Gene IfkA (Slime mold)

IfkA

Species: Slime mold
Alias: IfkA, DdisK182, DDB0185218e
External Links: DictyBase Link ,
Annotation: Secondary Group: Other, Secondary Family: PEK, Secondary Subfamily: GCN2

Classification

Group: STE
Family: STE-Unique

Sequence

Name Sequence Type Origin Length Description Download
IfkA.AA Protein None 2388 None Fasta, JSON
IfkA.kin_dom Protein Kinase Domain None 353 None Fasta, JSON
IfkA.kin_dom2 Protein Kinase Domain None 589 None Fasta, JSON

Protein domain

Protein domains of IfkA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD IfkA.AA RWD 40-149 22 1.9e-19 73.91 Pfam 1-119 (119) Show / Hide 
Range on Protein: 40-149
Range on HMM: 1-119/119
Sequence Identity: 22% (28 aa)

DNNQSQLEEIECLKSIYRDEF-----EELPTEAVCRRFKITLIPHPTNQYQNFCAVRLYVKYSPNYP-VSLPTIE-LEKVRGLS-------DDLIGELSF
.... | .|.| |.||| |.|     ..  ||  ...|.|..    ..  ...  ..| ......||  ..|.|. ..  ..|.         |. .|  
MCQEEQEDELEALESIYPDDFEDLRGTICWTEISPWHFTIKI---DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQQLCKKLQE

LLSQKMAPGEIIIFELCQAVQEFL
.. . .  |. .|||... .||.|
YWEENCH-GMVMIFEWIEWLQENL
RWD IfkA.AA RWD 47-152 26 1.4e-15 59.04 SMART 1-128 (128) Show / Hide 
Range on Protein: 47-152
Range on HMM: 1-128/128
Sequence Identity: 26% (34 aa)

EEIECLKSIYRDEFEELPTEAVC----RRFKITLIPHPTNQY-----------QNFCAVRLYVKYSPNYPVSLPTIELEKVR-GLSDDLIGE---LSFLL
.|.|.|.|||.|.||..  ..      . ..|.. ||  . .           ...  ..| .. ..||| ..|.|.|| .. .|||. ..    .. | 
MELEALESIYPDDFECIDEDRHHWVINCCIQIHIHPHEDEMQITNYDNFYEGEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQKHLQ

SQKMAP---GEIIIFELCQAVQEFLLLY
.. .     |. .|||..|.|||||  .
EIWEENWCRGMCMIFEWVQWVQEFLSEH
Kinase IfkA.AA STE-Unique 574-795 31 1e-108 367.49 In-house 366-616 (616) Show / Hide 
Range on Protein: 574-795
Range on HMM: 366-616/616
Sequence Identity: 31% (79 aa)

QNTLYIFQEYNSTLTLQQKILSNGIG--------FEESQVKKFTYQLLLGLLYLHSQH--IPHRDFKSHNIFFNQST----SKMLLSNYGGRNIKIFDHF
||...||.||....||||.|...|..        |.|..|...|||.|.||.||||||  |.|||.|.||||..|..    .|......|.......|||
QNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHF

EKLNSLKNLNSWISSTNN---------------SINNINNINNNNNNNNNNINTTTTQNQINNEIDRREDIINLGIVVLEMLCGSDLANNQTVLIYLAQL
||.|..||.|.||...||               .|||.....................|||||..|...||..||.....|.||................
EKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEM

NLLNNQQQNQNFIQPPPLQYQLQQQYDLIKEIEQKTHPSSPISNNAKDFLS
......|..|..|...|...|..||....|..|...|...........|..
CIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase IfkA.AA STE 449-821 20 7.1e-40 138.5 In-house 33-391 (359) Show / Hide 
Range on Protein: 449-821
Range on HMM: 33-391/359
Sequence Identity: 20% (90 aa)

WKKGSCIERKSNYSVYRGVDE------DTDRK---------LICKIVNLNIDDRSSSSLTSLSNSNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNLSIDV
|.. ..| . .  .||....       .|...            |..||. .. .. .                           | . .| . .     
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-E---------------------------N-Q-EN-Q-E-----

VELKKRLIEKVKMIQKEIESMKYLG--NPYIIKYLGTNFQEG-----QNTLYIFQEYNSTLTLQQKILSN-GIGFE------------ESQVKKFTYQLL
  |... .|... |.|||. || .    |.|.||.|. |.||      ..|.|. || .  .| . | .. |.|..            |||......|.|
--LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQIL

LG-LLYLHSQHIPHRDFKSHNIFFNQSTSKMLLSNYGGRNIKI--FDHFEKLNS-----------------LKNLNSWISSTNNSINNINNINNNNNNNN
 | | ||||.|| ||| |. ||..                .|.  | .  .|..                  .. |... .          |..|... .
KGLLYYLHSHHIIHRDIKPANILL----------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP---WMAPEVIQQNGQG-R

