303
Sequence Identity: 33% (26 aa)

IKLIDFGLSKGCDGDS---------------KYYSLV----GTSTHMPPEVALRNNT---ACRKSDIWSLGCTIIEMA
.||.||| .|   ..                 ....     ||   | ||| ... .    .||.||||||||.||||
CKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEV-IKQEGRDGYGRKADIWSLGCTVIEMA
Kinase FNIPK-A.AA STE11-Unclassified 253-310 33 5e-12 38.97 In-house 146-234 (308) Show / Hide 
Range on Protein: 253-310
Range on HMM: 146-234/308
Sequence Identity: 33% (30 aa)

IKLIDFGLSKGCD------------------GDSKYY--------SLVGTST---HMPPEVALR--NNTACRKSDIWSLGCTIIEMAGG
.|| |||..|  .                   ...          |. ||      | |||  .  .   ||||||||||||.|||| |
CKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATG
Kinase FNIPK-A.AA STE11-Unclassified 321-358 36 4.7e-10 31.88 In-house 260-308 (308) Show / Hide 
Range on Protein: 321-358
Range on HMM: 260-308/308
Sequence Identity: 36% (18 aa)

PKIPDHLS-----------ASCKNFIQRCLTIDPNHRDDIINLISHNFI
| || |||           . ||.|...|..|||. | .   |..| ||
PQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTANQLLQHPFI
Kinase FNIPK-A.AA STE11 321-358 34 1.7e-09 30.83 In-house 260-303 (303) Show / Hide 
Range on Protein: 321-358
Range on HMM: 260-303/303
Sequence Identity: 34% (15 aa)

PKIPDHLS------ASCKNFIQRCLTIDPNHRDDIINLISHNFI
| ||.|.|      . |..|...|...||. |     |  |.||
PPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase FNIPK-A.AA Pkinase_Tyr 11-151 29 8.4e-09 30.43 Pfam 1-149 (270) Show / Hide 
Range on Protein: 11-151
Range on HMM: 1-149/270
Sequence Identity: 29% (46 aa)

WEILSQLGTGAFGRVVKAKKI-NCDGTGIIIDICAIKIIKKSVFTKN--------EIEILKQL-DHPLIVKYYGYGV--GE-IDDNIYIYMEYIDGYPVS
 ... .|| ||||.|.|..     |.|.|    .|.|..| .   ..        |..|.||| .|| ||..||  .  || .  .||| |||  .    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKI---PVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLL

SILRKQ--PKNQFPEDIISKIVIDLALILSYIHDNERKIIHRDLKCDNIMLVNDNT
. |||.  .|....   . .. .. |  ..| .  ....||||| . |... ..|.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE--SKNCIHRDLAARNCLVTENNV
Kinase FNIPK-A.AA NEK 11-31 38 0.000102 12.98 In-house 1-21 (286) Show / Hide 
Range on Protein: 11-31
Range on HMM: 1-21/286
Sequence Identity: 38% (8 aa)

WEILSQLGTGAFGRVVKAKKI
 ||. ..| |.||.| |....
YEIIKKIGQGSFGKVYKVRRK
Kinase FNIPK-A.AA NEK 294-308 73 0.000159 12.3 In-house 204-218 (286) Show / Hide 
Range on Protein: 294-308
Range on HMM: 204-218/286
Sequence Identity: 73% (11 aa)

KSDIWSLGCTIIEMA
||||||||| . ||.
KSDIWSLGCVLYEMC
Kinase FNIPK-A.AA NEK 321-358 32 0.000194 11.99 In-house 247-286 (286) Show / Hide 
Range on Protein: 321-358
Range on HMM: 247-286/286
Sequence Identity: 32% (13 aa)

PKIPDH--LSASCKNFIQRCLTIDPNHRDDIINLISHNFI
|.||.|   |   .|.|...|. || .| ..  .... ||
PPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase FNIPK-A.AA STE11 11-28 44 0.003866 7.54 In-house 1-18 (303) Show / Hide 
Range on Protein: 11-28
Range on HMM: 1-18/303
Sequence Identity: 44% (8 aa)

WEILSQLGTGAFGRVVKA
|     .|.||||.| |.
WQKGEIIGKGAFGTVYKC
Kinase FNIPK-A.AA Pkinase_Tyr 294-307 50 5.301997 0.63 Pfam 194-207 (270) Show / Hide 
Range on Protein: 294-307
Range on HMM: 194-207/270
Sequence Identity: 50% (7 aa)