NNINTTTTQNQINNEIDRREDIINLGIVVLEMLCGSDLANNQTVLIYLAQLNLLNNQQQ-----NQNFIQPPPLQYQLQQQYDLIKEIEQKTHPS-----
            ... |.. ||  ||....||..|     . . .  . . .  .  ||     .... .||||.  |.|    |    .    |     
------------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEM-IS-Y-G-G--SGTTYP

SPISNNAKDFLSLCFTINGNGSTNDSLEAGILLK--HPFL
.  | . |||...|....     |.   |  |||  |||.
HKWSPEFKDFINKCLQKD----PNKRPTASQLLKSEHPFI
Kinase IfkA.AA STE-Unique 504-573 29 2.6e-22 75.63 In-house 261-334 (616) Show / Hide 
Range on Protein: 504-573
Range on HMM: 261-334/616
Sequence Identity: 29% (22 aa)

NNNNNNNNNNNNNNNNNNNNNNNNNLSIDVVELKKRLIEK----VKMIQKEIESMKYLGNPYIIKYLGTNFQEG
|...........|..|..|........|.|..||......    |.||..|||.||.|....|.||.|.....|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGG
Kinase IfkA.AA Pkinase 533-638 26 6.2e-16 57.43 Pfam 31-143 (293) Show / Hide 
Range on Protein: 533-638
Range on HMM: 31-143/293
Sequence Identity: 26% (31 aa)

VVELKKRLIEKVKMIQK--EIESMKYLGNPYIIKYLGTNFQEGQNTLYIFQEYNSTL----TLQQKILS--NGIGF--EESQVKKFTYQLLLGLLYLHSQ
.......  .| .   .  ||. || |. |.|......      . .|. .||         |   ..|  .. .|  .| ..|.. ||.| || |.||.
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF-DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM

HIPHRDFKSHNIFFNQ
 | ||| |. ||....
GIIHRDLKPENILIDN
Kinase IfkA.AA NEK 559-635 35 1.5e-15 51.62 In-house 215-303 (286) Show / Hide 
Range on Protein: 559-635
Range on HMM: 215-303/286
Sequence Identity: 35% (32 aa)

NPYIIKYLGTNFQEGQNTLYIFQEYNS-TLTLQQK---ILSN---GIGFEESQVKKFTYQLLLGLLYLHSQ-----HIPHRDFKSHNIF
.|.|.||    . |. |.|.|  ||     .|.||   |  .   |  |||.|. .. .|..|.| |.|..     .| ||| |. |||
HPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIF
Kinase IfkA.AA S_TKc 449-821 15 2.2e-14 34.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 449-821
Range on HMM: 1-231/231
Sequence Identity: 15% (60 aa)

WKKGSCIERKSNYSVYRGVDEDTDRKLICKIVNLNIDDRSSSSLTSLSNSNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNLSIDVVELKKRLIEKVKMIQ
....  | . .  .||.... .|.|.  .||..                                                               ..|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------------------------------------------------EHIR

KEIESMKYLGNPYIIKYLGTNFQEGQNTLYIFQEYNST--LTLQQKILSNGIG-----FEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSHNIFFNQSTS
.||. .|  . |.|.|....      . ||.. || ..   .| . | ..| .     | | ......||....| |.||..| ||| |  ||....   
REIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---

KMLLSNYGGRNIKIFD-----HFEKLNSLKNLNSWISSTNNSINNINNINNNNNNNNNNINTTTTQN-------QINNEIDR-REDIINLGIVVLEMLCG
          .||| |     ..                                      ||            .    .. . |.  .|... |||||
----------HIKICDFGLARQL--------------------------------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCG

SDLANNQTVLIYLAQLNLLNNQQQNQNFIQPPPLQYQLQQQYDLIKEIEQKTHPSSPISNNAKDFLSLCFTINGN--GSTNDSLEAGILLK-HPFL
  .   |  ...   .                                          |  ||||.. |.. . .   .  . |... . | ||..
YPPFP-QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IfkA.AA ULK 533-637 25 2.9e-12 39.21 In-house 153-282 (329) Show / Hide 
Range on Protein: 533-637
Range on HMM: 153-282/329
Sequence Identity: 25% (33 aa)

VVELKKRLIEKVK--------MIQKEIESMKYLG--------NPYIIKYLGTNFQEGQ--NTLYIFQEYNSTLTLQQKILSNGI---------GFEESQV
.....|  ...          ....||. || |         .|.|.|..   ..| .  | .||..||    .|.| |  |.           ..|...
MIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLY--DWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEA

KKFTYQLLLGLLYLHSQHIPHRDFKSHNIFFN
..| .|.| |. .||.. | ||| |  ||  .
IQFFKQILNGFKELHKHNIIHRDIKPQNILIH
Kinase IfkA.AA CAMKL 537-657 24 3.5e-12 35.04 In-house 218-353 (297) Show / Hide 
Range on Protein: 537-657
Range on HMM: 218-353/297
Sequence Identity: 24% (36 aa)

KKRLIEKVKM------------IQKEIESMKYLG---NPYIIKYLGTNFQEGQ----NTLYIFQEYNSTLT--LQQKILSNG---IGFEESQVKKFTYQL
|.......|.            |..||. || |     | ||| . .   .      . .|.. || |     |...| ..|     ..|.. ...  |.
KIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQI

LLGLLYLHSQHIPHRDFKSHNIFFNQSTSKMLLSNYGGRNIKIFD
. .. |.||..| ||| |  || . .. .          |||| |
VSAVNYCHSHGIVHRDIKPENILLDENGNN---------NIKIID
Kinase IfkA.AA ULK 533-637 26 4.5e-11 35.6 In-house 150-275 (324) Show / Hide 
Range on Protein: 533-637
Range on HMM: 150-275/324
Sequence Identity: 26% (34 aa)

VVELKKRLIEKVK--------MIQKEIESMKYLG---NPY--IIKYLGTNFQEGQ--NTLYIFQEYNSTLTLQQKILSNGI--------GFEESQVKKFT
....||  . | .        ....||. || |    .|.  |.|..   ..| .  | .||..||    .|.| |  |.          ..|.....| 
MIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLY--DWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFF

YQLLLGLLYLHSQHIPHRDFKSHNIFFN
.|.. |. .||.. | ||| |  ||  .
KQICNGFKELHKHNIIHRDIKPQNILIH
Kinase IfkA.AA PEK 496-636 19 5e-10 30.34 In-house 546-692 (655) Show / Hide 
Range on Protein: 496-636
Range on HMM: 546-692/655
Sequence Identity: 19% (36 aa)

SNSNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNLSIDVVELKKRLIEKVKMIQKEIESMKYLGNPYIIKYLGTNFQEGQNTLYIFQEYNSTLTLQQKILS
.|.| |.|..............||.|||.|..    ....                                    . . .||| .|| .  || . | .
DNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ------------------------------------YQCHYLYIQMEYCEKKTLRDWIDN

NG-------------------------------------------IGFEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSHNIFF
||                                            . .. |..... |.| || |.||| . ||| | .|||.
NGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFL
Kinase IfkA.AA GCN2 576-636 40 6.5e-09 26.92 In-house 364-424 (511) Show / Hide 
Range on Protein: 576-636
Range on HMM: 364-424/511
Sequence Identity: 40% (25 aa)

TLYIFQEYNSTLTLQQKILSNGIGFEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSHNIFF
.||| .|| .  || |.| ..| . .. .... . |.| || |.||| . ||| |  |||.
YLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFL
Kinase IfkA.AA HRI 602-635 41 0.000282 9.96 In-house 432-465 (613) Show / Hide 
Range on Protein: 602-635
Range on HMM: 432-465/613
Sequence Identity: 41% (14 aa)

ESQVKKFTYQLLLGLLYLHSQHIPHRDFKSHNIF
|  ..|.  |.. |. | |   | ||| |  |||
EKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIF
Kinase IfkA.AA PEK 611-636 50 0.00116 6.74 In-house 835-860 (758) Show / Hide 
Range on Protein: 611-636
Range on HMM: 835-860/758
Sequence Identity: 50% (13 aa)

QLLLGLLYLHSQHIPHRDFKSHNIFF
|.. |. |.||  . |||.|  ||||
QICEGVNYIHSKGMIHRDLKPSNIFF
Kinase IfkA.AA ULK 758-801 18 0.087835 2.18 In-house 249-308 (324) Show / Hide 
Range on Protein: 758-801
Range on HMM: 249-308/324
Sequence Identity: 18% (11 aa)

QPPPLQYQLQQQY----DLIKE-------IEQ--KTHPS----SPISNNAKDFLSLCFTIN
..|.  .  ..||    .||.        |..    .|.     .||.. ||... .....
KYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYD
Kinase IfkA.AA ULK 758-801 18 0.149544 1.29 In-house 253-313 (329) Show / Hide 
Range on Protein: 758-801
Range on HMM: 253-313/329
Sequence Identity: 18% (11 aa)

QPP----PLQYQLQQQYDLIKE---------IEQKTHP----SSPISNNAKDFLSLCFTIN
.||    . ...||....||.           ..   |    . .||.. ||... .....
KPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYD
Kinase IfkA.AA STE-Unique 1025-1612 68 0.0 1416.74 In-house 1-616 (616) Show / Hide 
Range on Protein: 1025-1612
Range on HMM: 1-616/616
Sequence Identity: 68% (423 aa)

EEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASEDW
....|||.|.||.|....|| ||...|||.|..|...|.|||||.|....|......||||..|.||..|....||||||||||||||||||||||||||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGGCDSFQSLEEGNEDLSGDLETDASEDW

FMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
FMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTN

KNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEATD
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEATD

DEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGG---------I
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.....|.||||...||...|...|.         .
DEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKEQNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLF

AEEEAFRLLRQIVEGLNHIHSQQ--IIHRDLKPANIFIDNEQ-----NVKIGDFGLATSGAPVSKSDDLNSSTSNTANNINLSSSTNSTAQQTPMWDLND
.|.|......||.|||...|||.  ||||||||.|||.....     .|||.|||.||...|.....|.||..|||..|||..||||||||||||||||.
PETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNI

ENLSMTGGVGTPFYCCPEILEKN---TKHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILR--DLRDNLKFPPG-------FESTKPDQTQIIRSLLSRD
.|..|....|||.|.|||.....   ...|.||||..|||...|.||........|.....  .........|.       .....|.|.|.|...|.|.
NNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERN

PTQRPSTKQLLESGLL
|..|||..|||....|
PHHRPSAHQLLHHFWL
Kinase IfkA.AA GCN2 1285-1612 33 9.3e-164 550.33 In-house 80-511 (511) Show / Hide 
Range on Protein: 1285-1612
Range on HMM: 80-511/511
Sequence Identity: 33% (148 aa)

NNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEATDDED-------IINNSGS-------------------------------------------
...||..| |||||||.||..|||...|........|....|.       ...|...                                           
TDTNNDDDTNNNYHSDDESECFSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYC

--------------------------FDENENDDDDEEDDDDEYDEEDDD------------------YETFDFQDKSRVVSNNSKLSTSSSRKKPPKET
                          .| ||...............||..                  ......|||........| .......|.|||.
HSDCEFDDDVFDIDWDIESNNVRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEV

HTLYIQMEYCSKKTLKTLIDN-VGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVS-------KSDDLNSSTS
|.||||||||..|||...||| . .....|..|..|||.||||.||||..|||||||.|||.|...|||||||||||.....|       |.....||..
HYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHW

NTANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSL-GIIFFEMCFQ-FQTQMERSNILRDLRDNLKFPPGFES
. .|.|......|....|...||..||....||.||||||.|||..   ..||..||||||| |||||||... |.|||||..||..|| ...||..|..
AIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ---KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-SCEFPQDFDK

----TKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
    ...||...||..|..||..|||..|||....|
KVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase IfkA.AA PEK 1255-1612 20 5.3e-128 431.54 In-house 1-655 (655) Show / Hide 
Range on Protein: 1255-1612
Range on HMM: 1-655/655
Sequence Identity: 20% (132 aa)

EQSSSDSENGEN-GMKSRIIENASDSYSDDDNNNNNNNDNN------------NNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNS---------
 .  .    |.  |.  . .. ... |      . |.....            ...|....   ..   ...  |  .|..  .|. ....         
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

-------------------------------------------------------------GSFDENENDDDDEEDDDD---------------------
                                                             ....|.......|..|..                     
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

--------------------------------------------------------------------------EYDEEDDDYETFDFQD----------
                                                                          ||...||..|..|.|.          
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

------------------------KSRVVSNNSKLSTSSSRKKPPKET-------HTLYIQMEYCSKKTLKTLIDNVG----------------------
                        .|.  ..... .|.....|....        |.||||||||.||||...||| |                      
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIM

----------------------GIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN-----VKIGDFGLATSGAPVSKSDDLN--------
                      ........|..|||.||||.||||..|||||||.|||.|....     ||||||||||. ...|. ...|        
NQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQ-SQKNYNQQDQSY

--SSTSNTANNINLSSSTNSTAQQTPMWDLND-----------ENLSMTGGVGTPFYCCPEILEKN---TKHYGTKVDMYSLGIIFFEMCFQFQTQM-ER
  ..  . ....| ... ..| |.|.|| .|.           |....||||||..|..|| |...   ..||..||||||||||||||...|.|.| ||
WKYVANDNCQWWNTNQQNSPTGQDTHMW-SNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMER

SNILRDLRD------NLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
...|.||||      .  .|. |... |.| ..|. .||.||.||||..|.|.....
VKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase IfkA.AA STE 1024-1612 12 2.2e-66 226.87 In-house 1-359 (359) Show / Hide 
Range on Protein: 1024-1612
Range on HMM: 1-359/359
Sequence Identity: 12% (88 aa)

FEEIEMIGKGGFGVVVKSRNKLDC---------------RYYAIKKIKTKGYTDSNQE------------PLTNKLLREVTTLSRLH--HQFVVRYYQAW
.| ||.||||.||.|.| .|. .|               ...|||... .  . .. |               ...|.|. ......  |...|.|| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

IEKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSS
. .. .                                                                                              
FKEGHN----------------------------------------------------------------------------------------------

LLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLY
                                                                                             |. ..|.
--------------------------------------------------------------------------------------------HKNDDELW

IQMEYCSKKTLKTLIDNVGGIA--------------EEEAFRLLRQIVEG-LNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNS
| |||..  .|  .|....|.               |..  . .|||..| |...||..|||||.|||||..     ||. |||.... .. . .. . |
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S

STSNTANNINLSSSTNSTAQQTPMWDLNDENLSMTGG------VGTPFYCCPEILEKNT----KHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILRDLR
     .| |.                    . . |..      |||| .  ||....|.    |.|.||.|..|||.   ||.      .. ..    ..
-----NN-II--------------------DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFM

DNLK---------------FPPGFEST--------------------KPDQTQIIRSLLSRDPTQRPSTKQLLE--SGLL
 . .                || ....                     |.  . |.  | .|| .||...|||.     .
IPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase IfkA.AA PEK 1373-1612 24 2.4e-55 182.77 In-house 396-758 (758) Show / Hide 
Range on Protein: 1373-1612
Range on HMM: 396-758/758
Sequence Identity: 24% (88 aa)

NNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLL---RQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN-------------
|| ..... . .. ..   ..||||..| |.||| .. |   . . ...  |    ||.||.| |||  .|||||||.|||   .               
NNNNNKNWKMHPTGNC--IYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSS

-----------VKIGDFGLAT-----------------------------------SGAP-------------------------------------VSK
           .|||||||.|                                   .  |                                     || 
FEENSDGGHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTITTISVSP

SDDLNSSTSNTANNINLS-------SSTNSTAQQTPMWDLNDENL-----SMTGGVGTPFYCCPEILEKN--------TK------HYGTKVDMYSLGII
|  . .||. ..    .        ..| .||. . |    .  .       |..|||. | .|| .  .        |       .|  ||| ||||.|
SKPSSISTPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLI

FFEMCFQ-FQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
|||. .  | |||||  ...||| |...|. | .  |..   |  ..| .|..||...|.... . 
FFELIHPGFSTQMERIRTMCDLR-NGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF
Kinase IfkA.AA S_TKc 1024-1612 12 1.5e-54 188.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 1024-1612
Range on HMM: 1-231/231
Sequence Identity: 12% (79 aa)

FEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASED
.| .. ||||.||.| | |.| . |..|||.||                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

WFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNT
                                                                                                    
----------------------------------------------------------------------------------------------------

NKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEAT
                                                                                                    
----------------------------------------------------------------------------------------------------

DDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSK--KTLKTLIDNVGG------I
                             .      .     .   .|       .           . ||. ||||.    .|...|.. |.      .
-----------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

AEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNTANNINLSSSTNSTAQQTPMWDLNDENLSMTG
 | .| ....||...|...||..||||||||.||..|.  ..||.|||||.                                               | 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------------------------TT

GVGTPFYCCPEILEKNTKHYGT-KVDMYSLGIIFFEMCF---QFQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLE---
 .|||.|. ||.|     .||. |.|..|.|.|..||.     |.   .   ... ..             |.  ..|| .| .||..||.  ..|.   
FCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

----SGLL
       .
DIKCHPWF
Kinase IfkA.AA CAMKL 1024-1547 12 2.6e-50 158.69 In-house 1-225 (297) Show / Hide 
Range on Protein: 1024-1547
Range on HMM: 1-225/297
Sequence Identity: 12% (68 aa)

FEEIEMIGKGGFGVVVKSRN-KLDCRYYAIKKIKTKGYT-DSNQEPL---------TNKLLREVTTLSRLH---HQFVVRYYQAWIEKSCDSFQSLEEGN
.. .. .|||.||.|   .. ..  . .||| |. |. . | . .             .. ||.  ...|.   |. ... |. .  ...          
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEH----------

EDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKS
                                                                                                    
----------------------------------------------------------------------------------------------------

TSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGS
                                                                                                    
----------------------------------------------------------------------------------------------------

ISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPK-ETHTLYIQMEYCSKKT--LK
                                                                              . ||  .|. |||||     | 
------------------------------------------------------------------------------DIETKKIYLVMEYCSGGEMDLF

TLIDNVGG----IAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQ--NVKIGDFGLATS---GAPVSKSDDLNSSTSNTANNINLSSSTNST
  |.. |.    . |.|| |. ||||...|..||. |.|||.|| || .|. .  |.|| |||...    .                             
DYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-----------------------------

AQQTPMWDLNDENLSMTGGVGTPFYCCPEILEK-NTKHYGTKVDMYSLGII
         . ..  ..   |.| |..|||... |....| |||. |.|.|
--------IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVI
Kinase IfkA.AA Pkinase 1393-1612 26 7.5e-49 173.41 Pfam 75-293 (293) Show / Hide 
Range on Protein: 1393-1612
Range on HMM: 75-293/293
Sequence Identity: 26% (69 aa)