KSDIWSLGCTIIEM
|||.|| | .. |.
KSDVWSFGVLMWEI
FNIP FNIPK-A.AA FNIP 403-444 36 2.2e-10 39.9 Pfam 1-46 (46) Show / Hide 
Range on Protein: 403-444
Range on HMM: 1-46/46
Sequence Identity: 36% (17 aa)

FNQT-IIPGTM-NSVKKIEFGGSFNKELL-IDSLP-SATSITFGAR
|||  ...|.  ||.|...|| .||.... |..|| | ....||  
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC
FNIP FNIPK-A.AA FNIP 375-402 30 13.893732 2.05 Pfam 17-46 (46) Show / Hide 
Range on Protein: 375-402
Range on HMM: 17-46/46
Sequence Identity: 30% (9 aa)

KIQFDDEFNEIIS-PGDL-DSVNEVVFGFD
...| |.||. |. .. | .|. .  || .
HLIFGDNFNQPIEDINVLPNSLKHLEFGYC
FNIP FNIPK-A.AA FNIP 449-491 40 6.8e-13 48.73 Pfam 2-46 (46) Show / Hide 
Range on Protein: 449-491
Range on HMM: 2-46/46
Sequence Identity: 40% (18 aa)

NKP-FAIGAIPSTCKSITFGWTYNQPFY-PGILPNSLKKLIFQEG
|.| . .| .|. .|...||. .|||.  .. ||||||.|.| . 
NQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC
FNIP FNIPK-A.AA FNIP 515-557 41 2.4e-18 67.84 Pfam 1-46 (46) Show / Hide 
Range on Protein: 515-557
Range on HMM: 1-46/46
Sequence Identity: 41% (19 aa)

YDQK-IEKGVLPSSLTILELGGEFNQPLE--GSIPDSVTSLTLGYR
..|. .|||.||.|...|..| .||||.|  ...|.|...|..|| 
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC
FNIP FNIPK-A.AA FNIP 558-601 41 6.4e-18 66.35 Pfam 1-46 (46) Show / Hide 
Range on Protein: 558-601
Range on HMM: 1-46/46
Sequence Identity: 41% (19 aa)

FNKA-LTENCIPPNCKFLKFGSNFNKDLS-PGILPSSIETLILGYC
||.. |. .|.|...| |.||.|||. .. .. ||.|...|..|||
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC
FNIP FNIPK-A.AA FNIP 494-514 59 1e-06 26.55 Pfam 1-22 (46) Show / Hide 
Range on Protein: 494-514
Range on HMM: 1-22/46
Sequence Identity: 59% (13 aa)

FNRI-LEVGSLPSSITTLILGD
||.. ||.|.||.||. ||.||
FNQPFLEKGCLPNSIKHLIFGD
FNIP FNIPK-A.AA FNIP 602-619 52 0.038191 11.03 Pfam 1-19 (46) Show / Hide 
Range on Protein: 602-619
Range on HMM: 1-19/46
Sequence Identity: 52% (10 aa)

FNKE-LVEGSLPLSITTLI
||.. |  |.|| ||. ||
FNQPFLEKGCLPNSIKHLI
FNIP FNIPK-A.AA FNIP 691-733 30 1.7e-11 43.79 Pfam 1-46 (46) Show / Hide 
Range on Protein: 691-733
Range on HMM: 1-46/46
Sequence Identity: 30% (14 aa)

FIRP-LIPRDLPSSITSVKL-YNYNYEIK-KTSIPKSVTSLQLGSR
| .| |.. .||.||.. .. .|.|..|. . ..|.|...|..|. 
FNQPFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC
FNIP FNIPK-A.AA FNIP 650-690 39 5.4e-05 21.01 Pfam 4-46 (46) Show / Hide 
Range on Protein: 650-690
Range on HMM: 4-46/46
Sequence Identity: 39% (17 aa)

P-LTPESLPESITKLTIGKNQNHVIE-FNCLPPDLQCLKYHGG
| |....||.||..|. |.| |. || .|.||. |  |. .  
PFLEKGCLPNSIKHLIFGDNFNQPIEDINVLPNSLKHLEFGYC
FNIP FNIPK-A.AA FNIP 765-789 34 0.941297 6.15 Pfam 1-28 (46) Show / Hide 
Range on Protein: 765-789
Range on HMM: 1-28/46
Sequence Identity: 34% (10 aa)

YNLK-DI---IPQTITSLIINGDNIDLPI
.| .  .   .|. |..||  ||| . ||
FNQPFLEKGCLPNSIKHLIF-GDNFNQPI