LYIQMEYCSKK----TLKTLID--NVGGI--AEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNV----KIGDFGLATSGAPVSKSDDLNSS
.|. |||| .      |...|   . |..   |.|. . ..||..||...||. ||||||||.||.|||. ..    ||.|||||               
IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------

TSNTANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQ---FQTQ------MERSNILRDLRDN
                          .  |  ||. .|||.|. ||..    ..||.||||.|.|.|..||..    |. .       ..  | |...  
--------------------------Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPP

LKFPPGFESTK------------------PDQTQIIRSLLSRDPTQRPSTKQLLESGLL
|.|.   ....                  ..  ..|...| .||..||. .|.|..  .
LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase IfkA.AA ULK 1096-1612 10 1e-33 115.13 In-house 122-329 (329) Show / Hide 
Range on Protein: 1096-1612
Range on HMM: 122-329/329
Sequence Identity: 10% (58 aa)

EKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSL
|                                                                                                   
E---------------------------------------------------------------------------------------------------

LSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYI
                                                                                                    
----------------------------------------------------------------------------------------------------

QMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN------------VKIGDFGLATSGAPVSKSDDLNSSTSN
               . . . |.||   ..||..|. ..|...|||||.||.|| |.| |             .||.|||.| .    ....... ...|
---------------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVN

TANNINLSSSTNSTAQQTPMWDLNDENLSMTGGV---GTPFYCCPEILEKN--TKHYG-TKVDMYSLGIIFFEMCF-Q--FQTQMERSNILRDLRDNLK-
                         |           ||| | .|.||...   |.|.  |.|..|||.||.|| . .  |...  .. .|. ...... 
-------------------------E-------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINN

----------FPPGFE------STKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
          .|. |.         |.  ..|| .| .|...| |  .|..  ..
PPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase IfkA.AA ULK 1096-1612 10 2e-33 115.95 In-house 118-324 (324) Show / Hide 
Range on Protein: 1096-1612
Range on HMM: 118-324/324
Sequence Identity: 10% (59 aa)

EKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSL
|                                                                                                   
E---------------------------------------------------------------------------------------------------

LSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYI
                                                                                                    
----------------------------------------------------------------------------------------------------

QMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN------------VKIGDFGLATSGAPVSKSDDLNSSTSN
               . . . |.||   ..||..|. ..|...|||||.||.|| | | |             .||.|||.| .    ....... .. |
---------------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVN

TANNINLSSSTNSTAQQTPMWDLNDENLSMTGGV---GTPFYCCPEILEKN--TKHYG-TKVDMYSLGIIFFEMCF-Q--FQTQMERSNILR--DLRDN-
                         |           ||| | .|.||...   |.|.  |.|..|||.||.|| . .  |...  .. .|.  .| .| 
-------------------------E-------KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNG

-----------LKFPP--GFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
           ..||.        |.  ..|| .| .|...| |  ....  ..
KEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase IfkA.AA PEK 1024-1251 17 1.6e-31 106.51 In-house 1-343 (655) Show / Hide 
Range on Protein: 1024-1251
Range on HMM: 1-343/655
Sequence Identity: 17% (64 aa)

FEEIEMIGKGGF-GVVVKSRNKLDCRYYAIKKIKTKGYTDS-----------NQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIE-------KSCDSFQS
||||. .||||| |.|.| .|||| .|||||.|| .  ...           .  ..  | ||||.||.||.|. .|||..||||        . |.. .
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

LEEGNEDLSGD----------------------------------------------------LETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVG
|.. ... .|.                                                    .| . ... . .|. .| .                  
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPN-----------------

GVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLL--------------------------------------------------------
           ..| .|  .  ..|.|..   ..|.....||                                                          
-----------IENQFSINF-GTENENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNW

--------------SNNKSKILNTSKSTSTNTSTSTS----TSNTNKNKKISKKKKSKLSPLMKPKNKKNKNN
              ....||....  ..... ...|.    ..| | | . . ...|. .  |. ....|||.
EQYEYSDQDDEHEQNDCQSKQCDSKNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNK
Kinase IfkA.AA GCN2 1024-1234 20 5.4e-29 98.41 In-house 1-274 (511) Show / Hide 
Range on Protein: 1024-1234
Range on HMM: 1-274/511
Sequence Identity: 20% (59 aa)

FEEIEMIGKGGFGVVVK-SRNKLDCRYYAIKKIKTKGYTDSNQEPLTNK--LLREVTTLSRLHHQFVVRYYQAWIE-----------------------K
||||. .|||||| ||| .||..| |||||||.. .    ..|. |. |   .|||..|.||||| ||||||||||                       .
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPIN----WKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDD

SCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNS---------------------------------------NVGGVNNTA
 ...| .  | .  ..   | . .|.   .|..|.|.  .. . ..   . .                                       .|  ... .
ESECFSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWDI

GGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSS------SSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKK
.. .  .   .. .    . |  . . ......      ...  .. ...    .|..| . ... . ...|| .......|
ESNNVRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQ----NKKKSQQQDKMCQNQHKNKVHYKCMNCK
Kinase IfkA.AA HRI 1024-1096 53 5.7e-25 84.56 In-house 1-69 (613) Show / Hide 
Range on Protein: 1024-1096
Range on HMM: 1-69/613
Sequence Identity: 53% (39 aa)

FEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIE
||. | |||||.| | | |.|||  .||||||| |. |         |..||| .|  | |  .||| |||||
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCS----CMKMQREVKVLACLQHHNIVRYHQAWIE
Kinase IfkA.AA PEK 1024-1096 44 6e-24 75.84 In-house 1-76 (758) Show / Hide 
Range on Protein: 1024-1096
Range on HMM: 1-76/758
Sequence Identity: 44% (34 aa)

FEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKG---YTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIE
||.|. .|.|||||| .. ||.|  .||||.|  .        | |   .| .||| ||  | |   |||. || |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase IfkA.AA NEK 1388-1465 31 8.8e-22 73.77 In-house 76-170 (286) Show / Hide 
Range on Protein: 1388-1465
Range on HMM: 76-170/286
Sequence Identity: 31% (30 aa)

KETHTLYIQMEYCS-KKTLKTL---IDNVG----GIAEEEAFRLLRQIVEGLNHIHSQ-----QIIHRDLKPANIFIDNEQN----VKIGDFGLA
.. ..|.| ||||  . .|  .   | .       . ||.  . . |.. .|...|..      |.|||.||.|||.... |    |||||||..
EQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase IfkA.AA HRI 1514-1612 40 2.2e-19 64.41 In-house 518-613 (613) Show / Hide 
Range on Protein: 1514-1612
Range on HMM: 518-613/613
Sequence Identity: 40% (40 aa)

TGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
| .|||  |  || |.  .  |  | ||||.|.| ||.   | | ||| ..|  .|   . |       | |   |  |  |   ||||  ||| | | 
TSRVGTCTYASPEQLDGSQ--YDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTG-QIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase IfkA.AA HRI 1417-1465 49 1.5e-16 54.24 In-house 432-484 (613) Show / Hide 
Range on Protein: 1417-1465
Range on HMM: 432-484/613
Sequence Identity: 49% (26 aa)

EEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQN----VKIGDFGLA
| .. ..  |||||.. ||   |.|||.|| |||     .    |||||||||
EKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLA
Kinase IfkA.AA NEK 1024-1099 32 1.1e-14 48.46 In-house 1-80 (286) Show / Hide 
Range on Protein: 1024-1099
Range on HMM: 1-80/286
Sequence Identity: 32% (27 aa)

FEEIEMIGKGGFGVVVKSRNKLDCRY-----YAIKKIKTKGYTDSNQEPLTNKLL-REVTTLSRLHHQFVVRYYQAWIEKS--C
.|.|..||.| ||.| | | | | .      |..|||.... .. ...    ...  ||  |..|.|. .|.|| ..||.   |
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQ----NAQNNEVRILKQLKHPNIVKYYDSFIEEQNNC
Kinase IfkA.AA ULK 1024-1091 25 4.8e-13 41.97 In-house 1-84 (329) Show / Hide 
Range on Protein: 1024-1091
Range on HMM: 1-84/329
Sequence Identity: 25% (21 aa)

FEEIEMIGKGGFGVVVKSRNKLD----CRYYAIKKIKTKGYTDSNQEP----LTNKLLREVTTLSRLH----HQF----VVRYY
.. ....||| ||.| | ||| .      ..|.|.|  .    .|.|     . . | .|. .. .|.    |..    .|..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLY
Kinase IfkA.AA ULK 1024-1091 27 5.1e-13 42.58 In-house 1-81 (324) Show / Hide 
Range on Protein: 1024-1091
Range on HMM: 1-81/324
Sequence Identity: 27% (22 aa)

FEEIEMIGKGGFG-VVVKSRNKLD---CRYYAIKKIKTKGYTDSNQEP----LTNKLLREVTTLSRLH---HQF--VVRYY
.. ....||| || .| | ||| .     |.|.|.|  |.  ....|     . ..| .|. ..  |.   |..  .|..|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLY
Kinase IfkA.AA TyrKc 1024-1612 8 3.1e-12 -24.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 1024-1612
Range on HMM: 1-280/280
Sequence Identity: 8% (54 aa)

FEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRL--HHQFVVRYYQAWIEK--------------------SCDS
 . ....| | ||.|.| . |   .  |.|..|               ..||   ...|  ||. .|| | . ...                    ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKS
.    ...                                                                                            
YLRKHRPK--------------------------------------------------------------------------------------------

KILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDN
                                                                                                    
----------------------------------------------------------------------------------------------------

ESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCS
                                                                                                    
----------------------------------------------------------------------------------------------------

KKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPV-SKSDDLNSSTSNTANNINLSSSTNSTAQQ
             .  ..      || .| ...||...|||||   |. ..... |||.||||.  .    ..                           
-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--------------------------

TPMWDLNDENLSMTGGVGTP-----FYCCPEILEKNTKHYGTKVDMYSLGIIFFEM---CFQFQTQ-----MERSNILRDLRDNLKFPPGFE--------
      ...  ..... |.        . || .  |.. . || | .| |.  .|.   . |         |. . .......    |.  .        
-----ESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVC

STKPDQTQIIRSLLSRDPTQRPSTKQLLESGLL
 ..   . |...   .|| .||. ...    ..
CPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase IfkA.AA Pkinase 1024-1098 26 7.1e-12 43.06 Pfam 1-73 (293) Show / Hide 
Range on Protein: 1024-1098
Range on HMM: 1-73/293
Sequence Identity: 26% (20 aa)

FEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKS
.. .. ||.|.||.| | ..| ... .|.|.|| ..  .. .. ...   .|.  . ||.| ..||.| .. .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKD
Kinase IfkA.AA NEK 1587-1612 42 7.5e-08 24.16 In-house 261-286 (286) Show / Hide 
Range on Protein: 1587-1612
Range on HMM: 261-286/286
Sequence Identity: 42% (11 aa)

QIIRSLLSRDPTQRPSTKQLLESGLL
..|...| .||.||||..|.||  ..
NLISQMLQKDPEQRPSCNQILEMPFI
Kinase IfkA.AA Pkinase_Tyr 1138-1465 5 1e-06 23.35 Pfam 102-158 (270) Show / Hide 
Range on Protein: 1138-1465
Range on HMM: 102-158/270
Sequence Identity: 5% (19 aa)

RDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKL
|                                                                                                   
R---------------------------------------------------------------------------------------------------

SPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDE
                                                                                                    
----------------------------------------------------------------------------------------------------

NENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQ
                                                                        .. . .  ..     .|| .|... .|.
------------------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESK

QIIHRDLKPANIFIDNEQNVKIGDFGLA
..|||||   |. ....  |||.|||||
NCIHRDLAARNCLVTENNVVKICDFGLA
Kinase IfkA.AA NEK 1517-1552 47 3e-06 18.41 In-house 185-218 (286) Show / Hide 
Range on Protein: 1517-1552
Range on HMM: 185-218/286
Sequence Identity: 47% (17 aa)

VGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMC
|||| | .||...   | |. |.|. ||| . .|||
VGTPYYMSPEVCQ--NKPYNNKSDIWSLGCVLYEMC
Kinase IfkA.AA Pkinase_Tyr 1024-1091 22 9.5e-05 16.71 Pfam 101-170 (270) Show / Hide 
Range on Protein: 1024-1091
Range on HMM: 101-170/270
Sequence Identity: 22% (18 aa)

FEEIEMIGKGGFGVVVKSRNKLDCRYY----------AIKKIKTKGYTDS-NQEPLTNKLLREVTTLSRL-HHQFVVRYY
 . ....|.| ||.|.|      ....          |.|..   |.... |   .  ...||. ... | ||. .||.|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLY
Kinase IfkA.AA CAMKL 1587-1612 26 0.000132 10.45 In-house 272-297 (297) Show / Hide 
Range on Protein: 1587-1612
Range on HMM: 272-297/297
Sequence Identity: 26% (7 aa)

QIIRSLLSRDPTQRPSTKQLLESGLL
..||..| ..|..||. .|...   .
DLIRKMLQVNPEKRPTIHQIMNHPWM
HGTP_anticodon IfkA.AA HGTP_anticodon 2057-2149 15 1e-06 27.81 Pfam 1-95 (95) Show / Hide 
Range on Protein: 2057-2149
Range on HMM: 1-95/95
Sequence Identity: 15% (15 aa)

EVFVCSLGS---SLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENGIPWVVILREKAFQIGKLKVKQIETRQERTVARKDLVDFFLKSR
.|.|  ..     .. . . ....|. |||....  .. ..    . .. . |||..... ..  . |...|.  .|..  |... ..|.. .|..
QVVVIPVNEKAEKHMDYAQKLYQELRDAGIRVEVDDRRNERIGKKFRDWDLIGIPYMIVVGDRELENGTVTVRDRDTGEQYTMSIDEFVEW-IKEL